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Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments

Published: 01 June 2013 Publication History

Abstract

Neural synchronization is considered as an important mechanism for information processing. In addition, based on recent neurophysiologic findings, it is believed that astrocytes regulate the synaptic transmission of neuronal networks. Therefore, the present study focused on determining the functional contribution of astrocytes in neuronal synchrony using both computer simulations and extracellular field potential recordings. For computer simulations, as a first step, a minimal network model is constructed by connecting two Morris-Lecar neuronal models. In this minimal model, astrocyte-neuron interactions are considered in a functional-based procedure. Next, the minimal network is extended and a biologically plausible neuronal population model is developed which considers functional outcome of astrocyte-neuron interactions too. The employed structure is based on the physiological and anatomical network properties of the hippocampal CA1 area. Utilizing these two different levels of modeling, it is demonstrated that astrocytes are able to change the threshold value of transition from synchronous to asynchronous behavior among neurons. In this way, variations in the interaction between astrocytes and neurons lead to the emergence of synchronous/asynchronous patterns in neural responses. Furthermore, population spikes are recorded from CA1 pyramidal neurons in rat hippocampal slices to validate the modeling results. It demonstrates that astrocytes play a primary role in neuronal firing synchronicity and synaptic coordination. These results may offer a new insight into understanding the mechanism by which astrocytes contribute to stabilizing neural activities.

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  • (2021)Astrocytic control in in vitro and simulated neuron-astrocyte networksProceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication10.1145/3477206.3477458(1-7)Online publication date: 7-Sep-2021
  • (2020)Spatiotemporal model of tripartite synapse with perinodal astrocytic processJournal of Computational Neuroscience10.1007/s10827-019-00734-448:1(1-20)Online publication date: 1-Feb-2020
  • (2019)Empowering the impaired astrocytes in the tripartite synapses to improve accuracy of pattern recognitionSoft Computing - A Fusion of Foundations, Methodologies and Applications10.1007/s00500-018-03671-z23:17(8307-8319)Online publication date: 1-Sep-2019
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  1. Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments

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      Published In

      cover image Journal of Computational Neuroscience
      Journal of Computational Neuroscience  Volume 34, Issue 3
      June 2013
      176 pages

      Publisher

      Springer-Verlag

      Berlin, Heidelberg

      Publication History

      Published: 01 June 2013

      Author Tags

      1. Astrocyte
      2. Functional modeling
      3. Neural population model
      4. Neural synchrony

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      • (2021)Astrocytic control in in vitro and simulated neuron-astrocyte networksProceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication10.1145/3477206.3477458(1-7)Online publication date: 7-Sep-2021
      • (2020)Spatiotemporal model of tripartite synapse with perinodal astrocytic processJournal of Computational Neuroscience10.1007/s10827-019-00734-448:1(1-20)Online publication date: 1-Feb-2020
      • (2019)Empowering the impaired astrocytes in the tripartite synapses to improve accuracy of pattern recognitionSoft Computing - A Fusion of Foundations, Methodologies and Applications10.1007/s00500-018-03671-z23:17(8307-8319)Online publication date: 1-Sep-2019
      • (2018)Digital configuration of astrocyte stimulation as a new technique to strengthen the impaired astrocytes in the tripartite synapse networkJournal of Computational Electronics10.1007/s10825-018-1207-817:3(1382-1398)Online publication date: 1-Sep-2018
      • (2018)Circuit modelling of 2-AG indirect pathway via astrocyte as a catalyst for synaptic self repairAnalog Integrated Circuits and Signal Processing10.1007/s10470-018-1106-895:1(127-139)Online publication date: 1-Apr-2018
      • (2017)Autaptic Modulation of Electrical Activity in a Network of Neuron-Coupled AstrocyteComplexity10.1155/2017/46316022017Online publication date: 5-Jun-2017
      • (2017)On the role of astrocyte analog circuit in neural frequency adaptationNeural Computing and Applications10.1007/s00521-015-2112-828:5(1109-1121)Online publication date: 1-May-2017
      • (2017)The role of neuron---glia interactions in the emergence of ultra-slow oscillationsBiological Cybernetics10.1007/s00422-017-0740-z111:5-6(459-472)Online publication date: 1-Dec-2017
      • (2016)Analog implementation of neuron---astrocyte interaction in tripartite synapseJournal of Computational Electronics10.1007/s10825-015-0727-815:1(311-323)Online publication date: 1-Mar-2016
      • (2015)A bio-inspired stimulator to desynchronize epileptic cortical population modelsNeural Networks10.1016/j.neunet.2015.02.00567:C(74-83)Online publication date: 1-Jul-2015
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