article

Analog implementation of neuron---astrocyte interaction in tripartite synapse

Authors:

Mahnaz Ranjbar,

Mahmood AmiriAuthors Info & Claims

Journal of Computational Electronics, Volume 15, Issue 1

Pages 311 - 323

https://doi.org/10.1007/s10825-015-0727-8

Published: 01 March 2016 Publication History

Abstract

Neural synchronization is considered as an important mechanism for information processing. In addition, recent neurophysiological findings approve that astrocytes adjust the synaptic transmission of neural networks. Motivated by these observations, we develop an analog neuromorphic circuit to implement the tripartite synapse. To model the dynamics of the intracellular calcium waves produced by the astrocytes, we utilize a simplified model which considers the key physiological pathways of neuron---astrocyte communication. Next, using an astrocyte analog circuit, a tripartite synapse circuit is constructed by connecting two modified differential pair integrator neurons and one astrocyte circuits. It is designed and simulated using HSPICE simulator in $$0.35\,\upmu \hbox {m}$$0.35μm standard CMOS technology. The simulation results of the tripartite synapse circuit, demonstrate that astrocyte circuit plays a crucial role in neuronal firing synchronicity from hardware point of view. In this way, astrocyte---neuron collaboration leads to the emergence of synchronous/asynchronous patterns in neural responses. Therefore, it makes possible to have a new circuit in which astrocyte actively contributes in neural information processing.

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Cited By

Tir SShalchian MMoezzi M(2020)Design of bioinspired tripartite synapse analog integrated circuit in 65-nm CMOS TechnologyJournal of Computational Electronics10.1007/s10825-020-01514-519:3(1313-1328)Online publication date: 18-May-2020
https://dl.acm.org/doi/10.1007/s10825-020-01514-5
Karimi GRanjbar MAmirian MShahim-aeen A(2018)A neuromorphic real-time VLSI design of Ca2+ dynamic in an astrocyteNeurocomputing10.1016/j.neucom.2017.06.071272:C(197-203)Online publication date: 10-Jan-2018
https://dl.acm.org/doi/10.1016/j.neucom.2017.06.071
Ranjbar MAmiri M(2017)On the role of astrocyte analog circuit in neural frequency adaptationNeural Computing and Applications10.1007/s00521-015-2112-828:5(1109-1121)Online publication date: 1-May-2017
https://dl.acm.org/doi/10.1007/s00521-015-2112-8

Analog implementation of neuron---astrocyte interaction in tripartite synapse
1. Applied computing
  1. Life and medical sciences
2. Computing methodologies
  1. Modeling and simulation
    1. Model development and analysis

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cover image Journal of Computational Electronics

Journal of Computational Electronics Volume 15, Issue 1

March 2016

346 pages

ISSN:1569-8025

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Copyright © Copyright © 2016 Springer Science+Business Media New York.

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Springer-Verlag

Berlin, Heidelberg

Publication History

Published: 01 March 2016

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Cited By

Tir SShalchian MMoezzi M(2020)Design of bioinspired tripartite synapse analog integrated circuit in 65-nm CMOS TechnologyJournal of Computational Electronics10.1007/s10825-020-01514-519:3(1313-1328)Online publication date: 18-May-2020
https://dl.acm.org/doi/10.1007/s10825-020-01514-5
Karimi GRanjbar MAmirian MShahim-aeen A(2018)A neuromorphic real-time VLSI design of Ca2+ dynamic in an astrocyteNeurocomputing10.1016/j.neucom.2017.06.071272:C(197-203)Online publication date: 10-Jan-2018
https://dl.acm.org/doi/10.1016/j.neucom.2017.06.071
Ranjbar MAmiri M(2017)On the role of astrocyte analog circuit in neural frequency adaptationNeural Computing and Applications10.1007/s00521-015-2112-828:5(1109-1121)Online publication date: 1-May-2017
https://dl.acm.org/doi/10.1007/s00521-015-2112-8

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