article

Digital configuration of astrocyte stimulation as a new technique to strengthen the impaired astrocytes in the tripartite synapse network

Authors:

Soheila Nazari,

Mahyar JanahmadiAuthors Info & Claims

Journal of Computational Electronics, Volume 17, Issue 3

Pages 1382 - 1398

https://doi.org/10.1007/s10825-018-1207-8

Published: 01 September 2018 Publication History

Abstract

Recent findings have proven that glial cells and particularly astrocytes are responsible for some important roles in the central nervous system. Due to laboratory technical difficulties in the examination of astrocyte's functions in information processing of neural systems, computational modeling is a suitable approach. In this paper, the process of synchronization in neuronal fluctuations in view of the role of astrocytes was investigated. Then, due to the destructive effects of hyper-synchronization, based on the dynamical model of the astrocyte biophysical model, a new bio-inspired stimulator was introduced. Many patients suffer from astrocyte-related epilepsy; however, drugs that affect astrocytes are not available currently. Therefore, here a new concept of "stimulating the impaired astrocytes to compensate for their malfunction" was introduced. This new mechanism was proposed to stimulate the impaired astrocytes in a population of tripartite synapses for restoration of the normal neural oscillations. Finally, a closed-loop interaction between the proposed stimulating method and a population of tripartite synapses was implemented on a Zynq system-on-chip (SoC) platform from Xilinx, because the Zynq SoC is an appropriate control platform in the implementation of the proposed architecture. Stimulator hardware design was optimized to attain a very low power consumption platform in real-time application. Results of hardware and software simulations confirmed that hyper-synchronization of a neuronal population caused by astrocytes dysfunction could be compensated by the bio-inspired stimulator.

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Cited By

Haghiri SAhmadi A(2021)An investigation on neuron–astrocyte interaction system: network behavior and synchronizationAnalog Integrated Circuits and Signal Processing10.1007/s10470-020-01735-5108:3(569-576)Online publication date: 1-Sep-2021
https://dl.acm.org/doi/10.1007/s10470-020-01735-5

Digital configuration of astrocyte stimulation as a new technique to strengthen the impaired astrocytes in the tripartite synapse network
1. Computing methodologies
  1. Modeling and simulation
    1. Model development and analysis

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cover image Journal of Computational Electronics

Journal of Computational Electronics Volume 17, Issue 3

September 2018

518 pages

ISSN:1569-8025

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Copyright © Copyright © 2018 Springer Science+Business Media, LLC, part of Springer Nature.

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Springer-Verlag

Berlin, Heidelberg

Publication History

Published: 01 September 2018

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Cited By

Haghiri SAhmadi A(2021)An investigation on neuron–astrocyte interaction system: network behavior and synchronizationAnalog Integrated Circuits and Signal Processing10.1007/s10470-020-01735-5108:3(569-576)Online publication date: 1-Sep-2021
https://dl.acm.org/doi/10.1007/s10470-020-01735-5

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