research-article

A bio-inspired stimulator to desynchronize epileptic cortical population models

Authors:

Mahmood AmiriAuthors Info & Claims

Neural Networks, Volume 67, Issue C

Pages 74 - 83

https://doi.org/10.1016/j.neunet.2015.02.005

Published: 01 July 2015 Publication History

Abstract

Pathophysiologic neural synchronization is a hallmark of several neurological disorders such as epilepsy. In addition, based on established neurophysiologic findings, astrocytes dynamically regulate the synaptic transmission and have key roles in stabilizing neural synchronization. Therefore, in the present study, based on the dynamic model of astrocyte, a digital bio-inspired stimulator is proposed to avoid the hyper-synchronous seizure-like activities in a cortical population model. The complete digital circuit of the close loop system that is the bio-inspired stimulator and the cortical population model are implemented in hardware on the ZedBoard development kit. Based on the results of MATLAB simulations, hardware synthesis and FPGA implementation, it is demonstrated that the digital bio-inspired stimulator can effectively prevent the occurrence of spontaneous paroxysmal episodes with a demand-controlled characteristic. In this way, the designed digital stimulator successfully maintains the normal ongoing activity.

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Cited By

Ranjbar MAmiri M(2018)Analog implementation of neuron---astrocyte interaction in tripartite synapseJournal of Computational Electronics10.1007/s10825-015-0727-815:1(311-323)Online publication date: 21-Dec-2018
https://dl.acm.org/doi/10.1007/s10825-015-0727-8
Nazari SFaez KAmiri M(2018)A multiplier-less digital design of a bio-inspired stimulator to suppress synchronized regime in a large-scale, sparsely connected neural networkNeural Computing and Applications10.1007/s00521-015-2071-028:2(375-390)Online publication date: 27-Dec-2018
https://dl.acm.org/doi/10.1007/s00521-015-2071-0
Ranjbar MAmiri M(2017)On the role of astrocyte analog circuit in neural frequency adaptationNeural Computing and Applications10.1007/s00521-015-2112-828:5(1109-1121)Online publication date: 1-May-2017
https://dl.acm.org/doi/10.1007/s00521-015-2112-8

A bio-inspired stimulator to desynchronize epileptic cortical population models
1. Applied computing
  1. Life and medical sciences
2. Computing methodologies
  1. Modeling and simulation
    1. Model development and analysis

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cover image Neural Networks

Neural Networks Volume 67, Issue C

July 2015

156 pages

ISSN:0893-6080

Issue’s Table of Contents

Copyright © Elsevier Ltd.

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Elsevier Science Ltd.

United Kingdom

Publication History

Published: 01 July 2015

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Cited By

Ranjbar MAmiri M(2018)Analog implementation of neuron---astrocyte interaction in tripartite synapseJournal of Computational Electronics10.1007/s10825-015-0727-815:1(311-323)Online publication date: 21-Dec-2018
https://dl.acm.org/doi/10.1007/s10825-015-0727-8
Nazari SFaez KAmiri M(2018)A multiplier-less digital design of a bio-inspired stimulator to suppress synchronized regime in a large-scale, sparsely connected neural networkNeural Computing and Applications10.1007/s00521-015-2071-028:2(375-390)Online publication date: 27-Dec-2018
https://dl.acm.org/doi/10.1007/s00521-015-2071-0
Ranjbar MAmiri M(2017)On the role of astrocyte analog circuit in neural frequency adaptationNeural Computing and Applications10.1007/s00521-015-2112-828:5(1109-1121)Online publication date: 1-May-2017
https://dl.acm.org/doi/10.1007/s00521-015-2112-8

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