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A bio-inspired stimulator to desynchronize epileptic cortical population models

Published: 01 July 2015 Publication History

Abstract

Pathophysiologic neural synchronization is a hallmark of several neurological disorders such as epilepsy. In addition, based on established neurophysiologic findings, astrocytes dynamically regulate the synaptic transmission and have key roles in stabilizing neural synchronization. Therefore, in the present study, based on the dynamic model of astrocyte, a digital bio-inspired stimulator is proposed to avoid the hyper-synchronous seizure-like activities in a cortical population model. The complete digital circuit of the close loop system that is the bio-inspired stimulator and the cortical population model are implemented in hardware on the ZedBoard development kit. Based on the results of MATLAB simulations, hardware synthesis and FPGA implementation, it is demonstrated that the digital bio-inspired stimulator can effectively prevent the occurrence of spontaneous paroxysmal episodes with a demand-controlled characteristic. In this way, the designed digital stimulator successfully maintains the normal ongoing activity.

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Cited By

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  • (2018)Analog implementation of neuron---astrocyte interaction in tripartite synapseJournal of Computational Electronics10.1007/s10825-015-0727-815:1(311-323)Online publication date: 21-Dec-2018
  • (2018)A multiplier-less digital design of a bio-inspired stimulator to suppress synchronized regime in a large-scale, sparsely connected neural networkNeural Computing and Applications10.1007/s00521-015-2071-028:2(375-390)Online publication date: 27-Dec-2018
  • (2017)On the role of astrocyte analog circuit in neural frequency adaptationNeural Computing and Applications10.1007/s00521-015-2112-828:5(1109-1121)Online publication date: 1-May-2017
  1. A bio-inspired stimulator to desynchronize epileptic cortical population models

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      Published In

      cover image Neural Networks
      Neural Networks  Volume 67, Issue C
      July 2015
      156 pages

      Publisher

      Elsevier Science Ltd.

      United Kingdom

      Publication History

      Published: 01 July 2015

      Author Tags

      1. DBS
      2. Epilepsy
      3. Hardware implementation
      4. Neural population model
      5. Synchronization

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      View all
      • (2018)Analog implementation of neuron---astrocyte interaction in tripartite synapseJournal of Computational Electronics10.1007/s10825-015-0727-815:1(311-323)Online publication date: 21-Dec-2018
      • (2018)A multiplier-less digital design of a bio-inspired stimulator to suppress synchronized regime in a large-scale, sparsely connected neural networkNeural Computing and Applications10.1007/s00521-015-2071-028:2(375-390)Online publication date: 27-Dec-2018
      • (2017)On the role of astrocyte analog circuit in neural frequency adaptationNeural Computing and Applications10.1007/s00521-015-2112-828:5(1109-1121)Online publication date: 1-May-2017

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