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The role of neuron---glia interactions in the emergence of ultra-slow oscillations

Published: 01 December 2017 Publication History

Abstract

Ultra-slow cortical oscillatory activity of 1---100 mHz has been recorded in human by electroencephalography and in dissociated cultures of cortical rat neurons, but the underlying mechanisms remain to be elucidated. This study presents a computational model of ultra-slow oscillatory activity based on the interaction between neurons and astrocytes. We predict that the frequency of these oscillations closely depends on activation of astrocytes in the network, which is reflected by oscillations of their intracellular calcium concentrations with periods between tens of seconds and minutes. An increase of intracellular calcium in astrocytes triggers the release of adenosine triphosphate from these cells which may alter transmission at nearby synapses by increasing or decreasing neurotransmitter release. These results provide theoretical support for the emerging awareness of astrocytes as active players in the regulation of neural activity and identify neuron---astrocyte interactions as a potential primary mechanism for the emergence of ultra-slow cortical oscillations.

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  • (2019)Spatiotemporal model of tripartite synapse with perinodal astrocytic processJournal of Computational Neuroscience10.1007/s10827-019-00734-448:1(1-20)Online publication date: 3-Dec-2019
  1. The role of neuron---glia interactions in the emergence of ultra-slow oscillations

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      Published In

      cover image Biological Cybernetics
      Biological Cybernetics  Volume 111, Issue 5-6
      December 2017
      137 pages

      Publisher

      Springer-Verlag

      Berlin, Heidelberg

      Publication History

      Published: 01 December 2017

      Author Tags

      1. Cortical culture
      2. Neuron---glia interactions
      3. Ultra-slow oscillations

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      • (2019)Spatiotemporal model of tripartite synapse with perinodal astrocytic processJournal of Computational Neuroscience10.1007/s10827-019-00734-448:1(1-20)Online publication date: 3-Dec-2019

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