NO315609B1 - Substituerte 1,2,3,4-tetrahydronaftalenderivater, farmasöytisk formuleringinneholdende slike, fremgangsmåte for deres fremstilling, oganvendelse derav - Google Patents
Substituerte 1,2,3,4-tetrahydronaftalenderivater, farmasöytisk formuleringinneholdende slike, fremgangsmåte for deres fremstilling, oganvendelse derav Download PDFInfo
- Publication number
- NO315609B1 NO315609B1 NO20000356A NO20000356A NO315609B1 NO 315609 B1 NO315609 B1 NO 315609B1 NO 20000356 A NO20000356 A NO 20000356A NO 20000356 A NO20000356 A NO 20000356A NO 315609 B1 NO315609 B1 NO 315609B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- formula
- tetrahydro
- methylpiperazin
- mmol
- Prior art date
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- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- DEEFVBOHUQYLLZ-XMMPIXPASA-N tert-butyl 4-[(7R)-4-methyl-7-[(4-morpholin-4-ylbenzoyl)amino]-5,6,7,8-tetrahydronaphthalen-1-yl]piperazine-1-carboxylate Chemical compound CC1=C2CC[C@H](CC2=C(C=C1)N1CCN(CC1)C(=O)OC(C)(C)C)NC(C1=CC=C(C=C1)N1CCOCC1)=O DEEFVBOHUQYLLZ-XMMPIXPASA-N 0.000 description 1
- GGGBHGKCSXURHO-JOCHJYFZSA-N tert-butyl 4-[(7r)-4-bromo-7-[(4-morpholin-4-ylbenzoyl)amino]-5,6,7,8-tetrahydronaphthalen-1-yl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=C(Br)C2=C1C[C@H](NC(=O)C=1C=CC(=CC=1)N1CCOCC1)CC2 GGGBHGKCSXURHO-JOCHJYFZSA-N 0.000 description 1
- DSNAAEGYBPDGNZ-CYBMUJFWSA-N tert-butyl 4-[(7r)-7-amino-4-bromo-5,6,7,8-tetrahydronaphthalen-1-yl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=C(Br)C2=C1C[C@H](N)CC2 DSNAAEGYBPDGNZ-CYBMUJFWSA-N 0.000 description 1
- KNODWTCYFYFCEU-OAHLLOKOSA-N tert-butyl 4-[(7r)-7-amino-4-methyl-5,6,7,8-tetrahydronaphthalen-1-yl]piperazine-1-carboxylate Chemical compound C([C@@H](N)CC=12)CC=1C(C)=CC=C2N1CCN(C(=O)OC(C)(C)C)CC1 KNODWTCYFYFCEU-OAHLLOKOSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- PNQBEPDZQUOCNY-UHFFFAOYSA-N trifluoroacetyl chloride Chemical compound FC(F)(F)C(Cl)=O PNQBEPDZQUOCNY-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702799A SE9702799D0 (sv) | 1997-07-25 | 1997-07-25 | New compounds |
PCT/SE1998/001390 WO1999005134A1 (en) | 1997-07-25 | 1998-07-15 | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20000356D0 NO20000356D0 (no) | 2000-01-24 |
NO20000356L NO20000356L (no) | 2000-03-27 |
NO315609B1 true NO315609B1 (no) | 2003-09-29 |
Family
ID=20407828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20000356A NO315609B1 (no) | 1997-07-25 | 2000-01-24 | Substituerte 1,2,3,4-tetrahydronaftalenderivater, farmasöytisk formuleringinneholdende slike, fremgangsmåte for deres fremstilling, oganvendelse derav |
Country Status (37)
Country | Link |
---|---|
US (3) | US6313118B1 (da) |
EP (1) | EP1000048B1 (da) |
JP (1) | JP3895923B2 (da) |
KR (1) | KR20010022171A (da) |
CN (1) | CN1270585A (da) |
AR (2) | AR013370A1 (da) |
AT (1) | ATE228510T1 (da) |
AU (1) | AU739569B2 (da) |
BR (1) | BR9811042A (da) |
CA (1) | CA2296518A1 (da) |
DE (1) | DE69809755T2 (da) |
DK (1) | DK1000048T3 (da) |
DZ (1) | DZ2569A1 (da) |
EE (1) | EE04238B1 (da) |
ES (1) | ES2187983T3 (da) |
HK (1) | HK1025963A1 (da) |
HR (1) | HRP980404B1 (da) |
HU (1) | HUP0004334A3 (da) |
ID (1) | ID24583A (da) |
IL (1) | IL134108A0 (da) |
IS (1) | IS5358A (da) |
MA (1) | MA26521A1 (da) |
NO (1) | NO315609B1 (da) |
NZ (1) | NZ502384A (da) |
PL (1) | PL338563A1 (da) |
PT (1) | PT1000048E (da) |
RU (1) | RU2194696C2 (da) |
SE (1) | SE9702799D0 (da) |
SI (1) | SI1000048T1 (da) |
SK (1) | SK283918B6 (da) |
TN (1) | TNSN98141A1 (da) |
TR (1) | TR200000229T2 (da) |
TW (1) | TW438781B (da) |
UA (1) | UA69389C2 (da) |
WO (1) | WO1999005134A1 (da) |
YU (1) | YU2300A (da) |
ZA (1) | ZA986588B (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
SE9900190D0 (sv) * | 1999-01-22 | 1999-01-22 | Astra Ab | New compounds |
SE9904724D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
SE0002729D0 (sv) * | 2000-07-20 | 2000-07-20 | Astrazeneca Ab | Novel compound form |
AR034206A1 (es) * | 2001-02-16 | 2004-02-04 | Solvay Pharm Bv | Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos |
SE0102856D0 (sv) * | 2001-08-27 | 2001-08-27 | Astrazeneca Ab | A new method |
SE0103644D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
US7101881B2 (en) * | 2003-06-11 | 2006-09-05 | Pfizer Inc | Tetrahydroquinolines |
SE0301798D0 (sv) * | 2003-06-19 | 2003-06-19 | Astrazeneca Ab | New use IV |
SE0301794D0 (sv) * | 2003-06-19 | 2003-06-19 | Astrazeneca Ab | New use III |
WO2005113527A1 (en) * | 2004-05-21 | 2005-12-01 | Pfizer Products Inc. | Tetrahydronaphthyl- piperazines as 5-ht1b antagonists, inverse agonists and partial agonists |
US20080033050A1 (en) * | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
WO2008130321A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or 5-heterocyclyl-chromane or 8-heterocyclyl-tetrahydronaphtalene derivatives for the treatment of pain |
WO2008130319A2 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel n-tetrahydronaphtalene or n-chromane carboxamide derivatives for the treatment of pain |
SA08290245B1 (ar) | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
WO2008130323A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 8-piperazine-tetrahydronaphtalene derivatives for the treatment of pain |
WO2008130322A1 (en) * | 2007-04-23 | 2008-10-30 | Astrazeneca Ab | Novel 5-heterocyclyl-chromane derivatives for the treatment of pain |
EP2098511A1 (en) | 2008-03-07 | 2009-09-09 | Solvias AG | Process for preparing compounds containing a hydronaphtalene structure with an unsymmetrically substituted benzene ring |
MY157518A (en) | 2008-06-20 | 2016-06-15 | Astrazeneca Ab | Dibenzothiazepine derivatives and use thereof |
GB201002563D0 (en) | 2010-02-15 | 2010-03-31 | Cambridge Entpr Ltd | Compounds |
GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
WO2014202999A1 (en) | 2013-06-21 | 2014-12-24 | Takeda Cambridge Limited | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors |
GB201314286D0 (en) | 2013-08-08 | 2013-09-25 | Takeda Pharmaceutical | Therapeutic Compounds |
GB201318222D0 (en) | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
TW201613864A (en) | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
GB201619514D0 (en) | 2016-11-18 | 2017-01-04 | Takeda Pharmaceuticals Co | Novel compounds |
JP2021138648A (ja) | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3919624A1 (de) | 1989-06-15 | 1990-12-20 | Boehringer Ingelheim Kg | Neue 2,5-diaminotetraline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
GB9119932D0 (en) | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
GB9119920D0 (en) | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
ES2162792T3 (es) | 1991-09-18 | 2002-01-16 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d. |
DK148392D0 (da) | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
GB2273930A (en) | 1992-12-30 | 1994-07-06 | Glaxo Group Ltd | Benzanilide derivatives |
CA2158457C (en) | 1993-03-16 | 2001-04-17 | Bertrand Leo Chenard | Naphthalene derivatives |
JPH09503773A (ja) | 1993-10-19 | 1997-04-15 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5ht−1dレセプター拮抗剤用のベンズアニリド誘導体 |
SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
-
1997
- 1997-07-25 SE SE9702799A patent/SE9702799D0/xx unknown
-
1998
- 1998-07-13 TW TW087111330A patent/TW438781B/zh not_active IP Right Cessation
- 1998-07-15 CA CA002296518A patent/CA2296518A1/en not_active Abandoned
- 1998-07-15 AT AT98934104T patent/ATE228510T1/de not_active IP Right Cessation
- 1998-07-15 WO PCT/SE1998/001390 patent/WO1999005134A1/en not_active Application Discontinuation
- 1998-07-15 DK DK98934104T patent/DK1000048T3/da active
- 1998-07-15 HU HU0004334A patent/HUP0004334A3/hu unknown
- 1998-07-15 EP EP98934104A patent/EP1000048B1/en not_active Expired - Lifetime
- 1998-07-15 SK SK1883-99A patent/SK283918B6/sk unknown
- 1998-07-15 BR BR9811042-0A patent/BR9811042A/pt not_active IP Right Cessation
- 1998-07-15 YU YU2300A patent/YU2300A/sh unknown
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- 1998-07-15 UA UA2000021064A patent/UA69389C2/uk unknown
- 1998-07-15 ES ES98934104T patent/ES2187983T3/es not_active Expired - Lifetime
- 1998-07-15 EE EEP200000041A patent/EE04238B1/xx not_active IP Right Cessation
- 1998-07-15 SI SI9830343T patent/SI1000048T1/xx unknown
- 1998-07-15 DE DE69809755T patent/DE69809755T2/de not_active Expired - Fee Related
- 1998-07-15 US US09/171,577 patent/US6313118B1/en not_active Expired - Fee Related
- 1998-07-15 CN CN98809246A patent/CN1270585A/zh active Pending
- 1998-07-15 PT PT98934104T patent/PT1000048E/pt unknown
- 1998-07-15 KR KR1020007000743A patent/KR20010022171A/ko not_active Application Discontinuation
- 1998-07-15 RU RU2000104802/04A patent/RU2194696C2/ru not_active IP Right Cessation
- 1998-07-15 IL IL13410898A patent/IL134108A0/xx unknown
- 1998-07-15 MA MA25169A patent/MA26521A1/fr unknown
- 1998-07-15 TR TR2000/00229T patent/TR200000229T2/xx unknown
- 1998-07-15 AU AU83703/98A patent/AU739569B2/en not_active Ceased
- 1998-07-15 JP JP2000504131A patent/JP3895923B2/ja not_active Expired - Fee Related
- 1998-07-15 PL PL98338563A patent/PL338563A1/xx unknown
- 1998-07-15 NZ NZ502384A patent/NZ502384A/en unknown
- 1998-07-22 DZ DZ980179A patent/DZ2569A1/xx active
- 1998-07-23 HR HR980404A patent/HRP980404B1/xx not_active IP Right Cessation
- 1998-07-23 TN TNTNSN98141A patent/TNSN98141A1/fr unknown
- 1998-07-23 ZA ZA986588A patent/ZA986588B/xx unknown
- 1998-07-24 AR ARP980103667A patent/AR013370A1/es unknown
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2000
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- 2000-01-24 NO NO20000356A patent/NO315609B1/no not_active IP Right Cessation
- 2000-08-17 HK HK00105178A patent/HK1025963A1/xx not_active IP Right Cessation
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2001
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2004
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