IL163752A0 - Use of epothilones in the treatment of brain diseases associated with proliferative processes - Google Patents
Use of epothilones in the treatment of brain diseases associated with proliferative processesInfo
- Publication number
- IL163752A0 IL163752A0 IL16375203A IL16375203A IL163752A0 IL 163752 A0 IL163752 A0 IL 163752A0 IL 16375203 A IL16375203 A IL 16375203A IL 16375203 A IL16375203 A IL 16375203A IL 163752 A0 IL163752 A0 IL 163752A0
- Authority
- IL
- Israel
- Prior art keywords
- epothilones
- treatment
- diseases associated
- brain diseases
- proliferative processes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36106202P | 2002-03-01 | 2002-03-01 | |
EP02004745A EP1340498A1 (fr) | 2002-03-01 | 2002-03-01 | Utilisation d'épothilones dans le traitement de maladies du cerveau associées aux processus de prolifération |
PCT/EP2003/002085 WO2003074053A1 (fr) | 2002-03-01 | 2003-02-28 | Utilisation d'epothilones pour le traitement de maladies du cerveau a caractere proliferatif |
Publications (1)
Publication Number | Publication Date |
---|---|
IL163752A0 true IL163752A0 (en) | 2005-12-18 |
Family
ID=27675676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16375203A IL163752A0 (en) | 2002-03-01 | 2003-02-28 | Use of epothilones in the treatment of brain diseases associated with proliferative processes |
Country Status (23)
Country | Link |
---|---|
US (1) | US20040019088A1 (fr) |
EP (2) | EP1340498A1 (fr) |
JP (1) | JP2005525360A (fr) |
KR (1) | KR20040095244A (fr) |
CN (1) | CN100473381C (fr) |
AR (1) | AR038712A1 (fr) |
AU (1) | AU2003215618B2 (fr) |
BR (1) | BR0308154A (fr) |
CA (1) | CA2477403A1 (fr) |
CR (1) | CR7444A (fr) |
EC (1) | ECSP045340A (fr) |
HK (1) | HK1079998A1 (fr) |
HR (1) | HRP20040892A2 (fr) |
IL (1) | IL163752A0 (fr) |
MX (1) | MXPA04008450A (fr) |
NO (1) | NO20044175L (fr) |
NZ (1) | NZ546617A (fr) |
PL (1) | PL370768A1 (fr) |
RU (1) | RU2351330C2 (fr) |
UA (1) | UA83798C2 (fr) |
WO (1) | WO2003074053A1 (fr) |
YU (1) | YU76404A (fr) |
ZA (1) | ZA200407905B (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0977563B1 (fr) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthese d'epothilones, intermediaires utilises dans leur synthese, analogues et utilisations de celles-ci |
ATE368036T1 (de) * | 1997-08-09 | 2007-08-15 | Bayer Schering Pharma Ag | Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung |
KR20010094763A (ko) * | 1999-02-11 | 2001-11-01 | 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만 | 에포틸론 유도체, 그 제조방법 및 제약적 용도 |
AU772750C (en) * | 1999-04-30 | 2005-02-24 | Schering Aktiengesellschaft | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations |
ATE450534T1 (de) | 2002-08-23 | 2009-12-15 | Sloan Kettering Inst Cancer | Synthese von epothilonen, zwischenprodukte davon, analoga und ihre verwendung |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
DE10331004A1 (de) * | 2003-07-03 | 2005-02-24 | Schering Ag | Verfahren für die Herstellung von C1-C15-Fragmenten von Epothilonen und deren Derivaten |
EP1559447A1 (fr) | 2004-01-30 | 2005-08-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Utilisation d'epothilone pour le traitement de defauts de connectivité neuronale comme par exemple la schizophrenie et l'autisme |
US20060069136A1 (en) * | 2004-09-24 | 2006-03-30 | Ulrich Klar | Use of Epothilones in the treatment of bone metastasis |
US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
EP1674098A1 (fr) * | 2004-12-23 | 2006-06-28 | Schering Aktiengesellschaft | Formulations parenterales stables et tolérables des substances de haut réactivité ayant une solubilité basse ou inexistante dans l'eau |
EP1700596A1 (fr) * | 2005-03-09 | 2006-09-13 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. | Utilisation de composés stabilisant les microtubules pour le traitement des lesions axonales du SNC |
DE102007016046A1 (de) * | 2007-03-30 | 2008-10-23 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von Epothilonderivaten durch selektive katalytische Epoxidierung |
SI2276485T1 (sl) * | 2008-04-24 | 2014-10-30 | Bristol-Myers Squibb Company | Uporaba epotilona D pri zdravljenju Tau- povezanih bolezni, vključno z Alzheimerjevo boleznijo |
US9764038B2 (en) | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
WO2014009426A2 (fr) | 2012-07-13 | 2014-01-16 | Innate Pharma | Criblage d'anticorps conjugués |
EP2916872B1 (fr) | 2012-11-09 | 2019-02-27 | Innate Pharma | Etiquettes de reconnaissance pour la conjugaison à médiation par la tgase |
WO2014140300A1 (fr) | 2013-03-15 | 2014-09-18 | Innate Pharma | Conjugaison d'anticorps en phase solide médiée par la tgase |
EP3010547B1 (fr) | 2013-06-20 | 2021-04-21 | Innate Pharma | Conjugaison enzymatique de polypeptides |
JP6744212B2 (ja) | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | ポリペプチドの酵素的結合 |
WO2019092148A1 (fr) | 2017-11-10 | 2019-05-16 | Innate Pharma | Anticorps avec des résidus de glutamine fonctionnalisés |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0833828T3 (da) * | 1995-06-09 | 2003-03-17 | Novartis Ag | Rapamycinderivater |
US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US6515016B2 (en) * | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
HUP0004326A3 (en) * | 1997-02-18 | 2003-07-28 | Canji Inc San Diego | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
GB9801231D0 (en) * | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
ATE368036T1 (de) * | 1997-08-09 | 2007-08-15 | Bayer Schering Pharma Ag | Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung |
KR100574454B1 (ko) * | 1997-12-04 | 2006-04-27 | 브리스톨-마이어즈 스퀴브 컴페니 | 옥시라닐 에포틸론을 환원시켜 올레핀계 에포틸론을 제조하는 방법 |
US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
WO1999067253A2 (fr) * | 1998-06-22 | 1999-12-29 | Novartis Ag | Desmethylepothilones |
YU59001A (sh) * | 1999-02-18 | 2005-07-19 | Schering Ag. | 16-halogen-epotilon-derivati, postupak za njihovo dobijanje i njihova farmaceutska primena |
PE20010116A1 (es) * | 1999-04-30 | 2001-02-15 | Schering Ag | Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion |
EP1229934B1 (fr) * | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques |
DE10020517A1 (de) * | 2000-04-19 | 2001-10-25 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
WO2001092255A2 (fr) * | 2000-05-26 | 2001-12-06 | Kosan Biosciences, Inc. | Derives d'epothilone, procedes de production et methodes d'utilisation |
GB0013643D0 (en) * | 2000-05-31 | 2000-07-26 | Unilever Plc | Targeted moieties for use in bleach catalysts |
MXPA03010909A (es) * | 2001-06-01 | 2004-02-17 | Bristol Myers Squibb Co | Derivados de epotilona. |
-
2002
- 2002-03-01 EP EP02004745A patent/EP1340498A1/fr not_active Withdrawn
-
2003
- 2003-02-28 BR BR0308154-0A patent/BR0308154A/pt not_active Withdrawn
- 2003-02-28 KR KR10-2004-7013549A patent/KR20040095244A/ko not_active Application Discontinuation
- 2003-02-28 AU AU2003215618A patent/AU2003215618B2/en not_active Expired - Fee Related
- 2003-02-28 CA CA002477403A patent/CA2477403A1/fr not_active Abandoned
- 2003-02-28 IL IL16375203A patent/IL163752A0/xx unknown
- 2003-02-28 UA UA20040907817A patent/UA83798C2/ru unknown
- 2003-02-28 RU RU2004129325/15A patent/RU2351330C2/ru active
- 2003-02-28 WO PCT/EP2003/002085 patent/WO2003074053A1/fr active Application Filing
- 2003-02-28 YU YU76404A patent/YU76404A/sh unknown
- 2003-02-28 JP JP2003572570A patent/JP2005525360A/ja active Pending
- 2003-02-28 PL PL03370768A patent/PL370768A1/xx not_active Application Discontinuation
- 2003-02-28 US US10/375,043 patent/US20040019088A1/en not_active Abandoned
- 2003-02-28 NZ NZ546617A patent/NZ546617A/en unknown
- 2003-02-28 CN CNB038097613A patent/CN100473381C/zh not_active Expired - Fee Related
- 2003-02-28 EP EP03743360A patent/EP1480643A1/fr not_active Withdrawn
- 2003-02-28 MX MXPA04008450A patent/MXPA04008450A/es not_active Application Discontinuation
- 2003-03-03 AR ARP030100696A patent/AR038712A1/es unknown
-
2004
- 2004-09-01 CR CR7444A patent/CR7444A/es not_active Application Discontinuation
- 2004-09-28 HR HRP20040892 patent/HRP20040892A2/hr not_active Application Discontinuation
- 2004-09-30 NO NO20044175A patent/NO20044175L/no not_active Application Discontinuation
- 2004-09-30 EC EC2004005340A patent/ECSP045340A/es unknown
- 2004-09-30 ZA ZA200407905A patent/ZA200407905B/en unknown
-
2006
- 2006-01-04 HK HK06100157.3A patent/HK1079998A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CR7444A (es) | 2005-10-05 |
RU2004129325A (ru) | 2005-07-10 |
YU76404A (sh) | 2006-08-17 |
NZ546617A (en) | 2007-12-21 |
BR0308154A (pt) | 2005-01-04 |
EP1480643A1 (fr) | 2004-12-01 |
EP1340498A1 (fr) | 2003-09-03 |
HK1079998A1 (zh) | 2006-04-21 |
UA83798C2 (ru) | 2008-08-26 |
CA2477403A1 (fr) | 2003-09-12 |
WO2003074053A1 (fr) | 2003-09-12 |
ECSP045340A (es) | 2004-11-26 |
NO20044175L (no) | 2004-12-01 |
AR038712A1 (es) | 2005-01-26 |
KR20040095244A (ko) | 2004-11-12 |
ZA200407905B (en) | 2006-04-26 |
MXPA04008450A (es) | 2005-07-13 |
CN1649587A (zh) | 2005-08-03 |
RU2351330C2 (ru) | 2009-04-10 |
PL370768A1 (en) | 2005-05-30 |
JP2005525360A (ja) | 2005-08-25 |
HRP20040892A2 (en) | 2004-12-31 |
US20040019088A1 (en) | 2004-01-29 |
CN100473381C (zh) | 2009-04-01 |
AU2003215618B2 (en) | 2009-06-04 |
AU2003215618A1 (en) | 2003-09-16 |
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