FR2775187B1 - Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo - Google Patents
Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivoInfo
- Publication number
- FR2775187B1 FR2775187B1 FR9901903A FR9901903A FR2775187B1 FR 2775187 B1 FR2775187 B1 FR 2775187B1 FR 9901903 A FR9901903 A FR 9901903A FR 9901903 A FR9901903 A FR 9901903A FR 2775187 B1 FR2775187 B1 FR 2775187B1
- Authority
- FR
- France
- Prior art keywords
- epothilone
- antiproliferative
- manufacture
- composition
- pharmaceutical preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9803905.0A GB9803905D0 (en) | 1998-02-25 | 1998-02-25 | Organic compounds |
GBGB9803907.6A GB9803907D0 (en) | 1998-02-25 | 1998-02-25 | Organic compounds |
GBGB9805937.1A GB9805937D0 (en) | 1998-03-19 | 1998-03-19 | Organic compounds |
GBGB9805936.3A GB9805936D0 (en) | 1998-03-19 | 1998-03-19 | Organic compounds |
US09/233,993 US6302838B1 (en) | 1998-02-25 | 1999-01-19 | Cancer treatment with epothilones |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2775187A1 FR2775187A1 (fr) | 1999-08-27 |
FR2775187B1 true FR2775187B1 (fr) | 2003-02-21 |
Family
ID=27517450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9901903A Expired - Fee Related FR2775187B1 (fr) | 1998-02-25 | 1999-02-16 | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
Country Status (10)
Country | Link |
---|---|
US (4) | US6635666B2 (fr) |
EP (1) | EP1056453B1 (fr) |
JP (1) | JP2002504511A (fr) |
AU (1) | AU755944B2 (fr) |
BE (1) | BE1011980A5 (fr) |
CA (1) | CA2319752A1 (fr) |
FR (1) | FR2775187B1 (fr) |
IT (1) | ITMI990375A1 (fr) |
NZ (1) | NZ506187A (fr) |
WO (1) | WO1999043320A1 (fr) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT873341E (pt) | 1995-11-17 | 2004-02-27 | Biotechnolog Forschung Mbh Gbf | Derivados de epotilona preparacao e utilizacao |
DK0941227T5 (da) | 1996-11-18 | 2009-10-05 | Biotechnolog Forschung Gmbh | Epothilon D, dens fremstilling samt dens anvendelse som cytostatisk middel og som plantebeskyttelsesmiddel |
EP0977563B1 (fr) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthese d'epothilones, intermediaires utilises dans leur synthese, analogues et utilisations de celles-ci |
US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
US6498257B1 (en) | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
US6399638B1 (en) | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
AU768220B2 (en) | 1998-11-20 | 2003-12-04 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
CA2366697A1 (fr) * | 1999-02-26 | 2000-08-31 | Larry Helson | Regime de traitement pour les cancers hormonodependants |
AU3606600A (en) * | 1999-02-26 | 2000-09-14 | Napro Biotherapeutics, Inc. | Treatment regimen for prostate cancer |
US20050042275A1 (en) * | 1999-08-04 | 2005-02-24 | Jean-Claude Sonntag | Epothilone compositions |
US6414015B1 (en) | 2000-01-28 | 2002-07-02 | Utah State University | Laulimalide microtubule stabilizing agents |
US6518421B1 (en) * | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
US6593115B2 (en) | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
UA75365C2 (en) | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
BR0206511A (pt) | 2001-01-25 | 2003-10-21 | Bristol Myeres Squibb Company | Formulação parenteral para análogos de epotilona |
CN100341505C (zh) * | 2001-01-25 | 2007-10-10 | 布里斯托尔-迈尔斯斯奎布公司 | 用于治疗癌症的埃博霉素类似物的给药方法 |
NZ526871A (en) | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
MXPA03006412A (es) * | 2001-01-25 | 2003-10-15 | Bristol Myers Squibb Co | Metodos para administrar analogos de epotilona para tratamiento de cancer. |
WO2002066038A1 (fr) | 2001-02-20 | 2002-08-29 | Bristol-Myers Squibb Company | Traitement de tumeurs refractaires a l'aide de derives d'epothilone |
RU2003128312A (ru) | 2001-02-20 | 2005-02-10 | Бристол-Маерс Сквибб Компани (Us) | Производные эпотилона, используемые для лечения резистентных опухлей |
US7312237B2 (en) | 2001-03-14 | 2007-12-25 | Bristol-Myers Squibb Co. | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases |
CA2449077A1 (fr) | 2001-06-01 | 2002-12-12 | Gregory D. Vite | Derives d'epothilone |
AU2008203233B2 (en) * | 2001-07-19 | 2010-04-29 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
TWI315982B (en) | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
TW200408407A (en) * | 2001-11-30 | 2004-06-01 | Dana Farber Cancer Inst Inc | Methods and compositions for modulating the immune system and uses thereof |
TWI287986B (en) * | 2001-12-13 | 2007-10-11 | Novartis Ag | Use of Epothilones for the treatment of the carcinoid syndrome |
JP5384777B2 (ja) * | 2001-12-18 | 2014-01-08 | 有限会社大長企画 | 強筋肉剤、抗炎症剤 |
NZ533940A (en) * | 2002-01-14 | 2007-06-29 | Novartis Ag | Combinations comprising epothilones and anti-metabolites |
EP1340498A1 (fr) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Utilisation d'épothilones dans le traitement de maladies du cerveau associées aux processus de prolifération |
AU2003218107A1 (en) | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
TW200403994A (en) | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
DE10217254A1 (de) * | 2002-04-15 | 2003-10-23 | Proteosys Ag | Verwendung von Substanzen zur Behandlung von Tumoren |
TW200400191A (en) | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
WO2003105828A1 (fr) | 2002-06-14 | 2003-12-24 | Bristol-Myers Squibb Company | Combinaison d'analogues d'epothilone et agents chimiotherapeutiques utiles dans le traitement des maladies proliferatives |
ES2336937T3 (es) * | 2002-08-23 | 2010-04-19 | Sloan-Kettering Institute For Cancer Research | Sintesis de epotilonas, sus intermedios, analogos y usos. |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
EP2280014B1 (fr) | 2002-09-23 | 2013-10-23 | Bristol-Myers Squibb Company | Procèdes de préparation, d'isolation et de purification d'épothilone B |
EP1553939A1 (fr) * | 2002-10-11 | 2005-07-20 | Dana-Farber Cancer Institute, Inc. | Derives epothilone pour le traitement du myelome multiple |
BR0317150A (pt) * | 2002-12-09 | 2005-11-01 | Novartis Ag | Estabilizadores de microtúbulos em stents para o tratamento de estenose |
US20040146632A1 (en) * | 2003-01-23 | 2004-07-29 | Cristina Sayman | Effective multi-component penetrating and flavoring marinade |
US20060205795A1 (en) * | 2003-06-27 | 2006-09-14 | David Parkinson | Cancer treatment with epothilones |
JP2007504259A (ja) * | 2003-09-02 | 2007-03-01 | ノバルティス アクチエンゲゼルシャフト | エポチロンでの癌処置 |
GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
EP1640004A1 (fr) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Utilisation des epothilones pour le traitement des metastases osseuses ou du cancer des os |
EP1824458A1 (fr) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Bille enrobee de keratine comprenant de l'epothilone ou un analogue d'epothilone, ainsi que preparation et administration de cette bille |
EP1817013B1 (fr) * | 2004-11-18 | 2008-06-04 | Brystol-Myers Squibb Company | Bille a enrobage enterique comprenant de l'ixabepilone |
US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
JO2596B1 (en) * | 2004-11-30 | 2011-02-27 | نوفارتيس ايه جي | Compositions include epothelones and tyrosine protein kinase inhibitors and their pharmaceutical uses |
DE102005008309A1 (de) * | 2005-02-17 | 2006-08-24 | Schering Ag | Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone |
KR20090005310A (ko) * | 2006-04-05 | 2009-01-13 | 노파르티스 아게 | 암을 치료하기 위한 치료제의 조합물 |
AU2007319193A1 (en) * | 2006-11-15 | 2008-05-22 | Dana-Farber Cancer Institute, Inc. | Stabilized MAML peptides and uses thereof |
US20100173718A1 (en) | 2007-06-20 | 2010-07-08 | Saluc Technologies S.A. | Convertible dining / billiard table |
EP2065054A1 (fr) | 2007-11-29 | 2009-06-03 | Bayer Schering Pharma Aktiengesellschaft | Combinaisons comprenant une prostaglandine et leurs utilisations |
DE102007059752A1 (de) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone |
EP2070521A1 (fr) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Nanoparticules à surface modifiée |
CN102256615A (zh) | 2009-01-14 | 2011-11-23 | 爱勒让治疗公司 | 拟肽大环化合物 |
EP2210584A1 (fr) | 2009-01-27 | 2010-07-28 | Bayer Schering Pharma Aktiengesellschaft | Composition polymère stable comprenant un copolymère séquencé d'épothilone et amphiphile |
CA2898996A1 (fr) * | 2013-01-23 | 2014-07-31 | The University Of Toledo | Agents anticancereux hautement selectifs ciblant le cancer de poumon non a petites cellules et d'autres formes de cancer |
US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
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US127432A (en) * | 1872-06-04 | Improvement in tuckers for sewing-machines | ||
US142990A (en) * | 1873-09-23 | Improvement in machines for burnishing the shanks of boots and shoes | ||
US260098A (en) * | 1882-06-27 | Rolls for longitudinally slitting railroad-rails | ||
US87634A (en) * | 1869-03-09 | Improvement in grain-storehouses | ||
US203876A (en) * | 1878-05-21 | Improvement in piston water-meters | ||
US34452A (en) * | 1862-02-18 | Improvement in railroad joints or chairs | ||
US253697A (en) * | 1882-02-14 | John halley and alexandee baee | ||
US203938A (en) * | 1878-05-21 | Improvement in wire fences | ||
US220295A (en) * | 1879-10-07 | Improvement in hinges | ||
US176429A (en) * | 1876-04-25 | Improvement in nut-locks | ||
DE4138042C2 (de) * | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
CA2167201A1 (fr) * | 1993-07-15 | 1995-01-26 | Kristin M. Lundy | Derives amides de macrolides antibiotiques a cycle de 16 chainons |
PT873341E (pt) * | 1995-11-17 | 2004-02-27 | Biotechnolog Forschung Mbh Gbf | Derivados de epotilona preparacao e utilizacao |
EP0923583A1 (fr) | 1996-08-30 | 1999-06-23 | Novartis AG | Procede de fabrication d'epothilones, et composes intermediaires obtenus au cours de ce procede |
US5969145A (en) * | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
DK0941227T5 (da) | 1996-11-18 | 2009-10-05 | Biotechnolog Forschung Gmbh | Epothilon D, dens fremstilling samt dens anvendelse som cytostatisk middel og som plantebeskyttelsesmiddel |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
EP0977563B1 (fr) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthese d'epothilones, intermediaires utilises dans leur synthese, analogues et utilisations de celles-ci |
US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6660758B1 (en) * | 1996-12-13 | 2003-12-09 | The Scripps Research Institute | Epothilone analogs |
DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
WO1998047891A1 (fr) * | 1997-04-18 | 1998-10-29 | Studiengesellschaft Kohle Mbh | Metathese olefinique selective de substrats bifonctionnels ou polyfonctionnels dans du dioxyde de carbone comprime en tant que milieu de reaction |
DE19720312A1 (de) * | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
ATE368036T1 (de) | 1997-08-09 | 2007-08-15 | Bayer Schering Pharma Ag | Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung |
KR100669174B1 (ko) * | 1998-02-05 | 2007-01-17 | 노파르티스 아게 | 유기화합물 함유 조성물 |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
FR2775187B1 (fr) * | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
CA2322157C (fr) | 1998-02-25 | 2012-05-29 | Sloan-Kettering Institute For Cancer Research | Synthese d'epothilones, de leurs intermediaires et de leurs analogues |
GB9810659D0 (en) | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
NZ508326A (en) | 1998-06-18 | 2003-10-31 | Novartis Ag | A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B |
US6121029A (en) * | 1998-06-18 | 2000-09-19 | Novartis Ag | Genes for the biosynthesis of epothilones |
WO1999067253A2 (fr) | 1998-06-22 | 1999-12-29 | Novartis Ag | Desmethylepothilones |
AU5036999A (en) | 1998-06-30 | 2000-01-17 | Schering Aktiengesellschaft | Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use |
DE19848306A1 (de) * | 1998-10-14 | 2000-04-20 | Schering Ag | Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren |
AU768220B2 (en) | 1998-11-20 | 2003-12-04 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
AU2001295195B2 (en) | 2000-04-28 | 2007-02-01 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
WO2005085209A1 (fr) * | 2004-03-10 | 2005-09-15 | Kureha Corporation | Composé aminé basique et son usage |
-
1999
- 1999-02-16 FR FR9901903A patent/FR2775187B1/fr not_active Expired - Fee Related
- 1999-02-23 AU AU29279/99A patent/AU755944B2/en not_active Ceased
- 1999-02-23 CA CA002319752A patent/CA2319752A1/fr not_active Withdrawn
- 1999-02-23 JP JP2000533117A patent/JP2002504511A/ja not_active Withdrawn
- 1999-02-23 EP EP99910257A patent/EP1056453B1/fr not_active Expired - Lifetime
- 1999-02-23 NZ NZ506187A patent/NZ506187A/en not_active IP Right Cessation
- 1999-02-23 WO PCT/EP1999/001147 patent/WO1999043320A1/fr active IP Right Grant
- 1999-02-24 IT IT99MI000375A patent/ITMI990375A1/it unknown
- 1999-02-25 BE BE9900126A patent/BE1011980A5/fr not_active IP Right Cessation
-
2001
- 2001-08-09 US US09/925,119 patent/US6635666B2/en not_active Expired - Fee Related
-
2003
- 2003-08-01 US US10/633,114 patent/US20040024033A1/en not_active Abandoned
-
2005
- 2005-03-24 US US11/089,269 patent/US7091226B2/en not_active Expired - Fee Related
-
2006
- 2006-04-19 US US11/406,896 patent/US7875601B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2775187A1 (fr) | 1999-08-27 |
AU2927999A (en) | 1999-09-15 |
US20060223867A1 (en) | 2006-10-05 |
US20020028839A1 (en) | 2002-03-07 |
US7091226B2 (en) | 2006-08-15 |
CA2319752A1 (fr) | 1999-09-02 |
JP2002504511A (ja) | 2002-02-12 |
NZ506187A (en) | 2003-11-28 |
US6635666B2 (en) | 2003-10-21 |
US20040024033A1 (en) | 2004-02-05 |
AU755944B2 (en) | 2003-01-02 |
BE1011980A5 (fr) | 2000-03-07 |
ITMI990375A1 (it) | 1999-08-25 |
EP1056453B1 (fr) | 2010-10-06 |
US7875601B2 (en) | 2011-01-25 |
WO1999043320A1 (fr) | 1999-09-02 |
US20050165071A1 (en) | 2005-07-28 |
EP1056453A1 (fr) | 2000-12-06 |
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