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CN1223340C - 电纺丝的药物组合物 - Google Patents

电纺丝的药物组合物 Download PDF

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Publication number
CN1223340C
CN1223340C CNB018042422A CN01804242A CN1223340C CN 1223340 C CN1223340 C CN 1223340C CN B018042422 A CNB018042422 A CN B018042422A CN 01804242 A CN01804242 A CN 01804242A CN 1223340 C CN1223340 C CN 1223340C
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CN
China
Prior art keywords
poly
activating agent
cellulose
agent
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018042422A
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English (en)
Chinese (zh)
Other versions
CN1396823A (zh
Inventor
弗朗西斯·伊格内修斯
约翰·M·鲍多尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
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SmithKline Beecham Corp
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Filing date
Publication date
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Publication of CN1396823A publication Critical patent/CN1396823A/zh
Application granted granted Critical
Publication of CN1223340C publication Critical patent/CN1223340C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/0023—Electro-spinning characterised by the initial state of the material the material being a polymer melt
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Textile Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
CNB018042422A 2000-01-28 2001-01-25 电纺丝的药物组合物 Expired - Fee Related CN1223340C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17868200P 2000-01-28 2000-01-28
US60/178,682 2000-01-28

Publications (2)

Publication Number Publication Date
CN1396823A CN1396823A (zh) 2003-02-12
CN1223340C true CN1223340C (zh) 2005-10-19

Family

ID=22653497

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018042422A Expired - Fee Related CN1223340C (zh) 2000-01-28 2001-01-25 电纺丝的药物组合物

Country Status (18)

Country Link
EP (1) EP1251829A4 (de)
JP (1) JP2003521493A (de)
KR (1) KR100806412B1 (de)
CN (1) CN1223340C (de)
AR (1) AR028204A1 (de)
AU (1) AU772830B2 (de)
BR (1) BR0107869A (de)
CA (1) CA2396640A1 (de)
HU (1) HUP0301130A3 (de)
IL (1) IL150642A0 (de)
MX (1) MXPA02007298A (de)
MY (1) MY129356A (de)
NO (1) NO20023338L (de)
NZ (1) NZ519992A (de)
PL (1) PL356924A1 (de)
TW (1) TWI289061B (de)
WO (1) WO2001054667A1 (de)
ZA (1) ZA200205989B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107072937A (zh) * 2014-06-10 2017-08-18 德姆特里特有限公司 包含通过水电动力得到的纤维的用于将特定剂量的活性物质施用于皮肤或粘膜的组合物

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US6685956B2 (en) * 2001-05-16 2004-02-03 The Research Foundation At State University Of New York Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications
GB0123951D0 (en) * 2001-10-05 2001-11-28 Glaxo Group Ltd Therapies for treating respiratory diseases
DE60320940D1 (de) 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
KR100549140B1 (ko) * 2002-03-26 2006-02-03 이 아이 듀폰 디 네모아 앤드 캄파니 일렉트로-브로운 방사법에 의한 초극세 나노섬유 웹제조방법
KR101027550B1 (ko) 2002-04-04 2011-04-06 더 유니버시티 오브 아크론 부직포 섬유 집합체
US8367570B2 (en) 2002-04-04 2013-02-05 The University Of Akron Mechanically strong absorbent non-woven fibrous mats
JP2005522594A (ja) * 2002-04-11 2005-07-28 セカント メディカル， インコーポレイテッド 非常に小さいペプチドの電気紡績を使用するカバープロセス
TW200410714A (en) * 2002-08-07 2004-07-01 Smithkline Beecham Corp Electrospun amorphous pharmaceutical compositions
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WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
ATE540671T1 (de) 2003-08-04 2012-01-15 Bend Res Inc Pharmazeutische zusammensetzungen von adsorbaten von amorphen arzneimitteln und lipophilen mikrophasen-bildenden materialien
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JP4526851B2 (ja) * 2004-03-31 2010-08-18 明彦 谷岡 多糖類のナノスケールの繊維および成形体
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CN100577720C (zh) * 2005-03-21 2010-01-06 中国科学院化学研究所 可生物降解及吸收的聚合物纳米纤维膜材料及制法和用途
JP2006299459A (ja) * 2005-04-20 2006-11-02 National Institute For Materials Science 生分解性高分子不織布チューブの製造方法
CN1300393C (zh) * 2005-07-01 2007-02-14 中国科学院长春应用化学研究所 超细纤维药物剂型的乳液电纺丝制备方法
JP5339328B2 (ja) * 2005-07-21 2013-11-13 独立行政法人物質・材料研究機構 薬物吸入デバイス
JP4787585B2 (ja) * 2005-09-29 2011-10-05 帝人株式会社 静電紡糸法による繊維構造体の製造方法
CN100556399C (zh) * 2005-12-23 2009-11-04 中国科学院广州化学研究所 一种肠靶向型药物控释纤维及其制备方法
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KR100824719B1 (ko) * 2006-09-04 2008-04-24 주식회사 아모메디 전분함유 나노섬유 부직포로 이루어진 생분해성 식품포장재 및 그 제조방법
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