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SK286072B6 - 1,2-anelované chinolínové deriváty, spôsob ich prípravy, medziprodukty, farmaceutický prostriedok aich použitie - Google Patents

1,2-anelované chinolínové deriváty, spôsob ich prípravy, medziprodukty, farmaceutický prostriedok aich použitie Download PDF

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Publication number
SK286072B6
SK286072B6 SK873-2001A SK8732001A SK286072B6 SK 286072 B6 SK286072 B6 SK 286072B6 SK 8732001 A SK8732001 A SK 8732001A SK 286072 B6 SK286072 B6 SK 286072B6
Authority
SK
Slovakia
Prior art keywords
alkyl
formula
hydrogen
compounds
radical
Prior art date
Application number
SK873-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK8732001A3 (en
Inventor
Patrick Ren Angibaud
Marc Gaston Venet
Xavier Marc Bourdrez
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK8732001A3 publication Critical patent/SK8732001A3/sk
Publication of SK286072B6 publication Critical patent/SK286072B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
SK873-2001A 1998-12-23 1999-12-17 1,2-anelované chinolínové deriváty, spôsob ich prípravy, medziprodukty, farmaceutický prostriedok aich použitie SK286072B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204444 1998-12-23
PCT/EP1999/010214 WO2000039082A2 (en) 1998-12-23 1999-12-17 1,2-annelated quinoline derivatives

Publications (2)

Publication Number Publication Date
SK8732001A3 SK8732001A3 (en) 2002-02-05
SK286072B6 true SK286072B6 (sk) 2008-02-05

Family

ID=8234557

Family Applications (1)

Application Number Title Priority Date Filing Date
SK873-2001A SK286072B6 (sk) 1998-12-23 1999-12-17 1,2-anelované chinolínové deriváty, spôsob ich prípravy, medziprodukty, farmaceutický prostriedok aich použitie

Country Status (32)

Country Link
US (2) US6458800B1 (es)
EP (1) EP1140935B1 (es)
JP (1) JP4725940B2 (es)
KR (2) KR100818541B1 (es)
CN (1) CN1178938C (es)
AR (1) AR021995A1 (es)
AT (1) ATE240327T1 (es)
AU (1) AU765437B2 (es)
BG (1) BG65124B1 (es)
BR (1) BR9916827A (es)
CA (1) CA2355717C (es)
CZ (1) CZ302374B6 (es)
DE (1) DE69907964T2 (es)
DK (1) DK1140935T3 (es)
EA (1) EA004542B1 (es)
EE (1) EE04962B1 (es)
ES (1) ES2200591T3 (es)
HK (1) HK1038746B (es)
HR (1) HRP20010454B1 (es)
HU (1) HU229404B1 (es)
ID (1) ID29241A (es)
IL (2) IL143859A0 (es)
NO (1) NO318922B1 (es)
PL (1) PL199080B1 (es)
PT (1) PT1140935E (es)
SI (1) SI1140935T1 (es)
SK (1) SK286072B6 (es)
TR (1) TR200101961T2 (es)
TW (1) TW531533B (es)
UA (1) UA71592C2 (es)
WO (1) WO2000039082A2 (es)
ZA (1) ZA200105136B (es)

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JP5491681B2 (ja) * 2000-02-04 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 乳ガンの治療のためのファルネシルタンパク質トランスフェラーゼ阻害剤
US6838467B2 (en) 2000-02-24 2005-01-04 Janssen Pharmaceutica N. V. Dosing regimen
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AU2001239275A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with anti-tumor podophyllotoxin derivatives
AU2001244167A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with anti-tumor anthracycline derivatives
AU2001244166A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with further anti-cancer agents
US20030186925A1 (en) * 2000-02-29 2003-10-02 Palmer Peter Albert Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives
EP1263437A2 (en) * 2000-02-29 2002-12-11 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with vinca alkaloids
AU2001246478A1 (en) * 2000-02-29 2001-09-12 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitor combinations with taxane compounds
US20030125326A1 (en) * 2000-02-29 2003-07-03 Rybak Mary Ellen Margaret Farnesyl protein transferase inhibitor combinations
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Publication number Publication date
CA2355717A1 (en) 2000-07-06
US6914066B2 (en) 2005-07-05
EE04962B1 (et) 2008-02-15
UA71592C2 (uk) 2004-12-15
ES2200591T3 (es) 2004-03-01
CN1331693A (zh) 2002-01-16
AR021995A1 (es) 2002-09-04
PT1140935E (pt) 2003-10-31
KR20010087396A (ko) 2001-09-15
JP2002533435A (ja) 2002-10-08
SK8732001A3 (en) 2002-02-05
BR9916827A (pt) 2001-10-16
TW531533B (en) 2003-05-11
CN1178938C (zh) 2004-12-08
SI1140935T1 (en) 2003-10-31
WO2000039082A3 (en) 2000-10-26
BG65124B1 (bg) 2007-03-30
ID29241A (id) 2001-08-16
KR100712226B1 (ko) 2007-04-27
TR200101961T2 (tr) 2001-12-21
IL143859A0 (en) 2002-04-21
KR20060117380A (ko) 2006-11-16
HRP20010454A2 (en) 2002-06-30
HU229404B1 (en) 2013-12-30
US20030119843A1 (en) 2003-06-26
AU765437B2 (en) 2003-09-18
BG105631A (en) 2002-02-28
EA200100708A1 (ru) 2001-12-24
JP4725940B2 (ja) 2011-07-13
ATE240327T1 (de) 2003-05-15
EE200100318A (et) 2002-10-15
DK1140935T3 (da) 2003-09-01
CZ20012142A3 (cs) 2002-01-16
PL199080B1 (pl) 2008-08-29
HRP20010454B1 (en) 2004-06-30
CZ302374B6 (cs) 2011-04-20
CA2355717C (en) 2011-02-08
KR100818541B1 (ko) 2008-04-02
NO20013088L (no) 2001-06-21
EP1140935B1 (en) 2003-05-14
HUP0104582A2 (hu) 2002-04-29
ZA200105136B (en) 2002-06-21
AU2795300A (en) 2000-07-31
PL349504A1 (en) 2002-07-29
DE69907964T2 (de) 2004-02-19
HK1038746A1 (en) 2002-03-28
NO20013088D0 (no) 2001-06-21
HK1038746B (zh) 2003-09-05
IL143859A (en) 2008-04-13
EP1140935A2 (en) 2001-10-10
US6458800B1 (en) 2002-10-01
EA004542B1 (ru) 2004-06-24
HUP0104582A3 (en) 2002-12-28
WO2000039082A2 (en) 2000-07-06
NO318922B1 (no) 2005-05-23
DE69907964D1 (de) 2003-06-18

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