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SE8306994L - Cefemderivat och forfarande for deras framstellning - Google Patents

Cefemderivat och forfarande for deras framstellning

Info

Publication number
SE8306994L
SE8306994L SE8306994A SE8306994A SE8306994L SE 8306994 L SE8306994 L SE 8306994L SE 8306994 A SE8306994 A SE 8306994A SE 8306994 A SE8306994 A SE 8306994A SE 8306994 L SE8306994 L SE 8306994L
Authority
SE
Sweden
Prior art keywords
group
general formula
alkyl
ester
given above
Prior art date
Application number
SE8306994A
Other languages
English (en)
Other versions
SE8306994D0 (sv
Inventor
W Durckheimer
D Bormann
E Ehlers
E Schrinner
R Haymes
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of SE8306994D0 publication Critical patent/SE8306994D0/sv
Publication of SE8306994L publication Critical patent/SE8306994L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (2)

PATENTKRAV Forfarande for framstallning av nya cememderivat reedh&llet salt overfors direkt till en ester, den allmanna formeln I att en erhallen ester fortvalas och eventuellt overfors till ett salt, y)att en grupp Ri och/eller 122 i betydelsen av en skydds- grupp avspaltas, COOR30)att, omstSr for vOte, en grupp Ri i betydelsen av eventuellt substituerad acyl, alkylsulfonyl eller ary1sulfcaly1 infors genom amsattning med de motsvarande aktiverade karboxyl- eller sulfonsyraderivaten, n)att, om Ft, star Dir en till en lagre alkoxigrupp omvand- lingsbar grupp, denna omvandling genomfbra, varvid en eller Piers av de under a) till c) angivna reaktionerna tan komma till anvandning. 114 = vate A = -CH2Y, ddr. Y betecknar -SR, dar R4-mety1-5-karboxi- metyltiazol-2-y17 triazinyl,tan vans substitue- \0112 i vilken = vOte eller en aminoskyddsgrupp R, = vOte, C1-C4-alkyl eller karboxi-C1-C4-alkyl 123 = vOte, en fysiologiskt fordragbar katDon eller en fysiologiskt fordragbar estergrupp radmed C1-C4-alkyl, hydroxi, oxo eller oxido och Aven kan vara halt eller delvis hydrerad, eller fir det fall att R2 = karboxi-C,-C4-alkyl, Y ockag XcID beteckna pyridinium, kannetecknat av
1. att laktamer med den allmAnna formeln II COOR3 darA, R3 och 14 liar de oven angivna betydelserna meninte kan sta far vAte, onsAtts med reaktiva derivat av en karboxyl- syre med den allminna formeln III CCOON III \OR 2 ddr R„ och R2 tar de ovan angivna betydelserna men 12, inte kan vara vita, eller
2. att cefemfareningar med den allminna formeln IV t 4 S j ''--.R2 CrN I \CH2B COON, dar 111, R2,och R4 tar de ovan angivna betydelserna men 13 late kann esterrupp och B stir fir en med en nukleo- fil grupp utbytbar grupp, i narvaro av haser osatts med en farening sac innehiller en nukleofil Y, till foreningar med den alimAnna formeln I,
SE8306994A 1977-04-02 1983-12-16 Cefemderivat och forfarande for deras framstellning SE8306994L (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772714880 DE2714880A1 (de) 1977-04-02 1977-04-02 Cephemderivate und verfahren zu ihrer herstellung
DE19772716707 DE2716707A1 (de) 1977-04-02 1977-04-15 Cephemderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
SE8306994D0 SE8306994D0 (sv) 1983-12-16
SE8306994L true SE8306994L (sv) 1983-12-16

Family

ID=25771827

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7803660A SE448378B (sv) 1977-04-02 1978-03-31 Forfarande for framstellning av nya 7-amino-tiazolyl-acetamido-cefalosporansyra
SE8306994A SE8306994L (sv) 1977-04-02 1983-12-16 Cefemderivat och forfarande for deras framstellning

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7803660A SE448378B (sv) 1977-04-02 1978-03-31 Forfarande for framstellning av nya 7-amino-tiazolyl-acetamido-cefalosporansyra

Country Status (28)

Country Link
US (4) US4758556A (sv)
JP (2) JPS5858354B2 (sv)
AT (1) AT367425B (sv)
AU (1) AU528277B2 (sv)
BE (1) BE865632A (sv)
CA (1) CA1259606A (sv)
CH (1) CH638810A5 (sv)
CS (1) CS208747B2 (sv)
DD (1) DD137231A5 (sv)
DE (2) DE2714880A1 (sv)
DK (1) DK165060C (sv)
ES (2) ES468475A1 (sv)
FI (1) FI70221C (sv)
FR (3) FR2385722B1 (sv)
GB (1) GB1604971A (sv)
GR (1) GR73632B (sv)
HK (1) HK39083A (sv)
IE (1) IE47211B1 (sv)
IL (1) IL54407A (sv)
IT (1) IT1093750B (sv)
LU (1) LU79350A1 (sv)
NL (1) NL7803486A (sv)
NO (1) NO160211C (sv)
NZ (1) NZ186842A (sv)
OA (1) OA05928A (sv)
PT (1) PT67856B (sv)
SE (2) SE448378B (sv)
YU (1) YU41827B (sv)

Families Citing this family (235)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4493833A (en) * 1976-04-12 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds
US4304770A (en) 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
BE878514A (fr) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4427674A (en) 1977-03-14 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4409217A (en) * 1977-03-14 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
PH17188A (en) 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
FR2399418A1 (fr) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques
US5089490A (en) * 1977-04-02 1992-02-18 Hoechst Aktiengesellschaft Cephem derivatives
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
JPS5936914B2 (ja) * 1978-06-24 1984-09-06 協和醗酵工業株式会社 セフアロスポリン類縁体
NO790956L (no) * 1978-03-25 1979-09-26 Kyowa Hakko Kogyo Kk Analogifremgangsmaate til fremstilling av cefalosporinanaloge eller farmasoeytisk akseptable salter derav
SE7902598L (sv) * 1978-03-25 1979-10-04 Kyowa Hakko Kogyo Kk Cephalosporinanaloger
SE448379B (sv) * 1978-03-31 1987-02-16 Roussel Uclaf O-substituerade oximderivat av 7-amino-tiazolyl-acetamidocefalosporansyra
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4374834A (en) * 1978-04-07 1983-02-22 Roussel Uclaf Novel compounds
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
AR229882A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
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US4284631A (en) 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
US4372952A (en) 1978-07-31 1983-02-08 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
FR2453161A1 (fr) * 1978-08-31 1980-10-31 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide thiazolylacetique et nouveaux produits ainsi obtenus
BE878637A (fr) * 1978-09-11 1980-03-06 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
DE2946415A1 (de) * 1978-11-17 1980-05-29 Glaxo Group Ltd Cephalosporinantibiotika
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS6058920B2 (ja) * 1978-12-26 1985-12-23 協和醗酵工業株式会社 セフアロスポリン類縁体
FR2448543A1 (fr) 1979-02-09 1980-09-05 Roussel Uclaf Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
JPS55108877A (en) * 1979-02-10 1980-08-21 Kyowa Hakko Kogyo Co Ltd Optically active cephalosporin analog
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
JPS5616491A (en) * 1979-07-19 1981-02-17 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
NO155547C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
CH651574A5 (de) * 1979-03-22 1985-09-30 Glaxo Group Ltd Cephalosporinantibiotika, ihre herstellung und pharmazeutische zubereitungen.
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YU76578A (en) 1983-04-30
IL54407A (en) 1985-09-29
DK165060C (da) 1993-02-22
GR73632B (sv) 1984-03-26
US5710146A (en) 1998-01-20
AU528277B2 (en) 1983-04-21
ATA229078A (de) 1981-11-15
PT67856A (de) 1978-04-01
FR2385722A1 (fr) 1978-10-27
NO160211C (no) 1989-03-22
ES477591A1 (es) 1980-01-01
CS208747B2 (en) 1981-09-15
CH638810A5 (de) 1983-10-14
JPS6228153B2 (sv) 1987-06-18
SE8306994D0 (sv) 1983-12-16
SE7803660L (sv) 1978-10-03
HK39083A (en) 1983-10-13
FR2485018B1 (sv) 1985-04-12
LU79350A1 (de) 1978-11-27
IE780642L (en) 1978-10-02
YU41827B (en) 1988-02-29
NO781130L (no) 1978-10-03
DK143378A (da) 1978-10-03
US4758556A (en) 1988-07-19
ES468475A1 (es) 1979-08-16
USRE35754E (en) 1998-03-24
BE865632A (fr) 1978-10-03
AU3464878A (en) 1979-10-04
IT1093750B (it) 1985-07-26
IT7821901A0 (it) 1978-03-31
FI780966A (fi) 1978-10-03
US4278793A (en) 1981-07-14
NO160211B (no) 1988-12-12
GB1604971A (en) 1981-12-16
FR2385722B1 (fr) 1985-09-27
NL7803486A (nl) 1978-10-04
CA1259606A (en) 1989-09-19
OA05928A (fr) 1981-06-30
DE2714880A1 (de) 1978-10-26
JPS5858354B2 (ja) 1983-12-24
PT67856B (de) 1979-12-19
FI70221B (fi) 1986-02-28
FR2485017B1 (sv) 1985-04-12
JPS5716887A (en) 1982-01-28
FI70221C (fi) 1986-09-15
IE47211B1 (en) 1984-01-25
DE2716707A1 (de) 1978-10-19
NZ186842A (en) 1980-11-14
DK165060B (da) 1992-10-05
FR2485018A1 (fr) 1981-12-24
FR2485017A1 (fr) 1981-12-24
JPS549296A (en) 1979-01-24
AT367425B (de) 1982-07-12
SE448378B (sv) 1987-02-16
DD137231A5 (de) 1979-08-22
IL54407A0 (en) 1978-06-15

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