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GR3023860T3 - Monomeric and dimeric antibody-fragment fusion proteins. - Google Patents

Monomeric and dimeric antibody-fragment fusion proteins.

Info

Publication number
GR3023860T3
GR3023860T3 GR970401501T GR970401501T GR3023860T3 GR 3023860 T3 GR3023860 T3 GR 3023860T3 GR 970401501 T GR970401501 T GR 970401501T GR 970401501 T GR970401501 T GR 970401501T GR 3023860 T3 GR3023860 T3 GR 3023860T3
Authority
GR
Greece
Prior art keywords
antibody
fusion proteins
pct
monomeric
fragment fusion
Prior art date
Application number
GR970401501T
Other languages
English (en)
Inventor
Andreas Plueckthun
Peter Pack
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of GR3023860T3 publication Critical patent/GR3023860T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
GR970401501T 1992-01-23 1997-06-20 Monomeric and dimeric antibody-fragment fusion proteins. GR3023860T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92101069 1992-01-23
PCT/EP1993/000082 WO1993015210A1 (en) 1992-01-23 1993-01-15 Monomeric and dimeric antibody-fragment fusion proteins

Publications (1)

Publication Number Publication Date
GR3023860T3 true GR3023860T3 (en) 1997-09-30

Family

ID=8209260

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401501T GR3023860T3 (en) 1992-01-23 1997-06-20 Monomeric and dimeric antibody-fragment fusion proteins.

Country Status (16)

Country Link
US (1) US5910573A (el)
EP (1) EP0654085B1 (el)
JP (2) JP3490437B2 (el)
KR (1) KR100254759B1 (el)
AT (1) ATE151113T1 (el)
AU (1) AU676150B2 (el)
CA (1) CA2128511C (el)
CZ (1) CZ287296B6 (el)
DE (1) DE69309472T2 (el)
DK (1) DK0654085T3 (el)
ES (1) ES2102007T3 (el)
GR (1) GR3023860T3 (el)
HU (1) HU215180B (el)
NO (1) NO942750L (el)
RU (1) RU2128709C1 (el)
WO (1) WO1993015210A1 (el)

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