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MX2020004756A - Terapias de combinacion. - Google Patents

Terapias de combinacion.

Info

Publication number
MX2020004756A
MX2020004756A MX2020004756A MX2020004756A MX2020004756A MX 2020004756 A MX2020004756 A MX 2020004756A MX 2020004756 A MX2020004756 A MX 2020004756A MX 2020004756 A MX2020004756 A MX 2020004756A MX 2020004756 A MX2020004756 A MX 2020004756A
Authority
MX
Mexico
Prior art keywords
inhibitor
combination therapies
treatment
agents
cancer
Prior art date
Application number
MX2020004756A
Other languages
English (en)
Inventor
Glenn Dranoff
Kenzie Macisaac
Shamsah Kazani
Lilli Petruzzelli
Catherine Anne Sabatos-Peyton
Jennifer Marie Mataraza
Eunice Kwak
Jason Faris
Marion Wiesmann
Fiona Sharp
Adam Crystal
John Scott Cameron
Robert Martin Strieter
David Andrew Sandham
Neil John Press
Keith Hoffmaster
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2020004756A publication Critical patent/MX2020004756A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Neurology (AREA)

Abstract

Terapias de combinación que comprenden inhibidores de PD-1 y otros agentes terapéuticos que se usan para el tratamiento o la prevención de las afecciones y los trastornos cancerosos como siguen. Terapias de combinación de tres agentes que son un inhibidor de PD-1, un inhibidor de CXCR2 y un agente de enlace de CSF-1/1R para el tratamiento de un cáncer pancreático o de un cáncer colo rectal. Terapias de combinación de tres agentes que son un inhibidor de PD-1, un inhibidor de CXCR2 y un inhibidor de cualquiera de TIM3, C-MET o A2aR, para el tratamiento de un cáncer pancreático o de un cáncer colo rectal. Terapias de combinación de tres agentes que son un inhibidor de PD-1, un inhibidor de LAG-3 y (i) un inhibidor de cualquiera de TGF-beta, TIM-3, C-MET, IL-1b o MEK, o (ii) un agonista de GITR, o (iii) un antagonista de A2aR, o (iv) un agente de enlace de CSF-1/1R, para el tratamiento de un cáncer de mama. Terapias de combinación de dos agentes que son un inhibidor de PD-1 y un inhibidor de CXCR2 para el tratamiento de un cáncer pancreático, de un cáncer colo rectal, de un cáncer de pulmón, o de un cáncer de mama.
MX2020004756A 2017-11-16 2018-11-16 Terapias de combinacion. MX2020004756A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762587370P 2017-11-16 2017-11-16
US201862645588P 2018-03-20 2018-03-20
US201862703736P 2018-07-26 2018-07-26
PCT/US2018/061534 WO2019099838A1 (en) 2017-11-16 2018-11-16 Combination therapies

Publications (1)

Publication Number Publication Date
MX2020004756A true MX2020004756A (es) 2020-08-20

Family

ID=64870550

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004756A MX2020004756A (es) 2017-11-16 2018-11-16 Terapias de combinacion.

Country Status (14)

Country Link
US (1) US20200277378A1 (es)
EP (1) EP3710053A1 (es)
JP (1) JP2021503478A (es)
KR (1) KR20200089286A (es)
CN (1) CN111655288A (es)
AU (1) AU2018368731A1 (es)
BR (1) BR112020008888A2 (es)
CA (1) CA3081602A1 (es)
CL (2) CL2020001255A1 (es)
IL (1) IL274407A (es)
MX (1) MX2020004756A (es)
RU (1) RU2020119578A (es)
TW (1) TW201922291A (es)
WO (1) WO2019099838A1 (es)

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MY187246A (en) * 2014-03-14 2021-09-14 Novartis Ag Antibody molecules to lag-3 and uses thereof
ES2771926T3 (es) 2014-09-13 2020-07-07 Novartis Ag Terapias de combinación
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US20240254230A1 (en) * 2021-03-19 2024-08-01 Shanghai Junshi Biosciences Co., Ltd. Method of treating urothelial carcinoma
KR20240153583A (ko) * 2022-02-25 2024-10-23 브리스톨-마이어스 스큅 컴퍼니 결장직장암종에 대한 병용 요법
CN116407526B (zh) * 2022-03-11 2024-07-05 复旦大学附属肿瘤医院 乳腺癌治疗药物、辅助治疗药物、抗肿瘤免疫激活剂及氧化三甲胺和其前体产物胆碱的用途
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BR112018002039A2 (pt) 2015-08-12 2018-09-18 Medimmune Ltd proteínas de fusão gitrl e usos das mesmas

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RU2020119578A (ru) 2021-12-17
CL2020001255A1 (es) 2020-09-04
EP3710053A1 (en) 2020-09-23
JP2021503478A (ja) 2021-02-12
CA3081602A1 (en) 2019-05-23
AU2018368731A1 (en) 2020-05-14
AU2018368731A8 (en) 2020-06-25
KR20200089286A (ko) 2020-07-24
CL2020003059A1 (es) 2021-06-18
WO2019099838A1 (en) 2019-05-23
US20200277378A1 (en) 2020-09-03
TW201922291A (zh) 2019-06-16

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