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DE733059T1 - Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen - Google Patents

Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen

Info

Publication number
DE733059T1
DE733059T1 DE0733059T DE95905337T DE733059T1 DE 733059 T1 DE733059 T1 DE 733059T1 DE 0733059 T DE0733059 T DE 0733059T DE 95905337 T DE95905337 T DE 95905337T DE 733059 T1 DE733059 T1 DE 733059T1
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Germany
Prior art keywords
nucleic acid
cell
region
regions
acid according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0733059T
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English (en)
Inventor
Eric B Kmiec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of DE733059T1 publication Critical patent/DE733059T1/de
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Claims (17)

95905337.2 2634 Patentansprüche
1. Chimäre Nukleinsäure mit nicht mehr als einem 3'-Ende und einem 5'-Ende, wobei diese Nukleinsäure außerdem aufweist:
a. einen Bereich von aneinander anschließenden nichtgepaarten Basen, die so angeordnet sind, daß der nicht-gepaarte Bereich die Nukleinsäure in einen ersten Strang und einen zweiten Strang aufteilt;
b. einen Bereich einer Watson-Crick-gepaarten Nukleinsäure einer Länge von wenigstens 15 Basenpaaren, in dem Basen des ersten Strangs den Basen des zweiten Strangs entsprechen, und in dem
c. der erste Strang einen Bereich aus wenigstens drei aufeinanderfolgenden Nukleotiden aufweist, die von einer 2'-O- oder 2'-OMe-Ribose gebildet werden, die als Hybrid-Duplex Watson-Crick-gepaart sind.
2. Nukleinsäure nach Anspruch 1, bei der der zweite Strang keine Nukleotide enthält, die von einer 2'-O- oder 2'-OMe-Ribose gebildet werden.
3. Nukleinsäure nach Anspruch 2, bei der der Hybrid-Duplex wenigstens 9 aufeinanderfolgende Nukleotide aufweist, die von einer 2'-0-Ribose gebildet werden, der von Nukleotiden flankiert wird, die von einer 2'-Desoxyribose gebildet werden.
4. Nukleinsäure nach Anspruch 2, bei der der erste Strang zwei Bereichen aus aufeinanderfolgenden Nukleotiden, die von einer 2'-O- oder 2'-OMe-Ribose gebildet werden, die zwei Hybrid-Duplex-Bereiche bilden, wobei jeder Hybrid-Duplex-Bereich eine Länge von wenigstens 4 Basenpaaren aufweist, sowie einen eingeschobenen Homo-Duplex-Bereich aus wenig-
stens einem Basenpaar, der zwischen den Hybrid-Duplex-Bereichen angeordnet ist, aufweist.
5. Nukleinsäure nach Anspruch 2, bei der der erste Strang zwei Bereiche von Nukleotiden, die von einer 2'-O- oder 2'-OMe-Ribose gebildet werden, die zwei Hybrid-Duplex-Bereiche bilden, wobei jeder Hybrid-Duplex-Bereich eine Länge von wenigstens 8 Basenpaaren aufweist, sowie einen eingeschobenen Homo-Duplex-Bereich aus wenigstens 4 Basenpaaren, der zwischen den Hybrid-Duplex-Bereichen angeordnet ist, aufweist.
6. Nukleinsäure nach Anspruch 5, bei der der eingeschobene Homo-Duplex-Bereich aus zwischen 4 bis 50 2'-Desoxyribose-Basenpaaren besteht.
7. Nukleinsäure nach Anspruch 5, bei der der eingeschobene Homo-Duplex-Bereich aus zwischen 30 und 1000 2'-Desoxyribose-Basenpaaren besteht.
8. Nukleinsäure nach Anspruch 2, bei der die 5'- und 3'-Enden miteinander verknüpft sind.
9. Nukleinsäure nach Anspruch 5, bei der die 5'- und 3'-Enden miteinander verknüpft sind.
10. Nukleinsäure nach Anspruch 6, bei der die 5'- und 3'-Enden miteinander verknüpft sind.
11. Nukleinsäure nach Anspruch 7, bei der die 5'- und 3'-Enden miteinander verknüpft sind.
12. Verfahren zur Einführung einer vorgegebenen Änderung in eine Zielsequenz des Genoms einer Zelle, die einen Kern aufweist, das die Stufen umfaßt:
a. Bereitstellen eines Chimären Vektors mit zwei Berei-
chen, die mit einer Zielsequenz homolog sind, sowie einem heterologen Bereich, der dazwischen angeordnet ist, der die Änderung kodiert;
b. Halten des Chimären Vektors innerhalb des Zellkerns, so daß der chimäre Vektor und die Zielsequenz genetisch rekombinieren.
13. Verfahren nach Anspruch 12, bei dem der Kern ein Vorkern einer Eizelle ist und die Einführung durch direkte Injektion erfolgt.
14. Verfahren nach Anspruch 12, bei dem der Kern der Kern einer embryonalen Stammzelle ist und die Einführung durch direkte Injektion erfolgt.
15. Verfahren zur Gewinnung einer Zellpopulation mit geänderten Eigenschaften, das die Schritte umfaßt:
a. Bereitstellen eines Chimären Vektors mit zwei Bereichen, die mit einer Zielsequenz homolog sind, sowie einem heterologen Bereich, der dazwischen angeordnet ist, der die Änderung codiert;
b. Halten des Chimären Vektors innerhalb des Zellkerns, so daß der chimäre Vektor und die Zielsequenz rekombinieren und die Zelle transformiert wird; und
c. Selektieren der transformierten Zellen.
16. Verfahren nach Anspruch 15, bei dem die Zelle eine Säugetierzelle ist.
17. Verfahren nach Anspruch 15, bei dem die Zelle eine Hefeoder Pilzzelle ist.
DE0733059T 1993-12-09 1994-12-09 Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen Pending DE733059T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16430393A 1993-12-09 1993-12-09
PCT/US1994/014181 WO1995015972A1 (en) 1993-12-09 1994-12-09 Compounds and methods for site-directed mutations in eukaryotic cells

Publications (1)

Publication Number Publication Date
DE733059T1 true DE733059T1 (de) 1997-08-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
DE0733059T Pending DE733059T1 (de) 1993-12-09 1994-12-09 Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen
DE69425903T Expired - Fee Related DE69425903T2 (de) 1993-12-09 1994-12-09 Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen

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Country Status (15)

Country Link
US (3) US5565350A (de)
EP (1) EP0733059B1 (de)
JP (1) JP3585238B2 (de)
KR (1) KR100386337B1 (de)
CN (2) CN1048254C (de)
AT (1) ATE196311T1 (de)
AU (1) AU691550B2 (de)
CA (1) CA2178729A1 (de)
DE (2) DE733059T1 (de)
DK (1) DK0733059T3 (de)
ES (1) ES2149962T3 (de)
GR (1) GR3034988T3 (de)
NZ (1) NZ278490A (de)
PT (1) PT733059E (de)
WO (1) WO1995015972A1 (de)

Families Citing this family (801)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017320A1 (en) * 1991-07-03 1998-04-30 Hyal Pharmaceutical Corporation Use of hyaluronan in gene therapy
US6335434B1 (en) 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
US8153602B1 (en) 1991-11-19 2012-04-10 Isis Pharmaceuticals, Inc. Composition and methods for the pulmonary delivery of nucleic acids
US20020108136A1 (en) * 1997-03-21 2002-08-08 Sri Transgenic animals produced by homologous sequence targeting
US5523389A (en) * 1992-09-29 1996-06-04 Isis Pharmaceuticals, Inc. Inhibitors of human immunodeficiency virus
AU679566B2 (en) 1993-09-03 1997-07-03 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
US6420549B1 (en) 1995-06-06 2002-07-16 Isis Pharmaceuticals, Inc. Oligonucleotide analogs having modified dimers
US5731181A (en) * 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
US5760012A (en) * 1996-05-01 1998-06-02 Thomas Jefferson University Methods and compounds for curing diseases caused by mutations
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20030044941A1 (en) 1996-06-06 2003-03-06 Crooke Stanley T. Human RNase III and compositions and uses thereof
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
AU6659898A (en) * 1997-03-03 1998-09-22 Perkin-Elmer Corporation, The Improved chimeric oligonucleotide vectors
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
GB9711015D0 (en) * 1997-05-28 1997-07-23 Zeneca Ltd Improvements in or relating to organic compounds
ATE321882T1 (de) 1997-07-01 2006-04-15 Isis Pharmaceuticals Inc Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre
JP2001512687A (ja) * 1997-08-05 2001-08-28 キメラジェン，インコーポレーテッド 植物に局在性遺伝子変化を生じさせるための混合二本鎖オリゴヌクレオチドの使用
US7102055B1 (en) 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
ATE401410T1 (de) 1997-11-18 2008-08-15 Pioneer Hi Bred Int Zusammensetzungen und verfahren für die genetische modifizierung von pflanzen
CA2309719A1 (en) * 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Targeted manipulation of genes in plants
EP0945507A1 (de) * 1998-03-27 1999-09-29 Boehringer Mannheim Gmbh Tumorspezifische Expressionskontrollregion und deren Verwendung
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US6004804A (en) 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6010907A (en) 1998-05-12 2000-01-04 Kimeragen, Inc. Eukaryotic use of non-chimeric mutational vectors
EP1469009A2 (de) * 1998-05-21 2004-10-20 Isis Parmaceuticals, Inc. Zusammensetzungen und Verfahren für nicht-parenterale Verabreichung von Oligonukleotiden
CA2329252A1 (en) 1998-05-21 1999-11-25 Isis Pharmaceuticals Inc. Compositions and methods for topical delivery of oligonucleotides
US6693185B2 (en) 1998-07-17 2004-02-17 Bayer Bioscience N.V. Methods and means to modulate programmed cell death in eukaryotic cells
DE19836098A1 (de) 1998-07-31 2000-02-03 Hoechst Schering Agrevo Gmbh Pflanzen, die eine modifizierte Stärke synthetisieren, Verfahren zur Herstellung der Pflanzen, ihre Verwendung sowie die modifizierte Stärke
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
BR9914465A (pt) 1998-09-29 2001-10-09 Gamida Cell Ltd Métodos para controlar a proliferação e a diferenciação de células-tronco e células progenitoras e uma composição farmacêutica para induzir a diferenciação em uma população de células
CN100408687C (zh) 1998-11-09 2008-08-06 拜尔生物科学有限公司 来自稻米的核酸分子及其用于生产改性淀粉的用途
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
AU2415200A (en) * 1999-01-18 2000-08-01 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) * 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
EP1108783A3 (de) * 1999-01-19 2001-09-05 Maxygen, Inc. Oligonukletiden-gesteuerte Nukleinsäurerekombination
US6127124A (en) * 1999-01-20 2000-10-03 Isis Pharmaceuticals, Inc. Fluorescence based nuclease assay
US7098192B2 (en) 1999-04-08 2006-08-29 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of STAT3 expression
CA2368655A1 (en) * 1999-04-08 2000-10-19 Gregory M. Glenn Dry formulation for transcutaneous immunization
DE60040659D1 (de) 1999-05-07 2008-12-11 Du Pont Auxin transportproteine
US6656730B1 (en) 1999-06-15 2003-12-02 Isis Pharmaceuticals, Inc. Oligonucleotides conjugated to protein-binding drugs
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
AR025996A1 (es) 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
AU7875400A (en) * 1999-10-07 2001-05-10 Valigen, Inc. Compositions and methods for plant genetic modification
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US7253334B2 (en) 2000-12-22 2007-08-07 Aurox, Llc Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells
US7074983B2 (en) 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US20020055479A1 (en) 2000-01-18 2002-05-09 Cowsert Lex M. Antisense modulation of PTP1B expression
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
US6897020B2 (en) * 2000-03-20 2005-05-24 Newlink Genetics Inc. Methods and compositions for elucidating relative protein expression levels in cells
US20060134629A1 (en) * 2000-03-20 2006-06-22 Link Charles J Methods and compositions for elucidating protein expression profiles in cells
JP2003528607A (ja) * 2000-03-27 2003-09-30 ユニバーシティー、オブ、デラウェア 修飾一本鎖オリゴヌクレオチドを使用した標的染色体ゲノム変換
US6936467B2 (en) * 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
EP1284985A2 (de) * 2000-05-17 2003-02-26 University Of Delaware Dns-olinucleotide für zielgerichtete veränderung von pflanzengenen
US6656700B2 (en) 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
US6686188B2 (en) 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
WO2001094610A2 (en) * 2000-06-05 2001-12-13 Thomas Jefferson University Binary hybrid mutational vectors
US7468475B2 (en) 2000-06-16 2008-12-23 Schmuelling Thomas Method for modifying plant morphology, biochemistry and physiology
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
AU2001279069A1 (en) * 2000-07-27 2002-02-13 University Of Delaware Methods for enhancing targeted gene alteration using oligonucleotides
US6875907B2 (en) 2000-09-13 2005-04-05 Pioneer Hi-Bred International, Inc. Antimicrobial peptides and methods of use
WO2002026967A2 (en) * 2000-09-25 2002-04-04 Thomas Jefferson University Targeted gene correction by single-stranded oligodeoxynucleotides
US20020123474A1 (en) * 2000-10-04 2002-09-05 Shannon Mark E. Human GTP-Rho binding protein2
US7560622B2 (en) 2000-10-06 2009-07-14 Pioneer Hi-Bred International, Inc. Methods and compositions relating to the generation of partially transgenic organisms
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US20020142397A1 (en) * 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
WO2002059337A1 (en) * 2001-01-26 2002-08-01 Georgetown University School Of Medicine Anti-apoptopic gene scc-s2 and diagnostic and therapeutic uses thereof
WO2002079495A2 (en) * 2001-03-27 2002-10-10 University Of Delaware Genomics applications for modified oligonucleotides
WO2002081641A2 (en) * 2001-04-06 2002-10-17 Georgetown University Gene scc-112 and diagnostic and therapeutic uses thereof
WO2002081639A2 (en) * 2001-04-06 2002-10-17 Georgetown University Gene brcc2 and diagnostic and therapeutic uses thereof
AU2002258728A1 (en) 2001-04-06 2002-10-21 Georgetown University Gene brcc-3 and diagnostic and therapeutic uses thereof
AU2002303262A1 (en) * 2001-04-06 2002-10-21 Georgetown University Gene shinc-1 and diagnostic and therapeutic uses thereof
US20040063922A1 (en) * 2001-04-17 2004-04-01 Conrad Charles A. Methods and compositions for catalytic DNA exchange in a sequence specific manner
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
US7053195B1 (en) 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
CA2633171C (en) 2001-06-20 2012-11-20 Genentech, Inc. Antibodies against tumor-associated antigenic target (tat) polypeptides
US7803915B2 (en) 2001-06-20 2010-09-28 Genentech, Inc. Antibody compositions for the diagnosis and treatment of tumor
CA2451643C (en) 2001-06-21 2012-11-13 Isis Pharmaceuticals, Inc. Antisense modulation of superoxide dismutase 1, soluble expression
EP1925672A1 (de) 2001-06-22 2008-05-28 Syngeta Participations AG Auf abiotischen Stress ansprechende Polynukleotide und Polypeptide
US7425545B2 (en) 2001-07-25 2008-09-16 Isis Pharmaceuticals, Inc. Modulation of C-reactive protein expression
US6964950B2 (en) 2001-07-25 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of C-reactive protein expression
US20030096772A1 (en) 2001-07-30 2003-05-22 Crooke Rosanne M. Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7227014B2 (en) 2001-08-07 2007-06-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein (a) expression
EP1423537A4 (de) * 2001-08-07 2006-11-29 Univ Delaware Zusammensetzungen und verfahren zur vorbeugung und behandlung von morbus huntington
AU2002322435A1 (en) * 2001-08-09 2003-02-24 Cibus Genetics Non-transgenic herbicide resistant plants
US7456335B2 (en) * 2001-09-03 2008-11-25 Basf Plant Science Gmbh Nucleic acid sequences and their use in methods for achieving pathogen resistance in plants
EP1427856B1 (de) 2001-09-18 2011-05-11 Carnegie Institution Of Washington Fusionsproteine zur detektion von analyten
JP2005536439A (ja) 2001-09-18 2005-12-02 ジェネンテック・インコーポレーテッド 腫瘍の診断及び治療のための組成物と方法
AU2002331897A1 (en) 2001-09-27 2003-04-07 Pioneer Hi-Bred International, Inc. Phytate polynucleotides and methods of use
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
WO2003027264A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Coisogenic eukaryotic cell collections
WO2003027265A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration
AU2002334895B2 (en) 2001-10-09 2006-10-19 Isis Pharmaceuticals, Inc. Antisense modulation of insulin-like growth factor binding protein 5 expression
US6750019B2 (en) 2001-10-09 2004-06-15 Isis Pharmaceuticals, Inc. Antisense modulation of insulin-like growth factor binding protein 5 expression
US20030228319A1 (en) 2002-04-16 2003-12-11 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US6965025B2 (en) 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
NZ556415A (en) 2002-01-02 2009-02-28 Genentech Inc Compositions and methods for the diagnosis and treatment of glioma tumor
IL152904A0 (en) 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (en) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
EP2213292B2 (de) 2002-02-01 2016-06-22 Life Technologies Corporation Doppelsträngige Oligonukleotide
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
WO2003064621A2 (en) 2002-02-01 2003-08-07 Ambion, Inc. HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
AU2003216438B2 (en) * 2002-02-07 2008-05-01 E.I. Du Pont De Nemours And Company UDP-glucosyltransferases
CA2476894A1 (en) 2002-02-20 2003-08-28 American Integrated Biologics, Inc. Transgenic production in saliva
ATE458047T1 (de) * 2002-03-07 2010-03-15 Univ Delaware Verfahren zur verstärkung der oligonucleotid- vermittelten nucleinsäuresequenzänderung unter verwendung von zusammensetzungen mit einem hydroxyharnstoff
NZ535602A (en) 2002-04-08 2006-07-28 Pioneer Hi Bred Int Enhanced silk exsertion under stress in Zea mays plants
US7138512B2 (en) * 2002-04-10 2006-11-21 Georgetown University Gene SHINC-2 and diagnostic and therapeutic uses thereof
US7244565B2 (en) * 2002-04-10 2007-07-17 Georgetown University Gene shinc-3 and diagnostic and therapeutic uses thereof
WO2003093296A2 (en) 2002-05-03 2003-11-13 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
WO2003095655A2 (de) 2002-05-08 2003-11-20 Basf Plant Science Gmbh Verfahren zum erhöhen des ölgehaltes in pflanzen
US20030228317A1 (en) * 2002-05-22 2003-12-11 Prafulla Gokhale Gene BRCC-1 and diagnostic and therapeutic uses thereof
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US20030228558A1 (en) * 2002-06-11 2003-12-11 Bloom William Dennis Method of training brokers in a multi-level marketing business
AU2003231912A1 (en) * 2002-06-12 2003-12-31 Tel Aviv Medical Center Research Development Fund Methods of detecting and treating prostate cancer
EP1550463A4 (de) * 2002-09-20 2006-12-27 Dainippon Sumitomo Pharma Co Vorbereitungsweg zur erleichterung der situsspezifischen genumwandlung und vorbereitungsweg für die gentherapie
AU2003278957A1 (en) 2002-09-26 2004-04-23 Amgen, Inc. Modulation of forkhead box o1a expression
WO2004033708A2 (en) * 2002-10-07 2004-04-22 University Of Delaware Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
US9150606B2 (en) 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
CA2504720C (en) 2002-11-05 2013-12-24 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
AU2003290597A1 (en) 2002-11-05 2004-06-03 Isis Pharmaceuticals, Inc. Modified oligonucleotides for use in rna interference
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
KR20050093761A (ko) * 2002-11-08 2005-09-23 헤마테크, 엘엘씨 프리온 단백질 활성이 감소된 트랜스제닉 유제동물 및 그의용도
EP2336318B1 (de) 2002-11-13 2013-04-24 Genzyme Corporation Antisense-modulation von apolipoprotein-b-expression
ES2417879T3 (es) 2002-11-13 2013-08-09 Genzyme Corporation Modulación antisentido de la expresión de la apolipoproteína B
EP1572971B1 (de) 2002-11-15 2009-09-30 Morphotek Inc. Verfahren zur erzeugung einer hohen antikörperproduktion von durch in-vitro-immunisierung entstandenen hybridomen
US7144999B2 (en) 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
EP1578973B1 (de) 2002-12-19 2008-08-20 Bayer CropScience AG Pflanzenzellen und pflanzen, die eine stärke mit erhöhter endviskosität synthetisieren
US7468356B2 (en) 2003-02-11 2008-12-23 Antisense Therapeutics Ltd. Modulation of insulin like growth factor I receptor expression
AU2004213800A1 (en) 2003-02-17 2004-09-02 Metanomics Gmbh Preparation of organisms with faster growth and/or higher yield
US7803781B2 (en) 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US20040185559A1 (en) 2003-03-21 2004-09-23 Isis Pharmaceuticals Inc. Modulation of diacylglycerol acyltransferase 1 expression
CA2868312A1 (en) 2003-03-31 2004-10-14 University Of Bristol Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids
US20040205840A1 (en) * 2003-04-11 2004-10-14 Pioneer Hi-Bred International, Inc. Method for reducing gene expression
CA2521754A1 (en) 2003-04-15 2004-10-28 Basf Plant Science Gmbh Nucleic acid sequences encoding proteins associated with abiotic stress response and plant cells and plants with increased tolerance to environmental stress
US7598227B2 (en) 2003-04-16 2009-10-06 Isis Pharmaceuticals Inc. Modulation of apolipoprotein C-III expression
US7399853B2 (en) 2003-04-28 2008-07-15 Isis Pharmaceuticals Modulation of glucagon receptor expression
BRPI0410886A (pt) 2003-06-03 2006-07-04 Isis Pharmaceuticals Inc composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único
WO2004113496A2 (en) * 2003-06-20 2004-12-29 Isis Pharmaceuticals, Inc. Double stranded compositions comprising a 3’-endo modified strand for use in gene modulation
US7683036B2 (en) 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
PT2166069T (pt) 2003-08-01 2016-09-13 Basf Plant Science Gmbh Método de produção de ácidos gordos polinsaturados em organismos transgénicos
EP2434019A1 (de) 2003-08-01 2012-03-28 BASF Plant Science GmbH Verfahren zur Herstellung von Feinchemikalien
UA90849C2 (ru) 2003-08-11 2010-06-10 Квеек-Эн Рисерчбедрейф Агрико Б.В. Стойкие к грибкам растения семьи solanaceae
US7825235B2 (en) 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
US20050053981A1 (en) 2003-09-09 2005-03-10 Swayze Eric E. Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
WO2005027962A1 (en) 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
CA2539181A1 (en) 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. Modulation of eif4e expression
CN1882602B (zh) 2003-10-10 2011-02-09 阿尔卡米亚肿瘤股份有限公司 在疾病治疗中乙酰透明质酸合成的调节和降解
CN102174538B (zh) 2003-10-23 2013-06-19 奇尼塔二有限责任公司 检测与抗病毒感染性有关的基因oas1中的突变的方法
US20050191653A1 (en) 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
NZ547558A (en) 2003-11-17 2009-06-26 Genentech Inc Compositions and methods for the treatment of tumor of hematopoietic origin
US20050120397A1 (en) * 2003-11-24 2005-06-02 Hermann Steller Compounds and methods for regulation of spermatid differentiation
MXPA06006998A (es) 2003-12-17 2007-04-17 Cropdesign Nv Plantas que tienen caracteristicas de crecimiento modificadas y metodo para producir las mismas.
WO2005062923A2 (en) * 2003-12-24 2005-07-14 Massachusetts Institute Of Technology Gene targets for enhanced carotenoid production
US7741070B2 (en) 2003-12-24 2010-06-22 Massachusetts Institute Of Technology Gene targets for enhanced carotenoid production
US7608699B2 (en) * 2003-12-29 2009-10-27 Rockefeller University Synthetic nuclear localization signal derived from lentiviral integrase and methods of use thereof
EP1711606A2 (de) 2004-01-20 2006-10-18 Isis Pharmaceuticals, Inc. Modulation der expression des glucocorticoidrezeptors
US7468431B2 (en) 2004-01-22 2008-12-23 Isis Pharmaceuticals, Inc. Modulation of eIF4E-BP2 expression
US7208474B2 (en) 2004-02-25 2007-04-24 Pioneer Hi-Bred International, Inc. Bacillus thuringiensis crystal polypeptides, polynucleotides, and compositions thereof
JP4567047B2 (ja) 2004-02-27 2010-10-20 ビーエーエスエフ プラント サイエンス ゲーエムベーハー トランスジェニック植物における多価不飽和脂肪酸の製造方法
WO2005083053A2 (de) 2004-02-27 2005-09-09 Basf Plant Science Gmbh Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
EP1730309B1 (de) * 2004-03-15 2016-05-04 Ionis Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur optimierung der spaltung von rna durch rnase h
WO2005094370A2 (en) * 2004-03-29 2005-10-13 The General Hospital Corporation Oligonucleotide complex compositions and methods of use as gene alteration tools
EP2540734B1 (de) 2004-04-05 2016-03-30 Alnylam Pharmaceuticals, Inc. Prozess und Reagenzien für Oligonukleotidsynthese und -reinigung
US20050244869A1 (en) 2004-04-05 2005-11-03 Brown-Driver Vickie L Modulation of transthyretin expression
AU2005237494B2 (en) 2004-04-22 2010-06-10 Kyowa Hakko Kirin Co., Ltd Transgenic animals and uses thereof
US20070072815A1 (en) * 2004-05-04 2007-03-29 Kmiec Eric B Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
US7825293B2 (en) 2004-05-28 2010-11-02 Cropdesign N.V. Plants having improved growth characteristics and a method for making the same
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
CA2734624A1 (en) 2004-06-09 2005-12-29 Pioneer Hi-Bred International, Inc. Plastid transit peptides
WO2006069610A2 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
US8680062B2 (en) 2004-07-06 2014-03-25 Deliversir Ltd. System for delivering therapeutic agents into living cells and cells nuclei
EP1768997A1 (de) 2004-07-12 2007-04-04 CropDesign N.V. Pflanzen mit verbesserten wuchseigenschaften und methoden um sie herzustellen
ES2430827T3 (es) 2004-07-31 2013-11-21 Metanomics Gmbh Preparación de organismos con crecimiento más rápido y/o rendimiento más alto
DK1786472T3 (da) 2004-08-10 2013-04-15 Genzyme Corp Antisense-modulering af apolipoprotein B-ekspression
AU2005273864B2 (en) 2004-08-16 2010-09-30 Cropdesign N.V. Plants having improved growth characteristics and method for making the same
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
WO2006030442A2 (en) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
AU2005286738A1 (en) 2004-09-17 2006-03-30 Isis Pharmaceuticals, Inc. Enhanced antisense oligonucleotides
BRPI0515902A (pt) 2004-09-24 2008-08-12 Basf Plant Science Gmbh célula de planta, planta, semente, molécula de ácido nucleico isolada, construto de ácido nucleico, vetor, célula hospedeira, proteìna relacionada à tensão isolada, métodos de produção de uma planta transgênica e de modificação de toleráncia à tensão de uma planta, e, usos de um ácido nucleico que codifica srp e de toleráncia e/ou resistência aumentada à tensão ambiental e/ou ácido nucleico
DK1809302T3 (da) 2004-10-20 2012-11-26 Antisense Therapeutics Ltd Antisense-modulation af integrin-alfa-4-ekspression
CA2588281A1 (en) 2004-10-29 2006-05-04 Cropdesign N.V. Plants having improved growth characteristics and method for making the same
EP2199304A1 (de) 2004-12-17 2010-06-23 Metanomics GmbH Verfahren zur Steuerung der Chemikalienherstellung
AR051866A1 (es) 2004-12-24 2007-02-14 Cropdesign Nv Plantas con aumento del rendimiento y metodo de prepracion
MX2007007948A (es) 2004-12-28 2007-09-11 Pioneer Hi Bred Int Calidad de grano mejorada a traves de la expresion alterada de las proteinas de semilla.
CA2595672A1 (en) 2005-01-27 2006-08-03 Cropdesign N.V. Plants having increased yield and a method for making the same
BRPI0519985B1 (pt) 2005-02-23 2018-01-30 University Of Kentucky Research Foundation Método para redução do nível de nornicotina ou n’-nitrosonornicotina em uma planta do gênero nicotiana ou parte desta ou em um produto de tabaco, cassete de expressão e método para a produção de uma planta do gênero nicotiana
EP2573188A2 (de) 2005-03-02 2013-03-27 Metanomics GmbH Verfahren zur Herstellung von Feinchemikalien
EP1871883A1 (de) 2005-03-02 2008-01-02 Metanomics GmbH Verfahren zur produktion von feinchemikalien
CN101137752B (zh) 2005-03-08 2013-04-03 巴斯福植物科学有限公司 增强表达的内含子序列
WO2006098998A2 (en) 2005-03-10 2006-09-21 Genentech, Inc. Methods and compositions for modulating vascular integrity
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
EP1707632A1 (de) 2005-04-01 2006-10-04 Bayer CropScience GmbH Phosphorylierte waxy-Kartoffelstärke
EP1879626A4 (de) 2005-04-19 2011-03-23 Massachusetts Inst Technology Amphiphile polymere und verfahren zur verwendung davon
EP1874936B1 (de) 2005-04-19 2013-10-30 BASF Plant Science GmbH Verbesserte verfahren zur kontrolle der genexpression
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
US20060272057A1 (en) 2005-05-25 2006-11-30 Pioneer Hi-Bred International, Inc. Methods for improving crop plant architecture and yield
JP5329949B2 (ja) 2005-05-31 2013-10-30 エコーレ ポリテクニーク フェデラーレ デ ローザンヌ 遺伝子に基づいた薬物の細胞質送達のためのトリブロックコポリマー
WO2006138145A1 (en) 2005-06-14 2006-12-28 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
DE602006019588D1 (de) 2005-06-23 2011-02-24 Basf Plant Science Gmbh Verbesserte verfahren zur herstellung stabil transformierter und fruchtbarer buntmais-pflanzen
US8119858B2 (en) 2005-07-06 2012-02-21 Cropdesign N.V. Plant yield improvement by Ste20-like gene expression
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
CN101365794A (zh) 2005-08-12 2009-02-11 巴斯福植物科学有限公司 编码与非生物性胁迫应答相关的蛋白质的核酸序列和具有增加的环境胁迫耐受性的植物细胞及植物
US7842856B2 (en) 2005-08-25 2010-11-30 The Board Of Trustees Of The University Of Illinois Herbicide resistance gene, compositions and methods
BRPI0615941A2 (pt) 2005-09-15 2011-05-31 Cropdesign Nv método para aumentar o rendimento de planta em relação às plantas de controle, planta, construção, método para a produção de uma planta transgênica, planta transgênica, partes colhìveis de uma planta, produtos, uso de um ácido nucleico/gene oslea3a ou variante do mesmo ou uso de um polipeptìdeo oslea3a ou um homólogo do mesmo, e, semente de planta
EP1931789B1 (de) 2005-09-20 2016-05-04 BASF Plant Science GmbH VERFAHREN ZUR STEUERUNG DER GENEXPRESSION MITTELS ta- siRNA
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
RU2008122542A (ru) 2005-11-07 2009-12-20 КРОПДИЗАЙН Н.Фи. (BE) Растения, характеризующиеся улучшенными ростовыми характеристиками, и способ их получения
US8853492B2 (en) 2005-11-07 2014-10-07 Cropdesign N.V. Plants having improved growth characteristics and a method for making the same
AU2006311005B2 (en) 2005-11-08 2013-06-06 Cropdesign N.V. Plants having improved growth characteristics and a method for making the same
AU2006311089C1 (en) 2005-11-08 2012-11-08 Basf Plant Science Gmbh Use of armadillo repeat (ARM1) polynucleotides for obtaining pathogen resistance in plants
CA2629521A1 (en) 2005-11-10 2007-05-24 Pioneer Hi-Bred International, Inc. Dof (dna binding with one finger) sequences and methods of use
US20070199096A1 (en) 2005-11-14 2007-08-23 E.I. Du Pont De Nemours And Company Compositions and Methods for Altering Alpha- and Beta-Tocotrienol Content
WO2007062380A2 (en) 2005-11-21 2007-05-31 Isis Pharmaceuticals, Inc. Modulation of eif4e-bp2 expression
WO2007060117A2 (de) * 2005-11-24 2007-05-31 Basf Se Chimäre keratinbindende effektorproteine
US7723574B2 (en) 2005-11-24 2010-05-25 Basf Plant Science Gmbh Process for the production of Δ5-unsaturated fatty acids in transgenic organisms
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
CA2631779C (en) 2005-12-01 2015-10-27 Cropdesign N.V. Plants having improved growth characteristics and methods for making the same
CN101341254A (zh) 2005-12-24 2009-01-07 蒂加斯克乳制品研究中心 反-10，顺-12十八碳二烯酸的生产方法
US8288354B2 (en) 2005-12-28 2012-10-16 The Scripps Research Institute Natural antisense and non-coding RNA transcripts as drug targets
US7592505B2 (en) 2005-12-30 2009-09-22 Pioneer Hi-Bred International, Inc. UDP-xylose synthases (UXS) polynucleotides, polypeptides, and uses thereof
US8178751B2 (en) 2006-01-12 2012-05-15 Basf Plant Science Gmbh Use of stomatin (STM1) polynucleotides for achieving a pathogen resistance in plants
EP2465341B1 (de) 2006-01-12 2014-12-17 Cibus Europe B.V. EPSPS-Mutanten
EP2428227B1 (de) 2006-01-26 2016-06-22 Ionis Pharmaceuticals, Inc. Zusammensetzung und deren Verwendungen in Bezug auf Huntingtin
EP2388327A1 (de) 2006-01-27 2011-11-23 Isis Pharmaceuticals, Inc. Oligomerverbindungen und Zusammensetzungen zur Verwendung bei der Modulation von microRNAs
DE602007009487D1 (de) 2006-01-27 2010-11-11 Isis Pharmaceutical Inc 6-modifizierte bicyclische nukleinsäureanaloga
US7569686B1 (en) 2006-01-27 2009-08-04 Isis Pharmaceuticals, Inc. Compounds and methods for synthesis of bicyclic nucleic acid analogs
US7589257B2 (en) 2006-02-09 2009-09-15 Pioneer Hi-Bred International Inc. Genes for enhancing nitrogen utilization efficiency in crop plants
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
CA2647115A1 (en) 2006-03-24 2007-10-04 Basf Plant Science Gmbh Proteins associated with abiotic stress response and homologs
EP2436771B1 (de) 2006-03-31 2015-08-19 BASF Plant Science GmbH Pflanzen mit verbesserten Ertragseigenschaften und Verfahren zu ihrer Herstellung
CA2644273A1 (en) 2006-04-05 2008-03-27 Metanomics Gmbh Process for the production of a fine chemical
AR060523A1 (es) 2006-04-19 2008-06-25 Pioneer Hi Bred Int Moleculas de polinucleotidos aislados que corresponden a alelos mutantes y tipo salvaje del gen de maiz d9 y metodos para usarlas
US20090292006A1 (en) 2006-05-05 2009-11-26 Sanjay Bhanot Compounds and methods for modulating expression of dgat2
AU2007249349B2 (en) 2006-05-11 2012-03-08 Isis Pharmaceuticals, Inc. 5'-Modified bicyclic nucleic acid analogs
US7666854B2 (en) 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
CN103103199A (zh) 2006-05-30 2013-05-15 克罗普迪塞恩股份有限公司 具有增强的产量相关性状的伸展蛋白受体样激酶受调节表达的植物和用于产生该植物的方法
WO2007137973A2 (en) 2006-05-31 2007-12-06 Metanomics Gmbh Manipulation of the nitrogen metabolism using ammonium transporter or glucose 6-phosphate deshydrogenases or farnesyl phosphate synthetase (fpp)
US8273952B2 (en) 2006-06-08 2012-09-25 Basf Plant Science Gmbh Plants having improved growth characteristics and method for making the same
BRPI0712507A2 (pt) 2006-06-15 2011-07-05 Cropdesign Nv método para intensificar caracterìsticas relacionadas ao rendimento em plantas, planta ou parte da mesma, contrução uso de uma construção planta, parte de planta ou célula vegetal, método para a produção de uma planta transgência, partes colhìveis de um planta, produtos, uso de um ácido nucleico, molécula isolada de ácido nucleico, e, polipeptìdeo isolado
EP2032704A2 (de) 2006-06-15 2009-03-11 CropDesign N.V. Pflanzen mit modulierter expression von nac-transkriptionsfaktoren mit verbesserten ertragseigenschaften sowie herstellungsverfahren dafür
CA2656557C (en) 2006-06-28 2015-08-11 Cibus, Llc Fatty acid blends and uses therefor
US8198253B2 (en) 2006-07-19 2012-06-12 Isis Pharmaceuticals, Inc. Compositions and their uses directed to HBXIP
EP2189533A1 (de) 2006-08-02 2010-05-26 CropDesign N.V. Pflanzen mit verbesserten Eigenschaften bezüglich des Ertrags und Verfahren zu ihrer Herstellung
ES2558133T3 (es) 2006-08-02 2016-02-02 Cropdesign N.V. Plantas transformadas con el polipéptido SYT que tienen el rendimiento aumentado en estrés abiótico y procedimiento de producción de las mismas
CA2669812A1 (en) 2006-08-30 2008-03-06 Basf Plant Science Gmbh Method for increasing resistance to pathogens in transgenic plants
US9127084B2 (en) 2006-09-14 2015-09-08 Medgenics Medical Israel Ltd. Long lasting drug formulations
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
CN102886052B (zh) 2006-09-14 2014-07-30 迈德詹尼克斯医疗以色列有限公司 长效药物制剂
CA2665336C (en) 2006-10-06 2016-01-05 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
CA2660861A1 (en) 2006-10-12 2008-04-17 Basf Plant Science Gmbh Method for increasing pathogen resistance in transgenic plants
MX2009003824A (es) 2006-10-13 2010-04-07 Basf Plant Science Gmbh Plantas con rendimiento aumentado.
US8373022B2 (en) 2006-10-24 2013-02-12 Basf Plant Science Gmbh Methods for increasing the resistance in plants to biotropic fungi
AR064252A1 (es) 2006-11-16 2009-03-25 Cropdesign Nv Plantas que presentan caracteristicas acrecentadas relacionadas con el rendimiento y un metodo para producir las mismas
CA2664987A1 (en) 2006-11-24 2008-05-29 Cropdesign N.V. Transgenic plants comprising as transgene a class i tcp or clavata 1 (clv1) or cah3 polypeptide having increased seed yield and a method for making the same
WO2008071767A1 (en) 2006-12-15 2008-06-19 Cropdesign N.V. Plants having enhanced seed yield-related traits and a method for making the same
CA2671401A1 (en) 2006-12-21 2008-06-26 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
EP1935428A1 (de) * 2006-12-22 2008-06-25 Antisense Pharma GmbH Oligonukleotid-Polymer Konjugate
EP2102364B1 (de) 2006-12-28 2019-01-23 Pioneer Hi-Bred International, Inc. Genetische marker für sommerwurzresistenz bei sonnenblumen
EP2617431B1 (de) * 2007-01-10 2017-04-12 Purdue Research Foundation Polypeptid-Inhibitoren von HSP27-Kinase und Verwendungen dafür
DK2202314T3 (da) 2007-01-15 2014-06-16 Basf Plant Science Gmbh Anvendelse af subtilisin (RNR9)-polynukleotider til opnåelse af patogenresistens i planter
MX2009007246A (es) 2007-01-30 2009-09-16 Cropdesign Nv Plantas con rasgos relacionados con el rendimiento mejorado y un metodo para producirlas.
ES2485384T3 (es) 2007-01-31 2014-08-13 Basf Plant Science Gmbh Plantas que tienen rasgos potenciados relacionados con el rendimiento y/o mayor resistencia al estrés abiótico y un procedimiento para fabricar las mismas
JP5512285B2 (ja) 2007-02-09 2014-06-04 ノースウェスタン ユニバーシティ 細胞内標的を検出するための粒子
AR065552A1 (es) 2007-02-28 2009-06-17 Crop Functional Genomics Ct Plantas con rasgos aumentados relacionados con el rendimiento y un metodo para producirlas
US8153863B2 (en) 2007-03-23 2012-04-10 New York University Transgenic plants expressing GLK1 and CCA1 having increased nitrogen assimilation capacity
AR065938A1 (es) 2007-04-04 2009-07-15 Basf Plant Science Gmbh Mutantes de ahas
US9556210B2 (en) 2007-04-23 2017-01-31 Sabag-Rfa Ltd. System for delivering therapeutic agents into living cells and cells nuclei
EP2144633B1 (de) * 2007-04-23 2014-07-16 Deliversir Ltd System zur Abgabe von therapeutischen Mitteln in lebenden Zellen und Zellkernen
US9156865B2 (en) 2007-04-23 2015-10-13 Deliversir Ltd System for delivering therapeutic agents into living cells and cells nuclei
EP2228386B1 (de) 2007-05-03 2015-03-18 BASF Plant Science GmbH Pflanzen mit verbesserten Eigenschaften bezüglich des Ertrags und Verfahren zu ihrer Herstellung
AR066642A1 (es) 2007-05-22 2009-09-02 Basf Plant Gmbh Celulas vegetales y plantas con mayor tolerancia y/o resistencia al estres ambiental y mayor produccion de biomasa producidas por silenciamiento de genes
DE112008001452T5 (de) 2007-05-22 2010-12-16 Basf Plant Science Gmbh Pflanzen mit erhöhter Toleranz und/oder Resistenz gegen Umweltstress und erhöhter Biomasseproduktion
CN101688214A (zh) 2007-05-23 2010-03-31 克罗普迪塞恩股份有限公司 具有增强的产量相关性状的植物和用于产生该植物的方法
BRPI0811242A2 (pt) 2007-05-25 2014-11-04 Cropdesign Nv Polinucleotídeo isolado, cassete de expressão, planta, métodos para aumentar o nível de um polipeptídeo em uma planta, e para aumentar o rendimento em uma planta, e, polipeptídeo isolado
CA3055145A1 (en) 2007-05-30 2008-12-11 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US8278425B2 (en) 2007-05-30 2012-10-02 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
ES2386492T3 (es) 2007-06-08 2012-08-21 Isis Pharmaceuticals, Inc. Análogos de ácidos nucleicos bicíclicos carbocíclicos
BRPI0813114A2 (pt) 2007-06-29 2014-11-11 Basf Plant Scinece Gmbh Método para melhorar características relacionadas a rendimento em plantas em relação a plantas de controle, construção, uso de uma construção, planta, parte de planta ou célula de planta, método para a produção de uma planta transgênica, partes colhíveis de uma planta, produtos, e, uso de um ácido nucleico
AU2008272918B2 (en) 2007-07-05 2012-09-13 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
US8697947B2 (en) 2007-07-20 2014-04-15 Basf Plant Science Gmbh Plants having increased yield-related traits and a method for making the same
CN103397049A (zh) 2007-07-31 2013-11-20 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物及其制备方法
AR067748A1 (es) 2007-07-31 2009-10-21 Basf Plant Science Gmbh Plantas que tienen rasgos mejorados relacionados con el rendimiento y un metodo para obtenerlas
EP2185698B1 (de) 2007-08-07 2015-04-22 Purdue Research Foundation Kinasehemmer und ihre verwendung
US8088904B2 (en) 2007-08-15 2012-01-03 Isis Pharmaceuticals, Inc. Tetrahydropyran nucleic acid analogs
CA2699066A1 (en) 2007-09-14 2009-03-19 Basf Plant Science Gmbh Plants having increased yield-related traits and a method for making the same comprising expression of a growth-regulating factor (grf) polypeptide
CN103695459A (zh) 2007-09-18 2014-04-02 巴斯夫植物科学有限公司 产量提高的植物
BRPI0816880A2 (pt) 2007-09-21 2015-09-08 Basf Plant Science Gmbh métodos para produzir uma planta com rendimento aumentado em comparação com uma planta do tipo selvagem correspondente, para produzir uma planta transgênica com rendimento aumentado em comparação com uma planta do tipo selvagem não transformada correspondente, para produzir uma composição agrícola, para identificar uma planta com um rendimento aumentado, e para aumentar o rendimento de uma população de plantas, molécula de ácido nucleico isolada, construção de ácido nucléico, vetor, processos para produzir um polipeptídeo, e para identificar um composto, polipeptídeo, anticorpo, núcleo de célula de planta, célula de planta, tecido de planta, material de propagação, pólen, progênie, material colhido ou planta, semente, parte de planta, planta transgênica, planta transgênica, núcleo de célula de planta transgênica, célula de planta transgênica, planta que compreende um ou mais de tais núcleos de célula de planta transgênica ou células de planta, progênie, semente ou pólen derivado de ou produzido por uma planta transgênica, composição, e, uso dos ácidos nucleicos.
ES2390523T3 (es) 2007-09-21 2012-11-13 Basf Plant Science Gmbh Plantas que tienen características incrementadas relacionadas con el rendimiento y un método para elaboración de las mismas
US7951785B2 (en) 2007-09-21 2011-05-31 California Institute Of Technology NFIA in glial fate determination, glioma therapy and astrocytoma treatment
PL2700721T3 (pl) 2007-10-05 2019-06-28 Cibus Europe B.V. Zmutowane geny kodujące syntazę kwasu acetohydroksylowego w brassica
US20100280098A1 (en) * 2007-10-05 2010-11-04 Juliano Rudolph L Receptor targeted oligonucleotides
US20090111099A1 (en) * 2007-10-27 2009-04-30 Yongsheng Ma Promoter Detection and Analysis
US20110071047A1 (en) * 2007-10-27 2011-03-24 O.D. 260 Inc. Promoter detection and analysis
CA2703827A1 (en) 2007-10-29 2009-05-07 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
US8124851B2 (en) 2007-11-12 2012-02-28 North Carolina State University Alteration of tobacco alkaloid content through modification of specific cytochrome P450 genes
US8637478B2 (en) * 2007-11-13 2014-01-28 Isis Pharmaceuticals, Inc. Compounds and methods for modulating protein expression
CN103952415A (zh) 2007-11-20 2014-07-30 先锋国际良种公司 用于改善植物应激耐性的玉米乙烯信号转导基因及其调节
EP2222851B1 (de) 2007-11-20 2017-06-28 Ionis Pharmaceuticals, Inc. Modulation der cd40-expression
WO2009067647A1 (en) * 2007-11-21 2009-05-28 Isis Pharmaceuticals, Inc. Carbocyclic alpha-l-bicyclic nucleic acid analogs
CA2706506A1 (en) 2007-11-22 2009-05-28 Valerie Frankard Plants having increased yield-related traits and a method for making the same
EP2574621A1 (de) 2007-11-26 2013-04-03 BASF Plant Science GmbH Pflanzen mit verbesserten Ertragseigenschaften und Verfahren zu ihrer Herstellung
US20110098183A1 (en) * 2007-12-19 2011-04-28 Basf Plant Science Gmbh Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
CN101969759A (zh) 2007-12-20 2011-02-09 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物及其制备方法
BRPI0821009A2 (pt) * 2007-12-21 2019-09-24 Basf Plant Science Gmbh métodos para aumentar o rendimento de uma planta e para produzir uma célula de planta transgênica, uma planta ou uma parte e para determinar o teor de nitrogênio de solo de teste, moléculas, moléculas de ácido nucléico isolada e de ácido nucleico viral, oligoiniciador, mutante negativo dominante de polipeptideo, construto de ácido nucleico, vetor, célula de planta transgênica, planta ou uma parte da mesma, polipeptideo, anticorpo, tecido de planta, planta, material de planta colhida ou material de propagação de uma planta, processo para produzir um polipeptideo, composição de alimento ou ração, e, uso
JP2011508047A (ja) * 2007-12-27 2011-03-10 サイバス，エルエルシー アルキルエステル脂肪酸配合物およびその用途
EP2245168A2 (de) 2008-01-25 2010-11-03 BASF Plant Science GmbH Pflanzen mit eigenschaften in verbindung mit verbessertem ertrag sowie verfahren zu deren herstellung
BRPI0906719A2 (pt) 2008-01-31 2015-08-04 Nat Inst For Biolog Sciences Método para alterar o crescimento e/ou desenvolvimento de planta, construção, uso de uma construção, planta, parte de planta ou célula de planta, método para a produção de uma planta transgênica, partes colhíveis de uma planta, produtos derivados de uma planta, e, uso de um ácido nucleico.
WO2009100320A2 (en) 2008-02-07 2009-08-13 Isis Pharmaceuticals, Inc. Bicyclic cyclohexitol nucleic acid analogs
BRPI0908093A2 (pt) 2008-02-27 2019-01-15 Basf Plant Science Gmbh núcleo de célula de planta transgênica, célula de planta transgênica, planta ou parte da mesma, molécula de ácido nucleico isolada, construto de ácido nucleico, vetor, núcleo hospedeiro ou célula hospedeira, anticorpo, tecido de planta, material de propagação, pólen, progênie, material colhido ou uma planta, processo para a identificação de um composto, composição, uso de uma molécula de ácido nucleico, processo para produzir um polipeptídeo, polipeptídeo, e, métodos para produzir uma planta transgênica ou uma parte da mesma, para produzir uma composição agrícola, para produzir um núcleo de célula de planta transgênica, uma célula de planta transgênica
EP2282744B1 (de) 2008-03-21 2018-01-17 Ionis Pharmaceuticals, Inc. Oligomere verbindungen mit trizyklischen nukleosiden und anwendungsverfahren dafür
US9290534B2 (en) 2008-04-04 2016-03-22 Ionis Pharmaceuticals, Inc. Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
DE112009000705T5 (de) 2008-04-16 2011-06-16 Basf Plant Science Gmbh Pflanzen mit gesteigerten ertragsbezogenen Eigenschaften und Verfahren zur Herstellung derselben
US20110061134A1 (en) 2008-05-05 2011-03-10 Basf Plant Science Gmbh Plants Having Enhanced Yield-Related Traits and a Method for Making the Same
KR20170010072A (ko) * 2008-05-23 2017-01-25 누셀리스 인크. 효모를 사용한 스쿠알렌 생산
US20110099669A1 (en) 2008-06-20 2011-04-28 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
EP2975130A3 (de) 2008-06-26 2016-04-20 BASF Plant Science GmbH Pflanzen mit verbesserten ertragseigenschaften und verfahren zur herstellung davon
WO2010000794A1 (en) 2008-07-04 2010-01-07 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same by overexpressing a polynucleotide encoding a tfl1-like protein
AU2009272815B2 (en) 2008-07-17 2016-05-12 Basf Plant Science Gmbh Plants having enhanced yield-related traits and a method for making the same
CN102144033A (zh) 2008-07-31 2011-08-03 巴斯夫植物科学有限公司 具有修饰的生长特征的植物及其制备方法
AU2009279682B2 (en) 2008-08-04 2015-01-22 University Of Miami STING (stimulator of interferon genes), a regulator of innate immune responses
CA2734347A1 (en) 2008-08-19 2010-02-25 Basf Plant Science Gmbh Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
US20110145949A1 (en) 2008-08-20 2011-06-16 Basf Plant Science Gmbh Plants Having Enhanced Yield-Related Traits and a Method for Making the Same
US8252762B2 (en) 2008-08-25 2012-08-28 Excaliard Pharmaceuticals, Inc. Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
KR20110094268A (ko) 2008-09-11 2011-08-23 키진 엔.브이. 진단 마커 개발 방법
BRPI0919153A2 (pt) 2008-09-23 2019-05-07 Basf Plant Science Gmbh método para produzir uma planta com rendimento aumentado, molécula de ácido nucleico, construto de ácido nucleico, vetor, processo para produzir um polipeptídeo, poliptídeo, anticorpo, núcleo de célula de planta, célula de planta, tecido de planta, material de propagação, pólen, progênie, material coletado, ou uma planta, ou uma parte da planta, planta transgênica, processo para identificar um composto, método para a produção de uma composição agrícola, composição, uso de ácido nucleico, e, método para a identificação de uma planta com um rendimento aumentado, e para aumentar o rendimento de uma população de plantas
US8604192B2 (en) 2008-09-24 2013-12-10 Isis Pharmaceuticals, Inc. Cyclohexenyl nucleic acids analogs
EP2334797A1 (de) 2008-09-24 2011-06-22 BASF Plant Science GmbH Pflanzen mit eigenschaften in verbindung mit verbessertem ertrag sowie verfahren zu deren herstellung
WO2010036698A1 (en) 2008-09-24 2010-04-01 Isis Pharmaceuticals, Inc. Substituted alpha-l-bicyclic nucleosides
PL2342331T3 (pl) 2008-09-26 2016-05-31 Basf Agrochemical Products Bv Mutanty ahas odporne na herbicydy i sposoby ich zastosowania
CN109797150A (zh) 2008-10-15 2019-05-24 Ionis制药公司 因子11表达的调节
WO2010065206A1 (en) * 2008-10-20 2010-06-10 Moerae Matrix, Inc. Polypeptide for treating or preventing adhesions
AR075466A1 (es) 2008-10-22 2011-04-06 Basf Se Uso de herbicidas tipo auxina en plantas cultivadas
WO2010046423A2 (en) 2008-10-22 2010-04-29 Basf Se Use of sulfonylurea herbicides on cultivated plants
EP2350287A2 (de) 2008-10-23 2011-08-03 BASF Plant Science GmbH Verfahren zur herstellung einer transgenen zelle mit erhöhtem gamma-aminobuttersäure-(gaba-)gehalt
CN102264907A (zh) 2008-10-23 2011-11-30 巴斯夫植物科学有限公司 产量增加的植物(nue)
EP2358398A2 (de) 2008-10-24 2011-08-24 Isis Pharmaceuticals, Inc. Oligomere verbindungen und verfahren
AU2009308217B2 (en) 2008-10-24 2016-01-21 Ionis Pharmaceuticals, Inc. 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
EP2184351A1 (de) 2008-10-30 2010-05-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Polynukleotid-kondierende Caryophyllen-Synthase und ihre Verwendung
EP2344640A1 (de) 2008-10-30 2011-07-20 Pioneer Hi-Bred International Inc. Manipulation von glutamin-synthetasen (gs) zur verbesserung der stickstoffnutzungseffizienz und kornausbeute bei höheren pflanzen
AU2009315732A1 (en) 2008-11-12 2010-05-20 Basf Plant Science Gmbh Plants having enhanced abiotic stress tolerance and/or enhanced yield-related traits and a method for making the same
MX307031B (es) 2008-11-14 2012-12-13 Fujian Fuda Biotech Co Ltd Una fitasa escherichia coli no-k12 termotolerante y su produccion.
EP3335705A1 (de) 2008-11-24 2018-06-20 Northwestern University Polyvalente rna-nanopartikelzusammensetzungen
BRPI0924537A2 (pt) 2008-12-03 2015-08-11 Basf Plant Science Gmbh Método para aumentar as características relacionadas ao rendimento em plantas, plantas ou parte das mesmas, ou células de planta, construto, uso de um construto e de uma sequência de ácido nucleico, método para a produção de plantas transgênicas, partes colhíveis, e, produtos
US8921329B2 (en) 2008-12-04 2014-12-30 Curna, Inc. Treatment of erythropoietin (EPO) related diseases by inhibition of natural antisense transcript to EPO
CA2743707A1 (en) 2008-12-04 2010-06-10 Pioneer Hi-Bred International, Inc. Methods and compositions for enhanced yield by targeted expression of knotted1
KR20110091796A (ko) 2008-12-04 2011-08-12 오피케이오 큐알엔에이, 엘엘씨 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
US20110237649A1 (en) 2008-12-04 2011-09-29 Opko Curna, Llc Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirtuin 1
JP6108660B2 (ja) 2008-12-10 2017-04-05 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 細胞透過性ペプチドを用いたキナーゼ阻害剤
PL2376638T3 (pl) 2008-12-12 2014-01-31 Basf Plant Science Gmbh Desaturazy oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych w organizmach transgenicznych
WO2010080554A1 (en) 2008-12-17 2010-07-15 Avi Biopharma, Inc. Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
EP2379582A1 (de) 2008-12-17 2011-10-26 BASF Plant Science GmbH Pflanzen mit gesteigerten ertragsbezogenen eigenschaften und/oder gesteigerter abiotischer stresstoleranz und verfahren zur herstellung derselben
EP2204086A1 (de) 2009-01-02 2010-07-07 Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK) Sechszeilige Gerste
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
WO2010083328A2 (en) 2009-01-14 2010-07-22 The Salk Institute For Biological Studies Methods for screening and compounds that protect against amyloid diseases
AU2010209875A1 (en) 2009-01-28 2011-08-18 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
EP2393825A2 (de) 2009-02-06 2011-12-14 Isis Pharmaceuticals, Inc. Oligomere verbindungen und verfahren
WO2010090969A1 (en) 2009-02-06 2010-08-12 Isis Pharmaceuticals, Inc. Tetrahydropyran nucleic acid analogs
WO2010093906A2 (en) 2009-02-12 2010-08-19 Curna, Inc. Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
DK2396038T3 (en) 2009-02-12 2016-02-01 Curna Inc TREATMENT OF BRAIN-DERIVATED NEUROTROPHIC FACTOR- (BDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTION TO BDNF
CA2751323A1 (en) 2009-02-25 2010-09-02 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
US8716553B2 (en) 2009-03-02 2014-05-06 Pioneer Hi Bred International Inc NAC transcriptional activators involved in abiotic stress tolerance
EP2403946A4 (de) 2009-03-04 2012-11-14 Behandlung von sirtuin 1 (sirt1)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen sirt 1
ES2656290T3 (es) 2009-03-16 2018-02-26 Curna, Inc. Tratamiento de enfermedades relacionadas con el factor nuclear (derivado de eritroide 2) similar al 2 (NRF2) mediante inhibición del transcrito antisentido natural a NRF2
EP2408920B1 (de) 2009-03-17 2017-03-08 CuRNA, Inc. Behandlung von erkrankungen im zusammenhang mit dem delta-like-1-homolog (dlk1) mittels hemmung des natürlichen antisense-transkripts gegen dlk1
CA2757581A1 (en) 2009-04-14 2010-10-21 Pioneer Hi-Bred International, Inc. Modulation of acc synthase improves plant yield under low nitrogen conditions
WO2010121956A1 (en) 2009-04-21 2010-10-28 Basf Plant Science Company Gmbh Rna-mediated induction of gene expression in plants
US20120047602A1 (en) 2009-04-21 2012-02-23 Basf Plant Science Company Gmbh RNA-Mediated Induction of Gene Expression in Plants
EP3524275A1 (de) 2009-04-22 2019-08-14 Massachusetts Institute Of Technology Angeborene immununterdrückung ermöglicht die wiederholte verabreichung von langen rna-molekülen
EP2424994B1 (de) 2009-04-29 2015-08-12 BASF Plant Science Company GmbH Pflanzen mit eigenschaften in verbindung mit verbessertem ertrag sowie verfahren zu deren herstellung
MX2011011454A (es) 2009-04-29 2011-11-18 Basf Plant Science Co Gmbh Plantas que tienen mejores rasgos relacionados con el rendimiento y un metodo para producirlas.
CA2760589C (en) 2009-05-01 2019-08-20 Joseph Collard Treatment of hemoglobin (hbf/hbg) related diseases by inhibition of natural antisense transcript to hbf/hbg
WO2010129501A1 (en) 2009-05-04 2010-11-11 Pioneer Hi-Bred International, Inc. Yield enhancement in plants by modulation of ap2 transcription factor
JP5883782B2 (ja) 2009-05-06 2016-03-15 クルナ・インコーポレーテッド 脂質輸送代謝遺伝子に対する天然アンチセンス転写物の抑制による脂質輸送代謝遺伝子関連疾患の治療
EP2427480A1 (de) 2009-05-06 2012-03-14 BASF Plant Science Company GmbH Pflanzen mit gesteigerten ertragseigenschaften und/oder einer gesteigerten toleranz gegenüber abiotischem stress, und ein verfahren zu deren herstellung
CN102803492B (zh) 2009-05-06 2016-06-29 库尔纳公司 通过抑制针对三重四脯氨酸(ttp)的天然反义转录物来治疗ttp相关疾病
NO2432881T3 (de) 2009-05-18 2018-04-14
JP2012527248A (ja) 2009-05-22 2012-11-08 クルナ・インコーポレーテッド 転写因子ｅ３（ｔｆｅ３）に対する天然アンチセンス転写物の阻害によるｔｆｅ３およびインスリン受容体基質２（ｉｒｓ２）関連疾患の処置
EP2435571B1 (de) 2009-05-28 2016-12-14 CuRNA, Inc. Behandlung von durch antivirale gene bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen ein antivirales gen
JP6128846B2 (ja) 2009-06-16 2017-05-17 クルナ・インコーポレーテッド パラオキソナーゼ（ｐｏｎ１）に対する天然アンチセンス転写物の抑制によるｐｏｎ１遺伝子関連疾患の治療
CN102695797B (zh) 2009-06-16 2018-05-25 库尔纳公司 通过抑制针对胶原基因的天然反义转录物来治疗胶原基因相关的疾病
WO2011006717A2 (en) 2009-06-19 2011-01-20 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
WO2010151671A2 (en) 2009-06-24 2010-12-29 Curna, Inc. Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
KR101807324B1 (ko) 2009-06-26 2017-12-08 큐알엔에이, 인크. 다운 증후군 유전자에 대한 천연 안티센스 전사체의 억제에 의한 다운 증후군 유전자 관련된 질환의 치료
CA2764073A1 (en) 2009-06-30 2011-01-20 E. I. Du Pont De Nemours And Company Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding cytosolic pyrophosphatase
ATE550350T1 (de) 2009-07-10 2012-04-15 Univ Berlin Freie Rock2 und rock3, zwei neue gain-of-function- varianten der cytokininrezeptoren ahk2 und ahk3
EP2275564A1 (de) 2009-07-17 2011-01-19 Freie Universität Berlin Mittel und Verfahren zur Produktion von transgenen Pflanzen, die gegenüber Kohlhernie resistent sind
AU2010275363A1 (en) 2009-07-23 2012-02-02 Basf Plant Science Company Gmbh Plants with increased yield
AU2010274146A1 (en) 2009-07-24 2012-02-02 Pioneer Hi-Bred International, Inc. The use of dimerization domain component stacks to modulate plant architecture
WO2011017132A2 (en) * 2009-07-27 2011-02-10 Purdue Research, Foundation Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration
CA2769665A1 (en) 2009-08-05 2011-02-10 Opko Curna, Llc Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
WO2011017492A2 (en) 2009-08-05 2011-02-10 Pioneer Hi-Bred International, Inc. Novel eto1 genes and use of same for reduced ethylene and improved stress tolerance in plants
EP2462153B1 (de) 2009-08-06 2015-07-29 Isis Pharmaceuticals, Inc. Bicyclische cyclohexosenukleinsäureanaloga
GB0914012D0 (en) 2009-08-11 2009-09-16 Plant Bioscience Ltd Stress tolerant plants
AU2010285126A1 (en) 2009-08-19 2012-03-01 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
CN102549149A (zh) 2009-08-20 2012-07-04 先锋国际良种公司 在玉蜀黍中功能性表达酵母硝酸盐转运蛋白(ynt1)以改善硝酸盐吸收
US9023822B2 (en) 2009-08-25 2015-05-05 Curna, Inc. Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP
AU2010288482A1 (en) 2009-08-31 2012-04-12 Basf Plant Science Company Gmbh Regulatory nucleic acid molecules for enhancing seed-specific gene expression in plants promoting enhanced polyunsaturated fatty acid synthesis
CA3031259C (en) 2009-08-31 2020-12-29 Basf Plant Science Company Gmbh Regulatory nucleic acid molecules for enhancing constitutive gene expression in plants
EP3156490B1 (de) 2009-08-31 2019-10-09 BASF Plant Science Company GmbH Regulatorische nukleinsäuremoleküle zur erhöhten keimspezifischen und/oder keimbevorzugten genexpression bei pflanzen
CA2772715C (en) 2009-09-02 2019-03-26 Genentech, Inc. Mutant smoothened and methods of using the same
CN102648282A (zh) 2009-09-25 2012-08-22 巴斯夫植物科学有限公司 具有增强的产量相关性状的植物和用于产生该植物的方法
CA2772983A1 (en) 2009-09-25 2011-03-31 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
MX2012003972A (es) 2009-10-02 2012-05-08 Pionner Hi Bred International Inc Regulacion a la baja de acc sintasa para mejorar el rendimiento de las plantas.
CA2778442A1 (en) 2009-10-22 2011-04-28 Genentech, Inc. Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
AU2010309990A1 (en) 2009-10-22 2012-05-24 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
AU2010313154B2 (en) 2009-10-30 2016-05-12 Northwestern University Templated nanoconjugates
AR078829A1 (es) 2009-10-30 2011-12-07 Du Pont Plantas y semillas con niveles alterados de compuesto de almacenamiento, construcciones relacionadas y metodos relacionados con genes que codifican proteinas similares a las aldolasas bacterianas de la clase ii del acido 2,4- dihidroxi-hept-2-eno-1,7-dioico
CA2779830C (en) 2009-11-13 2020-07-21 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
WO2011058029A1 (en) 2009-11-13 2011-05-19 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
WO2011061656A1 (en) 2009-11-17 2011-05-26 Basf Plant Science Company Gmbh Plants with increased yield
PL2504421T3 (pl) 2009-11-23 2017-12-29 Nucelis Llc Sposoby i kompozycje do wytwarzania skwalenu z użyciem drożdży
MX338694B (es) 2009-11-30 2016-04-27 Genentech Inc Composiciones y metodos para el diagnostico y el tratamiento de tumores.
ES2661813T3 (es) 2009-12-16 2018-04-04 Curna, Inc. Tratamiento de enfermedades relacionadas con la peptidasa del factor de transcripción de membrana, sitio 1 (mbtps1) mediante inhibición del transcrito antisentido natural al gen mbtps1
JP5934106B2 (ja) 2009-12-23 2016-06-15 カッパーアールエヌエー，インコーポレイテッド 肝細胞増殖因子（ｈｇｆ）に対する天然アンチセンス転写物の阻害によるｈｇｆ関連性疾患の治療
EP2515947B1 (de) 2009-12-23 2021-10-06 CuRNA, Inc. Behandlung von durch das uncoupling protein 2 (ucp2) bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts für ucp2
US8946514B2 (en) 2009-12-28 2015-02-03 E.I. Du Pont De Nemours And Company Sorghum fertility restorer genotypes and methods of marker-assisted selection
WO2011090741A2 (en) 2009-12-29 2011-07-28 Opko Curna, Llc TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
RU2615450C2 (ru) 2009-12-29 2017-04-04 Курна, Инк. Лечение заболеваний, связанных с ядерным респираторным фактором 1(nrf1), путем ингибирования природного антисмыслового транскрипта к nrf1
BR112012016290A2 (pt) 2009-12-31 2015-09-01 Pioneer Hi Bred Int Ácido nucléico isolado ou recombinante, cassete de expressão, célula hospedeira não humana, planta e semente transgênica, variante de polipeptídeo oxox isolado ou recombinante, método de modulação do nível de proteina oxalato oxidase (oxox) em uma planta ou célula vegetal, método para aumentar a resistência de uma planta a um patógeno, planta resistente a patógeno, método para identificar variantes oxox com atividade de oxox mantida ou aumentada, método para gerar uma planta que tem resistência aumentada a uma patógeno
DK2521784T3 (en) 2010-01-04 2018-03-12 Curna Inc TREATMENT OF INTERFERON REGULATORY FACTOR 8- (IRF8) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IRF8
JP5963680B2 (ja) 2010-01-06 2016-08-03 カッパーアールエヌエー，インコーポレイテッド 膵臓発生遺伝子に対する天然アンチセンス転写物の阻害による膵臓発生遺伝子疾患の治療
CN102906267A (zh) 2010-01-06 2013-01-30 先锋国际良种公司 玉米光合作用组织和非光合作用组织昼夜节律的鉴定及其在改良作物方面的用途
ES2664866T3 (es) 2010-01-11 2018-04-23 Curna, Inc. Tratamiento de enfermedades relacionadas con la globulina fijadora de hormonas sexuales (shbg) mediante inhibición del transcrito antisentido natural a shbg
WO2011085102A1 (en) 2010-01-11 2011-07-14 Isis Pharmaceuticals, Inc. Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
US20110236325A1 (en) 2010-01-21 2011-09-29 NellOne Therapeutics, Inc. Methods to treat or prevent a skin condition using a nell1 peptide
CA2786568A1 (en) 2010-01-25 2011-07-28 Curna, Inc. Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1
EP2529027A1 (de) 2010-01-26 2012-12-05 Pioneer-Hi-Bred International, Inc. Herbizidtoleranz für hppd-hemmer
US8962586B2 (en) 2010-02-22 2015-02-24 Curna, Inc. Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1
WO2011105900A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
WO2011105902A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-beta (c8-beta) and uses thereof
WO2011105901A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 9 (c9) and uses thereof
TWI429453B (zh) 2010-02-23 2014-03-11 Genentech Inc 抗tat419抗體及其用途
US20120331585A1 (en) 2010-02-24 2012-12-27 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
AU2011219990A1 (en) 2010-02-24 2012-08-16 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and a method for making the same
EP2361985A1 (de) 2010-02-26 2011-08-31 BASF Plant Science Company GmbH Pflanzen mit verbesserten Ertragseigenschaften und Verfahren zu ihrer Herstellung
EP2361927A1 (de) 2010-02-26 2011-08-31 BASF Plant Science Company GmbH Pflanzen mit verbesserten Ertragseigenschaften und Verfahren zu ihrer Herstellung
US20110219474A1 (en) 2010-03-03 2011-09-08 E.I. Du Pont De Nemours And Company Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding oxidoreductase motif polypeptides
GB201003702D0 (en) 2010-03-05 2010-04-21 Univ Warwick Molecular engineering of a floral inducer for crop improvement
WO2011112732A2 (en) 2010-03-12 2011-09-15 The Brigham And Women's Hospital, Inc. Methods of treating vascular inflammatory disorders
EP2545173A2 (de) 2010-03-12 2013-01-16 Sarepta Therapeutics, Inc. Antisense-modulation von nukleären hormonrezeptoren
US9193752B2 (en) 2010-03-17 2015-11-24 Isis Pharmaceuticals, Inc. 5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
AU2011228707A1 (en) 2010-03-18 2012-09-27 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and method for making the same
EA201290930A1 (ru) 2010-03-18 2013-04-30 Басф Плант Сайенс Компани Гмбх Растения с улучшенными характеристиками урожайности и способ их получения
AU2011228664A1 (en) 2010-03-19 2012-11-08 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and method for making same
AU2011228665A1 (en) 2010-03-19 2012-11-08 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and method for making the same
EP2371845A1 (de) 2010-03-22 2011-10-05 BASF Plant Science Company GmbH Installations dotées de caractéristiques de rendement améliorées et procédé de fabrication de celles-ci
TWI644675B (zh) 2010-04-09 2018-12-21 可娜公司 藉由抑制纖維母細胞生長因子２１（ｆｇｆ２１）之天然反義轉錄物以治療ｆｇｆ２１相關疾病
EP2385129A1 (de) 2010-05-03 2011-11-09 BASF Plant Science Company GmbH Verbessertes Verfahren zur Genregulierung in Pflanzen
US8980253B2 (en) 2010-04-26 2015-03-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ， インコーポレイテッド イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6008837B2 (ja) 2010-04-28 2016-10-19 エータイアー ファーマ， インコーポレイテッド アラニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6005628B2 (ja) 2010-04-28 2016-10-12 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物
US9127033B2 (en) 2010-04-28 2015-09-08 Isis Pharmaceuticals, Inc. 5′ modified nucleosides and oligomeric compounds prepared therefrom
WO2011139907A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
JP6008838B2 (ja) 2010-04-29 2016-10-19 エータイアー ファーマ， インコーポレイテッド アスパラギニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
BR112012027547B1 (pt) 2010-04-29 2022-06-14 Ionis Pharmaceuticals, Inc Oligonucleotídeo modificado de fita simples, composição, e seus usos para tratar amiloidose transtirretina, reduzir os seus sintomas e para reduzir a expressão de mrna ou de proteína de transtirretina
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
CA2797977C (en) 2010-05-03 2019-08-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
KR20130101442A (ko) 2010-05-03 2013-09-13 큐알엔에이, 인크. 시르투인 (sirt)에 대한 자연 안티센스 전사체의 저해에 의한 시르투인 (sirt) 관련된 질환의 치료
ES2668207T3 (es) 2010-05-03 2018-05-17 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas
CN107090045A (zh) 2010-05-03 2017-08-25 霍夫曼-拉罗奇有限公司 用于肿瘤诊断和治疗的组合物和方法
CN102971428A (zh) 2010-05-04 2013-03-13 巴斯夫欧洲公司 对除草剂具有增加的耐受性的植物
EP2566499B1 (de) 2010-05-04 2017-01-25 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten aus einem p38-multi-trna-synthetase-komplex
BR112012028052A2 (pt) 2010-05-06 2019-09-24 Du Pont polipeptídeo, polinucleotídeo, cassete de expressão,planta e método de melhoramento de tolerância a seca em uma planta.
GB201007834D0 (en) 2010-05-11 2010-06-23 Vib Vzw Growth promoting fusion proteins
JP5866106B2 (ja) 2010-05-12 2016-02-17 コロンビア ユニヴァーシティ インスリンを産生し分泌する腸内分泌細胞の製造方法
ES2816898T3 (es) 2010-05-13 2021-04-06 Sarepta Therapeutics Inc Compuestos que modulan la actividad de señalización de las interleucinas 17 y 23
TWI586356B (zh) 2010-05-14 2017-06-11 可娜公司 藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
CA2799197C (en) 2010-05-14 2019-10-29 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
WO2011150005A2 (en) 2010-05-26 2011-12-01 Opko Curna Llc Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1
US8957200B2 (en) 2010-06-07 2015-02-17 Isis Pharmaceuticals, Inc. Bicyclic nucleosides and oligomeric compounds prepared therefrom
EP2580228B1 (de) 2010-06-08 2016-03-23 Ionis Pharmaceuticals, Inc. Substituierte 2 '-amino- und 2 '-thio-bicyclische nukleoside und daraus hergestellte oligomere verbindungen
MX2012015045A (es) 2010-06-24 2013-01-29 Basf Plant Science Co Gmbh Plantas que tienen mejores rasgos relacionados con el rendimiento y un metodo para producirlas.
DE112011102151T5 (de) 2010-06-25 2013-07-11 Basf Plant Science Company Gmbh Pflanzen mit gesteigerten Ertragsmerkmalen und Verfahren zu deren Herstellung
CA2803609A1 (en) 2010-07-01 2012-01-05 E. I. Du Pont De Nemours And Company Plant seeds with altered storage compound levels, related constructs and methods involving genes encoding pae and pae-like polypeptides
EA201390077A1 (ru) 2010-07-08 2013-06-28 Байер Кропсайенс Нв Белок-переносчик глюкозинолатов и его применения
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ， インコーポレイテッド グリシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
NO2593547T3 (de) 2010-07-14 2018-04-14
EP2593555A4 (de) 2010-07-16 2014-02-26 Basf Plant Science Co Gmbh Pflanzen mit verbesserten ertragseigenschaften und verfahren zu ihrer herstellung
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
BR112013003224A2 (pt) 2010-08-13 2016-06-07 Pioneer Hi Bred Int "construto de promotor quimérico, cassete de expressão, vetor de expressão, método de obtenção de uma planta, método para regular a expressão de um polinucleotídeo de interesse, polinucleotídeo, método para expressar um polinucleotídeo de interesse"
WO2012025864A1 (en) 2010-08-24 2012-03-01 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and method for making the same
WO2012027611A2 (en) 2010-08-25 2012-03-01 Atyr Pharma, Inc. INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
WO2012028673A1 (en) 2010-09-02 2012-03-08 Ludwig-Maximilians-Universitaet Muenchen Spontaneous organogenesis in plants
EP2426204A1 (de) 2010-09-02 2012-03-07 Ludwig-Maximilians-Universität München Spontane Knöllchenorganogenese in Pflanzen
ES2588981T3 (es) 2010-10-05 2016-11-08 Genentech, Inc. Smoothened mutante y métodos de uso de la misma
CA2813901C (en) 2010-10-06 2019-11-12 Curna, Inc. Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4
WO2012048113A2 (en) 2010-10-07 2012-04-12 The General Hospital Corporation Biomarkers of cancer
CA2815212A1 (en) 2010-10-22 2012-04-26 Curna, Inc. Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
CN103201387B (zh) 2010-10-27 2018-02-02 库尔纳公司 通过抑制干扰素相关发育调节因子1(ifrd1)的天然反义转录物而治疗ifrd1相关疾病
BR112013011523A2 (pt) 2010-11-10 2019-09-24 Basf Plant Science Co Gmbh método, planta, construto, uso, planta transgênica, partes colhíveis de uma planta, produtos e partes colhíveis de uma planta
ES2633565T3 (es) 2010-11-12 2017-09-22 The General Hospital Corporation ARN no codificantes asociados a polycomb
US8609621B2 (en) 2010-11-15 2013-12-17 E I Du Pont De Nemours And Company Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
JP6126009B2 (ja) 2010-11-17 2017-05-10 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． α−シヌクレイン発現の調節
EP2643463B1 (de) 2010-11-23 2017-09-27 CuRNA, Inc. Behandlung von nanog-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen nanog
WO2012077020A1 (en) 2010-12-06 2012-06-14 Basf Plant Science Company Gmbh Methods for production of synthetic promoters with defined specificity
CN103261424B (zh) 2010-12-16 2017-12-12 巴斯夫农业公司 对除草剂具有增强的耐受性的植物
CA2823467C (en) 2010-12-22 2020-10-27 Pioneer Hi-Bred International, Inc. Qtls associated with and methods for identifying whole plant field resistance to sclerotinia
EP2663323B1 (de) 2011-01-14 2017-08-16 The General Hospital Corporation Verfahren zur anzielung von mir-128 zur regelung des cholesterin-/fettstoffwechsels
WO2012098517A1 (en) 2011-01-20 2012-07-26 Basf Plant Science Company Gmbh Plants having enhanced yield-related traits and method for making the same
US9243034B2 (en) 2011-01-27 2016-01-26 Ramot At Tel-Aviv University Ltd. Glycogen synthase kinase-3 inhibitors
US9688719B2 (en) 2011-01-27 2017-06-27 Ramot At Tel-Aviv University Ltd. Glycogen synthase kinase-3 inhibitors
CN107603960A (zh) 2011-02-01 2018-01-19 科罗拉多小麦研究基金会公司 乙酰辅酶a羧化酶除草剂抗性植物
DK2670404T3 (en) 2011-02-02 2018-11-19 Univ Princeton CIRCUIT MODULATORS AS VIRUS PRODUCTION MODULATORS
JP6177692B2 (ja) 2011-02-02 2017-08-09 エクスカリアード・ファーマシューティカルズ，インク 結合組織増殖因子（ｃｔｇｆ）をターゲティングするアンチセンス化合物を用いた、ケロイドまたは肥厚性瘢痕の治療法
US9273336B2 (en) 2011-02-21 2016-03-01 E. I. Du Pont De Nemours And Company Recombinant host cells having an increase in buoyant density
AR085394A1 (es) 2011-02-25 2013-09-25 Univ Nac De La Plata Unlp Proteasa de plantas
EA201391174A1 (ru) 2011-02-28 2014-04-30 Басф Плант Сайенс Компани Гмбх Растения с повышенной урожайностью и способ их получения
BR112013021836A2 (pt) 2011-02-28 2019-01-08 Basf Plant Science Co Gmbh plantas que possuem características relativas a rendimento aprimoradas e métodos de sua produção
MX2013009997A (es) 2011-03-01 2014-07-09 Basf Plant Science Co Gmbh Plantas que tienen rasgos relacionados con rendimiento mejorado y metodos para producir los mismos.
MX359516B (es) 2011-04-12 2018-10-01 Moerae Matrix Inc Composiciones y metodos para prevenir o tratar enfermedades, afecciones, o procesos caracterizados por la proliferacion abrellante de fibro blasto y deposicion de matriz extracelular.
US9890200B2 (en) 2011-04-12 2018-02-13 Moerae Matrix, Inc. Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
CN103502269A (zh) 2011-04-29 2014-01-08 先锋国际良种公司 下调同源域-亮氨酸拉链i类同源盒基因以改进植物性能
WO2012156760A1 (en) 2011-05-19 2012-11-22 Consejo Superior De Investigaciones Cientificas Process for modifying the architecture and improving the yield of crop plants
WO2012170347A1 (en) 2011-06-09 2012-12-13 Isis Pharmaceuticals, Inc. Bicyclic nucleosides and oligomeric compounds prepared therefrom
CA2838588C (en) 2011-06-09 2021-09-14 Curna, Inc. Treatment of frataxin (fxn) related diseases by inhibition of natural antisense transcript to fxn
EP2721160A2 (de) 2011-06-14 2014-04-23 Synthon Biopharmaceuticals B.V. Zusammensetzungen und verfahren zur herstellung und bioabdichtung auxotropher transgener pflanzen
WO2013009935A2 (en) 2011-07-12 2013-01-17 Two Blades Foundation Late blight resistance genes
WO2013012788A2 (en) 2011-07-15 2013-01-24 Syngenta Participations Ag Methods of increasing yield and stress tolerance in a plant
WO2013012643A1 (en) 2011-07-15 2013-01-24 Syngenta Participations Ag Polynucleotides encoding trehalose-6-phosphate phosphatase and methods of use thereof
BR112014002342A2 (pt) 2011-08-01 2020-11-17 Basf Plant Science Company Gmbh moléculas terminais, método de identificação e isolamento de moléculas terminais, método de produção de moléculas terminais recombinantes, método de produção de plantas ou suas partes com expressão amplificada, construção de expressão recombinante, vetor de expressão recombinante, célula transgênica, planta transgênica ou sua parte, cultivo de células transgênicas, sementes trasngênicas, partes ou material de propagação derivados de uma célula ou planta transgênica ou sua parte, uso da molécula terminal e método de produção de produto agrícola
EP3533873A1 (de) 2011-09-14 2019-09-04 Translate Bio MA, Inc. Multimere oligonukleotidverbindungen
JP2014526517A (ja) 2011-09-14 2014-10-06 ノースウェスタン ユニバーシティ 血液脳関門を通過することができるナノ抱合体
AU2012322788B2 (en) 2011-10-11 2018-01-04 The Brigham And Women's Hospital, Inc. Micrornas in neurodegenerative disorders
CN103906835A (zh) 2011-10-25 2014-07-02 先锋国际良种公司 改变植物细胞壁组成以改善生物燃料生产和青贮饲料可消化性的方法
CA2853775A1 (en) 2011-10-31 2013-05-10 Pioneer Hi-Bred International, Inc. Improving plant drought tolerance, nitrogen use efficiency and yield
US10557136B2 (en) 2011-12-12 2020-02-11 Oncolmmunin Inc. In vivo delivery of oligonucleotides
EP2814951B1 (de) 2012-02-13 2019-04-03 Gamida-Cell Ltd. Kultivierung mesenchymaler stammzellen
WO2013134636A1 (en) 2012-03-09 2013-09-12 Purdue Research Foundation Compositions and methods for delivery of kinase inhibiting peptides
WO2013138309A1 (en) 2012-03-13 2013-09-19 Pioneer Hi-Bred International, Inc. Genetic reduction of male fertility in plants
CA2867385A1 (en) 2012-03-13 2013-09-19 Pioneer Hi-Bred International, Inc. Genetic reduction of male fertility in plants
CA2867262C (en) 2012-03-15 2021-03-16 Curna, Inc. Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
US9610362B2 (en) 2012-03-16 2017-04-04 Valerion Therapeutics, Llc Antisense conjugates for decreasing expression of DMPK
US9221864B2 (en) 2012-04-09 2015-12-29 Isis Pharmaceuticals, Inc. Tricyclic nucleic acid analogs
WO2013154799A1 (en) 2012-04-09 2013-10-17 Isis Pharmaceuticals, Inc. Tricyclic nucleosides and oligomeric compounds prepared therefrom
CN107083385A (zh) 2012-04-20 2017-08-22 艾珀特玛治疗公司 产热的miRNA调节剂
EP2841572B1 (de) 2012-04-27 2019-06-19 Duke University Genetische korrektur mutierter gene
CN104540947A (zh) 2012-05-16 2015-04-22 Rana医疗有限公司 用于调节smn基因家族表达的组合物和方法
KR102028784B1 (ko) 2012-05-16 2019-10-04 트랜슬레이트 바이오 인코포레이티드 유전자 발현을 조절하기 위한 조성물 및 방법
US10045499B2 (en) 2012-05-24 2018-08-14 Iowa State University Research Foundation, Inc. Arabidopsis nonhost resistance gene(s) and use thereof to engineer disease resistant plants
WO2013184209A1 (en) 2012-06-04 2013-12-12 Ludwig Institute For Cancer Research Ltd. Mif for use in methods of treating subjects with a neurodegenerative disorder
AR091489A1 (es) 2012-06-19 2015-02-11 Basf Se Plantas que tienen una mayor tolerancia a herbicidas inhibidores de la protoporfirinogeno oxidasa (ppo)
EP2677035A1 (de) 2012-06-22 2013-12-25 BASF Plant Science Company GmbH Pflanzen mit verbesserten Ertragseigenschaften und Verfahren zu ihrer Herstellung
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US20150216892A1 (en) 2012-08-03 2015-08-06 Aptamir Therapeutics, Inc. Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders
KR102237882B1 (ko) 2012-08-15 2021-04-07 아이오니스 파마수티컬즈, 인코포레이티드 변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법
WO2014027021A1 (en) 2012-08-16 2014-02-20 Vib Vzw Means and methods for altering the lignin pathway in plants
WO2014037735A1 (en) 2012-09-10 2014-03-13 University Of Leicester Atsp1, an e3 ubiquitin ligase, and its use
US9029335B2 (en) 2012-10-16 2015-05-12 Isis Pharmaceuticals, Inc. Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
EP2908864B1 (de) 2012-10-22 2019-12-11 Sabag-Rfa Ltd. Phosphatverbindungen zur abgabe von therapeutika in lebende zellen und zellkerne
US20150299718A1 (en) 2012-11-20 2015-10-22 Rajeev Gupta Engineering Plants for Efficient Uptake and Utilization of Urea to Improve
WO2014100525A2 (en) 2012-12-21 2014-06-26 Pioneer Hi-Bred International, Inc. Compositions and methods for auxin-analog conjugation
EP2754715A1 (de) 2013-01-11 2014-07-16 Consejo Superior De Investigaciones Científicas (CSIC) Stresstolerante Pflanzen
CN104981149B (zh) 2013-01-29 2022-03-04 巴斯夫植物科学有限公司 表达ein2的抗真菌植物
CA2897485A1 (en) 2013-01-29 2014-08-07 Basf Plant Science Company Gmbh Fungal resistant plants expressing hcp6
CN104955324A (zh) 2013-01-29 2015-09-30 巴斯夫植物科学有限公司 表达hcp7的抗真菌植物
WO2014121436A1 (en) 2013-02-05 2014-08-14 Plant Bioscience Limited Transgenic plants
AR096014A1 (es) 2013-03-08 2015-12-02 Basf Plant Science Co Gmbh PLANTAS RESISTENTES A HONGOS QUE EXPRESAN EL FACTOR DE TRANSCRIPCIÓN Myb (MybTF)
US20160002648A1 (en) 2013-03-11 2016-01-07 Mei Guo Genes for improving nutrient uptake and abiotic stress tolerance in plants
US9803214B2 (en) 2013-03-12 2017-10-31 Pioneer Hi-Bred International, Inc. Breeding pair of wheat plants comprising an MS45 promoter inverted repeat that confers male sterility and a construct that restores fertility
RU2694686C2 (ru) 2013-03-12 2019-07-16 Е.И.Дюпон Де Немур Энд Компани Способы идентификации вариантных сайтов распознавания для редкощепящих сконструированных средств для индукции двунитевого разрыва, и композиции с ними, и их применения
WO2014164116A1 (en) 2013-03-13 2014-10-09 Pioneer Hi-Bred International, Inc. Functional expression of bacterial major facilitator superfamily (sfm) gene in maize to improve agronomic traits and grain yield
US20160010101A1 (en) 2013-03-13 2016-01-14 Pioneer Hi-Bred International, Inc. Enhanced nitrate uptake and nitrate translocation by over- expressing maize functional low-affinity nitrate transporters in transgenic maize
US20160024513A1 (en) 2013-03-14 2016-01-28 Pioneer Hi-Bred International Inc. Maize stress related transcription factor 18 and uses thereof
WO2014153178A2 (en) 2013-03-14 2014-09-25 Cibus Us Llc Mutated allene oxide synthase 2 (aos2) genes
HRP20220521T1 (hr) 2013-03-15 2022-06-10 Cibus Us Llc Ciljana genska modifikacija primjenom popravka gena posredovanog oligonukleotidom
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
WO2015139008A1 (en) 2014-03-14 2015-09-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US20140283216A1 (en) 2013-03-15 2014-09-18 Pioneer Hi Bred International Inc Compositions and methods of use of acc oxidase polynucleotides and polypeptides
CN105247056A (zh) 2013-03-15 2016-01-13 先锋国际良种公司 Acc脱氨酶表达的调节
KR102339732B1 (ko) * 2013-03-15 2021-12-15 시버스 유에스 엘엘씨 올리고뉴클레오타이드 매개 유전자 보수를 사용한 표적화된 유전자 변형의 효율을 증가시키기 위한 방법 및 조성물
US10017778B2 (en) 2013-03-21 2018-07-10 Vib Vzw Means and methods for the reduction of photorespiration in crops
CN105378085B (zh) 2013-05-01 2019-02-15 Ionis制药公司 用于调节hbv和ttr表达的组合物和方法
US20160129089A1 (en) 2013-06-13 2016-05-12 Antisense Therapeutics Ltd Combination therapy
EP2816115A1 (de) 2013-06-17 2014-12-24 BASF Plant Science Company GmbH Pflanzen mit einem oder mehreren Merkmalen eines erhöhten Ertrages und Verfahren zu deren Herstellung
WO2014207743A2 (en) 2013-06-24 2014-12-31 Ramot At Tel-Aviv University Ltd. Glycogen synthase kinase-3 inhibitors
WO2015006105A1 (en) 2013-07-09 2015-01-15 Board Of Trustees Of Michigan State University Transgenic plants produced with a k-domain, and methods and expression cassettes related thereto
US11459579B2 (en) 2013-07-09 2022-10-04 Board Of Trustees Of Michigan State University Transgenic plants produced with a K-domain, and methods and expression cassettes related thereto
US11162096B2 (en) 2013-10-14 2021-11-02 Ionis Pharmaceuticals, Inc Methods for modulating expression of C9ORF72 antisense transcript
CA2844640A1 (en) 2013-12-06 2015-06-06 The University Of British Columbia Method for treatment of castration-resistant prostate cancer
EP2896698A1 (de) 2014-01-17 2015-07-22 BASF Plant Science Company GmbH Pflanzen mit einer oder mehreren Merkmalen zum erhöhten Ertrag und Verfahren zu deren Herstellung
US20170166920A1 (en) 2014-01-30 2017-06-15 Two Blades Foundation Plants with enhanced resistance to phytophthora
CA3228845A1 (en) 2014-01-31 2015-08-06 Temple University Of The Commonwealth System Of Higher Education Bag3 and uses thereof in the treatment of heart failure with reduced ejection fraction
WO2015120075A2 (en) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened and methods of using the same
WO2015142910A1 (en) 2014-03-17 2015-09-24 Isis Pharmaceuticals, Inc. Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
PL3119888T3 (pl) 2014-03-19 2021-12-20 Ionis Pharmaceuticals, Inc. Kompozycje do modulacji ekspresji ataksyny 2
US10006027B2 (en) 2014-03-19 2018-06-26 Ionis Pharmaceuticals, Inc. Methods for modulating Ataxin 2 expression
HUE059109T2 (hu) 2014-04-01 2022-10-28 Biogen Ma Inc A SOD-1 expresszió modulálására szolgáló készítmények
WO2015150465A2 (en) 2014-04-03 2015-10-08 Basf Se Plants having increased tolerance to herbicides
US10221416B2 (en) 2014-04-24 2019-03-05 Ionis Pharmaceuticals, Inc. Oligomeric compounds comprising alpha-beta-constrained nucleic acid
PE20190626A1 (es) 2014-05-01 2019-04-26 Ionis Pharmaceuticals Inc Composiciones y metodos para modular la expresion del factor b del complemento
WO2015171603A1 (en) 2014-05-06 2015-11-12 Two Blades Foundation Methods for producing plants with enhanced resistance to oomycete pathogens
EP3508198A1 (de) 2014-06-04 2019-07-10 Exicure, Inc. Multivalente ausgabe von immunmodulatoren durch liposomale sphärische nukleinsäuren für prophylaktische oder therapeutische anwendungen
KR102524543B1 (ko) 2014-06-10 2023-04-20 에라스무스 유니버시티 메디컬 센터 로테르담 폼페병의 치료에 유용한 안티센스 올리고뉴클레오티드
US10301624B2 (en) 2014-06-25 2019-05-28 The General Hospital Corporation Targeting human satellite II (HSATII)
US10487314B2 (en) 2014-06-26 2019-11-26 The Trustees Of Columbia University In The City Of New York Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
EP3166964A1 (de) 2014-07-08 2017-05-17 Vib Vzw Mittel und verfahren zur steigerung des pflanzenertrags
EP4335926A3 (de) 2014-07-14 2024-06-12 Washington State University Nanos-knockout zur abladierung von keimbahnzellen
WO2016033424A1 (en) 2014-08-29 2016-03-03 Genzyme Corporation Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
BR112017004056A2 (pt) 2014-09-12 2017-12-05 Biogen Ma Inc composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo
WO2016049512A1 (en) 2014-09-26 2016-03-31 University Of Massachusetts Rna-modulating agents
EP3470521B1 (de) 2014-10-06 2020-07-15 Altria Client Services LLC Genetische kontrolle des achselknospenwachstums bei tabakpflanzen
KR20170083063A (ko) 2014-11-17 2017-07-17 모레 매트릭스 인코포레이티드 이상 섬유모세포 증식 및 세포외 기질 침착을 특징으로 하는 질병, 질환, 또는 과정의 예방 또는 치료용 조성물 및 방법
EP3220895B1 (de) 2014-11-21 2022-08-31 Northwestern University Sequenzspezifische zelluläre aufnahme von sphärischen nukleinsäurenanopartikelkonjugaten
CA2971425A1 (en) 2014-12-16 2016-06-23 Pioneer Hi-Bred International, Inc. Restoration of male fertility in wheat
US9688707B2 (en) 2014-12-30 2017-06-27 Ionis Pharmaceuticals, Inc. Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
WO2016112132A1 (en) 2015-01-06 2016-07-14 Ionis Pharmaceuticals, Inc. Compositions for modulating expression of c9orf72 antisense transcript
WO2016115490A1 (en) 2015-01-16 2016-07-21 Ionis Pharmaceuticals, Inc. Compounds and methods for modulation of dux4
EP3247200A4 (de) 2015-01-21 2018-06-13 Basf Se Pflanzen mit erhöhter toleranz gegen herbizide
WO2016124920A1 (en) 2015-02-03 2016-08-11 The Institute Of Genetics And Developmental Biology Rice plants with altered seed phenotype and quality
CN108012523A (zh) 2015-02-03 2018-05-08 中国科学院遗传与发育生物学研究所 具有增加的种子大小的植物
CN107429259A (zh) 2015-02-04 2017-12-01 巴斯夫植物科学有限公司 通过增加莨菪亭含量，增加转基因植物中大豆锈病抗性的方法
GB201501941D0 (en) 2015-02-05 2015-03-25 British American Tobacco Co Method
JP6929791B2 (ja) 2015-02-09 2021-09-01 デューク ユニバーシティ エピゲノム編集のための組成物および方法
BR112017016789A2 (pt) 2015-02-11 2018-05-08 Basf Se métodos para produzir uma planta transgênica, para controlar a vegetação indesejada e para o cultivo da planta, molécula de ácido nucleico, construção de ácido nucleico, vetor, polipeptídeo hppd mutado, núcleo de célula vegetal, núcleo de célula vegetal transgênica, planta transgênica, uso do ácido nucleico, combinação útil, processo para a preparação de uma combinação útil e uso de uma combinação útil
GB201502409D0 (en) 2015-02-13 2015-04-01 British American Tobacco Co Method
US11129844B2 (en) 2015-03-03 2021-09-28 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating MECP2 expression
JP2018512401A (ja) 2015-03-12 2018-05-17 モイライ マトリックス インコーポレイテッド Ｍｋ２阻害剤ペプチド含有組成物を用いた非小細胞肺癌の治療を目的とするその使用
MX2017011976A (es) 2015-03-18 2018-02-09 Basf Se Microorganismo recombinante para la produccion mejorada de quimicos finos.
WO2016164463A1 (en) 2015-04-07 2016-10-13 The General Hospital Corporation Methods for reactivating genes on the inactive x chromosome
WO2016167780A1 (en) 2015-04-16 2016-10-20 Ionis Pharmaceuticals, Inc. Compositions for modulating expression of c9orf72 antisense transcript
CN107709564B (zh) 2015-05-09 2021-11-02 双刃基金会 来自少花龙葵的抗晚疫病基因及使用方法
MX2017015668A (es) 2015-06-04 2018-08-15 Basf Se Microorganismos recombinante para la produccion mejorada de quimicos finos.
EP3307902A1 (de) 2015-06-12 2018-04-18 Basf Se Rekombinanter mikroorganismus zur verbesserten herstellung von alanin
CA2990852A1 (en) 2015-06-26 2016-12-29 Beth Israel Deaconess Medical Center, Inc. Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
AU2016298317B2 (en) 2015-07-28 2021-02-18 Caris Science, Inc. Targeted oligonucleotides
PT3353303T (pt) 2015-09-25 2023-10-10 Academisch Ziekenhuis Leiden Composições e métodos para modulação da expressão de ataxina 3
WO2017062790A1 (en) 2015-10-09 2017-04-13 Two Blades Foundation Cold shock protein receptors and methods of use
EP3362571A4 (de) 2015-10-13 2019-07-10 Duke University Genom-engineering mit typ-i-crispr-systemen in eukaryotischen zellen
CA3001979A1 (en) 2015-10-22 2017-04-27 Basf Se Plants having increased tolerance to herbicides
EP3370734B1 (de) 2015-11-05 2023-01-04 Children's Hospital Los Angeles Antisense-oligo zur verwendung bei der behandlung von akuter myeloischer leukämie
US11001622B2 (en) 2015-11-19 2021-05-11 The Brigham And Women's Hospital, Inc. Method of treating autoimmune disease with lymphocyte antigen CD5-like (CD5L) protein
WO2017096395A1 (en) 2015-12-04 2017-06-08 Ionis Pharmaceuticals, Inc. Methods of treating breast cancer
CA3007152A1 (en) 2015-12-07 2017-06-15 Erasmus University Medical Center Rotterdam Enzymatic replacement therapy and antisense therapy for pompe disease
CA3006599A1 (en) 2016-01-05 2017-07-13 Ionis Pharmaceuticals, Inc. Methods for reducing lrrk2 expression
CN109071625A (zh) 2016-02-04 2018-12-21 柯瑞斯公司 平滑化突变体和其使用方法
WO2017138986A1 (en) 2016-02-09 2017-08-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
JP7033072B2 (ja) 2016-02-25 2022-03-09 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Ｓｍｏｃ２を標的化する線維症のための治療方法
JP7015243B2 (ja) 2016-03-11 2022-02-02 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー 吸枝が減少又は消失したタバコ植物及びタバコ製品を生産する組成物及び方法
US10961271B2 (en) 2016-03-16 2021-03-30 Ionis Pharmaceuticals, Inc. Methods of modulating KEAP1
WO2017161168A1 (en) 2016-03-16 2017-09-21 Ionis Pharmaceuticals, Inc. Modulation of dyrk1b expression
EP4339288A3 (de) 2016-03-18 2024-06-05 Caris Science, Inc. Oligonukleotidsonden und verwendungen davon
US11913054B2 (en) 2016-03-30 2024-02-27 Basf Se Fermentative production of n-butylacrylate using alcohol acyl transferase enzymes
US10563216B2 (en) 2016-04-18 2020-02-18 Bloomsburg University of Pennsylvania Compositions and methods of delivering molecules to plants
EP4166661A1 (de) 2016-04-29 2023-04-19 BASF Plant Science Company GmbH Verbesserte verfahren zur modifizierung von zielnukleinsäuren
EP3054014A3 (de) 2016-05-10 2016-11-23 BASF Plant Science Company GmbH Benutzung einer fungizids auf transgenen pflanzen
UA127983C2 (uk) 2016-05-20 2024-03-06 Басф Агро Б.В. Подвійні транзитні пептиди для спрямування поліпептидів
BR112018072479B1 (pt) 2016-05-24 2023-01-31 Basf Se Método para controlar o crescimento de ervas daninhas, uso do composto de fórmula (i) e uso da composição
CA3025486A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
MA44031B1 (fr) 2016-05-26 2021-06-30 Nunhemes B V Plantes produisant des fruits sans graines
WO2017219017A1 (en) 2016-06-17 2017-12-21 Ionis Pharmaceuticals, Inc. Modulation of gys1 expression
MX2018015798A (es) 2016-06-22 2019-07-12 Univ North Carolina State Método para incrementar la eficiencia de uso de nitrógeno y/o la eficiencia de utilización de nitrógeno en plantas.
AU2017296195A1 (en) 2016-07-11 2019-01-24 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
WO2018011750A1 (en) 2016-07-15 2018-01-18 Basf Se Plants having increased tolerance to herbicides
BR112019001483A2 (pt) 2016-07-27 2019-09-10 Basf Agro Bv método para controlar a vegetação indesejada em um local de cultivo de plantas
WO2018019845A1 (en) 2016-07-29 2018-02-01 Basf Se Method for controlling ppo resistant weeds
CA3030354A1 (en) 2016-07-29 2018-02-01 Basf Se Method for controlling ppo resistant weeds
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
NL2017295B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Antisense oligomeric compound for Pompe disease
EP3278667A1 (de) 2016-08-05 2018-02-07 Basf Se Verfahren zur kontrolle von ppo-inhibitor resistenten unkräutern
WO2018024696A1 (en) 2016-08-05 2018-02-08 Basf Se Method for controlling ppo resistant weeds
US20210352900A1 (en) 2016-08-05 2021-11-18 Basf Se Method for Controlling PPO Resistant Weeds
EP3281524A1 (de) 2016-08-09 2018-02-14 Basf Se Verfahren zur bekämpfung von ppo-resistanten unkraut
EP3281523A1 (de) 2016-08-09 2018-02-14 Basf Se Verfahren zur bekämpfung von ppo-resistanten unkraut
WO2018029031A1 (en) 2016-08-09 2018-02-15 Basf Se Method for controlling ppo resistant weeds
CA3032238A1 (en) 2016-08-09 2018-02-15 Basf Se Method for controlling ppo resistant weeds
US11193136B2 (en) 2016-08-09 2021-12-07 Vib Vzw Cellulose synthase inhibitors and mutant plants
EP3281525A1 (de) 2016-08-09 2018-02-14 Basf Se Verfahren zur bekämpfung von ppo-resistanten unkraut
US10905121B2 (en) 2016-08-09 2021-02-02 Basf Se Method for controlling PPO resistant weeds
EP3522898A4 (de) 2016-10-06 2020-05-27 Ionis Pharmaceuticals, Inc. Verfahren zum konjugieren von oligomeren verbindungen
WO2018067985A1 (en) 2016-10-07 2018-04-12 Altria Client Services Llc Composition and methods for producing tobacco plants and products having reduced tobacco-specific nitrosamines (tsnas)
CA3037046A1 (en) 2016-10-31 2018-05-03 University Of Massachusetts Targeting microrna-101-3p in cancer therapy
JOP20190104A1 (ar) 2016-11-10 2019-05-07 Ionis Pharmaceuticals Inc مركبات وطرق لتقليل التعبير عن atxn3
WO2018102745A1 (en) 2016-12-02 2018-06-07 Cold Spring Harbor Laboratory Modulation of lnc05 expression
CN110462047A (zh) 2016-12-16 2019-11-15 双刃基金会 晚疫病抗性基因及使用方法
EP3559243A1 (de) 2016-12-20 2019-10-30 BASF Agro B.V. Pflanzen mit erhöhter toleranz gegen herbizide
US11535878B2 (en) 2016-12-27 2022-12-27 Inbiose N.V. In vivo synthesis of sialylated compounds
WO2018140214A1 (en) 2017-01-24 2018-08-02 Pioneer Hi-Bred International, Inc. Nematicidal protein from pseudomonas
CN110573623A (zh) 2017-02-09 2019-12-13 福建农林大学 用于提高植物产量的磷酸盐转运蛋白的表达
WO2018165564A1 (en) 2017-03-09 2018-09-13 Ionis Pharmaceuticals, Inc. Morpholino modified oligomeric compounds
WO2018195338A1 (en) 2017-04-20 2018-10-25 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
EP3612232A1 (de) 2017-04-21 2020-02-26 The Broad Institute, Inc. Gezielte abgabe an beta-zellen
US11445692B2 (en) 2017-05-15 2022-09-20 Equi-Nom Ltd. Quantitative trait loci (QTL) associated with shatter resistant capsules in sesame and uses thereof
WO2019023587A1 (en) 2017-07-28 2019-01-31 Two Blades Foundation POTYVIRUS RESISTANCE GENES AND METHODS OF USE
AU2018318231A1 (en) 2017-08-18 2020-02-13 Ionis Pharmaceuticals, Inc. Modulation of the notch signaling pathway for treatment of respiratory disorders
US10517889B2 (en) 2017-09-08 2019-12-31 Ionis Pharmaceuticals, Inc. Modulators of SMAD7 expression
JP2020533000A (ja) 2017-09-11 2020-11-19 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー 吸枝が減少又は消失したタバコ植物及びタバコ製品を生産する組成物及び方法
WO2019055460A1 (en) 2017-09-13 2019-03-21 The Children's Medical Center Corporation COMPOSITIONS AND METHODS FOR THE TREATMENT OF TRANSPOSON-ASSOCIATED DISEASES
TWI809004B (zh) 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
WO2019108619A1 (en) 2017-11-28 2019-06-06 Two Blades Foundation Methods and compositions for enhancing the disease resistance of plants
CN111801012A (zh) 2017-11-29 2020-10-20 巴斯夫欧洲公司 具有增加的除草剂耐受性的植物
US11634698B2 (en) 2017-12-20 2023-04-25 Basf Se Nucleases and methods for making and using them
WO2019126641A2 (en) 2017-12-21 2019-06-27 Ionis Pharmaceuticals, Inc. Modulation of frataxin expression
US11034969B2 (en) 2017-12-22 2021-06-15 Altria Client Services Llc Plant comprising recombinant polynucleotides encoding a pigment regulatory transcription factor with a tissue-preferred promoter
CN107868123B (zh) 2017-12-25 2020-05-12 中国农业科学院作物科学研究所 一种同时提高植物产量和抗性的基因及其应用
EP3737766A4 (de) 2018-01-09 2021-11-24 Cibus US LLC Bruchsichere gene und mutationen
US11732271B2 (en) 2018-01-12 2023-08-22 The Sainsbury Laboratory Stem rust resistance genes and methods of use
MX2020007369A (es) 2018-01-15 2020-10-28 Ionis Pharmaceuticals Inc Moduladores de la expresion de dnm2.
US11939587B2 (en) 2018-01-17 2024-03-26 Basf Se Plants having increased tolerance to herbicides
WO2019158911A1 (en) 2018-02-14 2019-08-22 Institute Of Genetics And Developmental Biology Chinese Academy Of Sciences Methods of increasing nutrient use efficiency
WO2019169243A1 (en) 2018-03-02 2019-09-06 Ionis Pharmaceuticals, Inc. Compounds and methods for the modulation of amyloid-beta precursor protein
TWI840345B (zh) 2018-03-02 2024-05-01 美商Ionis製藥公司 Irf4表現之調節劑
WO2019183440A1 (en) 2018-03-22 2019-09-26 Ionis Pharmaceuticals, Inc. Methods for modulating fmr1 expression
EP4051799A2 (de) 2018-03-30 2022-09-07 Rheinische Friedrich-Wilhelms-Universität Bonn Aptamere zur gezielten aktivierung von t-zellvermittelter immunität
EP4062774B1 (de) 2018-04-03 2024-03-20 Altria Client Services LLC Zusammensetzungen und verfahren zur herstellung von tabakpflanzen und -produkten mit erhöhtem phenylalanin und verringerten tabakspezifischen nitrosaminen (tsnas)
AU2019247490A1 (en) 2018-04-06 2020-10-22 Children's Medical Center Corporation Compositions and methods for somatic cell reprogramming and modulating imprinting
CN112041440A (zh) 2018-04-11 2020-12-04 Ionis制药公司 Ezh2表达的调节剂
CN112368375A (zh) 2018-04-26 2021-02-12 巴斯夫欧洲公司 脂肪酶
EP3788145A1 (de) 2018-05-03 2021-03-10 Basf Se Amylaseenzyme
SG11202010012PA (en) 2018-05-09 2020-11-27 Ionis Pharmaceuticals Inc Compounds and methods for reducing fxi expression
KR20210008497A (ko) 2018-05-09 2021-01-22 아이오니스 파마수티컬즈, 인코포레이티드 Atxn3 발현 감소용 화합물 및 방법
WO2019219933A1 (en) 2018-05-17 2019-11-21 Vib Vzw An engineered combinatorial module of transcription factors to boost production of monoterpenoid indole alkaloids
JP7557378B2 (ja) 2018-06-14 2024-09-27 アイオーニス ファーマシューティカルズ， インコーポレーテッド Ｓｔｍｎ２発現を増加させるための化合物及び方法
WO2019238832A1 (en) 2018-06-15 2019-12-19 Nunhems B.V. Seedless watermelon plants comprising modifications in an abc transporter gene
TWI833770B (zh) 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法
EP3817747A4 (de) 2018-07-02 2022-07-06 Aptamir Therapeutics, Inc. Gezielte abgabe von therapeutischen mitteln an menschliche adipozyten
KR20210038589A (ko) 2018-07-25 2021-04-07 아이오니스 파마수티컬즈, 인코포레이티드 Atxn2 발현 감소용 화합물 및 방법
EP3843845A4 (de) 2018-08-29 2022-05-11 University Of Massachusetts Hemmung von proteinkinasen zur behandlung von friedreich-ataxie
CA3110656A1 (en) 2018-09-07 2020-03-12 Basf Plant Science Company Gmbh Improved method for the production of high levels of pufa in plants
US20210317467A1 (en) 2018-09-07 2021-10-14 Basf Plant Science Copmany Gmbh Improved method for the production of high levels of pufa in plants
US20230183728A1 (en) 2018-09-07 2023-06-15 Basf Plant Science Company Gmbh Improved method for the production of high levels of pufa in plants
AU2019360338A1 (en) 2018-10-18 2021-05-20 Basf Se Method for the production of acrylic acid or salts thereof
TW202028222A (zh) 2018-11-14 2020-08-01 美商Ionis製藥公司 Foxp3表現之調節劑
AU2019380940A1 (en) 2018-11-15 2021-06-03 Ionis Pharmaceuticals, Inc. Modulators of IRF5 expression
CA3124395A1 (en) 2018-12-20 2020-06-25 Basf Plant Science Company Gmbh Native delivery of biomolecules into plant cells using ionic complexes with cell-penetrating peptides
CN113614242A (zh) 2019-01-22 2021-11-05 巴斯夫欧洲公司 4-氰基苯甲酸或其盐的生产方法
WO2020154466A1 (en) 2019-01-24 2020-07-30 Altria Client Services Llc Tobacco plants comprising reduced nicotine and reduced tobacco specific nitrosamines
US11214803B2 (en) 2019-01-31 2022-01-04 Ionis Pharmaceuticals, Inc. Modulators of YAP1 expression
WO2020171889A1 (en) 2019-02-19 2020-08-27 University Of Rochester Blocking lipid accumulation or inflammation in thyroid eye disease
GB201902253D0 (en) 2019-02-19 2019-04-03 Univ Court Univ Of Glasgow Methods for optogenetic manipulation of stomatal function
AU2020227824A1 (en) 2019-02-27 2021-08-26 Ionis Pharmaceuticals, Inc. Modulators of MALAT1 expression
US20220186200A1 (en) 2019-03-11 2022-06-16 Basf Se Amylases and methods for making and using them
WO2020183191A1 (en) 2019-03-14 2020-09-17 Rothamsted Research Limited Genetically modified plants with enhanced drought tolerance
US20220162576A1 (en) 2019-03-25 2022-05-26 Basf Se Amylase enzymes
WO2020193532A1 (en) 2019-03-25 2020-10-01 Basf Se Cleaning composition having amylase enzymes
EP3947664A2 (de) 2019-03-25 2022-02-09 Basf Se Amylaseenzyme
PE20220284A1 (es) 2019-03-29 2022-02-25 Ionis Pharmaceuticals Inc Compuestos y metodos para modular ube3a-ats
US20220220495A1 (en) 2019-05-10 2022-07-14 Basf Se Regulatory nucleic acid molecules for enhancing gene expression in plants
BR112021026248A2 (pt) 2019-06-27 2022-03-03 Two Blades Found Molécula de ácido nucleico isolada que codifica uma proteína atrlp23 engenheirada, proteína atrlp23 engenheirada, cassete de expressão, vetor, célula hospedeira, planta ou célula vegetal, métodos para fazer uma proteína atrlp23 engenheirada, para fazer uma molécula de ácido nucleico que codifica uma proteína atrlp23 engenheirada e para intensificar a resistência de uma planta
EP3990641A1 (de) 2019-06-27 2022-05-04 BASF Plant Science Company GmbH Verfahren zur transformation von pilzsporen
WO2021011348A1 (en) 2019-07-12 2021-01-21 The Regents Of The University Of California Plants with enhanced resistance to bacterial pathogens
WO2021021673A1 (en) 2019-07-26 2021-02-04 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating gfap
JP2022544587A (ja) 2019-08-15 2022-10-19 アイオーニス ファーマシューティカルズ， インコーポレーテッド 結合修飾オリゴマー化合物及びその使用
MX2022002182A (es) 2019-08-22 2022-03-11 Basf Se Variantes de amilasa.
US20230203515A1 (en) 2019-09-12 2023-06-29 Basf Se Regulatory Nucleic Acid Molecules for Enhancing Gene Expression in Plants
WO2021058691A1 (en) 2019-09-26 2021-04-01 Basf Se Method for the production of beta-alanine or salts thereof
WO2021069387A1 (en) 2019-10-07 2021-04-15 Basf Se Regulatory nucleic acid molecules for enhancing gene expression in plants
CA3159805A1 (en) 2019-12-03 2021-06-10 Frank Meulewaeter Regulatory nucleic acid molecules for enhancing gene expression in plants
AU2020404580A1 (en) 2019-12-16 2022-06-23 BASF Agricultural Solutions Seed US LLC Improved genome editing using paired nickases
KR20220116173A (ko) 2019-12-16 2022-08-22 바스프 아그리컬쳐럴 솔루션즈 시드 유에스 엘엘씨 밀의 게놈에의 dna 또는 돌연변이의 정확한 도입
EP4077651A1 (de) 2019-12-16 2022-10-26 BASF Agricultural Solutions Seed US LLC Für polynukleotid codierende codon-optimierte cas9-endonuklease
AR121446A1 (es) 2020-02-28 2022-06-08 Ionis Pharmaceuticals Inc Compuestos y métodos para modular smn2
CN115605597A (zh) 2020-03-04 2023-01-13 巴斯夫欧洲公司（De） 用于产生赋予低至中等表达的组成型细菌启动子的方法
KR20220149567A (ko) 2020-03-04 2022-11-08 바스프 에스이 이. 콜라이 및 바실루스에서의 발현을 위한 셔틀 벡터
KR20230005933A (ko) 2020-05-01 2023-01-10 아이오니스 파마수티컬즈, 인코포레이티드 Atxn1을 조정하는 화합물 및 방법
WO2021229106A1 (en) 2020-05-15 2021-11-18 Basf Se Improved method for the production of isoprenoids
JP2023532518A (ja) 2020-06-29 2023-07-28 アイオーニス ファーマシューティカルズ， インコーポレーテッド Ｐｌｐ１を調節するための化合物及び方法
US11730133B2 (en) 2020-10-21 2023-08-22 Equi-Nom Ltd High yield sesame
AU2021381363A1 (en) 2020-11-18 2023-06-15 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating angiotensinogen expression
CA3205040A1 (en) 2020-12-18 2022-06-23 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating factor xii
US20240218356A1 (en) 2021-05-11 2024-07-04 Two Blades Foundation Methods for preparing a library of plant disease resistance genes for functional testing for disease resistance
MX2023015230A (es) 2021-06-18 2024-01-18 Ionis Pharmaceuticals Inc Compuestos y metodos para reducir la expresion de ifnar1.
AU2022324708A1 (en) 2021-08-06 2024-02-15 Kws Vegetables B.V. Durable downy mildew resistance in spinach
CA3230261A1 (en) 2021-09-03 2023-03-09 Manuel Dubald Plants having increased tolerance to herbicides
US11395470B1 (en) 2021-09-14 2022-07-26 Equi-Nom Ltd. Sesame with high oil content and/or high yield
JP2024535869A (ja) 2021-09-16 2024-10-02 キューマイン・カンパニー・リミテッド Ｗｆｄｃ２の発現を調節するアンチセンス化合物
EP4408859A1 (de) 2021-09-30 2024-08-07 Two Blades Foundation Pflanzenkrankheitsresistenzgene gegen stammrost und verfahren zur verwendung
WO2023067192A1 (en) 2021-10-21 2023-04-27 Consejo Superior De Investigaciones Cientificas (Csic) Methods for improving abiotic stress resistance
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023118136A1 (en) 2021-12-22 2023-06-29 BASF Agricultural Solutions Seed US LLC Improved screening method for genome edited events
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
WO2024044352A1 (en) 2022-08-26 2024-02-29 The General Hospital Corporation Methods and compositions for prognosis and treatment of dilated cardiomyopathy and heart failure
WO2024083579A1 (en) 2022-10-20 2024-04-25 Basf Se Regulatory nucleic acid molecules for enhancing gene expression in plants
WO2024089011A1 (en) 2022-10-26 2024-05-02 BASF Agricultural Solutions Seed US LLC Excision of recombinant dna from the genome of plant cells
WO2024094678A2 (en) 2022-11-02 2024-05-10 Basf Se Improved method for the production of natural vanillin
WO2024098002A1 (en) 2022-11-04 2024-05-10 Regeneron Pharmaceuticals, Inc. Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
WO2024107765A2 (en) 2022-11-14 2024-05-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
WO2024126113A1 (en) 2022-12-12 2024-06-20 BASF Agricultural Solutions Seed US LLC Plants having increased tolerance to herbicides
WO2024132947A1 (en) 2022-12-19 2024-06-27 Basf Se New cellulase promoters for fungal protein production
WO2024156593A1 (en) 2023-01-27 2024-08-02 Basf Se New genomic integration site for fungal protein and fine chemicals production

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503151A (en) * 1980-12-10 1985-03-05 Research Corporation Recombinant cDNA construction method and hybrid nucleotides useful in cloning
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
EP0260032B1 (de) * 1986-09-08 1994-01-26 Ajinomoto Co., Inc. Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere
US4950599A (en) * 1987-01-29 1990-08-21 Wolf Bertling Method for exchanging homologous DNA sequences in a cell using polyoma encapsulated DNA fragments
WO1990014092A1 (en) * 1989-05-18 1990-11-29 Cell Genesys, Inc. Single-strand site-directed modification of mammalian genes in vivo
DE69333082T2 (de) * 1992-02-11 2004-05-06 Cell Genesys, Inc., Foster City Erzielen von homozygotem durch zielgerichtete genetische ereignisse
DE69333955D1 (de) * 1992-04-24 2006-02-02 Stanford Res Inst Int Targeting homologer sequenzen in eukaryotenzellen
AU5087193A (en) * 1992-08-21 1994-03-15 Regents Of The University Of California, The Composition and method for altering dna sequences by homologous recombination
EP0693123A1 (de) * 1993-03-31 1996-01-24 HYBRIDON, Inc. Veränderte Oligonukleotide mit verbesserter anti-grippe Aktivität

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