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CA2950423A1 - Compositions et procedes concernant des glycoformes universelles pour une efficacite d'anticorps amelioree - Google Patents

Compositions et procedes concernant des glycoformes universelles pour une efficacite d'anticorps amelioree Download PDF

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Publication number
CA2950423A1
CA2950423A1 CA2950423A CA2950423A CA2950423A1 CA 2950423 A1 CA2950423 A1 CA 2950423A1 CA 2950423 A CA2950423 A CA 2950423A CA 2950423 A CA2950423 A CA 2950423A CA 2950423 A1 CA2950423 A1 CA 2950423A1
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virus
cancer
cell
antibody
antibodies
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Chi-Huey Wong
Chung-Yi Wu
Che Ma
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Academia Sinica
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Academia Sinica
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • G—PHYSICS
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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Abstract

La présente invention concerne des glycoprotéines, en particulier des anticorps monoclonaux, comprenant une région Fc glycomodifiée, dans lesquelles ladite région Fc comprend un N-glycane optimisé ayant la structure de Sia2(a2-6)Gal2GlcNAc2Man3GlcNAc2 La région Fc glycomodifiée lie Fc?RIIA ou Fc?RIIIA avec une affinité plus élevée, par rapport à celle d'anticorps monoclonaux comparables comprenant la zone Fc de type sauvage. Les anticorps monoclonaux de l'invention sont particulièrement utiles dans la prévention, le traitement, ou l'amélioration d'un ou plusieurs symptômes associés à une maladie, un trouble, ou une infection dans lesquels une efficacité améliorée de la fonction cellulaire effectrice (par exemple, ADCC) médiée par Fc?R est souhaitée, par exemple, un cancer, une maladie auto-immune ou infectieuse, et dans l'amélioration de l'efficacité thérapeutique d'anticorps thérapeutiques dont l'effet est médié par ADCC.
CA2950423A 2014-05-27 2015-05-27 Compositions et procedes concernant des glycoformes universelles pour une efficacite d'anticorps amelioree Pending CA2950423A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201462003104P 2014-05-27 2014-05-27
US201462003136P 2014-05-27 2014-05-27
US62/003,136 2014-05-27
US62/003,104 2014-05-27
US201462003908P 2014-05-28 2014-05-28
US62/003,908 2014-05-28
US201462020199P 2014-07-02 2014-07-02
US62/020,199 2014-07-02
US201562110338P 2015-01-30 2015-01-30
US62/110,338 2015-01-30
PCT/US2015/032745 WO2015184009A1 (fr) 2014-05-27 2015-05-27 Compositions et procédés concernant des glycoformes universelles pour une efficacité d'anticorps améliorée

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CA2950423A1 true CA2950423A1 (fr) 2015-12-03

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CA2950577A Pending CA2950577A1 (fr) 2014-05-27 2015-05-27 Fucosidase issue de bacteroides et ses procedes d'utilisation
CA2950423A Pending CA2950423A1 (fr) 2014-05-27 2015-05-27 Compositions et procedes concernant des glycoformes universelles pour une efficacite d'anticorps amelioree

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CA2950577A Pending CA2950577A1 (fr) 2014-05-27 2015-05-27 Fucosidase issue de bacteroides et ses procedes d'utilisation

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US (4) US10023892B2 (fr)
EP (4) EP3149161B1 (fr)
JP (5) JP6894239B2 (fr)
KR (5) KR20230033737A (fr)
CN (3) CN106661562A (fr)
AU (3) AU2015267052A1 (fr)
CA (2) CA2950577A1 (fr)
DK (2) DK3149045T3 (fr)
FI (1) FI3149045T3 (fr)
IL (2) IL249195B (fr)
TW (2) TWI654202B (fr)
WO (2) WO2015184009A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
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WO2018133139A1 (fr) 2017-01-21 2018-07-26 宁波知明生物科技有限公司 Application de paeéniflorin-6'-o-benzène sulfonate en médecine pour le traitement du syndrome de sjögren
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