AR030432A1 - Uso de derivados de quinazolina en la preparacion de un medicamento para ser usado en la inhibicion de la quinasa aurora2, compuestos relacionados, y composicion farmaceutica. - Google Patents
Uso de derivados de quinazolina en la preparacion de un medicamento para ser usado en la inhibicion de la quinasa aurora2, compuestos relacionados, y composicion farmaceutica.Info
- Publication number
- AR030432A1 AR030432A1 ARP010103092A ARP010103092A AR030432A1 AR 030432 A1 AR030432 A1 AR 030432A1 AR P010103092 A ARP010103092 A AR P010103092A AR P010103092 A ARP010103092 A AR P010103092A AR 030432 A1 AR030432 A1 AR 030432A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- defined above
- represents hydrogen
- hydrogen
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 20
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 15
- 229910052739 hydrogen Inorganic materials 0.000 abstract 15
- 239000001257 hydrogen Substances 0.000 abstract 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 12
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 108090000461 Aurora Kinase A Proteins 0.000 abstract 1
- 102100032311 Aurora kinase A Human genes 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- AQYSYJUIMQTRMV-UHFFFAOYSA-N hypofluorous acid Chemical compound FO AQYSYJUIMQTRMV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
El uso de derivados de quinazolina de formula (1) o una sal, éster o amida del mismo; en la cual X es O, o S, S(O) o S(O)2, o NR6 donde R6 es hidrogeno o alquilo C1-6; R5 es un anillo heteroaromático de 5 miembros opcionalmente sustituido, R1, R2, R3, R4 están independientemente seleccionados entre halo, ciano, nitro, trifluormetilo, alquilo C1-3, NR7R8 (donde R7 y R8 que pueden ser iguales o diferentes, representan cada uno hidrogeno o alquilo C1-3), o -X1R9 (donde X1 representa un enlace directo, -O-, -CH2-, -OCO-, carbonilo, -S-, -SO-, -SO2-, -NR10CO-, -CONR11-, -SO2NR12-, -NR13SO2-, o NR14 - (donde R10, R11, R12, R13 y R14 representa cada uno independientemente hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3), y R9 está seleccionado entre uno de los siguientes grupos: 1) hidrogeno o alquilo C1-5 que puede estar no sustituido o puede estar sustituido con uno o más grupos seleccionados de hidroxi, fluor o amino, 2) alquilo C1-5X2COR15 (donde X2 representa -O- o -NR16- (en el cual R15 representa hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3 y R16 representa alquilo C1-3, -NR17R18 o -OR19 (donde R17, R18 y R19, que pueden ser iguales o diferentes, representan cada uno hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3)); 3) alquilo C1-5X3R20 (donde X3 representa -O-, -S-, -SO-, -SO2-, -OCO-, -NR21CO-, -CONR22-, -SO2NR23-, -NR24SO2- o -NR25- (donde R21, R22, R23, R24 y R25 representa cada uno independientemente hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3) y R20 representa hidrogeno, alquilo C1-3, ciclopentilo, ciclohexilo o un grupo heterocíclico saturado de 5-6 miembros con 1-2 heteroátomos, seleccionados independientemente de O, S y N, donde el grupo alquilo C1-3 puede ser portador de 1 o 2 sustituyentes seleccionados de oxo, hidroxi, halogeno y alcoxi C1-4 y donde el grupo cíclico puede ser portador de uno o dos sustituyentes seleccionados de oxo, hidroxi, halogeno, alquilo C1-4, hidroxialquilo C1-4, y alcoxi C1-4; 4) alquilo C1-5 X4 alquilo C1-5 X5R26 (donde X4 y X5, que pueden ser iguales o diferentes, son cada uno -O-, -S-, -SO-, -SO2-, -NR27CO-, -CONR28-, -SO2NR29-, -NR30SO2- o -NR31- (donde R27, R28, R29, R30 y R31 cada uno independientemente representa hidrogeno, alquilo C1-3 y alcoxi C1-3 alquilo C2-3) y R26 representa hidrogeno o alquilo C1-3); 5) R32 (donde R32 es un grupo heterocíclilo saturado de 5-6 miembros (ligado a través de carbono o nitrogeno) con 1-2 heteroátomos, seleccionados independientemente de O, S y N, donde el grupo heterocíclico puede ser portador de uno o dos sustituyentes seleccionados de oxo, hidroxi, halogeno, alquilo C1-4, hidroxialquilo C1-4, alcoxi C1-4, alcoxi C1-4 alquilo C1-4 y alquilsulfonil C1-4 alquilo C1-4); 6) alquilo C1-5 R32 (donde R32 es tal como se ha definido anteriormente); 7) alquenilo C2-5 R32 (donde R32 es tal como se ha definido anteriormente); 8) alquinilo C2-5R32 (donde R32 es tal como se ha definido anteriormente); 9) R33 (donde R33 representa un grupo piridona, fenilo o un grupo heterocíclico aromático de 5-6 miembros (ligado a través de carbono o nitrogeno) con 1-3 heterátomos seleccionados de O, N y S, donde el grupo piridona, fenilo o heterocíclico aromático puede ser portador de hasta 5 sustituyentes sobre un átomo de carbono asequible, seleccionados de hidroxi, halogeno, amino, alquilo C1-4, alcoxi C1-4, hidroxialquilo C1-4, aminoalquilo C1-4, alquilamino C1-4, hidroxialcoxi C1-4, carboxi, trifluormetilo, ciano, -CONR34R35 y -NR36COR37 (donde R34, R35,R36 y R37, que pueden ser iguales o diferentes, representa cada uno hidrogeno, alquilo C1-4 o alcoxi C1-3 alquilo C2-3)); 10) alquilo C1-5R33 (donde R33 es tal como se ha definido anteriormente); 11) alquenilo C2-5 R33(donde R33 es tal como se ha definido anteriormente); 12) alquinilo C2-5R33 (donde R33 es tal como se ha definido anteriormente); 13) alquilo C1-5X6R33 (donde X6 representa -O-, -S-, -SO2-, -NR38CO-, -CONR39-, -SO2NR40-, -NR41SO2- o -NR42- (donde R38, R39, R40, R41 y R42 representa cada uno independientemente hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3) y R33 es tal como se ha definido anteriormente); 14) alquenilo C2-5X7R33 (donde X7 representa -O-, -S-, -SO-, -SO2-, -NR43CO-, -CONR44-, -SO2NR45, -NR46SO2-, o -NR47- (donde R43, R44, R45, R46 y R47 cada uno independientemente representa hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3) y R33 es tal como se ha definido anteriormente); 15) alquinilo C2-5X8R33 (donde X8 representa -O-, -S-, -SO-, -SO2-, -NR48CO-, -CONR49-, -SO2NR50-, -NR51SO2- o -NR52- (donde R48, R49, R50, R51 y R52 cada uno independientemente representa hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3) y R33 es tal como se ha definido anteriormente); 16) alquilo C1-3X9 alquilo C1-3R33 (donde X9 representa -O-, -S-, -SO-, -SO2-, -NR53CO-, -CONR54-, -SO2NR55-, -NR56SO2- o -NR57- (donde R53, R54, R55, R56 y R57 cada uno de los cuales representa independientemente hidrogeno, alquilo C1-3 o alcoxi C1-3 alquilo C2-3) y R33 es tal como se ha definido anteriormente) y 17) alquilo C1-3X9 alquilo C1-3R32 (donde X9 y R28 son tal como se han definido anteriormente); que se usa en la preparacion de un medicamento para ser usado en la inhibicion de la quinasa aurora2, compuestos relacionados, y composicion farmacéutica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00401842 | 2000-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR030432A1 true AR030432A1 (es) | 2003-08-20 |
Family
ID=8173742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103092A AR030432A1 (es) | 2000-06-28 | 2001-06-28 | Uso de derivados de quinazolina en la preparacion de un medicamento para ser usado en la inhibicion de la quinasa aurora2, compuestos relacionados, y composicion farmaceutica. |
Country Status (27)
Country | Link |
---|---|
US (2) | US6919338B2 (es) |
EP (1) | EP1299381B1 (es) |
JP (1) | JP2004501914A (es) |
KR (1) | KR20030014411A (es) |
CN (1) | CN1267431C (es) |
AR (1) | AR030432A1 (es) |
AT (1) | ATE394102T1 (es) |
AU (1) | AU2001266505A1 (es) |
BG (1) | BG107376A (es) |
BR (1) | BR0111754A (es) |
CA (1) | CA2412592A1 (es) |
CZ (1) | CZ20024120A3 (es) |
DE (1) | DE60133897D1 (es) |
EE (1) | EE200200715A (es) |
ES (1) | ES2305081T3 (es) |
HK (1) | HK1053124A1 (es) |
HU (1) | HUP0301236A2 (es) |
IL (1) | IL153246A0 (es) |
IS (1) | IS6656A (es) |
MX (1) | MXPA02011974A (es) |
NO (1) | NO20026010D0 (es) |
NZ (1) | NZ522696A (es) |
PL (1) | PL360439A1 (es) |
RU (1) | RU2283311C2 (es) |
SK (1) | SK18102002A3 (es) |
WO (1) | WO2002000649A1 (es) |
ZA (1) | ZA200209412B (es) |
Families Citing this family (101)
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WO2002022606A1 (en) * | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP2264028A1 (en) | 2000-12-21 | 2010-12-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
AU2002353196B2 (en) | 2001-12-24 | 2008-01-17 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
KR20040084896A (ko) * | 2002-02-06 | 2004-10-06 | 버텍스 파마슈티칼스 인코포레이티드 | Gsk-3의 억제제로서 유용한 헤테로아릴 화합물 |
JP4481011B2 (ja) * | 2002-03-05 | 2010-06-16 | トランス テック ファーマ,インコーポレイテッド | リガンドのrageとの相互作用を阻害する単環式および二環式アゾール誘導体 |
DE60332604D1 (de) * | 2002-03-15 | 2010-07-01 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
EP2316834A1 (en) | 2002-05-06 | 2011-05-04 | Vertex Pharmaceuticals Incorporated | Thiadiazoles or oxadiazoles and their use as inhibitors of JAK protein kinase |
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JP4703183B2 (ja) | 2002-07-15 | 2011-06-15 | シンフォニー エボルーション, インク. | 受容体型キナーゼモジュレーターおよびその使用方法 |
NZ550883A (en) * | 2002-08-02 | 2008-06-30 | Vertex Pharma | Pyrazole compositions useful as inhibitors of glycogen synthase kinase-3 (GSK-3) |
GB0221245D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Chemical process |
ATE438644T1 (de) | 2002-12-24 | 2009-08-15 | Astrazeneca Ab | Chinazolinderivate |
CN100349906C (zh) * | 2002-12-24 | 2007-11-21 | 阿斯利康(瑞典)有限公司 | 膦酰氧基喹唑啉衍生物及其药物用途 |
CN1753889A (zh) * | 2002-12-24 | 2006-03-29 | 阿斯利康(瑞典)有限公司 | 喹唑啉化合物 |
WO2004072029A2 (en) * | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
EP1613619B1 (en) * | 2003-04-16 | 2008-03-26 | AstraZeneca AB | Quinazoline derivatives for treatment of cancer |
BRPI0410436A (pt) * | 2003-05-20 | 2006-05-30 | Transtech Pharma Inc | antagonistas de rage como agentes para amiloidose reversa e doenças associadas com a mesma |
ATE401080T1 (de) * | 2003-06-02 | 2008-08-15 | Astrazeneca Ab | (3-((chinazolin-4-yl)amino)-1h-pyrazol-1- yl)acetamid derivate und verwandte verbindungen als aurora kinase inhibitoren zur behandlung von proliferativen erkrankungen wie krebs |
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GB0320793D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Chemical process |
ATE517091T1 (de) | 2003-09-26 | 2011-08-15 | Exelixis Inc | C-met-modulatoren und verwendungsverfahren |
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US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
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EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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WO2002000649A1 (en) | 2002-01-03 |
RU2283311C2 (ru) | 2006-09-10 |
SK18102002A3 (sk) | 2003-07-01 |
AU2001266505A1 (en) | 2002-01-08 |
DE60133897D1 (de) | 2008-06-19 |
BG107376A (bg) | 2003-09-30 |
EP1299381B1 (en) | 2008-05-07 |
CA2412592A1 (en) | 2002-01-03 |
US20030187002A1 (en) | 2003-10-02 |
HK1053124A1 (en) | 2003-10-10 |
WO2002000649A9 (en) | 2007-09-20 |
CN1496364A (zh) | 2004-05-12 |
MXPA02011974A (es) | 2004-09-06 |
NZ522696A (en) | 2004-08-27 |
ZA200209412B (en) | 2004-02-19 |
EE200200715A (et) | 2004-08-16 |
BR0111754A (pt) | 2003-04-29 |
ATE394102T1 (de) | 2008-05-15 |
US6919338B2 (en) | 2005-07-19 |
CZ20024120A3 (cs) | 2003-03-12 |
ES2305081T3 (es) | 2008-11-01 |
JP2004501914A (ja) | 2004-01-22 |
PL360439A1 (en) | 2004-09-06 |
US20060046987A1 (en) | 2006-03-02 |
HUP0301236A2 (hu) | 2003-10-28 |
CN1267431C (zh) | 2006-08-02 |
IL153246A0 (en) | 2003-07-06 |
NO20026010D0 (no) | 2002-12-13 |
IS6656A (is) | 2002-12-17 |
KR20030014411A (ko) | 2003-02-17 |
EP1299381A1 (en) | 2003-04-09 |
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