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RS50218B - Kristalni monohidrat, postupak za njegovo pripremanje i njegova primena za pripremanje leka - Google Patents

Kristalni monohidrat, postupak za njegovo pripremanje i njegova primena za pripremanje leka

Info

Publication number
RS50218B
RS50218B YU27303A YUP27303A RS50218B RS 50218 B RS50218 B RS 50218B YU 27303 A YU27303 A YU 27303A YU P27303 A YUP27303 A YU P27303A RS 50218 B RS50218 B RS 50218B
Authority
RS
Serbia
Prior art keywords
medicament
producing
production
same
crystalline monohydrate
Prior art date
Application number
YU27303A
Other languages
English (en)
Inventor
Rolf Banholzer
Helmut Meissner
Michael Trunk
Christian Kulinna
Peter Sieger
Manfred Graulich
Peter Specht
Andreas Mathes
Original Assignee
Boehringer Ingelheim Pharma Gmbh. & Co.Kg.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS50218(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh. & Co.Kg., filed Critical Boehringer Ingelheim Pharma Gmbh. & Co.Kg.,
Priority to MEP-400/08A priority Critical patent/MEP40008A/xx
Publication of YU27303A publication Critical patent/YU27303A/sh
Publication of RS50218B publication Critical patent/RS50218B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Kristalni tiotropijumbromid-monohidrat. Prijava sadrži još 117 patentnih zahteva.
YU27303A 2000-10-12 2001-09-28 Kristalni monohidrat, postupak za njegovo pripremanje i njegova primena za pripremanje leka RS50218B (sr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-400/08A MEP40008A (en) 2000-10-12 2001-09-28 Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050621 2000-10-12

Publications (2)

Publication Number Publication Date
YU27303A YU27303A (sh) 2006-05-25
RS50218B true RS50218B (sr) 2009-07-15

Family

ID=7659568

Family Applications (1)

Application Number Title Priority Date Filing Date
YU27303A RS50218B (sr) 2000-10-12 2001-09-28 Kristalni monohidrat, postupak za njegovo pripremanje i njegova primena za pripremanje leka

Country Status (47)

Country Link
EP (2) EP1468998A1 (sr)
JP (1) JP3764422B2 (sr)
KR (1) KR100823860B1 (sr)
CN (2) CN100519558C (sr)
AP (1) AP1572A (sr)
AR (2) AR034389A1 (sr)
AT (1) ATE276253T1 (sr)
AU (2) AU1499602A (sr)
BG (1) BG66161B1 (sr)
BR (1) BR0114584A (sr)
CA (1) CA2425539C (sr)
CR (1) CR6938A (sr)
CZ (1) CZ301841B6 (sr)
DE (1) DE50103666D1 (sr)
DK (1) DK1326862T3 (sr)
DZ (1) DZ3478A1 (sr)
EA (1) EA004381B1 (sr)
EC (1) ECSP034540A (sr)
EE (1) EE04567B1 (sr)
EG (1) EG24142A (sr)
ES (1) ES2228965T3 (sr)
GE (1) GEP20063905B (sr)
HK (2) HK1060567A1 (sr)
HR (1) HRP20030276B1 (sr)
HU (1) HU226830B1 (sr)
IL (2) IL155335A0 (sr)
IS (1) IS2339B (sr)
MA (1) MA25842A1 (sr)
ME (2) MEP40008A (sr)
MX (1) MXPA03003221A (sr)
MY (1) MY126931A (sr)
NO (1) NO328465B1 (sr)
NZ (1) NZ525733A (sr)
OA (1) OA12403A (sr)
PE (1) PE20020422A1 (sr)
PL (1) PL207870B1 (sr)
PT (1) PT1326862E (sr)
RS (1) RS50218B (sr)
SA (1) SA01220412B1 (sr)
SI (1) SI1326862T1 (sr)
SK (1) SK287009B6 (sr)
TR (1) TR200402579T4 (sr)
TW (1) TW589313B (sr)
UA (1) UA74215C2 (sr)
UY (2) UY26962A1 (sr)
WO (1) WO2002030928A1 (sr)
ZA (1) ZA200302500B (sr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002345016B2 (en) * 2001-06-22 2008-04-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DE10214263A1 (de) * 2002-03-28 2003-10-16 Boehringer Ingelheim Pharma HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7311894B2 (en) 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
ME00349B (me) * 2003-11-03 2011-05-10 Boehringer Ingelheim Int Novi kristalni anhidrat sa antiholinergij skim dejstvom
UY28590A1 (es) * 2003-11-03 2005-06-30 Boehringer Ingelheim Int Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
US7968717B2 (en) 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
EP2319844A1 (de) * 2003-11-03 2011-05-11 Boehringer Ingelheim International GmbH Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
DE102004016179A1 (de) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Verbindungen zur Behandlung von proliferativen Prozessen
ES2380370T3 (es) 2004-04-22 2012-05-11 Boehringer Ingelheim International Gmbh Combinaciones farmacológicas que contienen benzoxazina para el tratamiento de enfermedades de las vías respiratorias
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ATE427108T1 (de) 2004-08-11 2009-04-15 Boehringer Ingelheim Pharma Anticholinergika enthaltende arzneimittel zur behandlung von krankheiten der ableitenden harnwege
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
JP5566576B2 (ja) * 2004-10-21 2014-08-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 吸入器用ブリスタ
EP1858554A2 (en) * 2005-03-09 2007-11-28 Boehringer Ingelheim International GmbH New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
AU2006237354B2 (en) 2005-04-21 2012-03-01 Boehringer Ingelheim International Gmbh Dihydrothienopyrimidines for the treatment of inflammatory diseases
JP5053997B2 (ja) 2005-04-28 2012-10-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症性疾患の治療用の新規化合物
BRPI0611091A2 (pt) * 2005-05-02 2010-08-03 Boehringer Ingelheim Int formas cristalinas de brometo de tiotrópico
DK1881980T3 (da) 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
EP1896026B1 (en) * 2005-06-15 2013-10-09 Boehringer Ingelheim International GmbH Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (de) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
KR20080039974A (ko) * 2005-08-06 2008-05-07 베링거 인겔하임 인터내셔날 게엠베하 중증 지속성 천식의 치료에서 티오트로퓸 염의 용도
BRPI0614410A2 (pt) 2005-08-15 2011-03-29 Boehringer Ingelheim Int processo para preparação de betamiméticos
US20070086957A1 (en) 2005-10-10 2007-04-19 Thierry Bouyssou Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) * 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
ES2396978T5 (es) * 2005-12-19 2015-12-04 Sicor, Inc. Forma cristalina novedosa de bromuro de tiotropio y procedimiento para la preparación de la misma
EP1966196A2 (en) * 2005-12-19 2008-09-10 Sicor, Inc. Pure and stable tiotropium bromide
EA015353B1 (ru) * 2006-01-04 2011-06-30 Бёрингер Ингельхайм Интернациональ Гмбх Применение солей тиотропия для лечения персистирующей астмы средней тяжести
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
JP2010500318A (ja) 2006-08-07 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療用医薬組成物
PE20080610A1 (es) 2006-08-22 2008-07-15 Boehringer Ingelheim Int Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
EP1923393A1 (en) * 2006-11-17 2008-05-21 Boehringer Ingelheim Pharma GmbH & Co. KG Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
PL2215092T3 (pl) 2007-10-19 2012-07-31 Boehringer Ingelheim Int Podstawione piperydyno-dihydrotienopirymidyny
EP2093219A1 (de) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
WO2010011813A1 (en) * 2008-07-23 2010-01-28 Alkermes, Inc. Complex of trospium and pharmaceutical compositions thereof
JP2012512834A (ja) 2008-12-19 2012-06-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 炎症、喘息及びｃｏｐｄの処置のためのｃｃｒ２受容体アンタゴニストとしての環状ピリミジン−４−カルボキサミド
EP2201934A1 (en) 2008-12-23 2010-06-30 CHIESI FARMACEUTICI S.p.A. Tiotropium aerosol formulation products with improved chemical stability
EP2403851B1 (en) 2009-03-06 2015-06-17 Mahmut Bilgic New crystalline forms of tiotropium bromide
WO2011015883A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Dichloromethane solvate of tiotropium bromide and its use
CA2768553C (en) 2009-08-07 2016-08-02 Generics [Uk] Limited Anhydrate of tiotropium bromide
NZ599770A (en) 2009-12-17 2014-06-27 Boehringer Ingelheim Int New ccr2 receptor antagonists and uses thereof
EP2513086B1 (en) 2009-12-17 2015-04-29 Boehringer Ingelheim International GmbH Novel antagonists for ccr2 and uses thereof
CA2786245A1 (en) 2010-01-29 2011-08-04 Boehringer Ingelheim International Gmbh Substituted naphthyridines and their use as syk kinase inhibitors
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8841313B2 (en) 2010-05-17 2014-09-23 Boehringer Ingelheim International Gmbh CCR2 antagonists and uses thereof
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
WO2011151251A1 (en) 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh New ccr2 antagonists
JP5959537B2 (ja) 2011-01-28 2016-08-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリジニル−ピリミジン及び医薬としてのその使用
TR201102068A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
WO2012171863A1 (en) 2011-06-16 2012-12-20 Boehringer Ingelheim International Gmbh New selective ccr2 antagonists
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
EP2736886B1 (en) 2011-07-26 2016-09-14 Boehringer Ingelheim International GmbH Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) 2011-11-28 2014-04-02 Zentiva, K.S. Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
EA025960B1 (ru) 2012-11-05 2017-02-28 Зентива, К.С. Стабилизация сольватов тиотропия
EP2913332A1 (en) * 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
CN110183440B (zh) 2014-03-19 2022-04-22 勃林格殷格翰国际有限公司 杂芳基syk抑制剂
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
RU2567539C1 (ru) * 2015-02-04 2015-11-10 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
EP3414243A1 (en) 2016-02-11 2018-12-19 Sima Patent Ve Lisanslama Hizmetleri Ltd. STI Crystalline form of tiotropium bromide anhydrate
WO2018084817A2 (en) * 2016-11-04 2018-05-11 Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ A new form of active agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
HU221163B1 (en) * 1992-12-09 2002-08-28 Boehringer Ingelheim Pharma Stabilized medicinal aerosol solution formulations and process for producing them
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
DE59904648D1 (de) * 1998-08-04 2003-04-24 Jago Res Ag Muttenz Medizinische aerosolformulierungen

Also Published As

Publication number Publication date
PL207870B1 (pl) 2011-02-28
ES2228965T3 (es) 2005-04-16
CN1469877A (zh) 2004-01-21
IS2339B (is) 2008-02-15
DK1326862T3 (da) 2004-11-22
EP1326862B1 (de) 2004-09-15
TR200402579T4 (tr) 2004-12-21
EA200300457A1 (ru) 2003-10-30
UA74215C2 (uk) 2005-11-15
AP2003002775A0 (en) 2003-03-31
AR034389A1 (es) 2004-02-25
ECSP034540A (es) 2003-07-25
AP1572A (en) 2006-02-13
SI1326862T1 (en) 2005-02-28
HRP20030276A2 (en) 2005-02-28
IL155335A0 (en) 2003-11-23
UY34901A (es) 2015-02-27
EP1326862A1 (de) 2003-07-16
CN1221549C (zh) 2005-10-05
HRP20030276B1 (en) 2006-02-28
NO328465B1 (no) 2010-02-22
BG66161B1 (bg) 2011-09-30
AU1499602A (en) 2002-04-22
HK1060567A1 (en) 2004-08-13
GEP20063905B (en) 2006-08-25
NO20031694L (no) 2003-04-11
PL366041A1 (en) 2005-01-24
HUP0301022A3 (en) 2005-12-28
TW589313B (en) 2004-06-01
DZ3478A1 (fr) 2002-04-18
HUP0301022A2 (hu) 2003-10-28
PE20020422A1 (es) 2002-06-28
NO20031694D0 (no) 2003-04-11
NZ525733A (en) 2005-01-28
UY26962A1 (es) 2002-06-20
DE50103666D1 (de) 2004-10-21
SK4362003A3 (en) 2003-08-05
MEP40008A (en) 2011-02-10
CZ301841B6 (cs) 2010-07-07
EA004381B1 (ru) 2004-04-29
KR100823860B1 (ko) 2008-04-21
EP1468998A1 (de) 2004-10-20
ATE276253T1 (de) 2004-10-15
JP3764422B2 (ja) 2006-04-05
EE200300171A (et) 2003-06-16
SK287009B6 (sk) 2009-09-07
CA2425539C (en) 2007-04-03
KR20030042008A (ko) 2003-05-27
ZA200302500B (en) 2004-04-22
AU2002214996B2 (en) 2007-03-15
CN1733761A (zh) 2006-02-15
BR0114584A (pt) 2003-08-26
IS6772A (is) 2003-04-09
WO2002030928A1 (de) 2002-04-18
EE04567B1 (et) 2005-12-15
ME00243B (me) 2011-05-10
PT1326862E (pt) 2004-11-30
YU27303A (sh) 2006-05-25
BG107687A (bg) 2003-09-30
HK1086557A1 (en) 2006-09-22
MY126931A (en) 2006-10-31
MXPA03003221A (es) 2004-12-03
CA2425539A1 (en) 2003-04-11
CR6938A (es) 2004-10-28
SA01220412B1 (ar) 2006-11-05
IL155335A (en) 2009-02-11
OA12403A (en) 2006-04-18
HU226830B1 (en) 2009-11-30
JP2004526668A (ja) 2004-09-02
AR068527A2 (es) 2009-11-18
MA25842A1 (fr) 2003-07-01
EG24142A (en) 2008-08-06
CN100519558C (zh) 2009-07-29

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