ECSP034540A - Monohidrato cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamento - Google Patents
Monohidrato cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamentoInfo
- Publication number
- ECSP034540A ECSP034540A EC2003004540A ECSP034540A ECSP034540A EC SP034540 A ECSP034540 A EC SP034540A EC 2003004540 A EC2003004540 A EC 2003004540A EC SP034540 A ECSP034540 A EC SP034540A EC SP034540 A ECSP034540 A EC SP034540A
- Authority
- EC
- Ecuador
- Prior art keywords
- preparation
- procedure
- crystalline
- monohidrate
- medicinal product
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a un monohidrato cristalino del bromuro de (1a,2b,4b,5a,7b)-7-(hidroxidi-2-tienilacetil)-oxi)-9,9-dimetil-3-oxa-9-azoniatricicllo (3.3.1.0) nonato, al procedimiento para su preparación así como a su utilización para la preparación de un medicamento especialmente para la preparación de un medicamento con efecto anticolinérgico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10050621 | 2000-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP034540A true ECSP034540A (es) | 2003-07-25 |
Family
ID=7659568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2003004540A ECSP034540A (es) | 2000-10-12 | 2003-04-07 | Monohidrato cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamento |
Country Status (46)
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101011353B1 (ko) * | 2001-06-22 | 2011-01-28 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 결정질 항콜린제, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| US6608055B2 (en) | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
| DE10212264A1 (de) | 2002-03-20 | 2003-10-02 | Boehringer Ingelheim Pharma | Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels |
| US7244415B2 (en) | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
| US7311894B2 (en) | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
| DE10214263A1 (de) * | 2002-03-28 | 2003-10-16 | Boehringer Ingelheim Pharma | HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum |
| US7056916B2 (en) | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
| DE10317461A1 (de) | 2003-04-16 | 2004-10-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung |
| JP5165244B2 (ja) | 2003-11-03 | 2013-03-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物 |
| UA82909C2 (en) * | 2003-11-03 | 2008-05-26 | Boehringer Ingelheim Int | Novel crystalline anhydride with anticholinergic effect |
| US7968717B2 (en) | 2003-11-03 | 2011-06-28 | Boehringer Ingelhein International Gmbh | Crystalline anhydrate with anticholinergic efficacy |
| EP1682543B1 (de) * | 2003-11-03 | 2010-08-18 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung neuer tiotropiumsalze |
| DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
| CA2559699C (en) | 2004-04-22 | 2012-06-19 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations containing benzoxazine for treating respiratory diseases |
| DE102004024454A1 (de) | 2004-05-14 | 2005-12-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US7220742B2 (en) | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
| ES2322148T3 (es) | 2004-08-11 | 2009-06-17 | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG | Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias. |
| US20060079544A1 (en) * | 2004-08-13 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic |
| DE102004048389A1 (de) | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa |
| UA95063C2 (ru) * | 2004-10-21 | 2011-07-11 | Бёрингер Ингельхайм Интернациональ Гмбх | Блистерная упаковка для применения в ингаляторах |
| CA2600636A1 (en) * | 2005-03-09 | 2006-09-14 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors |
| CN101163706A (zh) | 2005-04-21 | 2008-04-16 | 贝林格尔·英格海姆国际有限公司 | 用于治疗炎性疾病的二氢噻吩并嘧啶 |
| NZ563448A (en) | 2005-04-28 | 2011-01-28 | Boehringer Ingelheim Int | Benzofuranone derivatives for treating inflammatory diseases |
| CN101166738B (zh) | 2005-05-02 | 2011-06-01 | 贝林格尔·英格海姆国际有限公司 | 噻托溴铵的新晶型 |
| MX2007013691A (es) * | 2005-05-02 | 2008-01-21 | Boehringer Ingelheim Int | Nuevas formas cristalinas de bromuro de tiotropio. |
| NZ583872A (en) * | 2005-06-15 | 2011-10-28 | Boehringer Ingelheim Int | Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof |
| DE102005030733A1 (de) | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| AU2006277968A1 (en) * | 2005-08-06 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Use of tiotropium salts in the treatment of severe persistant asthma |
| KR101360803B1 (ko) | 2005-08-15 | 2014-02-11 | 베링거 인겔하임 인터내셔날 게엠베하 | 베타모방제의 제조방법 |
| US20070086957A1 (en) | 2005-10-10 | 2007-04-19 | Thierry Bouyssou | Combination of medicaments for the treatment of respiratory diseases |
| US7423146B2 (en) | 2005-11-09 | 2008-09-09 | Boehringer Ingelheim International Gmbh | Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones |
| DE102005059602A1 (de) * | 2005-12-14 | 2007-06-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mikronisierung |
| JP2008530251A (ja) * | 2005-12-19 | 2008-08-07 | シコール インコーポレイティド | 純粋且つ安定な臭化チオトロピウム |
| TW200732340A (en) * | 2005-12-19 | 2007-09-01 | Sicor Inc | Novel forms of tiotropium bromide and processes for preparation thereof |
| MY146362A (en) * | 2006-01-04 | 2012-08-15 | Boehringer Ingelheim Int | Use of tiotropium salts in the treatment of moderate persistent asthma |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| US20080051582A1 (en) | 2006-07-10 | 2008-02-28 | Sicor Inc. | Process for the preparation of tiotropium bromide |
| EP2051714B1 (de) | 2006-08-07 | 2011-04-13 | Boehringer Ingelheim International GmbH | Arzneimittelkombinationen zur behandlung von atemwegserkrankungen |
| PE20080610A1 (es) | 2006-08-22 | 2008-07-15 | Boehringer Ingelheim Int | Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos |
| EP1923393A1 (en) * | 2006-11-17 | 2008-05-21 | Boehringer Ingelheim Pharma GmbH & Co. KG | Crystalline form of tiotropium bromide and urea |
| EP1925295A1 (de) * | 2006-11-22 | 2008-05-28 | Boehringer Ingelheim Pharma GmbH & Co. KG | Stabile Pulverformulierung enthaltend ein Anticholinergikum |
| GB0716026D0 (en) * | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
| PT2215092E (pt) | 2007-10-19 | 2012-04-10 | Boehringer Ingelheim Int | Piperidino-di-hidrotienopirimidinas substituídas |
| EP2093219A1 (de) | 2008-02-22 | 2009-08-26 | Boehringer Ingelheim International Gmbh | Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel |
| WO2010011813A1 (en) * | 2008-07-23 | 2010-01-28 | Alkermes, Inc. | Complex of trospium and pharmaceutical compositions thereof |
| BRPI0923051B1 (pt) | 2008-12-19 | 2022-07-19 | Centrexion Therapeutics Corporation | Pirimidin-4-carboxamidas cíclicas como antagonistas do receptor de ccr2 para o tratamento de inflamação, asma e copd, seu uso, formulação e combinação farmacêutica que os compreende |
| EP2201934A1 (en) | 2008-12-23 | 2010-06-30 | CHIESI FARMACEUTICI S.p.A. | Tiotropium aerosol formulation products with improved chemical stability |
| EP2403851B1 (en) | 2009-03-06 | 2015-06-17 | Mahmut Bilgic | New crystalline forms of tiotropium bromide |
| NZ597920A (en) | 2009-08-07 | 2014-05-30 | Generics Uk Ltd | Anhydrate of tiotropium bromide |
| WO2011015883A1 (en) | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Dichloromethane solvate of tiotropium bromide and its use |
| DK2513093T3 (da) | 2009-12-17 | 2014-09-29 | Boehringer Ingelheim Int | Nye CCR2 receptor antagonister og anvendelser deraf |
| EP2513086B1 (en) | 2009-12-17 | 2015-04-29 | Boehringer Ingelheim International GmbH | Novel antagonists for ccr2 and uses thereof |
| EP2528915B1 (en) | 2010-01-29 | 2015-10-28 | Boehringer Ingelheim International GmbH | Substituted naphthyridines and their use as syk kinase inhibitors |
| US8946218B2 (en) | 2010-05-12 | 2015-02-03 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
| US8841313B2 (en) | 2010-05-17 | 2014-09-23 | Boehringer Ingelheim International Gmbh | CCR2 antagonists and uses thereof |
| US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
| WO2011151251A1 (en) | 2010-06-01 | 2011-12-08 | Boehringer Ingelheim International Gmbh | New ccr2 antagonists |
| EP2668177B1 (en) | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituted pyridinyl-pyrimidines and their use as medicaments |
| TR201102068A2 (tr) | 2011-03-03 | 2012-09-21 | Bi̇lgi̇ç Mahmut | Tiotropyum bromür içeren kristal maddeler |
| JP5786257B2 (ja) | 2011-06-16 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の選択的ｃｃｒ２拮抗薬 |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| KR101986484B1 (ko) | 2011-07-26 | 2019-06-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 치환된 퀴놀린 및 이의 약제로서의 용도 |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| CZ304368B6 (cs) * | 2011-11-28 | 2014-04-02 | Zentiva, K.S. | Směsný solvát tiotropium bromidu a způsob jeho přípravy |
| GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
| US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
| HUE032455T2 (en) | 2012-11-05 | 2017-09-28 | Zentiva Ks | Stabilization of thiotropium solvates |
| EP2913332A1 (en) * | 2014-02-27 | 2015-09-02 | Euticals S.P.A. | Crystalline form of tiotropium bromide with lactose |
| EP3119765B1 (en) | 2014-03-19 | 2019-07-17 | Boehringer Ingelheim International GmbH | Heteroaryl syk inhibitors |
| US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
| RU2567539C1 (ru) * | 2015-02-04 | 2015-11-10 | Индивидуальный предприниматель Михайлов Олег Ростиславович | КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ |
| EP3414243A1 (en) | 2016-02-11 | 2018-12-19 | Sima Patent Ve Lisanslama Hizmetleri Ltd. STI | Crystalline form of tiotropium bromide anhydrate |
| WO2018084817A2 (en) * | 2016-11-04 | 2018-05-11 | Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ | A new form of active agent |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| UA27143C2 (uk) * | 1992-12-09 | 2000-02-28 | Берінгер Інгельхейм Фармасьютікалс Інк | Рідка фармацевтичhа композиція в формі аерозолю |
| DE19834506A1 (de) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Transmucosales therapeutisches System zur Anwendung von Sildenafil |
| AU749697B2 (en) * | 1998-08-04 | 2002-07-04 | Jagotec Ag | Medicinal aerosol formulations |
-
2001
- 2001-09-28 PT PT01983510T patent/PT1326862E/pt unknown
- 2001-09-28 ES ES01983510T patent/ES2228965T3/es not_active Expired - Lifetime
- 2001-09-28 DK DK01983510T patent/DK1326862T3/da active
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active Active
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 CZ CZ20031025A patent/CZ301841B6/cs not_active IP Right Cessation
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/es active IP Right Grant
- 2001-09-28 EE EEP200300171A patent/EE04567B1/xx unknown
- 2001-09-28 EA EA200300457A patent/EA004381B1/ru not_active IP Right Cessation
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/fr active
- 2001-09-28 SI SI200130219T patent/SI1326862T1/xx unknown
- 2001-09-28 AU AU1499602A patent/AU1499602A/xx active Pending
- 2001-09-28 PL PL366041A patent/PL207870B1/pl unknown
- 2001-09-28 DE DE50103666T patent/DE50103666D1/de not_active Expired - Lifetime
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/ko not_active Expired - Lifetime
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/pt active Pending
- 2001-09-28 HR HR20030276A patent/HRP20030276B1/xx not_active IP Right Cessation
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/zh not_active Ceased
- 2001-09-28 HU HU0301022A patent/HU226830B1/hu unknown
- 2001-09-28 RS YU27303A patent/RS50218B/sr unknown
- 2001-09-28 UA UA2003054185A patent/UA74215C2/uk unknown
- 2001-09-28 ME MEP-400/08A patent/MEP40008A/xx unknown
- 2001-09-28 EP EP01983510A patent/EP1326862B1/de not_active Expired - Lifetime
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 TR TR2004/02579T patent/TR200402579T4/xx unknown
- 2001-09-28 AT AT01983510T patent/ATE276253T1/de active
- 2001-09-28 SK SK436-2003A patent/SK287009B6/sk not_active IP Right Cessation
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/ja not_active Expired - Lifetime
- 2001-09-28 OA OA1200300107A patent/OA12403A/fr unknown
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/de active IP Right Grant
- 2001-09-28 CN CNB018171435A patent/CN1221549C/zh not_active Ceased
- 2001-09-28 IL IL15533501A patent/IL155335A0/xx active IP Right Grant
- 2001-09-28 EP EP04016877A patent/EP1468998A1/de not_active Withdrawn
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/me unknown
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-10-02 SA SA01220412A patent/SA01220412B1/ar unknown
- 2001-10-09 TW TW090124963A patent/TW589313B/zh active
- 2001-10-09 EG EG20011058A patent/EG24142A/xx active
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/es active IP Right Grant
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-10 UY UY26962A patent/UY26962A1/es not_active Application Discontinuation
- 2001-10-12 AR ARP010104782A patent/AR034389A1/es active Pending
-
2003
- 2003-03-26 CR CR6938A patent/CR6938A/es unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/bg active Active
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/es unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/fr unknown
- 2003-04-09 IS IS6772A patent/IS2339B/is unknown
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-11 NO NO20031694A patent/NO328465B1/no not_active IP Right Cessation
-
2008
- 2008-09-19 AR ARP080104109A patent/AR068527A2/es unknown
-
2013
- 2013-07-11 UY UY34901A patent/UY34901A/es not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP034540A (es) | Monohidrato cristalino, procedimiento para su preparacion y su utilizacion para la preparacion de un medicamento | |
| UY27342A1 (es) | Agente anticolinérgico cristalino, procedimiento para su preparación y su utilización para la preparación de un medicamento | |
| UY27725A1 (es) | Material micronizado cristalino, procedimiento para su preparación y su utilización para la preparación de un medicamento. | |
| CU23366B7 (es) | Oxazolidinonas substituidas para terapia de combinación | |
| UY26139A1 (es) | Composiciones de medicamentos a base de compuestos anticolinérgicamente activos y beta- miméticos | |
| HN1998000155A (es) | Medicamentos | |
| BR0308429A (pt) | Aroilpiridinonas monocìclicas como agentes antiinflamatórios | |
| ES2086313T3 (es) | Nuevos derivados de xantina con efecto antagonista de adenosina. | |
| ECSP034883A (es) | Amidas de acidos antranilicos con cadena lateral de heteroarilsulfonilo, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como preparados farmaceuticos que las contienen | |
| AR004510A1 (es) | Composiciones que comprenden amoxicilina y clavulanato, procedimientos para su preparacion y el uso de las composiciones para la fabricacion de unmedicamento | |
| ES2148247T3 (es) | Procedimiento de preparacion de liofilizado de cetrorelix. | |
| BR0314195A (pt) | Derivados de piridina substituìda como agentes antitumorais | |
| AR024564A1 (es) | Composicion que comprende esfingomielinasa para el uso como una preparacion dietetica, suplemento dietario o producto farmaceutico | |
| BR0210224A (pt) | Formas de dosagem projetada para ser engolida diretamente e apresentada como uma formulação em comprimido ou cápsula deglutìvel, e, processo para preparação de uma forma de dosagem | |
| ES2191449T3 (es) | Derivados de ciclopentabenzofurano y su uso. | |
| AR021086A1 (es) | Omega-amidas de n-arilsulfonil-aminoacidos, un procedimiento para su preparacion, medicamento, uso de dichos compuestos para la preparacion de un medicamento y procedimiento para la preparacion de un medicamento. | |
| PA8509601A1 (es) | "PIRAZOLO [4,3,e] DIAZEPINAS SUSTITUIDAS NOVEDOSAS, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN, SU USO COMO PRODUCTOS MEDICINALES Y PROCESOS PARA PREPARARLAS | |
| HRP20020238A2 (en) | 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use | |
| AR023709A1 (es) | Semihidrocloruro del acido 8-ciano-1-ciclopropil-7-(1s, 6s-2,8-diazabiciclo[4.3.0]-nonan-8-il)-6-fluor-1,4-dihidro-4-oxo-3-quinolincarboxilico, procedimiento para su obtencion, medicamento, empleo de los mismos para la obtencion de medicamentos antibacterianos | |
| AR026451A1 (es) | Compuestos heterociclicos sililados | |
| AR030945A1 (es) | Amidas de acido fenilciclohexanocarboxilico sustituido y su uso | |
| BR0213122A (pt) | Compostos policìclicos tendo atividade antitumoral | |
| HN2000000072A (es) | Amidas de acidos fenilciclohexanocarboxilicos sustituidos | |
| ES2188232T3 (es) | Uso de cetirizina para impedir la aparicion del asma. | |
| NO20021710L (no) | Anvendelse av 2-amino-3,4-dihydro-kinazoliner for fremstilling av et medikament for behandling eller profylakse avsykdommer bevirket av iskemiske tilstander |