DK1326862T3 - Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel - Google Patents

Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel

Info

Publication number: DK1326862T3
Authority: DK; Denmark
Prior art keywords: drug; manufacture; preparation; tiotropium bromide; crystalline monohydrate
Prior art date: 2000-10-12

Application number

DK01983510T

Other languages

Danish (da)

English (en)

Inventor

Michael Trunk

Rolf Banholzer

Peter Sieger

Peter Specht

Andreas Mathes

Christian Kulinna

Manfred Ludwig August Graulich

Helmut Meissner

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2001-09-28

Publication date

2004-11-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1326862(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-09-28 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2004-11-22 Application granted granted Critical

2004-11-22 Publication of DK1326862T3 publication Critical patent/DK1326862T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK01983510T 2000-10-12 2001-09-28 Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel DK1326862T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10050621		2000-10-12
PCT/EP2001/011225 WO2002030928A1 (de)	2000-10-12	2001-09-28	Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (1)

Publication Number	Publication Date
DK1326862T3 true DK1326862T3 (da)	2004-11-22

Family

ID=7659568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01983510T DK1326862T3 (da)	2000-10-12	2001-09-28	Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel

Country Status (46)

Country	Link
EP (2)	EP1326862B1 (sr)
JP (1)	JP3764422B2 (sr)
KR (1)	KR100823860B1 (sr)
CN (2)	CN100519558C (sr)
AP (1)	AP1572A (sr)
AR (2)	AR034389A1 (sr)
AT (1)	ATE276253T1 (sr)
AU (2)	AU1499602A (sr)
BG (1)	BG66161B1 (sr)
BR (1)	BR0114584A (sr)
CA (1)	CA2425539C (sr)
CR (1)	CR6938A (sr)
CZ (1)	CZ301841B6 (sr)
DE (1)	DE50103666D1 (sr)
DK (1)	DK1326862T3 (sr)
DZ (1)	DZ3478A1 (sr)
EA (1)	EA004381B1 (sr)
EC (1)	ECSP034540A (sr)
EE (1)	EE04567B1 (sr)
EG (1)	EG24142A (sr)
ES (1)	ES2228965T3 (sr)
GE (1)	GEP20063905B (sr)
HR (1)	HRP20030276B1 (sr)
HU (1)	HU226830B1 (sr)
IL (2)	IL155335A0 (sr)
IS (1)	IS2339B (sr)
MA (1)	MA25842A1 (sr)
ME (2)	MEP40008A (sr)
MX (1)	MXPA03003221A (sr)
MY (1)	MY126931A (sr)
NO (1)	NO328465B1 (sr)
NZ (1)	NZ525733A (sr)
OA (1)	OA12403A (sr)
PE (1)	PE20020422A1 (sr)
PL (1)	PL207870B1 (sr)
PT (1)	PT1326862E (sr)
RS (1)	RS50218B (sr)
SA (1)	SA01220412B1 (sr)
SI (1)	SI1326862T1 (sr)
SK (1)	SK287009B6 (sr)
TR (1)	TR200402579T4 (sr)
TW (1)	TW589313B (sr)
UA (1)	UA74215C2 (sr)
UY (2)	UY26962A1 (sr)
WO (1)	WO2002030928A1 (sr)
ZA (1)	ZA200302500B (sr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101011353B1 (ko) *	2001-06-22	2011-01-28	베링거 잉겔하임 파르마 게엠베하 운트 코 카게	결정질 항콜린제, 이의 제조방법 및 이를 포함하는 약제학적 조성물
US6608055B2 (en)	2001-06-22	2003-08-19	Boehringer Ingelheim Pharma Kg	Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (de)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7244415B2 (en)	2002-03-28	2007-07-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations of an anhydrate
US7311894B2 (en)	2002-03-28	2007-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations containing an anticholinergic
DE10214263A1 (de) *	2002-03-28	2003-10-16	Boehringer Ingelheim Pharma	HFA-Suspensionsformulierungen enthaltend ein Anticholinergikum
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (de)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
JP5165244B2 (ja)	2003-11-03	2013-03-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
UA82909C2 (en) *	2003-11-03	2008-05-26	Boehringer Ingelheim Int	Novel crystalline anhydride with anticholinergic effect
US7968717B2 (en)	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
EP1682543B1 (de) *	2003-11-03	2010-08-18	Boehringer Ingelheim International Gmbh	Verfahren zur herstellung neuer tiotropiumsalze
DE102004016179A1 (de) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Verbindungen zur Behandlung von proliferativen Prozessen
CA2559699C (en)	2004-04-22	2012-06-19	Boehringer Ingelheim International Gmbh	Pharmaceutical combinations containing benzoxazine for treating respiratory diseases
DE102004024454A1 (de)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
ES2322148T3 (es)	2004-08-11	2009-06-17	BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG	Medicamentos que contienen anticolinergicos para el tratamiento en las vias urinarias.
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
UA95063C2 (ru) *	2004-10-21	2011-07-11	Бёрингер Ингельхайм Интернациональ Гмбх	Блистерная упаковка для применения в ингаляторах
CA2600636A1 (en) *	2005-03-09	2006-09-14	Boehringer Ingelheim International Gmbh	New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
CN101163706A (zh)	2005-04-21	2008-04-16	贝林格尔·英格海姆国际有限公司	用于治疗炎性疾病的二氢噻吩并嘧啶
NZ563448A (en)	2005-04-28	2011-01-28	Boehringer Ingelheim Int	Benzofuranone derivatives for treating inflammatory diseases
CN101166738B (zh)	2005-05-02	2011-06-01	贝林格尔·英格海姆国际有限公司	噻托溴铵的新晶型
MX2007013691A (es) *	2005-05-02	2008-01-21	Boehringer Ingelheim Int	Nuevas formas cristalinas de bromuro de tiotropio.
NZ583872A (en) *	2005-06-15	2011-10-28	Boehringer Ingelheim Int	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (de)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
AU2006277968A1 (en) *	2005-08-06	2007-02-15	Boehringer Ingelheim International Gmbh	Use of tiotropium salts in the treatment of severe persistant asthma
KR101360803B1 (ko)	2005-08-15	2014-02-11	베링거 인겔하임 인터내셔날 게엠베하	베타모방제의 제조방법
US20070086957A1 (en)	2005-10-10	2007-04-19	Thierry Bouyssou	Combination of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (de) *	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
JP2008530251A (ja) *	2005-12-19	2008-08-07	シコールインコーポレイティド	純粋且つ安定な臭化チオトロピウム
TW200732340A (en) *	2005-12-19	2007-09-01	Sicor Inc	Novel forms of tiotropium bromide and processes for preparation thereof
MY146362A (en) *	2006-01-04	2012-08-15	Boehringer Ingelheim Int	Use of tiotropium salts in the treatment of moderate persistent asthma
EP1847543A1 (de)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
US20080051582A1 (en)	2006-07-10	2008-02-28	Sicor Inc.	Process for the preparation of tiotropium bromide
EP2051714B1 (de)	2006-08-07	2011-04-13	Boehringer Ingelheim International GmbH	Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
PE20080610A1 (es)	2006-08-22	2008-07-15	Boehringer Ingelheim Int	Nuevos beta-agonistas enantiomericamente puros, procedimientos para su preparacion y uso como medicamentos
EP1923393A1 (en) *	2006-11-17	2008-05-21	Boehringer Ingelheim Pharma GmbH & Co. KG	Crystalline form of tiotropium bromide and urea
EP1925295A1 (de) *	2006-11-22	2008-05-28	Boehringer Ingelheim Pharma GmbH & Co. KG	Stabile Pulverformulierung enthaltend ein Anticholinergikum
GB0716026D0 (en) *	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
PT2215092E (pt)	2007-10-19	2012-04-10	Boehringer Ingelheim Int	Piperidino-di-hidrotienopirimidinas substituídas
EP2093219A1 (de)	2008-02-22	2009-08-26	Boehringer Ingelheim International Gmbh	Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
WO2010011813A1 (en) *	2008-07-23	2010-01-28	Alkermes, Inc.	Complex of trospium and pharmaceutical compositions thereof
BRPI0923051B1 (pt)	2008-12-19	2022-07-19	Centrexion Therapeutics Corporation	Pirimidin-4-carboxamidas cíclicas como antagonistas do receptor de ccr2 para o tratamento de inflamação, asma e copd, seu uso, formulação e combinação farmacêutica que os compreende
EP2201934A1 (en)	2008-12-23	2010-06-30	CHIESI FARMACEUTICI S.p.A.	Tiotropium aerosol formulation products with improved chemical stability
EP2403851B1 (en)	2009-03-06	2015-06-17	Mahmut Bilgic	New crystalline forms of tiotropium bromide
NZ597920A (en)	2009-08-07	2014-05-30	Generics Uk Ltd	Anhydrate of tiotropium bromide
WO2011015883A1 (en)	2009-08-07	2011-02-10	Generics [Uk] Limited	Dichloromethane solvate of tiotropium bromide and its use
DK2513093T3 (da)	2009-12-17	2014-09-29	Boehringer Ingelheim Int	Nye CCR2 receptor antagonister og anvendelser deraf
EP2513086B1 (en)	2009-12-17	2015-04-29	Boehringer Ingelheim International GmbH	Novel antagonists for ccr2 and uses thereof
EP2528915B1 (en)	2010-01-29	2015-10-28	Boehringer Ingelheim International GmbH	Substituted naphthyridines and their use as syk kinase inhibitors
US8946218B2 (en)	2010-05-12	2015-02-03	Boehringer Ingelheim International Gmbh	CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP2013526507A (ja)	2010-05-12	2013-06-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用
US8841313B2 (en)	2010-05-17	2014-09-23	Boehringer Ingelheim International Gmbh	CCR2 antagonists and uses thereof
US9018212B2 (en)	2010-05-25	2015-04-28	Boehringer Ingelheim International Gmbh	Pyridazine carboxamides as CCR2 receptor antagonists
WO2011151251A1 (en)	2010-06-01	2011-12-08	Boehringer Ingelheim International Gmbh	New ccr2 antagonists
EP2668177B1 (en)	2011-01-28	2014-10-22	Boehringer Ingelheim International GmbH	Substituted pyridinyl-pyrimidines and their use as medicaments
TR201102068A2 (tr)	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Tiotropyum bromür içeren kristal maddeler
JP5786257B2 (ja)	2011-06-16	2015-09-30	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規の選択的ｃｃｒ２拮抗薬
JP5786258B2 (ja)	2011-07-15	2015-09-30	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規かつ選択的なｃｃｒ２拮抗薬
KR101986484B1 (ko)	2011-07-26	2019-06-10	베링거 인겔하임 인터내셔날 게엠베하	치환된 퀴놀린 및 이의 약제로서의 용도
US20130059866A1 (en)	2011-08-24	2013-03-07	Boehringer Ingelheim International Gmbh	Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
CZ304368B6 (cs) *	2011-11-28	2014-04-02	Zentiva, K.S.	Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en)	2011-12-19	2012-02-29	Teva Branded Pharmaceutical Prod R & D Inc	An inhalable medicament
US9096579B2 (en)	2012-04-20	2015-08-04	Boehringer Ingelheim International Gmbh	Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
HUE032455T2 (en)	2012-11-05	2017-09-28	Zentiva Ks	Stabilization of thiotropium solvates
EP2913332A1 (en) *	2014-02-27	2015-09-02	Euticals S.P.A.	Crystalline form of tiotropium bromide with lactose
EP3119765B1 (en)	2014-03-19	2019-07-17	Boehringer Ingelheim International GmbH	Heteroaryl syk inhibitors
US10034866B2 (en)	2014-06-19	2018-07-31	Teva Branded Pharmaceutical Products R&D, Inc.	Inhalable medicament comprising tiotropium
RU2567539C1 (ru) *	2015-02-04	2015-11-10	Индивидуальный предприниматель Михайлов Олег Ростиславович	КРИСТАЛЛИЧЕСКАЯ γ-МОДИФИКАЦИЯ (1α,2β,4β,5α,7β-7)-[(ГИДРОКСИДИ-2-ТИЕНИЛАЦЕТИЛ)ОКСИ]-9,9-ДИМЕТИЛ-3-ОКСА-9-АЗОНИАТРИЦИКЛО[3.3.1.02,4]НОНАН БРОМИДА МОНОГИДРАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
EP3414243A1 (en)	2016-02-11	2018-12-19	Sima Patent Ve Lisanslama Hizmetleri Ltd. STI	Crystalline form of tiotropium bromide anhydrate
WO2018084817A2 (en) *	2016-11-04	2018-05-11	Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇	A new form of active agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3931041C2 (de) *	1989-09-16	2000-04-06	Boehringer Ingelheim Kg	Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
UA27143C2 (uk) *	1992-12-09	2000-02-28	Берінгер Інгельхейм Фармасьютікалс Інк	Рідка фармацевтичhа композиція в формі аерозолю
DE19834506A1 (de) *	1998-07-31	2000-02-03	Hexal Ag	Transmucosales therapeutisches System zur Anwendung von Sildenafil
AU749697B2 (en) *	1998-08-04	2002-07-04	Jagotec Ag	Medicinal aerosol formulations

2001
- 2001-09-28 PT PT01983510T patent/PT1326862E/pt unknown
- 2001-09-28 ES ES01983510T patent/ES2228965T3/es not_active Expired - Lifetime
- 2001-09-28 DK DK01983510T patent/DK1326862T3/da active
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active Active
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 CZ CZ20031025A patent/CZ301841B6/cs not_active IP Right Cessation
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/es active IP Right Grant
- 2001-09-28 EE EEP200300171A patent/EE04567B1/xx unknown
- 2001-09-28 EA EA200300457A patent/EA004381B1/ru not_active IP Right Cessation
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/fr active
- 2001-09-28 SI SI200130219T patent/SI1326862T1/xx unknown
- 2001-09-28 AU AU1499602A patent/AU1499602A/xx active Pending
- 2001-09-28 PL PL366041A patent/PL207870B1/pl unknown
- 2001-09-28 DE DE50103666T patent/DE50103666D1/de not_active Expired - Lifetime
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/ko not_active Expired - Lifetime
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/pt active Pending
- 2001-09-28 HR HR20030276A patent/HRP20030276B1/xx not_active IP Right Cessation
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/zh not_active Ceased
- 2001-09-28 HU HU0301022A patent/HU226830B1/hu unknown
- 2001-09-28 RS YU27303A patent/RS50218B/sr unknown
- 2001-09-28 UA UA2003054185A patent/UA74215C2/uk unknown
- 2001-09-28 ME MEP-400/08A patent/MEP40008A/xx unknown
- 2001-09-28 EP EP01983510A patent/EP1326862B1/de not_active Expired - Lifetime
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 TR TR2004/02579T patent/TR200402579T4/xx unknown
- 2001-09-28 AT AT01983510T patent/ATE276253T1/de active
- 2001-09-28 SK SK436-2003A patent/SK287009B6/sk not_active IP Right Cessation
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/ja not_active Expired - Lifetime
- 2001-09-28 OA OA1200300107A patent/OA12403A/fr unknown
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/de active IP Right Grant
- 2001-09-28 CN CNB018171435A patent/CN1221549C/zh not_active Ceased
- 2001-09-28 IL IL15533501A patent/IL155335A0/xx active IP Right Grant
- 2001-09-28 EP EP04016877A patent/EP1468998A1/de not_active Withdrawn
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/me unknown
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-10-02 SA SA01220412A patent/SA01220412B1/ar unknown
- 2001-10-09 TW TW090124963A patent/TW589313B/zh active
- 2001-10-09 EG EG20011058A patent/EG24142A/xx active
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/es active IP Right Grant
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-10 UY UY26962A patent/UY26962A1/es not_active Application Discontinuation
- 2001-10-12 AR ARP010104782A patent/AR034389A1/es active Pending
2003
- 2003-03-26 CR CR6938A patent/CR6938A/es unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/bg active Active
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/es unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/fr unknown
- 2003-04-09 IS IS6772A patent/IS2339B/is unknown
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-11 NO NO20031694A patent/NO328465B1/no not_active IP Right Cessation
2008
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2013
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Also Published As

Publication number	Publication date
CZ301841B6 (cs)	2010-07-07
MEP40008A (en)	2011-02-10
TR200402579T4 (tr)	2004-12-21
EP1326862B1 (de)	2004-09-15
AP1572A (en)	2006-02-13
NO20031694D0 (no)	2003-04-11
AP2003002775A0 (en)	2003-03-31
CR6938A (es)	2004-10-28
ZA200302500B (en)	2004-04-22
CN1733761A (zh)	2006-02-15
EA004381B1 (ru)	2004-04-29
DZ3478A1 (fr)	2002-04-18
TW589313B (en)	2004-06-01
ME00243B (me)	2011-05-10
ECSP034540A (es)	2003-07-25
EG24142A (en)	2008-08-06
IS6772A (is)	2003-04-09
MY126931A (en)	2006-10-31
EP1468998A1 (de)	2004-10-20
HUP0301022A3 (en)	2005-12-28
JP2004526668A (ja)	2004-09-02
SK287009B6 (sk)	2009-09-07
CN1221549C (zh)	2005-10-05
EE200300171A (et)	2003-06-16
EE04567B1 (et)	2005-12-15
PL207870B1 (pl)	2011-02-28
NZ525733A (en)	2005-01-28
IS2339B (is)	2008-02-15
ES2228965T3 (es)	2005-04-16
KR100823860B1 (ko)	2008-04-21
YU27303A (sh)	2006-05-25
MXPA03003221A (es)	2004-12-03
AU1499602A (en)	2002-04-22
CN100519558C (zh)	2009-07-29
WO2002030928A1 (de)	2002-04-18
UA74215C2 (uk)	2005-11-15
HK1086557A1 (zh)	2006-09-22
NO20031694L (no)	2003-04-11
BR0114584A (pt)	2003-08-26
IL155335A (en)	2009-02-11
AR034389A1 (es)	2004-02-25
CA2425539C (en)	2007-04-03
CA2425539A1 (en)	2003-04-11
SK4362003A3 (en)	2003-08-05
SI1326862T1 (en)	2005-02-28
HK1060567A1 (en)	2004-08-13
MA25842A1 (fr)	2003-07-01
KR20030042008A (ko)	2003-05-27
HRP20030276B1 (en)	2006-02-28
HU226830B1 (en)	2009-11-30
BG66161B1 (bg)	2011-09-30
AR068527A2 (es)	2009-11-18
JP3764422B2 (ja)	2006-04-05
PE20020422A1 (es)	2002-06-28
EA200300457A1 (ru)	2003-10-30
UY34901A (es)	2015-02-27
NO328465B1 (no)	2010-02-22
IL155335A0 (en)	2003-11-23
ATE276253T1 (de)	2004-10-15
BG107687A (bg)	2003-09-30
EP1326862A1 (de)	2003-07-16
CN1469877A (zh)	2004-01-21
UY26962A1 (es)	2002-06-20
OA12403A (en)	2006-04-18
RS50218B (sr)	2009-07-15
SA01220412B1 (ar)	2006-11-05
PL366041A1 (en)	2005-01-24
HUP0301022A2 (hu)	2003-10-28
PT1326862E (pt)	2004-11-30
DE50103666D1 (de)	2004-10-21
HRP20030276A2 (en)	2005-02-28
AU2002214996B2 (en)	2007-03-15
GEP20063905B (en)	2006-08-25

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