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DK4069691T3 - Substituerede tetrahydrofuraner som modulatorer af natriumkanaler - Google Patents

Substituerede tetrahydrofuraner som modulatorer af natriumkanaler Download PDF

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Publication number
DK4069691T3
DK4069691T3 DK20825397.1T DK20825397T DK4069691T3 DK 4069691 T3 DK4069691 T3 DK 4069691T3 DK 20825397 T DK20825397 T DK 20825397T DK 4069691 T3 DK4069691 T3 DK 4069691T3
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DK
Denmark
Prior art keywords
modulators
sodium channels
substituted tetrahydrofurans
tetrahydrofurans
substituted
Prior art date
Application number
DK20825397.1T
Other languages
English (en)
Inventor
Steven John Durrant
Nadia Ahmad
Elizabeth Mary Beck
Meireles Lidio Carvalho
Ewa Iwona Chudyk
Jardi Gorka Etxebarria
Bhairavi Galan
Ruah Sara S Hadida
Dennis James Hurley
Ronald Marcellus Knegtel
Timothy Donald Neubert
Joanne Louise Pinder
Joseph Pontillo
Robert Pullin
Yvonne Schmidt
David Matthew Shaw
Sarah Skerratt
Dean Stamos
Stephen Andrew Thomson
Anisa Nizarali Virani
Christopher Wray
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of DK4069691T3 publication Critical patent/DK4069691T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Details Of Television Scanning (AREA)
  • Amplitude Modulation (AREA)
  • Amplifiers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Liquid Crystal Substances (AREA)
DK20825397.1T 2019-12-06 2020-12-04 Substituerede tetrahydrofuraner som modulatorer af natriumkanaler DK4069691T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962944869P 2019-12-06 2019-12-06
PCT/US2020/063290 WO2021113627A1 (en) 2019-12-06 2020-12-04 Substituted tetrahydrofurans as modulators of sodium channels

Publications (1)

Publication Number Publication Date
DK4069691T3 true DK4069691T3 (da) 2024-10-28

Family

ID=73854989

Family Applications (1)

Application Number Title Priority Date Filing Date
DK20825397.1T DK4069691T3 (da) 2019-12-06 2020-12-04 Substituerede tetrahydrofuraner som modulatorer af natriumkanaler

Country Status (21)

Country Link
US (2) US11834441B2 (da)
EP (1) EP4069691B1 (da)
JP (1) JP2023504546A (da)
KR (1) KR20220124176A (da)
AR (1) AR120680A1 (da)
AU (1) AU2020397059A1 (da)
BR (1) BR112022010924A2 (da)
CA (1) CA3164134A1 (da)
CL (1) CL2022001489A1 (da)
CO (1) CO2022008969A2 (da)
CR (1) CR20220316A (da)
DK (1) DK4069691T3 (da)
DO (1) DOP2022000115A (da)
EC (1) ECSP22052564A (da)
IL (1) IL293592A (da)
JO (1) JOP20220130A1 (da)
MX (1) MX2022006865A (da)
PE (1) PE20230300A1 (da)
TW (1) TW202128675A (da)
UY (1) UY38979A (da)
WO (1) WO2021113627A1 (da)

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MX2022006865A (es) 2019-12-06 2022-07-11 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio.
CN117794919A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺类似物作为钠通道调节剂
WO2022256622A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
AU2022286511A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
JP2024520648A (ja) 2021-06-04 2024-05-24 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルの調節因子としての置換テトラヒドロフラン－２－カルボキサミド
AU2022285758A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
BR112023025264A2 (pt) 2021-06-04 2024-02-20 Vertex Pharma Formas farmacêuticas sólidas e regimes posológicos compreendendo (2r,3s,4s,5r)-4-[[3- (3,4-difluoro-2-metóxi-fenil)-4,5-dimetil-5-(trifluorometil) tetra-hidrofuran-2-carbonil]amino ]piridina-2-carboxamida
IL308934A (en) * 2021-06-04 2024-01-01 Vertex Pharma Manufacturing process of converted natran tetrahydrofuran channel modulators
TW202317520A (zh) 2021-06-15 2023-05-01 德商歌林達有限公司 經取代之吡唑醯胺
WO2023211990A1 (en) 2022-04-25 2023-11-02 Siteone Therapeutics, Inc. Bicyclic heterocyclic amide inhibitors of na v1.8 for the treatment of pain
TW202409017A (zh) * 2022-08-24 2024-03-01 大陸商江蘇恆瑞醫藥股份有限公司 雜環類化合物、其製備方法及其在醫藥上的應用
WO2024123815A1 (en) * 2022-12-06 2024-06-13 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
US20240252473A1 (en) 2022-12-14 2024-08-01 Gruenenthal Gmbh Sulfoximines as inhibitors of NaV1.8
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