SG11202000230VA - Carboxamides as modulators of sodium channels - Google Patents
Carboxamides as modulators of sodium channelsInfo
- Publication number
- SG11202000230VA SG11202000230VA SG11202000230VA SG11202000230VA SG11202000230VA SG 11202000230V A SG11202000230V A SG 11202000230VA SG 11202000230V A SG11202000230V A SG 11202000230VA SG 11202000230V A SG11202000230V A SG 11202000230VA SG 11202000230V A SG11202000230V A SG 11202000230VA
- Authority
- SG
- Singapore
- Prior art keywords
- carboxamides
- modulators
- sodium channels
- channels
- sodium
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762531313P | 2017-07-11 | 2017-07-11 | |
US201762608283P | 2017-12-20 | 2017-12-20 | |
PCT/US2018/041649 WO2019014352A1 (en) | 2017-07-11 | 2018-07-11 | Carboxamides as modulators of sodium channels |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000230VA true SG11202000230VA (en) | 2020-02-27 |
Family
ID=63036498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000230VA SG11202000230VA (en) | 2017-07-11 | 2018-07-11 | Carboxamides as modulators of sodium channels |
Country Status (23)
Country | Link |
---|---|
US (3) | US10647661B2 (en) |
EP (1) | EP3651752A1 (en) |
JP (1) | JP7277431B2 (en) |
KR (1) | KR20200026987A (en) |
CN (1) | CN111065383A (en) |
AU (1) | AU2018300150A1 (en) |
BR (1) | BR112020000553A2 (en) |
CA (1) | CA3069720A1 (en) |
CL (1) | CL2020000075A1 (en) |
CO (1) | CO2020000145A2 (en) |
CR (1) | CR20200064A (en) |
DO (1) | DOP2020000004A (en) |
EC (1) | ECSP20003147A (en) |
IL (1) | IL271948A (en) |
JO (1) | JOP20200001A1 (en) |
MA (1) | MA49566A (en) |
PE (1) | PE20201164A1 (en) |
PH (1) | PH12020500066A1 (en) |
SG (1) | SG11202000230VA (en) |
TN (1) | TN2020000001A1 (en) |
TW (1) | TW201920081A (en) |
UY (1) | UY37806A (en) |
WO (1) | WO2019014352A1 (en) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE033370T2 (en) | 2013-01-31 | 2017-11-28 | Vertex Pharma | Pyridone amides as modulators of sodium channels |
US11203571B2 (en) | 2013-07-19 | 2021-12-21 | Vertex Pharmaceuticals Incorporated | Sulfonamides as modulators of sodium channels |
AU2014362255B2 (en) | 2013-12-13 | 2019-08-29 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
MA49137A (en) | 2017-05-16 | 2021-04-21 | Vertex Pharma | DEUTERATED PYRIDONE AMIDES AND THEIR PREDICTIONS USED AS SODIUM CHANNEL MODULATORS |
SG11202000230VA (en) | 2017-07-11 | 2020-02-27 | Vertex Pharma | Carboxamides as modulators of sodium channels |
AU2019218387A1 (en) | 2018-02-12 | 2020-08-27 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
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AU2019301628B2 (en) * | 2018-07-09 | 2024-10-31 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
BR112021008524A8 (en) * | 2018-11-02 | 2023-02-07 | Merck Sharp & Dohme | 2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV 1.8 INHIBITORS |
US20220110923A1 (en) * | 2019-01-10 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
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MX2022003032A (en) * | 2019-09-12 | 2022-07-12 | Shanghai Jemincare Pharmaceuticals Co Ltd | Pyridine oxynitride, preparation method therefor and use thereof. |
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CN117794921A (en) * | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | Methods for synthesizing substituted sodium tetrahydrofurane channel modulators |
KR20240031300A (en) | 2021-06-04 | 2024-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | N-(Hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide as a sodium channel modulator |
CA3221960A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
CN117794918A (en) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | Substituted tetrahydrofuran analogues as sodium channel modulators |
AR126670A1 (en) | 2021-08-02 | 2023-11-01 | Eurofarma Laboratorios S A | N-ACYLYDRAZONIC COMPOUNDS INHIBITORS OF Nav 1.7 AND/OR Nav 1.8, THEIR OBTAINING PROCESSES, COMPOSITIONS, USES, TREATMENT METHODS OF THESE AND KITS |
AR126669A1 (en) | 2021-08-02 | 2023-11-01 | Eurofarma Laboratorios S A | N-ACYLYDRAZONIC COMPOUNDS INHIBITORS OF Nav 1.7 AND/OR Nav 1.8, THEIR OBTAINING PROCESSES, COMPOSITIONS, USES, TREATMENT METHODS OF THESE AND KITS |
CN116462662A (en) | 2022-01-18 | 2023-07-21 | 成都康弘药业集团股份有限公司 | Aromatic ring Nav1.8 inhibitor and application thereof |
CN116891432A (en) * | 2022-04-02 | 2023-10-17 | 武汉人福创新药物研发中心有限公司 | Nav1.8 inhibitors and uses thereof |
WO2023205468A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
AU2023255558A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
TW202408501A (en) | 2022-04-22 | 2024-03-01 | 美商維泰克斯製藥公司 | Heteroaryl compounds for the treatment of pain |
US20230373925A1 (en) | 2022-04-22 | 2023-11-23 | Vertex Pharma | Heteroaryl compounds for the treatment of pain |
CN116947713A (en) * | 2022-04-25 | 2023-10-27 | 中国科学院上海药物研究所 | Ring-merging compound and application thereof |
WO2023211990A1 (en) | 2022-04-25 | 2023-11-02 | Siteone Therapeutics, Inc. | Bicyclic heterocyclic amide inhibitors of na v1.8 for the treatment of pain |
WO2023246867A1 (en) * | 2022-06-22 | 2023-12-28 | 武汉人福创新药物研发中心有限公司 | Nav1.8 inhibitor |
WO2024041613A1 (en) * | 2022-08-24 | 2024-02-29 | 江苏恒瑞医药股份有限公司 | Heterocyclic compound, method for preparing same, and pharmaceutical use thereof |
WO2024046253A1 (en) * | 2022-08-28 | 2024-03-07 | 上海汇伦医药股份有限公司 | Sodium channel regulator and use thereof |
WO2024046409A1 (en) * | 2022-08-31 | 2024-03-07 | 江苏恒瑞医药股份有限公司 | Heterocyclic compound, preparation method therefor, and pharmaceutical use thereof |
WO2024054622A2 (en) * | 2022-09-09 | 2024-03-14 | Latigo Biotherapeutics, Inc. | Sodium channel blocking compounds, derivatives thereof, and methods of their use |
WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
WO2024146632A1 (en) * | 2023-01-06 | 2024-07-11 | 西藏海思科制药有限公司 | Tetrahydrothiophene derivative and use thereof in medicine |
WO2024153856A1 (en) * | 2023-01-18 | 2024-07-25 | Orion Corporation | Process for the preparation of 3-(4,5-dichloro-2-(4-(trifluoromethoxy)phenoxy)benzamido)pyridine 1-oxide |
WO2024217344A1 (en) * | 2023-04-19 | 2024-10-24 | 中国科学院上海药物研究所 | Nav1.8 inhibitors, preparation method therefor and use thereof |
Family Cites Families (249)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1025305A (en) | 1910-07-29 | 1912-05-07 | Andrew Rasmussen | Feeding means for power hacksaw-machines. |
US1008714A (en) | 1910-12-27 | 1911-11-14 | Henry M Hammer | Delinting-machine. |
US2511231A (en) | 1949-03-26 | 1950-06-13 | Eastman Kodak Co | 1-cyanophenyl-3-acylamino-5-pyrazolone couplers for color photography |
US2688617A (en) | 1951-07-17 | 1954-09-07 | American Cyanamid Co | Sulfonated dihalogeno diaminostilbenes |
US2657134A (en) | 1951-12-05 | 1953-10-27 | Eastman Kodak Co | Photographic emulsion with colored couplers containing isophthalic ester groups |
BE516025A (en) | 1951-12-05 | |||
US2725292A (en) | 1952-05-15 | 1955-11-29 | Eastman Kodak Co | Colored couplers containing solubilizing groups |
US2710802A (en) | 1953-03-16 | 1955-06-14 | Eastman Kodak Co | Dialkyl-5-(oxanilamido) isophthalate couplers for color photography |
US2710803A (en) | 1953-03-26 | 1955-06-14 | Eastman Kodak Co | Color couplers containing hydroxyalkyl groups |
BE528163A (en) | 1953-04-17 | |||
BE531589A (en) | 1953-09-02 | |||
US4218765A (en) | 1974-10-03 | 1980-08-19 | Standard Oil Company (Indiana) | Two-dimensional frequency domain filtering |
DE2623228C3 (en) | 1976-05-24 | 1981-09-10 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | N-acyl-substituted benzamides, processes for their preparation and pharmaceuticals containing such benzamides |
US4639273A (en) | 1983-05-06 | 1987-01-27 | Morton Thiokol, Inc. | Asphalt-adhesion improving additives prepared by formaldehyde condensation with polyamines |
JPS63182182A (en) | 1987-01-23 | 1988-07-27 | Fuji Photo Film Co Ltd | Thermal recording material |
FR2628864B1 (en) | 1988-03-21 | 1990-06-15 | France Etat | METHOD FOR SEGMENTATION OF A FIELD OF SPEED VECTORS, IN PARTICULAR OF SPEEDS FOR MOVING POINTS OF AN IMAGE IN A SEQUENCE OF IMAGES |
AU6062590A (en) | 1989-07-07 | 1991-02-06 | Schering Corporation | Pharmaceutically active compounds |
JP2766323B2 (en) | 1989-07-19 | 1998-06-18 | 株式会社東芝 | Display adjustment device |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
DE4019307A1 (en) | 1990-06-16 | 1991-12-19 | Bayer Ag | 2-METHOXIMINOCARBONIC ACID ESTER |
US5449691A (en) | 1991-12-31 | 1995-09-12 | Sterling Winthrop Inc. | 3,4-disubstituted anilines-immunomodulating agents |
US5258407A (en) | 1991-12-31 | 1993-11-02 | Sterling Winthrop Inc. | 3,4-disubstituted phenols-immunomodulating agents |
FR2687932A1 (en) | 1992-02-27 | 1993-09-03 | Oreal | OIL-IN-WATER DISPERSION CAPABLE OF FORMING COMPOSITE FILMS. |
JPH05313169A (en) | 1992-05-08 | 1993-11-26 | Fuji Photo Film Co Ltd | Liquid crystal oriented film |
HUT63941A (en) | 1992-05-15 | 1993-11-29 | Hoechst Ag | Process for producing 4-alkyl-substituted pyrimidine-5-carboxanilide derivatives, and fungicidal compositions comprising same |
US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
GB9408185D0 (en) | 1994-04-25 | 1994-06-15 | Fujisawa Pharmaceutical Co | New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
KR100287579B1 (en) | 1994-05-31 | 2001-05-02 | 야스이 쇼사꾸 | Naphthalene derivative |
US5536718A (en) | 1995-01-17 | 1996-07-16 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
AR002459A1 (en) | 1995-01-17 | 1998-03-25 | American Cyanamid Co | TRASCINIC BENZACEPINE VASOPRESIN ANTAGONISTS, A PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM, A METHOD FOR TREATING DISEASES AND A PROCEDURE FOR THEIR PREPARATION. |
US5532235A (en) | 1995-01-17 | 1996-07-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
DE19523640A1 (en) | 1995-06-29 | 1997-01-02 | Bayer Ag | Substituted carbonylaminophenyluracile |
DE19621522A1 (en) | 1996-05-29 | 1997-12-04 | Hoechst Schering Agrevo Gmbh | New N-acylsulfonamides, new mixtures of herbicides and antidots and their use |
JP3731963B2 (en) | 1997-01-14 | 2006-01-05 | 株式会社シマノ | Fishing rod plug |
JPH10213820A (en) | 1997-01-31 | 1998-08-11 | Canon Inc | Liquid crystal element and liquid crystal device |
CA2285424A1 (en) | 1997-04-22 | 1998-10-29 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
WO1999047529A1 (en) | 1998-03-18 | 1999-09-23 | Ariad Pharmaceuticals, Inc. | Heterocyclic signal transduction inhibitors, compositions containing them |
JP2002512997A (en) | 1998-04-29 | 2002-05-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | Inhibitor of IMPDH enzyme |
JP2002179651A (en) | 1998-06-19 | 2002-06-26 | Wakamoto Pharmaceut Co Ltd | Benzanilide derivative and medicine composition |
NZ510098A (en) | 1998-10-22 | 2003-09-26 | Neurosearch As | Substituted phenyl derivatives, pharmaceuticals thereof and their use as blockers of the chloride channel |
CN1183113C (en) | 1999-04-28 | 2005-01-05 | 阿文蒂斯药物德国有限公司 | Tri-aryl acid derivatives as PPAR receptor ligands |
WO2001007028A2 (en) | 1999-07-23 | 2001-02-01 | Allergan Sales, Inc. | The use of retinoid receptor antagonists in the treatment of prostate carcinoma |
BR0014076A (en) | 1999-09-17 | 2002-10-15 | Millennium Pharm Inc | Benzamides and related factor xa inhibitors |
US6531291B1 (en) | 1999-11-10 | 2003-03-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof |
US20030114482A1 (en) | 1999-12-15 | 2003-06-19 | Maurizio Pacifici | Use of retinoid receptor antagonists or agonists in the treatment of cartilage and bone pathologies |
US6313168B1 (en) | 1999-12-15 | 2001-11-06 | Allergan Sales, Inc. | Use of retinoid receptor antagonists in the treatment of cartilage and bone pathologies |
US20020065303A1 (en) | 2000-02-01 | 2002-05-30 | Bing-Yan Zhu | Bivalent phenylene inhibitors of factor Xa |
DK1259485T3 (en) | 2000-02-29 | 2006-04-10 | Millennium Pharm Inc | Benzamides and related inhibitors of factor Xa |
CA2402315A1 (en) | 2000-03-09 | 2001-09-13 | Michael Jaye | Therapeutic uses of ppar mediators |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
DE10033337A1 (en) | 2000-07-08 | 2002-01-17 | Boehringer Ingelheim Pharma | Biphenylcarboxamides, their preparation and their use as medicaments |
US20020032238A1 (en) * | 2000-07-08 | 2002-03-14 | Henning Priepke | Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments |
US20040058903A1 (en) | 2000-10-05 | 2004-03-25 | Hisashi Takasugi | Benzamide compounds as apo b secretion inhibitors |
WO2002034711A1 (en) | 2000-10-20 | 2002-05-02 | Biocryst Pharmaceuticals, Inc. | Biaryl compounds as serine protease inhibitors |
JP2004514669A (en) | 2000-11-07 | 2004-05-20 | ブリストル−マイヤーズ スクイブ カンパニー | Acid derivatives useful as serine protease inhibitors |
CA2425892A1 (en) | 2000-11-28 | 2003-04-11 | Hiroyuki Koshio | 1,4,5,6-tetrahydroimidazo[4,5-d]diazepine derivative or salt thereof |
KR20040015036A (en) | 2000-12-06 | 2004-02-18 | 아벤티스 파마 도이칠란트 게엠베하 | Guanidine and amidine derivatives as factor Xa inhibitors |
CN1289072C (en) | 2000-12-22 | 2006-12-13 | 石原产业株式会社 | Aniline derivatives or salts thereof and cytokine prodn inhibitors contg. same |
EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
WO2002054077A2 (en) | 2000-12-29 | 2002-07-11 | 7Tm Pharma A/S | Validating biological molecules as drug targets by metal-ion chelates in animal test models |
IL156994A0 (en) | 2001-03-05 | 2004-02-08 | Du Pont | Heterocyclic diamide invertebrate pest control agent |
EP1383731B1 (en) | 2001-04-06 | 2009-08-05 | Biocryst Pharmaceuticals, Inc. | Biaryl compounds as serine protease inhibitors |
JP2004532856A (en) | 2001-04-30 | 2004-10-28 | 藤沢薬品工業株式会社 | Biarylcarboxamide compounds as apolipoprotein B inhibitors |
WO2002098839A1 (en) | 2001-06-01 | 2002-12-12 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamides and process for preparation thereof |
US20030236198A1 (en) | 2001-06-13 | 2003-12-25 | Genesoft, Inc. | Antipathogenic benzamide compounds |
WO2003003009A1 (en) | 2001-06-29 | 2003-01-09 | 7Tm Pharma A/S | Use of metal-ion chelates in validating biological molecules as drug targets in test animal models |
WO2003003008A1 (en) | 2001-06-29 | 2003-01-09 | 7Tm Pharma A/S | Chemical libraries useful for drug discovery processes |
DE10132686A1 (en) | 2001-07-05 | 2003-01-16 | Boehringer Ingelheim Pharma | Heteroarylcarboxamides, their preparation and their use as medicines |
AU2002317377A1 (en) | 2001-07-20 | 2003-03-03 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
WO2003013516A1 (en) | 2001-08-10 | 2003-02-20 | Adipogenix, Inc. | Fat accumulation-modulating compounds |
AUPR738301A0 (en) | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
US20050038035A1 (en) | 2001-11-28 | 2005-02-17 | Hisashi Takasugi | Heterocyclic amide compounds as apolipoprotein b inhibitors |
AU2002367087A1 (en) | 2001-12-21 | 2003-07-15 | 7Tm Pharma A/S | Method for the treatment of mc receptor related disorders with a chelate and/or a chelator |
WO2003057205A2 (en) | 2002-01-10 | 2003-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Combination of mtp inhibitors or apob secretion inhibitors with fibrates for use as drugs |
JP2005516037A (en) | 2002-01-22 | 2005-06-02 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Diamide Invertebrate Pest Control Agent |
MXPA04002602A (en) | 2002-02-28 | 2004-08-11 | Japan Tobacco Inc | Ester compound and medicinal use thereof. |
EP1485079B1 (en) | 2002-03-11 | 2014-04-02 | Janssen R&D Ireland | Small molecule entry inhibitors |
US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
JP2003342175A (en) | 2002-05-24 | 2003-12-03 | Yamanouchi Pharmaceut Co Ltd | Therapeutic agent for meniere disease comprising new benzazepine derivative or its salt as active ingredient |
JP2004043456A (en) | 2002-05-24 | 2004-02-12 | Yamanouchi Pharmaceut Co Ltd | Medicine containing benzazepine derivative or its salt as active component |
WO2004000820A2 (en) | 2002-06-21 | 2003-12-31 | Cellular Genomics, Inc. | Certain aromatic monocycles as kinase modulators |
EP1546089A2 (en) | 2002-08-09 | 2005-06-29 | TransTech Pharma Inc. | Aryl and heteroaryl compounds and methods to modulate coagulation |
US20040110802A1 (en) | 2002-08-23 | 2004-06-10 | Atli Thorarensen | Antibacterial benzoic acid derivatives |
JP2004175739A (en) | 2002-11-28 | 2004-06-24 | Tanabe Seiyaku Co Ltd | Medicinal composition |
KR101057747B1 (en) | 2002-12-12 | 2011-08-19 | 시바 홀딩 인코포레이티드 | Amino Substituted Hydroxyphenyl Benzophenone Derivatives |
AU2003286311A1 (en) | 2002-12-20 | 2004-07-14 | Pfizer Products Inc. | Microsomal triglyceride transfer protein inhibitors |
SG2012000667A (en) | 2003-01-08 | 2015-03-30 | Univ Washington | Antibacterial agents |
TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
JP2004315395A (en) | 2003-04-14 | 2004-11-11 | Yamanouchi Pharmaceut Co Ltd | New benzoic acid derivative or its salt |
WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
CA2538820A1 (en) | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
EP1669348A4 (en) | 2003-09-30 | 2009-03-11 | Eisai R&D Man Co Ltd | Novel antifungal agent comprising heterocyclic compound |
WO2005040135A1 (en) | 2003-10-24 | 2005-05-06 | Ono Pharmaceutical Co., Ltd. | Antistress drug and medical use thereof |
NZ548793A (en) | 2004-01-28 | 2009-12-24 | Mitsui Chemicals Inc | Amide derivatives, process for preparation thereof and use thereof as insecticide |
DE102004009238A1 (en) | 2004-02-26 | 2005-09-08 | Merck Patent Gmbh | New aryl amide compounds are kinase inhibitors useful for the treatment and/or prophylaxis of e.g. tumors, psoriasis, rheumatoid arthritis, contact dermatitis, inflammations, endometriosis, scar and benign prostatic hyperplasia |
US7427390B2 (en) | 2004-03-10 | 2008-09-23 | Schering Ag | Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy |
WO2006007864A1 (en) | 2004-07-17 | 2006-01-26 | Max Planck Geselllschaft Zur Förderung Der Wissenschaft | Treating neurodegenerative conditions |
US7649004B2 (en) | 2004-07-23 | 2010-01-19 | Pfizer, Inc. | Pyridine derivatives |
DE102004050196A1 (en) | 2004-10-15 | 2006-04-20 | Sanofi-Aventis Deutschland Gmbh | Substituted 2-pyridone derivatives, process for their preparation and their use as medicaments |
US20080125432A1 (en) | 2004-12-01 | 2008-05-29 | Devgen Nv | 5-Carboxamido Substituted Thiazole Derivatives that Interact With Ion Channels, In Particular With Ion Channels From the Kv Family |
WO2006067445A2 (en) | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Csf-1r kinase inhibitors |
WO2006068199A1 (en) | 2004-12-22 | 2006-06-29 | Mochida Pharmaceutical Co., Ltd. | Metabolically stable 3-oxy-1,2,4-triazole derivatives |
BRPI0611596A2 (en) | 2005-06-21 | 2010-09-21 | Mitsui Chemicals Inc | amine and insecticide derivative containing the same |
US7750004B2 (en) | 2005-07-07 | 2010-07-06 | Abbott Laboratories | Apoptosis promoters |
JP4580836B2 (en) | 2005-07-25 | 2010-11-17 | 三井化学アグロ株式会社 | Insecticidal composition |
US20080249137A1 (en) | 2005-09-07 | 2008-10-09 | Jack Lin | PPAR active compounds |
EP1942732A2 (en) | 2005-11-02 | 2008-07-16 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
WO2007052843A1 (en) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | Heterocyclic amide compound and use thereof |
EP1966184B1 (en) | 2005-12-20 | 2010-08-25 | NeuroSearch A/S | Pyridinyl-quinazoline derivatives and their medical use |
UY30117A1 (en) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | AMIS TRISUSTITUDED COMPOUND |
US7351434B2 (en) | 2006-04-07 | 2008-04-01 | Academia Sinica | Therapeutic Gastrodia extracts |
MX2008013194A (en) | 2006-04-11 | 2008-12-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated sodium channels. |
TW200833695A (en) | 2006-10-12 | 2008-08-16 | Xenon Pharmaceuticals Inc | Use of spiro-oxindole compounds as therapeutic agents |
US20090325956A1 (en) | 2006-10-13 | 2009-12-31 | Takahiko Taniguchi | Aromatic amine derivative and use thereof |
JP2008106017A (en) | 2006-10-27 | 2008-05-08 | Tokyo Univ Of Science | Compound having selective oatp-inhibiting property, and selective oatp-inhibiting agent containing the compound |
EP2101760B1 (en) | 2006-12-08 | 2013-02-27 | Millennium Pharmaceuticals, Inc. | Unit dose formulations and methods of treating thrombosis with an oral factor xa inhibitor |
GB0625659D0 (en) | 2006-12-21 | 2007-01-31 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
JP4325681B2 (en) | 2007-02-13 | 2009-09-02 | ソニー株式会社 | Solid-state imaging device, imaging device |
CN101622231B (en) | 2007-02-28 | 2013-12-04 | 艾德维纳斯医疗私人有限公司 | 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application |
MX2009011816A (en) | 2007-05-03 | 2009-11-19 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators. |
WO2008140810A1 (en) | 2007-05-11 | 2008-11-20 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
WO2008156783A2 (en) | 2007-06-18 | 2008-12-24 | University Of Louisville Research Foundation, Inc. | Family of pfkfb3 inhibitors with anti-neoplastic activities |
EP2173721B1 (en) | 2007-06-26 | 2011-12-28 | Sanofi | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
US20090012091A1 (en) | 2007-07-02 | 2009-01-08 | Kinagen, Inc. | Oximide derivatives and their therapeutical application |
JP5473921B2 (en) | 2007-10-10 | 2014-04-16 | ビーエーエスエフ ソシエタス・ヨーロピア | Sulfonium salt initiator |
KR101571912B1 (en) | 2007-10-10 | 2015-11-25 | 바스프 에스이 | Sulphonium salt initiators |
CA2701946A1 (en) | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Heteroaryl amides useful as inhibitors of voltage-gated sodium channels |
NZ584519A (en) | 2007-10-11 | 2012-07-27 | Vertex Pharma | Aryl amides useful as inhibitors of voltage-gated sodium channels |
US8389734B2 (en) | 2007-10-11 | 2013-03-05 | Vertex Pharmaceuticals Incorporated | Amides useful as inhibitors of voltage-gated sodium channels |
JP2009108152A (en) | 2007-10-29 | 2009-05-21 | Sumitomo Chemical Co Ltd | Polymerizable compound and optical film |
WO2009070533A1 (en) | 2007-11-29 | 2009-06-04 | Complegen, Inc. | Methods of inhibiting steroyl coa desaturase |
JP2009149754A (en) | 2007-12-20 | 2009-07-09 | Sumitomo Chemical Co Ltd | Polymerizable compound and optical film produced by polymerizing the polymerizable compound |
AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
JP2009209090A (en) | 2008-03-04 | 2009-09-17 | Mitsui Chemicals Inc | Insecticide, compound contained in the insecticide, and method of using the compound |
US20100009970A1 (en) | 2008-03-19 | 2010-01-14 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
JP5219583B2 (en) | 2008-03-31 | 2013-06-26 | 住友化学株式会社 | Composition, optical film and method for producing the same, optical member and display device |
JP2010001284A (en) | 2008-05-20 | 2010-01-07 | Sumitomo Chemical Co Ltd | Compound and optical film |
HUE060249T2 (en) | 2008-06-16 | 2023-02-28 | Univ Tennessee Res Found | Compounds for treatment of cancer |
MX2011002060A (en) | 2008-08-25 | 2011-04-05 | Irm Llc | Hedgehog pathway modulators. |
JP5443720B2 (en) | 2008-09-05 | 2014-03-19 | 住友化学株式会社 | Composition, optical film and method for producing the same, optical member, and display device |
JP2010066630A (en) | 2008-09-12 | 2010-03-25 | Sumitomo Chemical Co Ltd | Method for manufacturing optical film, and optical film |
US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
PL2340021T3 (en) | 2008-09-18 | 2013-04-30 | Hoffmann La Roche | Substituted pyrrolidine-2-carboxamides |
WO2010048149A2 (en) | 2008-10-20 | 2010-04-29 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
JP5649779B2 (en) | 2008-11-28 | 2015-01-07 | 住友化学株式会社 | Liquid crystalline composition and optical film |
KR101663336B1 (en) | 2008-12-26 | 2016-10-06 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Novel bicyclic heterocyclic compound |
TWI482769B (en) | 2009-03-16 | 2015-05-01 | Sumitomo Chemical Co | Compound, optical film and method for making an optical film |
JP5899607B2 (en) | 2009-03-16 | 2016-04-06 | 住友化学株式会社 | Compound, optical film and method for producing optical film |
UA105527C2 (en) | 2009-05-18 | 2014-05-26 | Оріон Корпорейшн | Matriptase inhibitor compound for the treatment of cancer |
EP2253617A1 (en) | 2009-05-20 | 2010-11-24 | Bayer CropScience AG | Halogenated compounds as pesticides |
WO2010138901A1 (en) | 2009-05-29 | 2010-12-02 | Biogen Idec Ma Inc | Carboxylic acid-containing compounds, derivatives thereof, and related methods of use |
JP2011006360A (en) | 2009-06-26 | 2011-01-13 | Sumitomo Chemical Co Ltd | Compound, optical film and method for producing optical film |
AR077252A1 (en) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | ESPIROOXINDOL COMPOUND ENANTIOMERS AND THEIR USES AS THERAPEUTIC AGENTS |
KR101256018B1 (en) | 2009-08-20 | 2013-04-18 | 한국과학기술연구원 | 1,3,6-Substituted indole derivatives having inhibitory activity for protein kinase |
US8629149B2 (en) | 2009-09-04 | 2014-01-14 | Zalicus Pharmaceuticals Ltd. | Oxopiperazine derivatives for the treatment of pain and epilepsy |
WO2011032169A2 (en) | 2009-09-14 | 2011-03-17 | Phusis Therapeutics Inc. | Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same |
US8420647B2 (en) | 2010-01-21 | 2013-04-16 | Hoffmann-La Roche Inc. | 4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds |
JP5375644B2 (en) | 2010-02-10 | 2013-12-25 | 住友化学株式会社 | Composition and optical film |
CN102883607B (en) | 2010-03-01 | 2015-07-22 | Gtx公司 | Compounds for treatment of cancer |
WO2011133729A2 (en) | 2010-04-23 | 2011-10-27 | Kineta, Inc. | Anti-viral compounds |
EP2563759B1 (en) | 2010-04-27 | 2022-04-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
CA2812526A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
WO2012016133A2 (en) | 2010-07-29 | 2012-02-02 | President And Fellows Of Harvard College | Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers |
EP2616453A4 (en) | 2010-08-24 | 2014-07-02 | Univ Brigham Young | Antimetastatic compounds |
WO2012026931A1 (en) | 2010-08-25 | 2012-03-01 | Synta Pharmaceuticals Corp. | Method of synthesizing substituted 2-alkyl phenols |
EP2651404B1 (en) | 2010-12-14 | 2015-10-14 | Electrophoretics Limited | Casein kinase 1delta (ck1delta) inhibitors |
TW201604196A (en) | 2011-02-02 | 2016-02-01 | 維泰克斯製藥公司 | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
MX2013009393A (en) | 2011-02-18 | 2013-08-29 | Vertex Pharma | Chroman - spirocyclic piperidine amides as modulators of ion channels. |
EP2681200A4 (en) | 2011-03-03 | 2015-05-27 | Zalicus Pharmaceuticals Ltd | Benzimidazole inhibitors of the sodium channel |
WO2012125613A1 (en) | 2011-03-14 | 2012-09-20 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
DK2713722T3 (en) | 2011-05-31 | 2017-07-03 | Celgene Int Ii Sarl | Newly known GLP-1 receptor stabilizers and modulators |
US20140113934A1 (en) | 2011-06-20 | 2014-04-24 | E I Du Pont De Nemours And Company | Heterocyclic compounds for treating helminth infections |
CA2839451A1 (en) | 2011-06-27 | 2013-01-03 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
DK2573073T3 (en) | 2011-09-26 | 2015-01-19 | Sanofi Sa | Pyrazolquinolinonderivater, their preparation and therapeutic use thereof |
US9169246B2 (en) | 2011-09-26 | 2015-10-27 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
CN103012397B (en) | 2011-09-26 | 2017-03-01 | 赛诺菲 | Pyrazolo (E)-3-(3-Acetyl-4-hydroxy-5-methoxy-phenyl)-N-(4-hydroxy-1-methyl-3-octyloxy-2-oxo-1,2-dihydro-quinolin-7-yl)-acrylamide, its preparation method and its therapeutic use |
US9079878B2 (en) | 2011-10-26 | 2015-07-14 | Pfizer Limited | (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators |
GB201119799D0 (en) | 2011-11-16 | 2011-12-28 | Sentinel Oncology Ltd | Pharmaceutical compounds |
WO2013086229A1 (en) | 2011-12-07 | 2013-06-13 | Amgen Inc. | Bicyclic aryl and heteroaryl sodium channel inhibitors |
EP2606726A1 (en) | 2011-12-21 | 2013-06-26 | Bayer CropScience AG | N-Arylamidine-substituted trifluoroethylsulfide derivatives as acaricides and insecticides |
JP2015503519A (en) | 2011-12-23 | 2015-02-02 | ノバルティス アーゲー | Compound for inhibiting interaction between BCL2 and binding partner |
AU2013209958B2 (en) | 2012-01-16 | 2017-09-07 | Vertex Pharmaceuticals Incorporated | Pyran-spirocyclic piperidine amides as modulators of ion channels |
ES2548228T3 (en) | 2012-02-03 | 2015-10-15 | Pfizer Inc | Benzimidazole and imidazopyridine derivatives as sodium channel modulators |
WO2013131018A1 (en) | 2012-03-02 | 2013-09-06 | Zalicus Pharmaceuticals Ltd. | Biaryl inhibitors of the sodium channel |
US8481479B1 (en) | 2012-03-07 | 2013-07-09 | Shaker A. Mousa | Formulations of factor VIIa inhibitors and utility |
US8980823B2 (en) | 2012-03-07 | 2015-03-17 | Shaker A. Mousa | Formulations of Factor VIIa inhibitors and utility |
WO2014041125A1 (en) | 2012-09-13 | 2014-03-20 | Baden-Württemberg Stiftung Gmbh | Specific inhibitors of protein p21 as therapeutic agents |
US20150272939A1 (en) | 2012-10-02 | 2015-10-01 | Yale University | Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase |
WO2014055644A2 (en) | 2012-10-02 | 2014-04-10 | New York University | Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated rna decay |
US20140200215A1 (en) | 2013-01-15 | 2014-07-17 | Intermune, Inc. | Lysophosphatidic acid receptor antagonists |
SG11201505952WA (en) | 2013-01-31 | 2015-08-28 | Vertex Pharma | Quinoline and quinazoline amides as modulators of sodium channels |
CN104968647B (en) | 2013-01-31 | 2018-01-26 | 沃泰克斯药物股份有限公司 | Acid amides as sodium channel modulators |
HUE033370T2 (en) | 2013-01-31 | 2017-11-28 | Vertex Pharma | Pyridone amides as modulators of sodium channels |
CN103961348B (en) | 2013-02-05 | 2016-08-17 | 上海交通大学医学院 | SENP1 micromolecular inhibitor and application thereof |
WO2014134127A1 (en) | 2013-02-26 | 2014-09-04 | Northeastern University | Cannabinergic nitrate esters and related analogs |
WO2014149207A2 (en) | 2013-03-15 | 2014-09-25 | Dow Agrosciences Llc | Benzimidazole-based insecticidal compositions and related methods |
JP5902641B2 (en) | 2013-03-27 | 2016-04-13 | 富士フイルム株式会社 | Optical interference pigment and method for producing the same |
JP2014232188A (en) | 2013-05-29 | 2014-12-11 | コニカミノルタ株式会社 | Cellulose acylate film, circularly polarizing plate and image display device |
JP6387960B2 (en) | 2013-05-31 | 2018-09-12 | コニカミノルタ株式会社 | Resin composition, optical member, optical film, polarizing plate, circularly polarizing plate, and image display device |
WO2015030898A2 (en) | 2013-06-07 | 2015-03-05 | The Regents Of The University Of California | Micromechanical resonant switches and charge pumps |
EP3010512B1 (en) | 2013-06-18 | 2017-12-27 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
US20160145304A1 (en) | 2013-07-12 | 2016-05-26 | Helmholtz-Zentrum für Infektionsforschung GmbH | Cystobactamides |
US11203571B2 (en) | 2013-07-19 | 2021-12-21 | Vertex Pharmaceuticals Incorporated | Sulfonamides as modulators of sodium channels |
CN105611924A (en) | 2013-07-25 | 2016-05-25 | 泰莱托恩基金会 | Inhibitors of FAPP2 and uses thereof |
WO2015014900A1 (en) | 2013-07-31 | 2015-02-05 | Minoryx Therapeutics S.L. | Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof |
KR101628288B1 (en) | 2013-09-30 | 2016-06-08 | 주식회사 엘지화학 | Composition for manufacturing optical elements with negative optical dispersion and optically anisotropic body manufactured therefrom |
WO2015085238A1 (en) | 2013-12-05 | 2015-06-11 | The Regents Of The University Of California, A California Corporation | Inhibitors of lpxc |
AU2014362255B2 (en) | 2013-12-13 | 2019-08-29 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
US9204150B2 (en) | 2014-02-26 | 2015-12-01 | Intel Corporation | Techniques for evaluating compressed motion video quality |
WO2015196072A2 (en) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
WO2016022626A1 (en) | 2014-08-06 | 2016-02-11 | Merck Sharp & Dohme Corp. | Heterocyclic cgrp receptor antagonists |
WO2016040449A1 (en) | 2014-09-10 | 2016-03-17 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
EP2997966A1 (en) | 2014-09-16 | 2016-03-23 | Sanofi | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders |
CN106317027A (en) | 2015-06-15 | 2017-01-11 | 山东轩竹医药科技有限公司 | Heteroaryl amide derivative and use thereof as TGR5 agonist |
EP3350181B1 (en) | 2015-09-02 | 2023-11-01 | The Regents of The University of California | Her3 ligands and uses thereof |
US11413278B2 (en) | 2015-10-08 | 2022-08-16 | The Regents Of The University Of California | Compounds and methods for promoting stress resistance |
US20180305334A1 (en) | 2015-10-14 | 2018-10-25 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use against stress granules |
US10781218B2 (en) | 2016-03-16 | 2020-09-22 | Kura Oncology, Inc. | Substituted inhibitors of menin-MLL and methods of use |
AU2017336523B2 (en) | 2016-09-28 | 2022-07-21 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
KR102458810B1 (en) | 2016-09-28 | 2022-10-26 | 메르크 파텐트 게엠베하 | Polymerizable liquid crystal material and polymerized liquid crystal film |
WO2018161033A1 (en) | 2017-03-02 | 2018-09-07 | Wright, Adrian | Small molecule ire1-alpha inhibitors |
BR112019021899A2 (en) | 2017-04-20 | 2020-08-18 | The Regents Of The University Of California | k-ras modulators |
WO2018202681A1 (en) | 2017-05-04 | 2018-11-08 | Bayer Cropscience Aktiengesellschaft | Use of disubstituted benzenes to control insecticide-resistant pests |
JP2019015998A (en) | 2017-07-03 | 2019-01-31 | 東芝テック株式会社 | Information processing system and program |
SG11202000230VA (en) | 2017-07-11 | 2020-02-27 | Vertex Pharma | Carboxamides as modulators of sodium channels |
WO2019018119A1 (en) | 2017-07-18 | 2019-01-24 | Pairnomix, Llc | Methods of treating epilepsy and kcnti related conditions |
CN111163766A (en) | 2017-08-17 | 2020-05-15 | 医肯纳肿瘤学公司 | AHR inhibitors and uses thereof |
AU2019213694B2 (en) | 2018-01-30 | 2023-04-06 | Pi Industries Ltd. | Novel anthranilamides, their use as insecticide and processes for preparing the same. |
AU2019218387A1 (en) | 2018-02-12 | 2020-08-27 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
CN112041413A (en) | 2018-04-27 | 2020-12-04 | 默克专利股份有限公司 | Polymerizable liquid crystal material and polymerized liquid crystal film |
CN112041414B (en) | 2018-04-27 | 2024-07-19 | 默克专利股份有限公司 | Polymerizable liquid crystal material and polymerized liquid crystal film |
WO2019241787A1 (en) | 2018-06-15 | 2019-12-19 | The Regents Of The University Of Colorado A Body Corporate | Novel cyclic gmp-amp synthase (cgas) inhibitors and their method of use |
EP3847159A2 (en) | 2018-09-04 | 2021-07-14 | Magenta Therapeutics, Inc. | Aryl hydrocarbon receptor antagonists and methods of use |
WO2020081572A1 (en) | 2018-10-15 | 2020-04-23 | Dana-Farber Cancer Institute, Inc. | Transcriptional enhanced associate domain (tead) transcription factor inhibitors and uses thereof |
WO2020123675A1 (en) | 2018-12-11 | 2020-06-18 | Duke University | Compositions and methods for the treatment of cancer |
CA3124970A1 (en) | 2018-12-28 | 2020-07-02 | Cedars-Sinai Medical Center | Methods of treating inflammatory bowel diseases that target ripk2 |
US20230062053A1 (en) | 2019-01-10 | 2023-03-02 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
US20220110923A1 (en) | 2019-01-10 | 2022-04-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
CN113302262A (en) | 2019-01-22 | 2021-08-24 | 默克专利股份有限公司 | Method for preparing liquid crystal polymer film |
AU2019427489A1 (en) | 2019-01-28 | 2021-07-22 | Mitochondria Emotion, Inc. | Mitofusin activators and methods of use thereof |
WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
MX2021011209A (en) | 2019-03-15 | 2022-01-19 | Massachusetts Gen Hospital | Novel small molecule inhibitors of tead transcription factors. |
US12109179B2 (en) | 2019-03-28 | 2024-10-08 | Essa Pharma Inc. | Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof |
WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
KR20220019234A (en) | 2019-04-30 | 2022-02-16 | 메르크 파텐트 게엠베하 | reactive mesogen |
WO2020251974A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca inhibitors and uses thereof |
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TW201920081A (en) | 2019-06-01 |
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JP7277431B2 (en) | 2023-05-19 |
AU2018300150A1 (en) | 2020-01-30 |
EP3651752A1 (en) | 2020-05-20 |
WO2019014352A1 (en) | 2019-01-17 |
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