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MX2020004994A - Inhibidores de acss2 y metodos de uso de los mismos. - Google Patents

Inhibidores de acss2 y metodos de uso de los mismos.

Info

Publication number
MX2020004994A
MX2020004994A MX2020004994A MX2020004994A MX2020004994A MX 2020004994 A MX2020004994 A MX 2020004994A MX 2020004994 A MX2020004994 A MX 2020004994A MX 2020004994 A MX2020004994 A MX 2020004994A MX 2020004994 A MX2020004994 A MX 2020004994A
Authority
MX
Mexico
Prior art keywords
cancer
methods
alcoholism
viral infection
alcoholic steatohepatitis
Prior art date
Application number
MX2020004994A
Other languages
English (en)
Inventor
Marc Labelle
Philippe Nakache
Omri Erez
Simone Botti
Andreas Goutopoulos
Original Assignee
Metabomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabomed Ltd filed Critical Metabomed Ltd
Publication of MX2020004994A publication Critical patent/MX2020004994A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a nuevos inhibidores de ACSS2 que tienen actividad como terapia anticancerígena, tratamiento del alcoholismo e infección viral (por ejemplo, CMV), composición y métodos de preparación de los mismos, y usos de los mismos para el tratamiento de infecciones virales, alcoholismo, esteatohepatitis alcohólica (ASH), esteatohepatitis no alcohólica (NASH), obesidad/aumento de peso, ansiedad, depresión, trastorno de estrés postraumático, afecciones inflamatorias/autoinmunes y cáncer, incluido cáncer metastásico, cáncer avanzado, y cáncer resistente a los medicamentos de varios tipos.
MX2020004994A 2017-11-15 2018-11-15 Inhibidores de acss2 y metodos de uso de los mismos. MX2020004994A (es)

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US201762586195P 2017-11-15 2017-11-15
PCT/IL2018/051232 WO2019097515A1 (en) 2017-11-15 2018-11-15 Acss2 inhibitors and methods of use thereof

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US12133852B2 (en) 2017-11-15 2024-11-05 Epivario, Inc. ACSS2 inhibitors and methods of use thereof
WO2020069093A1 (en) * 2018-09-26 2020-04-02 The Trustees Of The University Of Pennsylvania Compositions and methods for inhibiting acss2
US11795160B2 (en) 2019-02-22 2023-10-24 Insilico Medicine Ip Limited Kinase inhibitors
BR112021023030A2 (pt) * 2019-05-14 2022-01-04 Metabomed Ltd Compostos inibidores de acss2 e métodos de uso dos mesmos
CA3143196A1 (en) * 2019-06-12 2020-12-17 The Wistar Institute Acetyl-coa synthetase 2 (acss2) inhibitors and methods using same
US20220257750A1 (en) * 2019-07-05 2022-08-18 Longlong Si Proteolysis-targeting virus, live vaccine thereof, preparation method and use thereof
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
CA3221259A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
CN113912596B (zh) * 2021-11-25 2022-12-02 江苏科技大学 一种基于苯并噻唑母体的钯离子检测荧光探针及其制备方法与应用

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AR034897A1 (es) 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
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WO2011143425A2 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
WO2013159224A1 (en) * 2012-04-25 2013-10-31 University Of Manitoba 2-carbamo(thio)yl-1,3- dioxopropyl derivatives in cancer therapy
US10040767B2 (en) 2014-05-15 2018-08-07 Peloton Therapeutics, Inc. Benzimidazole derivatives and uses thereof

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SG11202004318PA (en) 2020-06-29
JP7217752B2 (ja) 2023-02-03
EP3710430A1 (en) 2020-09-23
MA50912A (fr) 2020-09-23
EP3710430B9 (en) 2024-10-30
IL274504B1 (en) 2024-08-01
CN111566092A (zh) 2020-08-21
US10851064B2 (en) 2020-12-01
IL274504A (en) 2020-06-30
DK3710430T3 (da) 2024-09-09
CA3080675A1 (en) 2019-05-23
KR20200089291A (ko) 2020-07-24
AU2018370096A1 (en) 2020-06-11
EP3710430B1 (en) 2024-07-03
EP3710430A4 (en) 2021-06-23
WO2019097515A1 (en) 2019-05-23
US20190263758A1 (en) 2019-08-29
JP2021503013A (ja) 2021-02-04
BR112020009729A2 (pt) 2020-11-03
AU2018370096B2 (en) 2023-08-31

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