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CN101675051A - 吡唑并嘧啶类似物及其作为mTOR激酶和PI3激酶抑制剂的用途 - Google Patents

吡唑并嘧啶类似物及其作为mTOR激酶和PI3激酶抑制剂的用途 Download PDF

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Publication number
CN101675051A
CN101675051A CN200880014750A CN200880014750A CN101675051A CN 101675051 A CN101675051 A CN 101675051A CN 200880014750 A CN200880014750 A CN 200880014750A CN 200880014750 A CN200880014750 A CN 200880014750A CN 101675051 A CN101675051 A CN 101675051A
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CN
China
Prior art keywords
pyrimidine
pyrazolo
base
phenyl
morpholine
Prior art date
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Pending
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CN200880014750A
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Chinese (zh)
Inventor
阿里·扎什克
帕维尔·沃伊切赫·诺瓦克
叶罗恩·费尔海耶恩
凯文·J·柯伦
约书亚·卡普兰
戴维·马尔维茨
马修·格雷戈里·比尔萨维奇
德雷克·塞西尔·科尔
塞米拉米斯·艾拉尔-卡劳斯蒂安
柯尔·于
戴维·詹姆斯·理查德
马克·勒菲弗
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Wyeth LLC
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Wyeth LLC
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Publication of CN101675051A publication Critical patent/CN101675051A/zh
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880014750A 2007-03-21 2008-03-19 吡唑并嘧啶类似物及其作为mTOR激酶和PI3激酶抑制剂的用途 Pending CN101675051A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91930107P 2007-03-21 2007-03-21
US60/919,301 2007-03-21
PCT/US2008/057467 WO2008115974A2 (en) 2007-03-21 2008-03-19 Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors

Publications (1)

Publication Number Publication Date
CN101675051A true CN101675051A (zh) 2010-03-17

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CN200880014750A Pending CN101675051A (zh) 2007-03-21 2008-03-19 吡唑并嘧啶类似物及其作为mTOR激酶和PI3激酶抑制剂的用途

Country Status (13)

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US (1) US20080234262A1 (es)
EP (1) EP2078021A2 (es)
JP (1) JP2010522195A (es)
CN (1) CN101675051A (es)
AR (1) AR065812A1 (es)
AU (1) AU2008228964A1 (es)
BR (1) BRPI0809239A2 (es)
CA (1) CA2681501A1 (es)
CL (1) CL2008000815A1 (es)
MX (1) MX2009010132A (es)
PE (1) PE20081888A1 (es)
TW (1) TW200900404A (es)
WO (1) WO2008115974A2 (es)

Cited By (10)

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CN102971324A (zh) * 2010-05-19 2013-03-13 艾科睿控股公司 mTOR选择性激酶抑制剂
CN103130793A (zh) * 2011-11-30 2013-06-05 中国人民解放军军事医学科学院毒物药物研究所 3-(1-芳基哌啶-4-基)-2-芳基噻唑啉-4-酮类化合物、其制备方法及用途
CN104540830A (zh) * 2012-06-07 2015-04-22 霍夫曼-拉罗奇有限公司 端锚聚合酶的吡唑并嘧啶酮和吡唑并吡啶酮抑制剂
CN106414446A (zh) * 2014-03-13 2017-02-15 新加坡科技研究局 基于稠合嘧啶的异羟肟酸盐衍生物
CN107205923A (zh) * 2014-12-17 2017-09-26 辉瑞大药厂 用于静脉内给药的pi3k/mtor‑抑制剂的制剂
CN110833551A (zh) * 2018-08-15 2020-02-25 广西梧州制药（集团）股份有限公司 吡唑并嘧啶衍生物在治疗急性胰腺炎的用途
CN111646995A (zh) * 2019-03-04 2020-09-11 四川大学 4-氨基-嘧啶并氮杂环-苯基脲类衍生物及其制备方法和用途
CN112552312A (zh) * 2020-12-07 2021-03-26 杭州科巢生物科技有限公司 一种瑞卢戈利或其盐的合成方法
CN115304600A (zh) * 2022-09-29 2022-11-08 北京鑫开元医药科技有限公司 mTOR抑制剂、制备方法及用途
WO2022268025A1 (zh) * 2021-06-22 2022-12-29 成都苑东生物制药股份有限公司 Atr抑制剂及其用途

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