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MX2020011639A - Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr). - Google Patents

Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).

Info

Publication number
MX2020011639A
MX2020011639A MX2020011639A MX2020011639A MX2020011639A MX 2020011639 A MX2020011639 A MX 2020011639A MX 2020011639 A MX2020011639 A MX 2020011639A MX 2020011639 A MX2020011639 A MX 2020011639A MX 2020011639 A MX2020011639 A MX 2020011639A
Authority
MX
Mexico
Prior art keywords
salts
fgfr
fgfr inhibitor
inhibitor
pyrido
Prior art date
Application number
MX2020011639A
Other languages
English (en)
Inventor
Qun Li
Zhongjiang Jia
Jiacheng Zhou
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2020011639A publication Critical patent/MX2020011639A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención hace referencia a formas de sal del inhibidor de receptores del factor de crecimiento de fibroblastos (FGFR) 3-(2,6-difluoro-3,5-dimetoxifenil)-1-etil-8-(morfolin-4-ilm etil)-1,3,4,7-tetrahidro-2H-pirrolo[3',2':5,6]pirido[4,3-d]pirimi din-2-ona, lo que incluye métodos para su preparación donde el compuesto es útil en el tratamiento de enfermedades mediadas por FGFR, tales como el cáncer.
MX2020011639A 2018-05-04 2019-05-03 Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr). MX2020011639A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862667040P 2018-05-04 2018-05-04
PCT/US2019/030578 WO2019213506A1 (en) 2018-05-04 2019-05-03 Salts of an fgfr inhibitor

Publications (1)

Publication Number Publication Date
MX2020011639A true MX2020011639A (es) 2021-02-15

Family

ID=66554496

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020011639A MX2020011639A (es) 2018-05-04 2019-05-03 Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).
MX2024000012A MX2024000012A (es) 2018-05-04 2020-11-03 Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2024000012A MX2024000012A (es) 2018-05-04 2020-11-03 Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).

Country Status (20)

Country Link
US (3) US11174257B2 (es)
EP (1) EP3788046A1 (es)
JP (1) JP7568512B2 (es)
KR (1) KR20210018264A (es)
CN (1) CN112566912A (es)
AU (1) AU2019262579B2 (es)
BR (1) BR112020022373A2 (es)
CA (1) CA3099116A1 (es)
CL (1) CL2020002848A1 (es)
CO (1) CO2020015228A2 (es)
CR (1) CR20200591A (es)
EA (1) EA202092649A1 (es)
EC (1) ECSP20078230A (es)
MA (1) MA52493A (es)
MX (2) MX2020011639A (es)
PE (1) PE20210919A1 (es)
PH (1) PH12020551843A1 (es)
SG (1) SG11202010882XA (es)
TW (1) TW201946630A (es)
WO (1) WO2019213506A1 (es)

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US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
AU2016219822B2 (en) 2015-02-20 2020-07-09 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
PT3788047T (pt) 2018-05-04 2024-10-22 Incyte Corp Formas sólidas de um inibidor de fgfr e processos para a sua preparação
SG11202010882XA (en) 2018-05-04 2020-11-27 Incyte Corp Salts of an fgfr inhibitor
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2022193227A1 (en) * 2021-03-18 2022-09-22 Nutshell Biotech (Shanghai) Co., Ltd. Fused ring compounds as inhibitors of fgfr tyrosine kinases
CA3215903A1 (en) 2021-04-12 2022-10-20 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
JP2024522189A (ja) 2021-06-09 2024-06-11 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式ヘテロ環
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