NS-11394

NS-11394
NS-11394
NS-11394 structure.png
식별자
  • 2-(3-[5-[2-섹시프로판-2-yl)벤치미다졸-1-yl]벤조니트릴
CAS 번호
펍켐 CID
켐스파이더
유니
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C23H19N3O
어금질량353.425 g·190−1
3D 모델(JSmol)
  • N#Cc2ccc2-c(ccc3)cc3-n1cnc(c4)c1ccc4C(C)o
  • InChI=1S/C23H19N3O/c1-23(2,27)18-10-11-22-21(13-18)25-15-26(22)19-8-5-7-16(12-19)20-9-4-3-6-17(20)14-24/h3-13,15,27H,1-2H3 ☒N
  • 키:HLKYSQGBIIQJN-UHFFFAOYSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

NS-11394는 GABAA 수용체에서 아형 선택적 양의 알로스테리학적 변조기 역할을 하는 약물로, α와3 α5 하위 유형의 선택성이 있다.[1][2] 만성통증이나 신경통증에 사용하는 진통제로 연구되어 왔다.[3]

참조

  1. ^ Munro G, Lopez-Garcia JA, Rivera-Arconada I, Erichsen HK, Nielsen EØ, Larsen JS, Ahring PK, Mirza NR (December 2008). "Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain". The Journal of Pharmacology and Experimental Therapeutics. 327 (3): 969–81. doi:10.1124/jpet.108.144568. PMID 18791060. S2CID 36490884.
  2. ^ Mirza NR, Larsen JS, Mathiasen C, Jacobsen TA, Munro G, Erichsen HK, Nielsen AN, Troelsen KB, Nielsen EØ, Ahring PK (December 2008). "NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy". The Journal of Pharmacology and Experimental Therapeutics. 327 (3): 954–68. doi:10.1124/jpet.108.138859. PMID 18791063. S2CID 206499795.
  3. ^ Munro G, Ahring PK, Mirza NR (September 2009). "Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets". Trends in Pharmacological Sciences. 30 (9): 453–9. doi:10.1016/j.tips.2009.06.004. PMID 19729210.