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SI9110500B - Naprave za razprševanje in postopki - Google Patents

Naprave za razprševanje in postopki Download PDF

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Publication number
SI9110500B
SI9110500B SI9110500A SI9110500A SI9110500B SI 9110500 B SI9110500 B SI 9110500B SI 9110500 A SI9110500 A SI 9110500A SI 9110500 A SI9110500 A SI 9110500A SI 9110500 B SI9110500 B SI 9110500B
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SI
Slovenia
Prior art keywords
fluid
chamber
energy
odi
spray
Prior art date
Application number
SI9110500A
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English (en)
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SI9110500A (en
Inventor
Stephen Terence Dunne
Terence Edward Weston
Original Assignee
Dmw (Technology) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909006340A external-priority patent/GB9006340D0/en
Priority claimed from GB909023767A external-priority patent/GB9023767D0/en
Application filed by Dmw (Technology) Limited filed Critical Dmw (Technology) Limited
Publication of SI9110500A publication Critical patent/SI9110500A/sl
Publication of SI9110500B publication Critical patent/SI9110500B/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/26—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets
    • B05B1/262—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets with fixed deflectors
    • B05B1/265—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with means for mechanically breaking-up or deflecting the jet after discharge, e.g. with fixed deflectors; Breaking-up the discharged liquid or other fluent material by impinging jets with fixed deflectors the liquid or other fluent material being symmetrically deflected about the axis of the nozzle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0041—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure without contact of the fluid remaining in the container with the atmospheric air
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
    • B05B11/026—Membranes separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1042—Components or details
    • B05B11/1073—Springs
    • B05B11/1074—Springs located outside pump chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/109—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring
    • B05B11/1091—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle the dispensing stroke being affected by the stored energy of a spring being first hold in a loaded state by locking means or the like, then released
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/40—Filters located upstream of the spraying outlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B9/00—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour
    • B05B9/03—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material
    • B05B9/04—Spraying apparatus for discharge of liquids or other fluent material, without essentially mixing with gas or vapour characterised by means for supplying liquid or other fluent material with pressurised or compressible container; with pump
    • B05B9/08—Apparatus to be carried on or by a person, e.g. of knapsack type
    • B05B9/085—Apparatus to be carried on or by a person, e.g. of knapsack type with a liquid pump
    • B05B9/0877—Apparatus to be carried on or by a person, e.g. of knapsack type with a liquid pump the pump being of pressure-accumulation type or being connected to a pressure accumulation chamber
    • B05B9/0883—Apparatus to be carried on or by a person, e.g. of knapsack type with a liquid pump the pump being of pressure-accumulation type or being connected to a pressure accumulation chamber having a discharge device fixed to the container
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
    • B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
    • B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
    • B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
    • B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
    • B05B1/3436—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a plane perpendicular to the outlet axis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nozzles (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Saccharide Compounds (AREA)
  • Lift-Guide Devices, And Elevator Ropes And Cables (AREA)
  • Massaging Devices (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
  • Pinball Game Machines (AREA)
  • External Artificial Organs (AREA)
  • Special Spraying Apparatus (AREA)
  • Crushing And Grinding (AREA)
  • Disintegrating Or Milling (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Manufacture, Treatment Of Glass Fibers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detail Structures Of Washing Machines And Dryers (AREA)
  • Steroid Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Colloid Chemistry (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Valve Device For Special Equipments (AREA)

Claims (22)

1 Boehringer Ingelheim International GmbH Ingelheim na Renu, Nemčija EP 0 521 061 BI Pršilne naprave in postopki razprševanja Patentni zahtevki 1. Inhalator na odmerjeno dozo (v nadaljnjem: ODI) za izdajanje odmerjene količine fluida kot spreja, ki ima kapljice tolikšne velikosti, kot je primerna za vdihavanje v pljuča, s pošiljanjem odmerjene količine fluida pod pritiskom skozi razprševalno sredstvo (22; 57; 80), pri čemer ODI vsebuje: komoro (4; 55; 75) za držanje odmerjene količine tekočine; sredstvo (6) za hranjenje energije; sredstvo (3, 31, 32, 34) za vnos vnaprej določene količine energije v omenjeno sredstvo (6) za hranjenje energije; sredstvo (33, 35) za sprostitev omenjene vnaprej določene količine energije iz omenjenega sredstva (6) za hranjenje energije v omenjeno komoro (4; 55; 75), rezultat česar je vnaprej določeno povečanje tlaka fluida na višji tlak in začetek izdajanja fluida iz omenjene komore (4; 55; 75); in razprševalno sredstvo (22; 57; 80) za sprejem odmerjene količine stisnjenega fluida iz omenjene komore (4; 55; 75) kot enega samega praznjenja iz omenjene komore (4; 55; 75) in za razpršitev odmerjene količine fluida.
2. ODI po zahtevku 1, pri katerem zadevni višji tlak znaša 50 bar ali več.
3. ODI po zahtevku 2, pri katerem je zadevni višji tlak v razponu 100 do 400 bar.
4. ODI po zahtevku 1, 2 ali 3, pri katerem razprševalno sredstvo (22; 57; 80) ob- 2 sega izpustno odprtino (90; 104), ki ima hidravlični premer velikosti 100 /xm ali manj.
5. ODI po zahtevku 4, pri katerem ima izpustna odprtina (90; 104) hidravlični premer v razponu 1 do 20 μτη.
6. ODI po zahtevku 5, pri katerem ima izpustna odprtina (90; 104) hidravlični premer v razponu 1 do 12 /um.
7. ODI po katerem koli predhodnem zahtevku, vsebujoč cevovod (21), ki veže omenjeno komoro (4; 55; 75) in omenjeno razprševalno sredstvo (22; 57; 80), pri čemer ta cevovod (21) ne vsebuje ventila (25) za sprostitev tlaka za uravnavanje toka fluida med komoro (4; 55; 75) in razprševalnim sredstvom (22; 57; 80).
8. ODI po katerem koli predhodnem zahtevku, vsebujoč sredstvo (33) za pridržanje omenjenega sredstva (6) za hranjenje energije v stanju, ko je zadržana vnaprej določena količina energije, in sprožilno sredstvo (35) za sprostitev omenjene vnaprej določene količine enrgije iz omenjenega sredstva (6) za hranjenje energije.
9. ODI po katerem koli predhodnem zahtevku, pri katerem omenjeno sredstvo (6) za hranjenje energije deluje na bat (3; 52), ki je razporejen za vplivanje na komoro (4) z namenom stiskanja odmerjene količine fluida.
10. ODI po zahtevku 9, pri katerem omenjeno sredstvo (6) za hranjenje energije tvori z vzmetjo obremenjen črpalni mehanizem (3, 4, 13, 23; 52, 55, 54, 56) in je omenjena komora (4; 55) zasnovana kot valjast prostor v črpalnem mehanizmu onstran bata (3; 52) črpalke.
11. ODI po zahtevku 10, pri katerem je črpalni mehanizem (3, 4, 13, 23) opremljen z mehanizmom (33), s pomočjo katerega lahko, preden sprostimo energijo iz vzmeti (6), črpalko držimo v napetem stanju.
12. ODI po enem od zahtevkov 9 - 11, pri katerem (52) je bat votel in obsega kanal za fluid za vstop v komoro (55). 3
13. ODI po zahtevku 12, pri katerem je kanal opremljen s protipovratnim vstopnim ventilskim sredstvom (54) za komoro (55).
14. ODI po zahtevku 12 ali 13, pri katerem bat (52) poteka iz rezervoarja (51) za fluid.
15. ODI po katerem koli zahtevku 1 -13, vsebujoč rezervoar (10; 16; 51) za fluid, iz katerega se omenjena komora (4; 55) lahko polni s fluidom.
16. ODI po zahtevku 14 ali 15, pri katerem je rezervoar (10; 51) zamenljiv.
17. ODI po zahtevku 14, 15 ali 16, pri katerem je rezervoar (10; 51) zmečkljiv (kolabira).
18. ODI po katerem koli predhodnem zahtevku, pri katerem je omenjena komora komora (4; 55; 75) spremenljive prostornine s protipovratnim vstopnim ventilskim sredstvom (13; 54; 74) in protipovratnim izstopnim ventilskim sredstvom (23; 56; 76), ki omogočata ponovljivo polnjenje fluida v omenjeno komoro (4; 55; 75) in izdajanje fluida iz omenjene komore (4; 55; 75).
19. ODI po katerem koli predhodnem zahtevku, pri katerem omenjeno razprševalno sredstvo (22; 57; 80) obsega izstopno odprtino (104), razporejeno za oblikovanje curka fluida (102), in telo (106) za trčenje, razporejeno v liniji trajektorije curka fluida (102) in nameščeno za povzročanje razbijanja curka fluida (102) v sprej kapljic.
20. ODI po katerem koli zahtevku 1 - 18, pri katerem omenjeno razprševalno sredstvo (22; 57; 80) sprej kapljic tvori z vzpostavitvijo curkov fluida (110), ki trčita drug ob drugega.
21. Postopek izdajanja odmerjene količine fluida kot spreja kapljic, pri katerem uporabimo ODI iz katerega koli predhodnega zahtevka.
22. Postopek po zahtevku 21, pri katerem imajo kapljice srednjo velikost v razponu 1 do 12 μτη. 22183-Ugot.odl.-SK-II/00
SI9110500A 1990-03-21 1991-03-21 Naprave za razprševanje in postopki SI9110500B (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909006340A GB9006340D0 (en) 1990-03-21 1990-03-21 Metered dose aerosol delivery system
GB909023767A GB9023767D0 (en) 1990-11-01 1990-11-01 Atomising devices and methods
YU50091A YU48710B (sh) 1990-03-21 1991-03-21 Naprava za raspršivanje

Publications (2)

Publication Number Publication Date
SI9110500A SI9110500A (en) 1996-02-29
SI9110500B true SI9110500B (sl) 2000-12-31

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SI9110500A SI9110500B (sl) 1990-03-21 1991-03-21 Naprave za razprševanje in postopki

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US (2) US5497944A (sl)
EP (2) EP0521061B1 (sl)
JP (1) JP2630347B2 (sl)
KR (1) KR0139652B1 (sl)
CN (2) CN1042203C (sl)
AT (2) ATE160947T1 (sl)
AU (1) AU650870B2 (sl)
BR (1) BR9106249A (sl)
CA (2) CA2078683C (sl)
CZ (1) CZ283820B6 (sl)
DE (2) DE69131966T2 (sl)
DK (2) DK0627230T3 (sl)
ES (2) ES2109943T3 (sl)
FI (1) FI104311B (sl)
GB (1) GB2256805B (sl)
GR (2) GR3026065T3 (sl)
HK (1) HK1005059A1 (sl)
HR (1) HRP921357B1 (sl)
HU (1) HU216121B (sl)
IE (1) IE62626B1 (sl)
IL (1) IL97619A (sl)
IN (1) IN177383B (sl)
MY (1) MY110310A (sl)
NO (1) NO303206B1 (sl)
NZ (1) NZ237502A (sl)
PH (1) PH30833A (sl)
PL (1) PL165926B1 (sl)
PT (1) PT97098B (sl)
RS (1) RS49548B (sl)
RU (1) RU2104048C1 (sl)
SG (1) SG45171A1 (sl)
SI (1) SI9110500B (sl)
SK (1) SK280225B6 (sl)
TW (1) TW253846B (sl)
UA (1) UA27777C2 (sl)
WO (1) WO1991014468A1 (sl)
YU (1) YU48710B (sl)

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GB9114080D0 (en) * 1991-06-28 1991-08-14 Weston Terence E Atomising valve
ES2099266T5 (es) * 1991-07-01 2004-01-01 Alexander George Brian O'neil Aparato de infusion controlada por el paciente.
DE69319107T2 (de) * 1992-03-25 1999-02-25 Tebro S.A., Luxembourg Pulverabgabevorrichtung für medizinische inhalationstherapien
IL107120A (en) * 1992-09-29 1997-09-30 Boehringer Ingelheim Int Atomising nozzle and filter and spray generating device
US6007676A (en) 1992-09-29 1999-12-28 Boehringer Ingelheim International Gmbh Atomizing nozzle and filter and spray generating device
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US5819726A (en) * 1993-01-29 1998-10-13 Aradigm Corporation Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease
US5888477A (en) * 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5934272A (en) * 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
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