KR950700298A - 뉴클레오시드 치료제(Therapeutic Nucleosides) - Google Patents
뉴클레오시드 치료제(Therapeutic Nucleosides)Info
- Publication number
- KR950700298A KR950700298A KR1019940702965A KR19940702965A KR950700298A KR 950700298 A KR950700298 A KR 950700298A KR 1019940702965 A KR1019940702965 A KR 1019940702965A KR 19940702965 A KR19940702965 A KR 19940702965A KR 950700298 A KR950700298 A KR 950700298A
- Authority
- KR
- South Korea
- Prior art keywords
- therapeutic nucleosides
- nucleosides
- therapeutic
- preparation
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9204015.3 | 1992-02-25 | ||
| GB929204015A GB9204015D0 (en) | 1992-02-25 | 1992-02-25 | Therapeutic nucleosides |
| PCT/GB1993/000378 WO1993017020A2 (en) | 1992-02-25 | 1993-02-24 | Therapeutic nucleosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950700298A true KR950700298A (ko) | 1995-01-16 |
| KR100282584B1 KR100282584B1 (ko) | 2001-02-15 |
Family
ID=10711016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940702965A KR100282584B1 (ko) | 1992-02-25 | 1993-02-24 | 뉴클레오시드 치료제 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US5641889A (ko) |
| EP (1) | EP0628044B1 (ko) |
| JP (1) | JP3172533B2 (ko) |
| KR (1) | KR100282584B1 (ko) |
| AT (1) | ATE245646T1 (ko) |
| AU (2) | AU3571093A (ko) |
| CA (1) | CA2130755C (ko) |
| DE (1) | DE69333109T2 (ko) |
| DK (1) | DK0628044T3 (ko) |
| ES (1) | ES2203615T3 (ko) |
| GB (1) | GB9204015D0 (ko) |
| HK (1) | HK1003941A1 (ko) |
| PT (1) | PT628044E (ko) |
| WO (1) | WO1993017020A2 (ko) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631370A (en) | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
| CA2001401A1 (en) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
| GB9204015D0 (en) | 1992-02-25 | 1992-04-08 | Wellcome Found | Therapeutic nucleosides |
| DE69431596D1 (de) * | 1993-06-10 | 2002-11-28 | Wake Forest University Winston | (phospho)lipide zum bekämpfen einer hepatitis b-infektion |
| DE69402548T2 (de) | 1993-06-21 | 1997-07-17 | Merrell Pharma Inc | Carbocyclische nucleoside mittel nützlich als selektive inhibitoren von proinflammatorischen cytokinen |
| EP0630897A3 (en) * | 1993-06-25 | 1995-03-01 | Bristol Myers Squibb Co | 3-hydroxy-4-hydroxymethyl-2-methylene-cyclopentyl purines and pyrimidines. |
| WO1995022330A1 (en) * | 1994-02-17 | 1995-08-24 | Commonwealth Scientific And Industrial Research Organisation | Antiviral agents |
| ATE395922T1 (de) | 1994-08-29 | 2008-06-15 | Univ Wake Forest | Lipid-analoge zur behandlung von viralen infektionen |
| US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
| AU3170597A (en) | 1996-05-30 | 1998-01-05 | Lonza A.G. | Process for the preparation of amino alcohols and derivatives thereof |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| SK284810B6 (sk) * | 1997-05-13 | 2005-12-01 | Lonza Ag | Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu |
| CZ298144B6 (cs) * | 1997-11-27 | 2007-07-04 | Lonza Ag | Zpusob výroby (1S,4R)- nebo (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyklopenten-1-methanolu |
| US6362225B1 (en) * | 1999-01-21 | 2002-03-26 | George Andreakos | Target therapies for treating common viral infections |
| US6514979B1 (en) | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
| YU25500A (sh) | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
| WO2001018003A1 (en) * | 1999-09-10 | 2001-03-15 | Stichting Rega Vzw | Carbocyclic nucleosides and process for obtaining such |
| US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| WO2002032885A1 (fr) * | 2000-10-18 | 2002-04-25 | Kuraray Co., Ltd. | Preparation d'esters d'acide amino-2-aza-1-oxybicyclo[3.3.0]oct-2-ene-6-carboxylique 4-n substitues et preparation de leurs produits intermediaires |
| GB2378180B8 (en) | 2001-06-27 | 2009-10-21 | Cyclacel Ltd | New purine derivatives |
| GB0219052D0 (en) | 2002-08-15 | 2002-09-25 | Cyclacel Ltd | New puring derivatives |
| CA2463719A1 (en) | 2003-04-05 | 2004-10-05 | F. Hoffmann-La Roche Ag | Nucleotide analogs with six membered rings |
| GB0320738D0 (en) * | 2003-09-04 | 2003-10-08 | Glaxo Group Ltd | Novel process |
| WO2005075426A1 (en) * | 2004-02-03 | 2005-08-18 | Glenmark Pharmaceuticals Ltd. | Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof |
| US7230002B2 (en) | 2004-02-03 | 2007-06-12 | Glenmark Pharmaceuticals Ltd. | Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof |
| US20070208042A1 (en) | 2006-03-03 | 2007-09-06 | Sherwood Services Ag | Method of using vasoconstrictive agents during energy-based tissue therapy |
| US7767686B2 (en) * | 2006-03-03 | 2010-08-03 | Covidien Ag | Method of using adenosine receptor blockers during tissue ablation |
| KR101925902B1 (ko) * | 2007-08-02 | 2018-12-06 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Ｅ1 활성화 효소 억제제의 합성 방법 |
| EP2326627A1 (en) * | 2008-08-20 | 2011-06-01 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| TW201020245A (en) | 2008-08-20 | 2010-06-01 | Schering Corp | Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| JP5654990B2 (ja) | 2008-08-20 | 2015-01-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アゾ置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用 |
| JP5619743B2 (ja) | 2008-08-20 | 2014-11-05 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | エテニル置換ピリジンおよびピリミジン誘導体およびウイルス感染の治療におけるそれらの使用 |
| LT3127542T (lt) | 2010-01-27 | 2018-11-26 | Viiv Healthcare Company | Antivirusinė terapija |
| EP2697983A1 (en) | 2011-04-14 | 2014-02-19 | Phonak AG | Hearing instrument |
| GB201513601D0 (en) * | 2015-07-31 | 2015-09-16 | Univ Liverpool | Antiviral compounds |
| CN106220515A (zh) * | 2016-08-12 | 2016-12-14 | 郸城巨鑫生物科技有限公司 | 一种(1r,4s)‑1‑氨基‑4‑羟甲基‑2‑环戊烯盐酸盐的合成方法 |
| JP7084591B2 (ja) * | 2017-03-29 | 2022-06-15 | ヤマサ醤油株式会社 | ヌクレオシド誘導体又はその塩、及びそれを含む医薬組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60139653A (ja) * | 1983-12-27 | 1985-07-24 | Yoshitomi Pharmaceut Ind Ltd | シクロペンテン誘導体 |
| US4543255A (en) * | 1984-05-10 | 1985-09-24 | Southern Research Institute | Carbocyclic analogs of purine 2'-deoxyribofuranosides |
| EP0219838A3 (en) * | 1985-10-22 | 1988-04-06 | Takeda Chemical Industries, Ltd. | Carbocyclic purine nucleosides, their production and use |
| IN164556B (ko) * | 1986-03-06 | 1989-04-08 | Takeda Chemical Industries Ltd | |
| US4734194A (en) * | 1986-03-25 | 1988-03-29 | The Upjohn Company | Combined filter and valve mechanism |
| IN166499B (ko) * | 1987-02-12 | 1990-05-19 | Takeda Chemical Industries Ltd | |
| GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| EP0452360A4 (en) * | 1988-12-12 | 1992-05-20 | Peter M. Palese | Methods and compositions for the prophylaxis and treatment of hepatitis b virus infections |
| ATE118208T1 (de) * | 1989-10-16 | 1995-02-15 | Chiroscience Ltd | Chirale azabicycloheptanone und verfahren zu ihrer herstellung. |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| JPH04505768A (ja) * | 1990-03-06 | 1992-10-08 | ヴィラケム・インコーポレーテッド | サイトメガロウイルス感染の予防および治療のための方法および組成物 |
| GB9204015D0 (en) | 1992-02-25 | 1992-04-08 | Wellcome Found | Therapeutic nucleosides |
-
1992
- 1992-02-25 GB GB929204015A patent/GB9204015D0/en active Pending
-
1993
- 1993-02-24 EP EP93904248A patent/EP0628044B1/en not_active Expired - Lifetime
- 1993-02-24 JP JP51465893A patent/JP3172533B2/ja not_active Expired - Lifetime
- 1993-02-24 WO PCT/GB1993/000378 patent/WO1993017020A2/en active IP Right Grant
- 1993-02-24 CA CA002130755A patent/CA2130755C/en not_active Expired - Lifetime
- 1993-02-24 AT AT93904248T patent/ATE245646T1/de active
- 1993-02-24 DE DE69333109T patent/DE69333109T2/de not_active Expired - Lifetime
- 1993-02-24 US US08/295,656 patent/US5641889A/en not_active Expired - Lifetime
- 1993-02-24 KR KR1019940702965A patent/KR100282584B1/ko not_active IP Right Cessation
- 1993-02-24 AU AU35710/93A patent/AU3571093A/en not_active Abandoned
- 1993-02-24 DK DK93904248T patent/DK0628044T3/da active
- 1993-02-24 ES ES93904248T patent/ES2203615T3/es not_active Expired - Lifetime
- 1993-02-24 PT PT93904248T patent/PT628044E/pt unknown
-
1996
- 1996-11-06 US US08/743,694 patent/US5840990A/en not_active Expired - Lifetime
-
1997
- 1997-06-13 AU AU24891/97A patent/AU707075B2/en not_active Expired
- 1997-11-07 US US08/965,986 patent/US5919941A/en not_active Expired - Lifetime
- 1997-11-07 US US08/965,987 patent/US5808147A/en not_active Expired - Lifetime
-
1998
- 1998-04-17 HK HK98103255A patent/HK1003941A1/xx not_active IP Right Cessation
- 1998-07-10 US US09/113,793 patent/US6392085B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU707075B2 (en) | 1999-07-01 |
| ATE245646T1 (de) | 2003-08-15 |
| US5808147A (en) | 1998-09-15 |
| EP0628044B1 (en) | 2003-07-23 |
| US6392085B2 (en) | 2002-05-21 |
| EP0628044A1 (en) | 1994-12-14 |
| CA2130755A1 (en) | 1993-08-26 |
| JPH07504185A (ja) | 1995-05-11 |
| DE69333109T2 (de) | 2004-04-15 |
| GB9204015D0 (en) | 1992-04-08 |
| CA2130755C (en) | 2004-03-30 |
| WO1993017020A2 (en) | 1993-09-02 |
| US5840990A (en) | 1998-11-24 |
| DE69333109D1 (de) | 2003-08-28 |
| ES2203615T3 (es) | 2004-04-16 |
| PT628044E (pt) | 2003-12-31 |
| WO1993017020A3 (en) | 1994-03-17 |
| JP3172533B2 (ja) | 2001-06-04 |
| AU3571093A (en) | 1993-09-13 |
| AU2489197A (en) | 1997-08-28 |
| DK0628044T3 (da) | 2003-11-17 |
| US5919941A (en) | 1999-07-06 |
| HK1003941A1 (en) | 1998-11-13 |
| US5641889A (en) | 1997-06-24 |
| KR100282584B1 (ko) | 2001-02-15 |
| US20010008946A1 (en) | 2001-07-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR950700298A (ko) | 뉴클레오시드 치료제(Therapeutic Nucleosides) | |
| FI913236A (fi) | 9-purinylfosfonsyraderivat. | |
| DK0626853T3 (da) | Anvendelse af substituerede adeninderivater til behandling af multipel sclerose | |
| DE69324923D1 (de) | Antiretrovirale, enantiomere Nukleotid-Analoge | |
| ES2191292T3 (es) | Compuestos antivirales poliaromaticos. | |
| AU8110991A (en) | Novel carbocyclic analogs of certain nucleosides | |
| ES2149157T3 (es) | Nuevo procedimiento para la preparacion de nucleotidos. | |
| DK0565631T3 (da) | Antivirale forbindelser | |
| ES2132419T3 (es) | Nuevos agentes de nucleosidos 9-n-biciclicos utiles como inhibidores selectivos de citocinas proinflamatorias. | |
| MX9305093A (es) | Nuevos derivadosindano-2 mercaptoacetilamina triciclicos 2-sustituidos, utiles como inhibidores de la encefalinasa. | |
| MX9303709A (es) | Nucleosidos de purina substituidos e intermediarios de los mismos, que tienen actividad anti-viral y anti-cancerigena y composicion farmaceutica que los contiene. | |
| ATE147746T1 (de) | Derivate von fluorphosphonat-nukleotiden | |
| SE9604582D0 (sv) | Novel compounds | |
| IT8721560A0 (it) | Procedimento per la purificazione di interferone. | |
| ES2133573T3 (es) | Analogos antiviricos de difluoro estatone. | |
| NO974512D0 (no) | Fremgangsmåte for syntese av nukleosid-analoger | |
| SE9603726D0 (sv) | Novel compounds | |
| ES2152982T3 (es) | Analogos de la difluoroestatona. | |
| AR240397A1 (es) | Banera para aplicacion de hidromasajes por burbujeo. | |
| IT8621033A0 (it) | Procedimento per la sintesi di dialcossi propani. | |
| JPS523079A (en) | Prepartion of amionuclesides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20121030 Year of fee payment: 13 |
|
| EXPY | Expiration of term |