IL91896A0 - Novel peptidase inhibitors - Google Patents

Novel peptidase inhibitors

Info

Publication number: IL91896A0
Authority: IL; Israel
Prior art keywords: alpha; amino acid; group; peptidase; alkyl
Prior art date: 1988-10-07

Application number

IL91896A

Other languages

English (en)

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-07

Filing date

1989-10-05

Publication date

1990-06-10

1989-10-05 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-06-10 Publication of IL91896A0 publication Critical patent/IL91896A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Crystallography & Structural Chemistry (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)
Detergent Compositions (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL91896A 1988-10-07 1989-10-05 Novel peptidase inhibitors IL91896A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25476288A	1988-10-07	1988-10-07

Publications (1)

Publication Number	Publication Date
IL91896A0 true IL91896A0 (en)	1990-06-10

Family

ID=22965502

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL91896A IL91896A0 (en)	1988-10-07	1989-10-05	Novel peptidase inhibitors
IL91895A IL91895A0 (en)	1988-10-07	1989-10-05	Novel peptidase inhibitors

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL91895A IL91895A0 (en)	1988-10-07	1989-10-05	Novel peptidase inhibitors

Country Status (18)

Country	Link
EP (2)	EP0364344B1 (pt)
JP (2)	JP3203579B2 (pt)
KR (2)	KR900006363A (pt)
CN (2)	CN1041951A (pt)
AT (2)	ATE153029T1 (pt)
AU (1)	AU617875B2 (pt)
CA (2)	CA2000340A1 (pt)
DE (2)	DE68928042T2 (pt)
DK (2)	DK494689A (pt)
ES (2)	ES2103709T3 (pt)
FI (2)	FI894748A (pt)
GR (1)	GR3024158T3 (pt)
HU (2)	HU895246D0 (pt)
IL (2)	IL91896A0 (pt)
NO (2)	NO894014L (pt)
NZ (2)	NZ230893A (pt)
PT (2)	PT91926B (pt)
ZA (2)	ZA897514B (pt)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5510531A (en) *	1989-04-10	1996-04-23	Suntory Limited	Proteinase inhibitor
WO1990012805A1 (en) *	1989-04-15	1990-11-01	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Postostatin and related compound thereof, or their salts
WO1991013904A1 (en) *	1990-03-05	1991-09-19	Cephalon, Inc.	Chymotrypsin-like proteases and their inhibitors
GB9019558D0 (en) *	1990-09-07	1990-10-24	Szelke Michael	Enzyme inhibitors
EP0564561A4 (en) *	1990-12-28	1994-08-10	Georgia Tech Res Inst	Peptides ketoamides, ketoacids, and ketoesters
US5444042A (en) *	1990-12-28	1995-08-22	Cortex Pharmaceuticals	Method of treatment of neurodegeneration with calpain inhibitors
HU217612B (hu) *	1991-05-23	2000-03-28	Merrel Dow Pharmaceuticals Inc.	Eljárás elasztáz és katepszin G inhibitor hatású peptidek előállítására
CA2071621C (en) *	1991-06-19	1996-08-06	Ahihiko Hosoda	Aldehyde derivatives
US6235929B1 (en)	1991-12-27	2001-05-22	Georgia Tech Research Corporation	Tripeptide α-ketoamides
US5610297A (en) *	1991-12-27	1997-03-11	Georgia Tech Research Corp.	Peptides ketoamides
US5514694A (en) *	1992-09-21	1996-05-07	Georgia Tech Research Corp	Peptidyl ketoamides
DE69414279T2 (de) *	1993-02-09	1999-04-08	Bayer Corp., Pittsburgh, Pa.	Sulfonamidaminomethylenderivate als Immunsuppressiva
US5672582A (en) *	1993-04-30	1997-09-30	Merck & Co., Inc.	Thrombin inhibitors
US5783563A (en) *	1993-06-03	1998-07-21	Astra Aktiebolag	Method for treatment or prophylaxis of venous thrombosis
SE9301916D0 (sv)	1993-06-03	1993-06-03	Ab Astra	New peptides derivatives
US6984627B1 (en)	1993-06-03	2006-01-10	Astrazeneca Ab	Peptide derivatives
US5541290A (en) *	1993-06-24	1996-07-30	Harbeson; Scott L.	Optically pure calpain inhibitor compounds
EP0639585A1 (en) *	1993-08-20	1995-02-22	Banyu Pharmaceutical Co., Ltd.	Elastase inhibitor
US5977074A (en) *	1993-10-01	1999-11-02	Merrell Pharmaceuticals, Inc.	Inhibitors of β-amyloid protein production
IT1270882B (it) *	1993-10-05	1997-05-13	Isagro Srl	Oligopeptidi ad attivita' fungicida
US6060462A (en) *	1993-10-20	2000-05-09	Dupont Pharmaceuticals Company	Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
US5486623A (en)	1993-12-08	1996-01-23	Prototek, Inc.	Cysteine protease inhibitors containing heterocyclic leaving groups
US5693617A (en) *	1994-03-15	1997-12-02	Proscript, Inc.	Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
US6660268B1 (en)	1994-03-18	2003-12-09	The President And Fellows Of Harvard College	Proteasome regulation of NF-KB activity
DE4421052A1 (de)	1994-06-17	1995-12-21	Basf Ag	Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DE4421884A1 (de)	1994-06-23	1996-01-04	Hoechst Ag	Verfahren zur Herstellung von Hydroxycarbonsäureaniliden
US5510369A (en) *	1994-07-22	1996-04-23	Merck & Co., Inc.	Pyrrolidine thrombin inhibitors
DE4427837A1 (de)	1994-08-05	1996-02-08	Hoechst Ag	Verfahren zur Herstellung von O-Acylglykolsäureaniliden
US6083903A (en)	1994-10-28	2000-07-04	Leukosite, Inc.	Boronic ester and acid compounds, synthesis and uses
SE9404196D0 (sv) *	1994-12-02	1994-12-02	Astra Ab	New antithrombotic formulation
US5863902A (en) *	1995-01-06	1999-01-26	Sibia Neurosciences, Inc.	Methods of treating neurodegenerative disorders using protease inhibitors
US5804560A (en) *	1995-01-06	1998-09-08	Sibia Neurosciences, Inc.	Peptide and peptide analog protease inhibitors
US5691368A (en) *	1995-01-11	1997-11-25	Hoechst Marion Roussel, Inc.	Substituted oxazolidine calpain and/or cathepsin B inhibitors
DE69629176T2 (de) *	1995-01-18	2004-06-03	Alteon Inc.	Verwendung von thiazoliumverbindungen zum verhindern und umkehren der bildung von endprodukten der fortgeschrittenen glykosylierung
FI119756B (fi) *	1995-01-18	2009-03-13	Alteon Inc	Tiatsoliumyhdisteiden käyttö pitkälle edenneen glykosylaation lopputuotteiden muodostumisen estossa ja suunnan muutoksessa
US5656261A (en)	1995-01-18	1997-08-12	The Picower Institute For Medical Research	Preventing and reversing advanced glycosylation endproducts
DE19504225A1 (de)	1995-02-09	1996-08-14	Hoechst Ag	Verfahren zur Herstellung von O-Acyloxycarbonsäureaniliden
WO1996025426A1 (de) *	1995-02-17	1996-08-22	Basf Aktiengesellschaft	Neue dipeptidische amidine als thrombin-inhibitoren
US5629324A (en) *	1995-04-10	1997-05-13	Merck & Co., Inc.	Thrombin inhibitors
US6211154B1 (en)	1995-06-07	2001-04-03	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US6022861A (en) *	1995-06-07	2000-02-08	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US6069130A (en)	1995-06-07	2000-05-30	Cor Therapeutics, Inc.	Ketoheterocyclic inhibitors of factor Xa
US6046169A (en) *	1995-06-07	2000-04-04	Cor Therapeutics, Inc.	Inhibitors of factor XA
US5919765A (en) *	1995-06-07	1999-07-06	Cor Therapeutics, Inc.	Inhibitors of factor XA
US5721214A (en) *	1995-06-07	1998-02-24	Cor Therapeutics, Inc.	Inhibitors of factor Xa
SA96170106A (ar) *	1995-07-06	2005-12-03	أسترا أكتيبولاج	مشتقات حامض أميني جديدة
US5723580A (en) *	1995-09-14	1998-03-03	Cephalon, Inc.	Ketomethylene group-containing aldehyde cysteine and serine protease inhibitors
US5827877A (en) *	1995-09-14	1998-10-27	Cephalon, Inc.	Ketomethylene group-containing cysteine and serine protease inhibitors
US5763576A (en) *	1995-10-06	1998-06-09	Georgia Tech Research Corp.	Tetrapeptide α-ketoamides
DE69625230T2 (de) *	1995-10-24	2003-09-04	Merck & Co., Inc.	Thrombininhibitoren
AU714324B2 (en) *	1995-11-28	2000-01-06	Cephalon, Inc.	D-amino acid derived inhibitors of cysteine and serine proteases
TW541316B (en) *	1995-12-21	2003-07-11	Astrazeneca Ab	Prodrugs of thrombin inhibitors
US6245743B1 (en)	1996-06-05	2001-06-12	Cor Therapeutics, Inc.	Inhibitors of factor Xa
SE9602263D0 (sv)	1996-06-07	1996-06-07	Astra Ab	New amino acid derivatives
SE9602646D0 (sv)	1996-07-04	1996-07-04	Astra Ab	Pharmaceutically-useful compounds
US5792761A (en) *	1996-08-12	1998-08-11	Merck & Co., Inc.	Thrombin inhibitors
IL128514A (en) *	1996-09-06	2003-07-06	Nippon Kayaku Kk	Acetamide derivatives, pharmaceutical compositions comprising them and a process for producing such derivatives
SI0932617T1 (en) *	1996-10-18	2002-06-30	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
KR100509388B1 (ko) *	1996-10-18	2005-08-23	버텍스 파마슈티칼스 인코포레이티드	세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제
US5798377A (en) *	1996-10-21	1998-08-25	Merck & Co., Inc.	Thrombin inhibitors
DE19648793A1 (de)	1996-11-26	1998-05-28	Basf Ag	Neue Benzamide und deren Anwendung
AU6134498A (en) *	1997-03-07	1998-09-22	Hoechst Marion Roussel, Inc.	Method of treating trauma associated with brain, spinal cord or peripheral nerveinjury using carbobenzyloxy n-protected di- and tripeptide phenylalaninals
AR013084A1 (es)	1997-06-19	2000-12-13	Astrazeneca Ab	Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
US6011047A (en) *	1997-11-26	2000-01-04	Corvas International Inc.	Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors
CA2311969A1 (en)	1997-11-26	1999-06-03	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
US6204384B1 (en)	1997-11-26	2001-03-20	Corvas International, Inc.	Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II)
SE9704543D0 (sv)	1997-12-05	1997-12-05	Astra Ab	New compounds
KR100689923B1 (ko)	1998-01-26	2007-03-09	애보트 게엠베하 운트 콤파니 카게	트롬빈 억제제
AU766219B2 (en)	1998-02-02	2003-10-09	1149336 Ontario Inc.	Method of regulating glucose metabolism, and reagents related thereto
NZ508669A (en)	1998-06-11	2003-06-30	Dimensional Pharm Inc	Pyrazinone protease inhibitors
SE9804313D0 (sv)	1998-12-14	1998-12-14	Astra Ab	New compounds
CZ20012529A3 (cs)	1999-01-13	2001-11-14	Astrazeneca Ab	Nový amidinobenzylamidový derivát a jeho pouľití jako inhibitoru thrombinu
AR023510A1 (es)	1999-04-21	2002-09-04	Astrazeneca Ab	Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
EP1189901A1 (en)	1999-05-27	2002-03-27	3-Dimensional Pharmaceuticals, Inc.	Oxazaheterocycles as protease inhibitors
ATE250056T1 (de)	1999-07-09	2003-10-15	Dimensional Pharm Inc	Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel
US6630510B1 (en) *	1999-10-28	2003-10-07	Merck & Co., Inc.	Substituted succinic acid metallo-β-lactamase inhibitors and their use in treating bacterial infections
KR20020067937A (ko) *	2000-01-26	2002-08-24	오노 야꾸힝 고교 가부시키가이샤	벤젠 축합 헤테로환 유도체 및 그 유도체를 유효성분으로서 함유하는 약제
SE0001803D0 (sv)	2000-05-16	2000-05-16	Astrazeneca Ab	New compounds i
WO2001092234A1 (en)	2000-06-01	2001-12-06	Merck & Co., Inc.	Pyrazinone thrombin inhibitors
AU2001278927A1 (en)	2000-07-17	2002-01-30	3-Dimensional Pharmaceuticals, Inc.	Cyclic oxyguanidine pyrazinones as protease inhibitors
CN102372764A (zh)	2000-07-21	2012-03-14	先灵公司	用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽
US7244721B2 (en)	2000-07-21	2007-07-17	Schering Corporation	Peptides as NS3-serine protease inhibitors of hepatitis C virus
CA2410682A1 (en) *	2000-07-21	2002-01-31	Schering Corporation	Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
EP1307432A1 (en)	2000-08-04	2003-05-07	3-Dimensional Pharmaceuticals, Inc.	Cyclic oxyguanidine protease inhibitors
US6433186B1 (en)	2000-08-16	2002-08-13	Astrazeneca Ab	Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es)	2000-12-01	2004-05-05	Astrazeneca Ab	Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en)	2000-12-01	2006-10-31	Astrazeneca Ab	Mandelic acid derivatives and their use as thrombin inhibitors
AU2002230836A1 (en)	2000-12-18	2002-07-01	Merck & Co., Inc.	Benzylamine derivatives and their use as thrombin inhibitors
US6528503B2 (en)	2000-12-18	2003-03-04	Merck & Co., Inc.	Thrombin inhibitors
US6610701B2 (en)	2001-02-09	2003-08-26	Merck & Co., Inc.	Thrombin inhibitors
CA2436176A1 (en)	2001-02-09	2002-08-22	Merck & Co., Inc.	Thrombin inhibitors
AR034517A1 (es)	2001-06-21	2004-02-25	Astrazeneca Ab	Formulacion farmaceutica
US6777431B2 (en)	2001-07-13	2004-08-17	Corvas International, Inc.	Non-convalent thrombin inhibitors
WO2003045228A2 (en)	2001-11-26	2003-06-05	Trustees Of Tufts College	Methods for treating autoimmune disorders, and reagents related thereto
US7084134B2 (en)	2002-05-02	2006-08-01	Merk & Co., Inc.	Thrombin inhibitors
SE0201659D0 (sv)	2002-05-31	2002-05-31	Astrazeneca Ab	Modified release pharmaceutical formulation
SE0201661D0 (sv)	2002-05-31	2002-05-31	Astrazeneca Ab	New salts
GB0217136D0 (en)	2002-07-24	2002-09-04	Renovo Ltd	Wound healing & treatment of fibrosis
JP5354836B2 (ja)	2002-11-06	2013-11-27	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	プロテアソームインヒビターを使用する癌を処置するための方法および組成物
US20050014747A1 (en)	2003-04-18	2005-01-20	Emily Reinhard	Dihydrothiazine prodrugs of thiazolium agents
US7781424B2 (en)	2003-05-27	2010-08-24	Astrazeneca Ab	Modified release pharmaceutical formulation
UY28500A1 (es)	2003-09-05	2005-04-29	Vertex Pharma	Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
US7795205B2 (en)	2004-04-12	2010-09-14	Canyon Pharmaceuticals, Inc.	Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
JP2009510131A (ja)	2005-10-07	2009-03-12	バイオファルミカリミテッド	Ｓｕｍｏ化制御剤及びその用途
CA2636765C (en)	2006-01-11	2014-03-18	Seikagaku Corporation	Cycloalkylcarbonylamino acid ester derivative and process for producing the same
JP4047365B2 (ja)	2006-01-11	2008-02-13	生化学工業株式会社	シクロアルカンカルボキサミド誘導体及びその製造方法
JP3975226B2 (ja)	2006-01-11	2007-09-12	生化学工業株式会社	シクロアルキルカルボニルアミノ酸誘導体及びその製造方法
WO2007115364A1 (en)	2006-04-07	2007-10-18	Biopharmica Limited	Transcription factor modulator
TW200827336A (en)	2006-12-06	2008-07-01	Astrazeneca Ab	New crystalline forms
WO2014081618A1 (en)	2012-11-20	2014-05-30	Merck Sharp & Dohme Corp.	Thrombin inhibitors
WO2019026208A1 (ja) *	2017-08-02	2019-02-07	株式会社広島メタル＆マシナリー	分散機と、スラリー中粒子の分散方法及びエマルジョン製造方法
CN112188892A (zh)	2018-03-20	2021-01-05	阿布拉科斯生物科学有限公司	通过mTOR抑制剂和白蛋白的纳米颗粒的施用治疗中枢神经系统障碍的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4920118A (pt) *	1972-06-23	1974-02-22
JPS594415B2 (ja) *	1974-02-18	1984-01-30	帝人株式会社	Ｄ，ｌ−２− アミノ −１− ブタノ−ルノコウガクブンカツホウ
JPS50142505A (pt) *	1974-05-08	1975-11-17
HU177098B (en) *	1979-01-04	1981-07-28	Gyogyszerkutato Intezet	Process for producing new peptidyl-n-carboxy-l-arginin-a
JPS55138389A (en) *	1979-04-14	1980-10-29	Denki Kagaku Kogyo Kk	Preparation of amino alcohols
FR2537131B1 (fr) *	1980-04-17	1986-05-09	Roques Bernard	Nouveaux derives d'acides amines et leur application therapeutique
JPS5754157A (en) *	1980-09-19	1982-03-31	Nippon Kayaku Co Ltd	L-argininal derivative and its preparation
JPS58198296A (ja) *	1982-05-12	1983-11-18	Chisso Corp	ｄ−２−アミノブタノ−ルの製造法
GB2124233B (en) *	1982-07-19	1985-09-18	Nat Res Dev	Synthetic peptides and their preparation
DE3481913D1 (de) *	1983-04-27	1990-05-17	Ici America Inc	Prolin-derivate.
GB8312339D0 (en) *	1983-05-05	1983-06-08	Austen B M	Peptides
FR2546164B1 (fr) *	1983-05-16	1987-07-17	Centre Nat Rech Scient	Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
CA1267499A (en) *	1983-07-12	1990-04-03	Cedric H. Hassall	Peptide amides and aldehydes
DK34086A (da) *	1985-01-23	1986-07-24	Abbott Lab	Peptidylaminodioler
AU600226B2 (en) *	1985-02-04	1990-08-09	Merrell Pharmaceuticals Inc.	Novel peptidase inhibitors
US4851387A (en) *	1986-10-14	1989-07-25	Banyu Pharmaceutical Co., Ltd.	5-substituted amino-4-hydroxy-pentanoic acid derivatives and their use
MY103189A (en) *	1986-10-31	1993-05-29	Pfizer	Nor-statine and nor-cyclostatine polypeptides
FI89058C (fi) *	1987-02-27	1993-08-10	Yamanouchi Pharma Co Ltd	Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
US4820691A (en) *	1987-06-24	1989-04-11	E. R. Squibb & Sons, Inc.	Amino acid 1,2-diketo derivatives as renin inhibitors
US4913296A (en) *	1988-03-30	1990-04-03	Applied Power Inc.	Storing and dispensing system
DE3827415A1 (de) *	1988-08-12	1990-02-15	Behringwerke Ag	Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung

1989
- 1989-10-03 ZA ZA897514A patent/ZA897514B/xx unknown
- 1989-10-03 ZA ZA897515A patent/ZA897515B/xx unknown
- 1989-10-04 NZ NZ230893A patent/NZ230893A/en unknown
- 1989-10-04 AU AU42491/89A patent/AU617875B2/en not_active Ceased
- 1989-10-05 IL IL91896A patent/IL91896A0/xx unknown
- 1989-10-05 IL IL91895A patent/IL91895A0/xx unknown
- 1989-10-05 NZ NZ230916A patent/NZ230916A/en unknown
- 1989-10-06 PT PT91926A patent/PT91926B/pt not_active IP Right Cessation
- 1989-10-06 ES ES89402762T patent/ES2103709T3/es not_active Expired - Lifetime
- 1989-10-06 AT AT89402762T patent/ATE153029T1/de not_active IP Right Cessation
- 1989-10-06 PT PT91927A patent/PT91927B/pt not_active IP Right Cessation
- 1989-10-06 KR KR1019890014375A patent/KR900006363A/ko not_active Application Discontinuation
- 1989-10-06 DE DE68928042T patent/DE68928042T2/de not_active Expired - Fee Related
- 1989-10-06 DK DK494689A patent/DK494689A/da not_active Application Discontinuation
- 1989-10-06 JP JP26036089A patent/JP3203579B2/ja not_active Expired - Fee Related
- 1989-10-06 ES ES89402763T patent/ES2118710T3/es not_active Expired - Lifetime
- 1989-10-06 NO NO89894014A patent/NO894014L/no unknown
- 1989-10-06 HU HU895246A patent/HU895246D0/hu unknown
- 1989-10-06 HU HU895247A patent/HUT54105A/hu unknown
- 1989-10-06 FI FI894748A patent/FI894748A/fi not_active IP Right Cessation
- 1989-10-06 DE DE68928662T patent/DE68928662T2/de not_active Expired - Fee Related
- 1989-10-06 DK DK494789A patent/DK494789A/da not_active Application Discontinuation
- 1989-10-06 JP JP1260361A patent/JPH02134398A/ja active Pending
- 1989-10-06 EP EP89402763A patent/EP0364344B1/en not_active Expired - Lifetime
- 1989-10-06 KR KR1019890014374A patent/KR900006362A/ko not_active Application Discontinuation
- 1989-10-06 EP EP89402762A patent/EP0363284B1/en not_active Expired - Lifetime
- 1989-10-06 AT AT89402763T patent/ATE165835T1/de not_active IP Right Cessation
- 1989-10-06 FI FI894747A patent/FI894747A/fi not_active IP Right Cessation
- 1989-10-06 NO NO89894013A patent/NO894013L/no unknown
- 1989-10-07 CN CN89107700A patent/CN1041951A/zh active Pending
- 1989-10-07 CN CN89107699A patent/CN1041950A/zh active Pending
- 1989-10-10 CA CA002000340A patent/CA2000340A1/en not_active Abandoned
- 1989-10-10 CA CA002000342A patent/CA2000342C/en not_active Expired - Fee Related
1997
- 1997-07-18 GR GR970401803T patent/GR3024158T3/el unknown

Also Published As

Publication number	Publication date
EP0363284A2 (en)	1990-04-11
JP3203579B2 (ja)	2001-08-27
AU626918B2 (en)	1992-08-13
HU895246D0 (en)	1990-01-28
FI894747A0 (fi)	1989-10-06
CN1041950A (zh)	1990-05-09
DK494789D0 (da)	1989-10-06
PT91927B (pt)	1995-07-03
HU895247D0 (pt)	1990-01-28
ES2118710T3 (es)	1998-10-01
EP0364344A3 (en)	1991-09-11
KR900006363A (ko)	1990-05-08
DE68928662T2 (de)	1998-11-26
GR3024158T3 (en)	1997-10-31
IL91895A0 (en)	1990-06-10
HUT54105A (en)	1991-01-28
PT91927A (pt)	1990-04-30
DK494689D0 (da)	1989-10-06
CA2000342C (en)	2000-10-03
PT91926A (pt)	1990-04-30
NO894013D0 (no)	1989-10-06
ATE153029T1 (de)	1997-05-15
JPH02134398A (ja)	1990-05-23
DE68928662D1 (de)	1998-06-10
DK494689A (da)	1990-04-08
ZA897515B (en)	1990-06-27
NO894014L (no)	1990-04-09
AU4262589A (en)	1990-04-12
ATE165835T1 (de)	1998-05-15
EP0363284B1 (en)	1997-05-14
DE68928042D1 (de)	1997-06-19
CA2000342A1 (en)	1990-04-07
ZA897514B (en)	1990-06-27
DK494789A (da)	1990-04-08
PT91926B (pt)	1995-07-03
NZ230916A (en)	1992-02-25
DE68928042T2 (de)	1997-08-28
JPH02256654A (ja)	1990-10-17
EP0364344A2 (en)	1990-04-18
NO894014D0 (no)	1989-10-06
KR900006362A (ko)	1990-05-08
CN1041951A (zh)	1990-05-09
AU4249189A (en)	1990-06-28
CA2000340A1 (en)	1990-04-07
FI894747A (fi)	1990-04-08
ES2103709T3 (es)	1997-10-01
FI894748A (fi)	1990-04-08
AU617875B2 (en)	1991-12-05
FI894748A0 (fi)	1989-10-06
NZ230893A (en)	1992-01-29
EP0364344B1 (en)	1998-05-06
NO894013L (no)	1990-04-09
EP0363284A3 (en)	1992-07-01

Publication	Publication Date	Title
AU617875B2 (en)	1991-12-05	Novel peptidase inhibitors
EP0393457B1 (en)	1994-07-06	Proteinase inhibitor
DE69315079D1 (de)	1997-12-11	Beta-aminoalkyl und beta-n-peptidylaminoalkylborsäure
MY137301A (en)	2009-01-30	Peptide analogs as irreversible interleukin-1b protease inhibitors
HK1010378A1 (en)	1999-06-17	Peptide derivatives of the boronic acid having protease inhibiting activity process for their production and pharmaceutical compositions comprising them
CO4950618A1 (es)	2000-09-01	Inhibidores de proteasas
EP0739886A3 (en)	1999-01-27	Selective thrombin inhibitors
CA2073189A1 (en)	1991-05-23	N-substituted azaheterocyclic carboxylic acids and a pharmaceutical composition
MY155266A (en)	2015-09-30	Selective thrombin inhibitors
MY155273A (en)	2015-09-30	Selective thrombin inhibitors

Legal Events

Date	Code	Title	Description
2006-09-05	HC	Change of name of proprietor(s)	Owner name: AVENTIS INC. Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.

Date

Code

Title

Description

2006-09-05

Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.