HK1116772A1 - Macrocylic inhibitors of hepatitis c virus - Google Patents

Macrocylic inhibitors of hepatitis c virus

Info

Publication number: HK1116772A1
Authority: HK; Hong Kong
Prior art keywords: hepatitis; virus; macrocylic; inhibitors; macrocylic inhibitors
Prior art date: 2005-07-29

Application number

HK08106769.8A

Other languages

English (en)

Inventor

Pierre Jean-Marie Bernard Raboisson

Kock Herman Augustinus De

Sandrine Marie Helene Vendeville

Lili Hu

Vreken Wim Van De

Gowan David Craig Mc

Abdellah Tahri

Dominique Louis Nestor Ghislain Surleraux

Kenneth Alan Simmen

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-29

Filing date

2008-06-18

Publication date

2009-01-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37036843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1116772(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-06-18 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2009-01-02 Publication of HK1116772A1 publication Critical patent/HK1116772A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HK08106769.8A 2005-07-29 2008-06-18 Macrocylic inhibitors of hepatitis c virus HK1116772A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05107067		2005-07-29
EP05107413		2005-08-11
PCT/EP2006/064813 WO2007014919A1 (en)	2005-07-29	2006-07-28	Macrocylic inhibitors of hepatitis c virus

Publications (1)

Publication Number	Publication Date
HK1116772A1 true HK1116772A1 (en)	2009-01-02

Family

ID=37036843

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK08106769.8A HK1116772A1 (en)	2005-07-29	2008-06-18	Macrocylic inhibitors of hepatitis c virus

Country Status (28)

Country	Link
US (1)	US7989471B2 (xx)
EP (1)	EP1912995B1 (xx)
JP (1)	JP5426163B2 (xx)
KR (1)	KR101074673B1 (xx)
CN (1)	CN101233137B (xx)
AP (1)	AP2473A (xx)
AR (1)	AR055104A1 (xx)
AT (1)	ATE517902T1 (xx)
AU (1)	AU2006274858B2 (xx)
BR (1)	BRPI0614670A2 (xx)
CA (1)	CA2617095C (xx)
DK (1)	DK1912995T3 (xx)
EA (1)	EA014646B1 (xx)
GT (1)	GT200600341A (xx)
HK (1)	HK1116772A1 (xx)
IL (1)	IL188283A (xx)
JO (1)	JO2768B1 (xx)
MX (1)	MX2008001395A (xx)
MY (1)	MY152153A (xx)
NO (1)	NO20081071L (xx)
NZ (1)	NZ564541A (xx)
PE (1)	PE20070221A1 (xx)
SG (1)	SG163613A1 (xx)
SI (1)	SI1912995T1 (xx)
SV (1)	SV2008002639A (xx)
TW (1)	TWI412534B (xx)
UY (1)	UY29705A1 (xx)
WO (1)	WO2007014919A1 (xx)

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MY140680A (en)	2002-05-20	2010-01-15	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
WO2005073195A2 (en)	2004-01-30	2005-08-11	Medivir Ab	Hcv ns-3 serine protease inhibitors
PE20070211A1 (es)	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
US7741281B2 (en)	2005-11-03	2010-06-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
KR20090024834A (ko) *	2006-07-05	2009-03-09	인터뮨, 인크.	Ｃ형 간염 바이러스 복제의 신규 억제제
US7935670B2 (en)	2006-07-11	2011-05-03	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2008008502A1 (en)	2006-07-13	2008-01-17	Achillion Pharmaceuticals, Inc.	4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
US8343477B2 (en)	2006-11-01	2013-01-01	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
US7772180B2 (en)	2006-11-09	2010-08-10	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2008070358A2 (en) *	2006-11-16	2008-06-12	Phenomix Corporation	N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain
US8003604B2 (en)	2006-11-16	2011-08-23	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7888464B2 (en)	2006-11-16	2011-02-15	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7763584B2 (en)	2006-11-16	2010-07-27	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US20100323953A1 (en) *	2007-01-08	2010-12-23	Phenomix Corporation	Macrocyclic hepatitis c protease inhibitors
WO2008096002A1 (en) *	2007-02-08	2008-08-14	Tibotec Pharmaceuticals Ltd.	Hcv inhibiting macrocyclic phosphonates and amidophosphates
EP2118091B1 (en) *	2007-02-08	2015-04-15	Janssen Sciences Ireland UC	Pyrimidine substituted macrocyclic hcv inhibitors
US8383583B2 (en)	2007-10-26	2013-02-26	Enanta Pharmaceuticals, Inc.	Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
CA2705803A1 (en)	2007-11-14	2009-05-22	Enanta Pharmaceuticals, Inc.	Macrocyclic tetrazolyl hepatitis c serine protease inhibitors
WO2009079353A1 (en)	2007-12-14	2009-06-25	Enanta Pharmaceuticals, Inc.	Triazole-containing macrocyclic hcv serine protease inhibitors
US8202996B2 (en)	2007-12-21	2012-06-19	Bristol-Myers Squibb Company	Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
WO2009117594A1 (en)	2008-03-20	2009-09-24	Enanta Pharmaceuticals, Inc.	Fluorinated macrocyclic compounds as hepatitis c virus inhibitors
US8163921B2 (en)	2008-04-16	2012-04-24	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7964560B2 (en)	2008-05-29	2011-06-21	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2009148923A1 (en)	2008-05-29	2009-12-10	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
US8207341B2 (en)	2008-09-04	2012-06-26	Bristol-Myers Squibb Company	Process or synthesizing substituted isoquinolines
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8044087B2 (en)	2008-09-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8563505B2 (en)	2008-09-29	2013-10-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
AU2009324643B2 (en)	2008-12-10	2014-08-28	Achillion Pharmaceuticals, Inc.	New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication
US8283310B2 (en)	2008-12-15	2012-10-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
TW201040181A (en) *	2009-04-08	2010-11-16	Idenix Pharmaceuticals Inc	Macrocyclic serine protease inhibitors
US8232246B2 (en)	2009-06-30	2012-07-31	Abbott Laboratories	Anti-viral compounds
CN101987825B (zh) *	2009-07-31	2014-04-02	上海开拓者医药发展有限公司	一种2-氨基-3-甲基-4-甲氧基苯乙酮的制备方法
CA2769652A1 (en)	2009-08-05	2011-02-10	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
US8937041B2 (en)	2010-12-30	2015-01-20	Abbvie, Inc.	Macrocyclic hepatitis C serine protease inhibitors
EP2658858A4 (en)	2010-12-30	2014-06-25	Enanta Pharm Inc	MACROCYCLIC INHIBITORS OF HEPATITIS C SERINE PROTEASE PHENANTHRIDINE
AR085352A1 (es)	2011-02-10	2013-09-25	Idenix Pharmaceuticals Inc	Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv
US8957203B2 (en)	2011-05-05	2015-02-17	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
US8691757B2 (en)	2011-06-15	2014-04-08	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CN104136453B (zh) *	2012-01-11	2018-01-12	艾伯维公司	用于制备hcv蛋白酶抑制剂的方法
CN104822682A (zh)	2012-10-08	2015-08-05	艾伯维公司	用于制备hcv蛋白酶抑制剂的化合物
SG11201502802PA (en)	2012-10-19	2015-05-28	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
WO2014071007A1 (en)	2012-11-02	2014-05-08	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
WO2014070964A1 (en)	2012-11-02	2014-05-08	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
US9643999B2 (en)	2012-11-02	2017-05-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
EP2914614B1 (en)	2012-11-05	2017-08-16	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
JP6342922B2 (ja)	2013-03-07	2018-06-13	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｃ型肝炎ウイルス阻害剤
US9115175B2 (en)	2013-03-14	2015-08-25	Achillion Pharmaceuticals, Inc.	Processes for Producing sovaprevir
US9227952B2 (en)	2013-03-15	2016-01-05	Achillion Pharmaceuticals, Inc.	Sovaprevir polymorphs and methods of manufacture thereof
US9006423B2 (en)	2013-03-15	2015-04-14	Achillion Pharmaceuticals Inc.	Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
WO2014145600A1 (en)	2013-03-15	2014-09-18	Achillion Pharmaceuticals, Inc.	Ach-0142684 sodium salt polymorphs, composition including the same, and method of manufacture thereof
WO2015103490A1 (en)	2014-01-03	2015-07-09	Abbvie, Inc.	Solid antiviral dosage forms
MA41812A (fr) *	2015-03-27	2018-01-30	Janssen Pharmaceuticals Inc	Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc

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PE20070343A1 (es) *	2005-07-29	2007-05-12	Medivir Ab	Inhibidores macrociclicos del virus de la hepatitis c

2006
- 2006-07-19 JO JO2006237A patent/JO2768B1/en active
- 2006-07-26 PE PE2006000917A patent/PE20070221A1/es not_active Application Discontinuation
- 2006-07-28 UY UY29705A patent/UY29705A1/es unknown
- 2006-07-28 CA CA2617095A patent/CA2617095C/en not_active Expired - Fee Related
- 2006-07-28 GT GT200600341A patent/GT200600341A/es unknown
- 2006-07-28 TW TW095127588A patent/TWI412534B/zh not_active IP Right Cessation
- 2006-07-28 SI SI200631129T patent/SI1912995T1/sl unknown
- 2006-07-28 MX MX2008001395A patent/MX2008001395A/es active IP Right Grant
- 2006-07-28 KR KR1020087003833A patent/KR101074673B1/ko not_active IP Right Cessation
- 2006-07-28 AT AT06764264T patent/ATE517902T1/de active
- 2006-07-28 SG SG201005107-6A patent/SG163613A1/en unknown
- 2006-07-28 MY MYPI20063671 patent/MY152153A/en unknown
- 2006-07-28 NZ NZ564541A patent/NZ564541A/en not_active IP Right Cessation
- 2006-07-28 CN CN200680027654.7A patent/CN101233137B/zh not_active Expired - Fee Related
- 2006-07-28 AP AP2008004305A patent/AP2473A/xx active
- 2006-07-28 AU AU2006274858A patent/AU2006274858B2/en not_active Ceased
- 2006-07-28 DK DK06764264.5T patent/DK1912995T3/da active
- 2006-07-28 AR ARP060103306A patent/AR055104A1/es unknown
- 2006-07-28 EP EP06764264A patent/EP1912995B1/en active Active
- 2006-07-28 BR BRPI0614670-8A patent/BRPI0614670A2/pt not_active Application Discontinuation
- 2006-07-28 WO PCT/EP2006/064813 patent/WO2007014919A1/en active Application Filing
- 2006-07-28 US US11/995,573 patent/US7989471B2/en not_active Expired - Fee Related
- 2006-07-28 EA EA200800484A patent/EA014646B1/ru not_active IP Right Cessation
- 2006-07-28 JP JP2008523375A patent/JP5426163B2/ja not_active Expired - Fee Related
- 2006-07-29 SV SV2006002639A patent/SV2008002639A/es unknown
2007
- 2007-12-20 IL IL188283A patent/IL188283A/en not_active IP Right Cessation
2008
- 2008-02-29 NO NO20081071A patent/NO20081071L/no not_active Application Discontinuation
- 2008-06-18 HK HK08106769.8A patent/HK1116772A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK1912995T3 (da)	2011-10-24
EA014646B1 (ru)	2010-12-30
UY29705A1 (es)	2007-05-31
KR20080041651A (ko)	2008-05-13
CA2617095C (en)	2014-05-13
SG163613A1 (en)	2010-08-30
JP5426163B2 (ja)	2014-02-26
TWI412534B (zh)	2013-10-21
JP2009502882A (ja)	2009-01-29
GT200600341A (es)	2007-02-26
EP1912995A1 (en)	2008-04-23
AU2006274858A1 (en)	2007-02-08
MY152153A (en)	2014-08-15
SI1912995T1 (sl)	2011-11-30
BRPI0614670A2 (pt)	2011-04-12
CA2617095A1 (en)	2007-02-08
AR055104A1 (es)	2007-08-08
AU2006274858B2 (en)	2012-05-24
JO2768B1 (en)	2014-03-15
CN101233137B (zh)	2014-05-07
US20100240698A1 (en)	2010-09-23
KR101074673B1 (ko)	2011-10-19
MX2008001395A (es)	2008-04-16
IL188283A0 (en)	2008-04-13
ATE517902T1 (de)	2011-08-15
US7989471B2 (en)	2011-08-02
TW200745165A (en)	2007-12-16
AP2473A (en)	2012-09-24
PE20070221A1 (es)	2007-04-16
EP1912995B1 (en)	2011-07-27
CN101233137A (zh)	2008-07-30
WO2007014919A1 (en)	2007-02-08
NZ564541A (en)	2010-03-26
SV2008002639A (es)	2008-07-23
NO20081071L (no)	2008-04-25
IL188283A (en)	2016-12-29
EA200800484A1 (ru)	2008-06-30

Publication	Publication Date	Title
HK1183872A1 (zh)	2014-01-10	丙型肝炎病毒的大環抑制劑
ME01318B (me)	2013-12-20	Makrociklički inhibitori virusa hepatitisa C
IL188283A0 (en)	2008-04-13	Macrocylic inhibitors of hepatitis c virus
AP2585A (en)	2013-02-04	Macrocyclic inhibitors of hepatitis C virus
PL1919904T3 (pl)	2014-06-30	Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
SI1919898T1 (sl)	2011-05-31	Makrociklični inhibitorji virusa hepatitisa C
SI1919899T1 (sl)	2011-05-31	Makrociklični inhibitorji virusa hepatitisa C
SI1913015T1 (sl)	2014-05-30	Makrociklični inhibitorji virusa Hepatitis C
IL188281A0 (en)	2008-04-13	Macrocyclic inhibitors of hepatitis c virus
HK1136824A1 (en)	2010-07-09	Macrocyclic inhibitors of hepatitis c virus
IL221361A0 (en)	2012-09-24	Novel macrocyclic inhibitors of hepatitis c virus replication
ZA200800859B (en)	2009-06-24	Macrocyclic inhibitors of hepatitis C virus
ZA200800860B (en)	2009-06-24	Macrocyclic inhibitors of hepatitis C virus
ZA200800856B (en)	2009-06-24	Macrocyclic inhibitors of hepatitis C virus
ZA200800715B (en)	2010-02-24	Novel macrocyclic inhibitors of hepatitis C virus replication

Legal Events

Date	Code	Title	Description
2016-02-26	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20150728