IL188281A0 - Macrocyclic inhibitors of hepatitis c virus - Google Patents

Macrocyclic inhibitors of hepatitis c virus

Info

Publication number: IL188281A0
Authority: IL; Israel
Prior art keywords: hepatitis; virus; macrocyclic inhibitors; macrocyclic; inhibitors
Prior art date: 2005-07-29

Application number

IL188281A

Other versions

IL188281A (en

Original Assignee

Medivir Ab

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-29

Filing date

2007-12-20

Publication date

2008-04-13

2007-12-20 Application filed by Medivir Ab, Tibotec Pharm Ltd filed Critical Medivir Ab

2008-04-13 Publication of IL188281A0 publication Critical patent/IL188281A0/en

2015-01-29 Publication of IL188281A publication Critical patent/IL188281A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)

IL188281A 2005-07-29 2007-12-20 Macrocyclic inhibitors of hepatitis c virus IL188281A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP05107066		2005-07-29
EP06101278		2006-02-03
PCT/EP2006/064812 WO2007014918A1 (en)	2005-07-29	2006-07-28	Macrocyclic inhibitors of hepatitis c virus

Publications (2)

Publication Number	Publication Date
IL188281A0 true IL188281A0 (en)	2008-04-13
IL188281A IL188281A (en)	2015-01-29

Family

ID=37102945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL188281A IL188281A (en)	2005-07-29	2007-12-20	Macrocyclic inhibitors of hepatitis c virus

Country Status (32)

Country	Link
US (1)	US8008251B2 (en)
EP (1)	EP1913014B1 (en)
JP (1)	JP5508713B2 (en)
KR (1)	KR101321392B1 (en)
CN (1)	CN101233147B (en)
AR (1)	AR054881A1 (en)
AT (1)	ATE496934T1 (en)
AU (1)	AU2006274857B2 (en)
BR (1)	BRPI0614515A2 (en)
CA (1)	CA2616954C (en)
CY (1)	CY1112001T1 (en)
DE (1)	DE602006019879D1 (en)
DK (1)	DK1913014T3 (en)
EA (1)	EA200800485A1 (en)
GT (1)	GT200600340A (en)
HK (1)	HK1116503A1 (en)
HR (1)	HRP20110289T1 (en)
IL (1)	IL188281A (en)
ME (1)	ME01233B (en)
MX (1)	MX2008001394A (en)
MY (1)	MY139987A (en)
NO (1)	NO20081074L (en)
NZ (1)	NZ564542A (en)
PE (1)	PE20070210A1 (en)
PL (1)	PL1913014T3 (en)
PT (1)	PT1913014E (en)
RS (1)	RS51776B (en)
SG (1)	SG163610A1 (en)
SI (1)	SI1913014T1 (en)
TW (1)	TWI437993B (en)
UY (1)	UY29702A1 (en)
WO (1)	WO2007014918A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY140680A (en)	2002-05-20	2010-01-15	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
WO2005073195A2 (en)	2004-01-30	2005-08-11	Medivir Ab	Hcv ns-3 serine protease inhibitors
WO2006116053A1 (en) *	2005-04-22	2006-11-02	Sciclone Pharmaceuticals, Inc.	Immunomodulator compounds as vaccine enhancers
PE20070211A1 (en)	2005-07-29	2007-05-12	Medivir Ab	MACROCYCLIC COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS
US7741281B2 (en)	2005-11-03	2010-06-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7935670B2 (en)	2006-07-11	2011-05-03	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8343477B2 (en)	2006-11-01	2013-01-01	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
US7772180B2 (en)	2006-11-09	2010-08-10	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8003604B2 (en)	2006-11-16	2011-08-23	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7763584B2 (en)	2006-11-16	2010-07-27	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7888464B2 (en)	2006-11-16	2011-02-15	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CL2007003299A1 (en) *	2006-11-17	2008-08-22	Tibotec Pharm Ltd	COMPOUNDS DERIVED FROM MACROCICLES, INHIBITORS OF THE HEPATITIS C VIRUS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF HEPATITIS C.
US8383583B2 (en)	2007-10-26	2013-02-26	Enanta Pharmaceuticals, Inc.	Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
US8202996B2 (en)	2007-12-21	2012-06-19	Bristol-Myers Squibb Company	Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
US8003659B2 (en)	2008-02-04	2011-08-23	Indenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors
WO2009117594A1 (en)	2008-03-20	2009-09-24	Enanta Pharmaceuticals, Inc.	Fluorinated macrocyclic compounds as hepatitis c virus inhibitors
US8163921B2 (en)	2008-04-16	2012-04-24	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2009148923A1 (en)	2008-05-29	2009-12-10	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
US7964560B2 (en)	2008-05-29	2011-06-21	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8207341B2 (en)	2008-09-04	2012-06-26	Bristol-Myers Squibb Company	Process or synthesizing substituted isoquinolines
US8563505B2 (en)	2008-09-29	2013-10-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8044087B2 (en)	2008-09-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8283310B2 (en)	2008-12-15	2012-10-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
TW201040181A (en)	2009-04-08	2010-11-16	Idenix Pharmaceuticals Inc	Macrocyclic serine protease inhibitors
CA2769652A1 (en)	2009-08-05	2011-02-10	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
AR085352A1 (en)	2011-02-10	2013-09-25	Idenix Pharmaceuticals Inc	MACROCICLIC INHIBITORS OF SERINA PROTEASA, ITS PHARMACEUTICAL COMPOSITIONS AND ITS USE TO TREAT HCV INFECTIONS
US8957203B2 (en)	2011-05-05	2015-02-17	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8691757B2 (en)	2011-06-15	2014-04-08	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US9207002B2 (en)	2011-10-12	2015-12-08	International Business Machines Corporation	Contaminant separator for a vapor-compression refrigeration apparatus
SG11201502802PA (en)	2012-10-19	2015-05-28	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
US9643999B2 (en)	2012-11-02	2017-05-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2014071007A1 (en)	2012-11-02	2014-05-08	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
WO2014070964A1 (en)	2012-11-02	2014-05-08	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
EP2914614B1 (en)	2012-11-05	2017-08-16	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
JP6342922B2 (en)	2013-03-07	2018-06-13	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Hepatitis C virus inhibitor

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EP1090914B1 (en)	1992-12-29	2003-01-02	Abbott Laboratories	Retroviral protease inhibiting compounds
IL110752A (en)	1993-09-13	2000-07-26	Abbott Lab	Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en)	1993-10-01	1996-09-24	Abbott Laboratories	Pharmaceutical composition
IL111991A (en)	1994-01-28	2000-07-26	Abbott Lab	Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
US6037157A (en)	1995-06-29	2000-03-14	Abbott Laboratories	Method for improving pharmacokinetics
US5807876A (en)	1996-04-23	1998-09-15	Vertex Pharmaceuticals Incorporated	Inhibitors of IMPDH enzyme
US6054472A (en)	1996-04-23	2000-04-25	Vertex Pharmaceuticals, Incorporated	Inhibitors of IMPDH enzyme
BR9708735A (en)	1996-04-23	1999-08-03	Vertex Pharma	Urea derivatives as inhibitors of the impdh enzyme
PL192280B1 (en)	1996-10-18	2006-09-29	Vertex Pharma	Inhibitors of serinic proteases in particular that of hepatitis c virus ns3
GB9623908D0 (en)	1996-11-18	1997-01-08	Hoffmann La Roche	Amino acid derivatives
EP0966465B1 (en)	1997-03-14	2003-07-09	Vertex Pharmaceuticals Incorporated	Inhibitors of impdh enzyme
HUP0100100A3 (en)	1997-08-11	2001-12-28	Boehringer Ingelheim Ca Ltd	Hepatitis c inhibitor peptide analogues, pharmaceutical compositions comprising thereof and their use
US6323180B1 (en)	1998-08-10	2001-11-27	Boehringer Ingelheim (Canada) Ltd	Hepatitis C inhibitor tri-peptides
EA004141B1 (en)	1999-03-19	2004-02-26	Вертекс Фармасьютикалз Инкорпорейтед	Inhibitors of impdh enzyme
UA74546C2 (en) *	1999-04-06	2006-01-16	Boehringer Ingelheim Ca Ltd	Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
SV2003000617A (en)	2000-08-31	2003-01-13	Lilly Co Eli	INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
US6867185B2 (en) *	2001-12-20	2005-03-15	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
NZ575692A (en)	2002-04-11	2009-10-30	Vertex Pharma	Inhibitors of Serine Proteases, Particularly Hepatitis C Virus NS3-NS4 Protease
US20050075279A1 (en) *	2002-10-25	2005-04-07	Boehringer Ingelheim International Gmbh	Macrocyclic peptides active against the hepatitis C virus
DE602004019518D1 (en) *	2003-04-16	2009-04-02	Bristol Myers Squibb Co	MACROCYCLIC ISOCHINOLINE PEPTIDINHIBITORS OF HEPATITIS C VIRUS
US7125845B2 (en) *	2003-07-03	2006-10-24	Enanta Pharmaceuticals, Inc.	Aza-peptide macrocyclic hepatitis C serine protease inhibitors
CN1856502A (en) *	2003-09-22	2006-11-01	贝林格尔.英格海姆国际有限公司	Macrocyclic peptides active against the hepatitis c virus
WO2005073195A2 (en) *	2004-01-30	2005-08-11	Medivir Ab	Hcv ns-3 serine protease inhibitors
AR055105A1 (en) *	2005-07-29	2007-08-08	Tibotec Pharm Ltd	MACROCICLIC INHIBITORS OF HEPATITIS C VIRUS
CN101273038A (en) *	2005-07-29	2008-09-24	美迪维尔公司	Macrocylic inhibitors of hepatitis C virus
CN101273030B (en) *	2005-07-29	2012-07-18	泰博特克药品有限公司	Macrocyclic inhibitors of hepatitis C virus
PE20070211A1 (en) *	2005-07-29	2007-05-12	Medivir Ab	MACROCYCLIC COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS

2006
- 2006-07-26 PE PE2006000905A patent/PE20070210A1/en not_active Application Discontinuation
- 2006-07-28 GT GT200600340A patent/GT200600340A/en unknown
- 2006-07-28 TW TW095127583A patent/TWI437993B/en not_active IP Right Cessation
- 2006-07-28 DK DK06764263.7T patent/DK1913014T3/en active
- 2006-07-28 PL PL06764263T patent/PL1913014T3/en unknown
- 2006-07-28 SI SI200630993T patent/SI1913014T1/en unknown
- 2006-07-28 RS RS20110174A patent/RS51776B/en unknown
- 2006-07-28 JP JP2008523374A patent/JP5508713B2/en not_active Expired - Fee Related
- 2006-07-28 MX MX2008001394A patent/MX2008001394A/en active IP Right Grant
- 2006-07-28 WO PCT/EP2006/064812 patent/WO2007014918A1/en active Application Filing
- 2006-07-28 EA EA200800485A patent/EA200800485A1/en unknown
- 2006-07-28 ME MEP-2011-73A patent/ME01233B/en unknown
- 2006-07-28 AR ARP060103302A patent/AR054881A1/en unknown
- 2006-07-28 DE DE602006019879T patent/DE602006019879D1/en active Active
- 2006-07-28 MY MYPI20063667A patent/MY139987A/en unknown
- 2006-07-28 BR BRPI0614515-9A patent/BRPI0614515A2/en not_active IP Right Cessation
- 2006-07-28 AT AT06764263T patent/ATE496934T1/en active
- 2006-07-28 NZ NZ564542A patent/NZ564542A/en not_active IP Right Cessation
- 2006-07-28 SG SG201005076-3A patent/SG163610A1/en unknown
- 2006-07-28 UY UY29702A patent/UY29702A1/en unknown
- 2006-07-28 US US11/995,888 patent/US8008251B2/en not_active Expired - Fee Related
- 2006-07-28 PT PT06764263T patent/PT1913014E/en unknown
- 2006-07-28 KR KR1020087004157A patent/KR101321392B1/en not_active IP Right Cessation
- 2006-07-28 CA CA2616954A patent/CA2616954C/en not_active Expired - Fee Related
- 2006-07-28 EP EP06764263A patent/EP1913014B1/en active Active
- 2006-07-28 AU AU2006274857A patent/AU2006274857B2/en not_active Ceased
- 2006-07-28 CN CN2006800275421A patent/CN101233147B/en not_active Expired - Fee Related
2007
- 2007-12-20 IL IL188281A patent/IL188281A/en not_active IP Right Cessation
2008
- 2008-02-29 NO NO20081074A patent/NO20081074L/en not_active Application Discontinuation
- 2008-06-20 HK HK08106902.6A patent/HK1116503A1/en not_active IP Right Cessation
2011
- 2011-04-19 HR HR20110289T patent/HRP20110289T1/en unknown
- 2011-04-26 CY CY20111100415T patent/CY1112001T1/en unknown

Also Published As

Publication number	Publication date
WO2007014918A1 (en)	2007-02-08
US8008251B2 (en)	2011-08-30
JP5508713B2 (en)	2014-06-04
MY139987A (en)	2009-11-30
DE602006019879D1 (en)	2011-03-10
TW200801044A (en)	2008-01-01
HRP20110289T1 (en)	2011-05-31
MX2008001394A (en)	2008-04-08
EP1913014A1 (en)	2008-04-23
EA200800485A1 (en)	2009-04-28
AR054881A1 (en)	2007-07-25
TWI437993B (en)	2014-05-21
DK1913014T3 (en)	2011-08-01
AU2006274857B2 (en)	2012-11-29
BRPI0614515A2 (en)	2011-03-29
AU2006274857A1 (en)	2007-02-08
JP2009502881A (en)	2009-01-29
CA2616954C (en)	2013-12-24
SI1913014T1 (en)	2011-06-30
UY29702A1 (en)	2007-05-31
NO20081074L (en)	2008-04-29
NZ564542A (en)	2010-03-26
CY1112001T1 (en)	2015-11-04
KR20080039430A (en)	2008-05-07
GT200600340A (en)	2007-02-26
US20080200503A1 (en)	2008-08-21
KR101321392B1 (en)	2013-10-30
ATE496934T1 (en)	2011-02-15
HK1116503A1 (en)	2008-12-24
EP1913014B1 (en)	2011-01-26
PT1913014E (en)	2011-04-20
IL188281A (en)	2015-01-29
PE20070210A1 (en)	2007-04-16
ME01233B (en)	2013-06-20
CA2616954A1 (en)	2007-02-08
CN101233147B (en)	2012-06-20
CN101233147A (en)	2008-07-30
PL1913014T3 (en)	2011-06-30
SG163610A1 (en)	2010-08-30
RS51776B (en)	2011-12-31

Publication	Publication Date	Title
IL240244A0 (en)	2015-09-24	Macrocyclic inhibitors of hepatitis c virus
AP2585A (en)	2013-02-04	Macrocyclic inhibitors of hepatitis C virus
AP2473A (en)	2012-09-24	Macrocyclic inhibitors of hepatitis C virus
SI1912997T1 (en)	2012-02-29	Macrocyclic inhibitors of hepatitis c virus
PL1919904T3 (en)	2014-06-30	Macrocyclic inhibitors of hepatitis c virus
PL1919898T3 (en)	2011-06-30	Macrocyclic inhibitors of hepatitis c virus
SI1913015T1 (en)	2014-05-30	Macrocyclic inhibitors of hepatitis c virus
SI1919899T1 (en)	2011-05-31	Macrocyclic inhibitors of hepatitis c virus
IL188281A0 (en)	2008-04-13	Macrocyclic inhibitors of hepatitis c virus
HK1136824A1 (en)	2010-07-09	Macrocyclic inhibitors of hepatitis c virus
IL221361A0 (en)	2012-09-24	Novel macrocyclic inhibitors of hepatitis c virus replication
ZA200800859B (en)	2009-06-24	Macrocyclic inhibitors of hepatitis C virus
ZA200800856B (en)	2009-06-24	Macrocyclic inhibitors of hepatitis C virus
ZA200800860B (en)	2009-06-24	Macrocyclic inhibitors of hepatitis C virus
ZA200800715B (en)	2010-02-24	Novel macrocyclic inhibitors of hepatitis C virus replication

Legal Events

Date	Code	Title	Description
2015-05-31	FF	Patent granted
2016-02-29	MM9K	Patent not in force due to non-payment of renewal fees