Nothing Special   »   [go: up one dir, main page]

FI65779C - Foerfarande foer framstaellning av en antimikrobisk cefemfoerening - Google Patents

Foerfarande foer framstaellning av en antimikrobisk cefemfoerening Download PDF

Info

Publication number
FI65779C
FI65779C FI780801A FI780801A FI65779C FI 65779 C FI65779 C FI 65779C FI 780801 A FI780801 A FI 780801A FI 780801 A FI780801 A FI 780801A FI 65779 C FI65779 C FI 65779C
Authority
FI
Finland
Prior art keywords
solution
compound
cephem
formula
amino
Prior art date
Application number
FI780801A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI65779B (fi
FI780801A (fi
Inventor
Takao Takaya
Hisashi Takasugi
Kiyoshi Tsuji
Toshiyuki Chiba
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB10699/77A external-priority patent/GB1600735A/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Priority claimed from KR7802782A external-priority patent/KR820001285B1/ko
Publication of FI780801A publication Critical patent/FI780801A/fi
Priority claimed from KR1019820000231A external-priority patent/KR830000455B1/ko
Priority to FI823884A priority Critical patent/FI823884A0/fi
Publication of FI65779B publication Critical patent/FI65779B/fi
Application granted granted Critical
Publication of FI65779C publication Critical patent/FI65779C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI780801A 1977-03-14 1978-03-14 Foerfarande foer framstaellning av en antimikrobisk cefemfoerening FI65779C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI823884A FI823884A0 (fi) 1977-03-14 1982-11-12 Mellanprodukt vid framstaellning av antimikroba, kefem- och kefamfoereningar

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GB10699/77A GB1600735A (en) 1977-03-14 1977-03-14 Cephem and cephem compounds and processes for preparation thereof
GB1069977 1977-03-14
GB2924577 1977-07-12
GB2924577 1977-07-12
GB4231577 1977-10-11
GB4231577 1977-10-11
GB7578 1978-01-03
GB7578 1978-01-03
KR780002782 1978-09-13
KR7802782A KR820001285B1 (ko) 1977-03-14 1978-09-13 세펨화합물의 제조방법
KR820000231 1982-01-18
KR1019820000231A KR830000455B1 (ko) 1977-03-14 1982-01-18 세펨화합물의 제조방법

Publications (3)

Publication Number Publication Date
FI780801A FI780801A (fi) 1978-09-15
FI65779B FI65779B (fi) 1984-03-30
FI65779C true FI65779C (fi) 1984-07-10

Family

ID=27546433

Family Applications (1)

Application Number Title Priority Date Filing Date
FI780801A FI65779C (fi) 1977-03-14 1978-03-14 Foerfarande foer framstaellning av en antimikrobisk cefemfoerening

Country Status (21)

Country Link
US (7) US4425341A (de)
JP (7) JPS53137988A (de)
AR (2) AR230452A1 (de)
AT (1) AT364456B (de)
BE (1) BE864810A (de)
CA (1) CA1321580C (de)
CH (1) CH637138A5 (de)
CS (1) CS217961B2 (de)
DD (2) DD144772A5 (de)
DE (1) DE2810922C2 (de)
DK (1) DK163832C (de)
ES (8) ES467828A1 (de)
FI (1) FI65779C (de)
FR (1) FR2383951A1 (de)
GR (1) GR63619B (de)
NL (2) NL182401C (de)
NZ (2) NZ199860A (de)
PH (2) PH17188A (de)
PT (1) PT67773A (de)
SE (3) SE438677B (de)
YU (3) YU41586B (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
FR2399418A1 (fr) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques
US4399133A (en) * 1977-03-14 1983-08-16 Fujisawa Pharmaceutical Company, Limited Cephem compounds
US4464369A (en) * 1977-03-14 1984-08-07 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions
US4409217A (en) 1977-03-14 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
US4268509A (en) * 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof
US4372952A (en) 1978-07-31 1983-02-08 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
US4305937A (en) * 1978-08-17 1981-12-15 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and antibacterial pharmaceutical compositions containing them
FR2453161A1 (fr) * 1978-08-31 1980-10-31 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide thiazolylacetique et nouveaux produits ainsi obtenus
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
EP0048504B1 (de) 1978-09-12 1988-08-17 Fujisawa Pharmaceutical Co., Ltd. Cephalosporinzwischenprodukte, Verfahren zu ihrer Herstellung und Verfahren zur Herstellung von Cephalosporinderivaten
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
FR2444032A2 (fr) * 1978-12-13 1980-07-11 Roussel Uclaf Nouveaux produits derives de l'acide 2-(2-tritylamino-4-thiazolyl) acetique et leur procede de preparation
AU536842B2 (en) * 1978-12-29 1984-05-24 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin antibiotics
FR2448543A1 (fr) * 1979-02-09 1980-09-05 Roussel Uclaf Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2461713A1 (fr) * 1979-07-19 1981-02-06 Roussel Uclaf Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
EP0025017A1 (de) * 1979-08-28 1981-03-11 Ciba-Geigy Ag Polyazathiaverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend solche Verbindungen und Verwendung von letzteren
DE3069560D1 (en) * 1979-09-03 1984-12-06 Fujisawa Pharmaceutical Co Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
FR2466468A1 (fr) * 1979-10-02 1981-04-10 Glaxo Group Ltd Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
GR78221B (de) 1980-02-01 1984-09-26 Ciba Geigy Ag
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS56131591A (en) * 1980-02-20 1981-10-15 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent
JPS5726692A (en) * 1980-07-22 1982-02-12 Fujisawa Pharmaceut Co Ltd Preparation of stable crystal of salt of ceftizoxime
DK416681A (da) * 1980-09-26 1982-03-27 Fujisawa Pharmaceutical Co Femgangsmaade til fremstilling af cephemforbindelser
DE3177090D1 (en) * 1980-12-31 1989-09-28 Fujisawa Pharmaceutical Co 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof
JPS58986A (ja) * 1981-05-07 1983-01-06 Fujisawa Pharmaceut Co Ltd セフェム化合物
JPS57193489A (en) * 1981-05-21 1982-11-27 Fujisawa Pharmaceut Co Ltd Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation
FR2506307A1 (fr) * 1981-05-22 1982-11-26 Roussel Uclaf Nouveaux derives substitues de l'acide 2-(2-amino 4-thiazolyl) 2-hydroxyimino acetique et leur procede de preparation
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS5874680A (ja) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
ATE18219T1 (de) * 1981-11-13 1986-03-15 Glaxo Group Ltd Thiazol-derivate und ihre verwendung bei der herstellung von beta-lactam-antibiotika.
DE3265277D1 (en) * 1981-11-13 1985-09-12 Glaxo Group Ltd Thiazole derivatives and their use in the manufacture of beta lactam antibiotics
JPS58135894A (ja) * 1982-01-22 1983-08-12 Fujisawa Pharmaceut Co Ltd ７―置換ブチルアミド―３―ビニルセファロスポラン酸誘導体
JPS58210074A (ja) * 1982-06-02 1983-12-07 Sankyo Co Ltd チアゾ−ル酢酸誘導体およびその製造法
FR2532936A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 2-amino-thiazolyl-4-yl acetique comportant une fonction oxime substituee et leur procede de preparation
JPS59116291A (ja) * 1982-12-06 1984-07-05 Fujisawa Pharmaceut Co Ltd ７−置換−３−セフエム−４−カルボン酸エステルおよびその製法
EP0115770B2 (de) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazolderivate
US4480120A (en) * 1983-03-24 1984-10-30 Eastman Kodak Company Process for the preparation of alkyl-2-alkoxyimino-3-oxo-4-chlorobutyrates
GB8318846D0 (en) * 1983-07-12 1983-08-10 Fujisawa Pharmaceutical Co Prophylactic/therapeutic agent against fish diseases
JPS6064986A (ja) * 1983-09-20 1985-04-13 Toyama Chem Co Ltd セファロスポリン類の製造法
GB8406231D0 (en) * 1984-03-09 1984-04-11 Fujisawa Pharmaceutical Co Cephem compounds
AT382149B (de) * 1984-04-10 1987-01-12 Biochemie Gmbh Verfahren zur herstellung von syn-isomeren von thioessigsaeureestern
GB8410992D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
GB8410991D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
JPH0645625B2 (ja) * 1984-12-28 1994-06-15 塩野義製薬株式会社 ヒドロキシセフアムカルボン酸エステルの製造法
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
GB8432295D0 (en) * 1984-12-20 1985-01-30 Fujisawa Pharmaceutical Co Cephem compounds
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
CN86107947A (zh) * 1985-11-22 1987-05-27 藤沢药品工业株式会社 新的头孢烯化合物及其制备方法
JPH0631258B2 (ja) * 1985-11-29 1994-04-27 武田薬品工業株式会社 セフアロスポリン誘導体の製造法
US5373000A (en) * 1985-12-26 1994-12-13 Eisai Co., Ltd. 7Beta-(thiadiazolyl)-2-iminoacetamido-3cephem compounds
EP0238060B1 (de) 1986-03-19 1992-01-08 Banyu Pharmaceutical Co., Ltd. Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und antibakterielle Mittel
US4777332A (en) * 1987-06-22 1988-10-11 Tandem Computers Incorporated Apparatus for controlling the connection of an electrical module to an electrical receptacle
JP2003001718A (ja) * 2001-06-20 2003-01-08 Aron Kasei Co Ltd ますの製造方法
WO2004083216A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of cephalosporins
JP6151257B2 (ja) 2011-09-09 2017-06-21 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 肺内感染症の治療方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
CN102993117A (zh) * 2012-11-28 2013-03-27 张家港市大伟助剂有限公司 2-胺基-5-(4-胺基苯基)-噻唑的制备方法
CN102977121A (zh) * 2012-12-25 2013-03-20 菏泽睿智科技开发有限公司 一种头孢唑肟酸的合成方法
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
BR112015023523B8 (pt) 2013-03-15 2023-03-07 Merck Sharp & Dohme Composições farmacêuticas e recipiente de forma de dosagem única
ES2800603T3 (es) 2013-09-09 2021-01-04 Merck Sharp & Dohme Tratamiento de infecciones con ceftolozano/tazobactam en sujetos con insuficiencia renal
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
JP6377570B2 (ja) * 2014-04-28 2018-08-22 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ ２−置換セフェム化合物を含有する医薬組成物
CN105315299B (zh) * 2015-09-22 2017-06-27 盐城开元医药化工有限公司 一种头孢唑肟母核7‑anca的合成方法
CN114105903B (zh) * 2021-12-16 2023-06-27 河北合佳医药科技集团股份有限公司 一种高纯度去甲基氨噻肟酸乙酯的制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660396A (en) * 1970-03-04 1972-05-02 Lilly Co Eli Cephalosporin intermediates and process therefor
GB1399086A (en) 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos
SE428022B (sv) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7beta-amino-cefam-3-on-4-karboxylsyraforeningar till anvendning for framstellning av cefalosporinderivat
AR208068A1 (es) * 1973-02-23 1976-11-30 Lilly Co Eli Un procedimiento para preparar derivados de acidos 7-acilamido-3-halo-cefem-4-carboxilico los esteres y las sales farmaceuticamente aceptables de los mismos
LU71550A1 (de) 1973-12-21 1976-04-13
NZ176206A (en) 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
DK154939C (da) 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
JPS5919114B2 (ja) * 1975-08-25 1984-05-02 武田薬品工業株式会社 セフアロスポリンの製造法
SE440655B (sv) 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
DE2760123C2 (de) 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2408613A2 (fr) * 1977-07-19 1979-06-08 Roussel Uclaf Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2340093A1 (fr) * 1976-02-05 1977-09-02 Roussel Uclaf Derives de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4299829A (en) * 1976-03-12 1981-11-10 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
DK162391C (da) 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
US4304770A (en) * 1976-04-12 1981-12-08 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
FR2361895A1 (fr) * 1976-08-20 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
JPS53103493A (en) 1977-02-18 1978-09-08 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
FR2384779A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-chloro ou 3-methoxy 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
SE439312B (sv) 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2716677C2 (de) 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
FR2410655A1 (fr) 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4284631A (en) 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
US4379922A (en) * 1978-09-12 1983-04-12 Fujisawa Pharmaceutical Co., Ltd. Cepham compounds
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
FR2448543A1 (fr) 1979-02-09 1980-09-05 Roussel Uclaf Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2461713A1 (fr) * 1979-07-19 1981-02-06 Roussel Uclaf Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS56125392A (en) * 1980-03-06 1981-10-01 Fujisawa Pharmaceut Co Ltd Cepham and cephem compound and preparation thereof
JPS6238569A (ja) * 1985-08-13 1987-02-19 Nec Corp 磁気デイスク制御装置
US5059611A (en) * 1988-11-18 1991-10-22 Allergan, Inc. Anti-inflammatory 5-hydroxy-2-furanones

Also Published As

Publication number Publication date
JPS6134435B2 (de) 1986-08-07
ATA181378A (de) 1981-03-15
JPH0720947B2 (ja) 1995-03-08
US4822888A (en) 1989-04-18
SE8304670D0 (sv) 1983-08-29
AR230452A1 (es) 1984-04-30
YU60878A (en) 1983-04-30
ES491184A0 (es) 1981-03-16
PH17188A (en) 1984-06-14
ES8203865A1 (es) 1982-04-01
US4447430A (en) 1984-05-08
FI65779B (fi) 1984-03-30
DK163832C (da) 1992-09-21
US4425341A (en) 1984-01-10
JPS53137988A (en) 1978-12-01
NL182401C (nl) 1988-03-01
DE2810922C2 (de) 1985-08-29
JPH03115256A (ja) 1991-05-16
SE456909B (sv) 1988-11-14
AT364456B (de) 1981-10-27
PT67773A (en) 1978-04-01
CS217961B2 (en) 1983-02-25
CA1321580C (en) 1993-08-24
DD136839A5 (de) 1979-08-01
SE7802933L (sv) 1978-09-15
NZ199860A (en) 1984-07-31
YU42061B (en) 1988-04-30
DK114878A (da) 1978-09-15
ES8101077A1 (es) 1980-12-01
ES491183A0 (es) 1981-03-16
ES487736A0 (es) 1980-11-01
ES487737A0 (es) 1980-12-01
JPH03135973A (ja) 1991-06-10
DD144772A5 (de) 1980-11-05
US4604456A (en) 1986-08-05
FR2383951A1 (fr) 1978-10-13
ES8103751A1 (es) 1981-03-16
AR226423A1 (es) 1982-07-15
NL7802792A (nl) 1978-09-18
BE864810A (fr) 1978-09-13
SE8304671D0 (sv) 1983-08-29
JPH03115288A (ja) 1991-05-16
YU274582A (en) 1983-06-30
JPH0639464B2 (ja) 1994-05-25
ES497084A0 (es) 1982-04-01
YU41586B (en) 1987-10-31
YU274682A (en) 1983-10-31
PH17064A (en) 1984-05-24
ES480598A1 (es) 1980-07-01
JPH052666B2 (de) 1993-01-13
JPH03135971A (ja) 1991-06-10
ES467828A1 (es) 1979-09-01
NL182401B (nl) 1987-10-01
US4294960A (en) 1981-10-13
JPH0517230B2 (de) 1993-03-08
ES8103752A1 (es) 1981-03-16
FI780801A (fi) 1978-09-15
CH637138A5 (de) 1983-07-15
US4460583A (en) 1984-07-17
SE8304670L (sv) 1983-08-29
JPS6434974A (en) 1989-02-06
NZ186679A (en) 1982-12-21
US4563522A (en) 1986-01-07
NL8501475A (nl) 1985-09-02
ES491182A0 (es) 1981-03-16
DK163832B (da) 1992-04-06
DE2810922A1 (de) 1978-09-21
JPH03135972A (ja) 1991-06-10
ES8103753A1 (es) 1981-03-16
SE438677B (sv) 1985-04-29
GR63619B (en) 1979-11-27
ES8100665A1 (es) 1980-11-01
FR2383951B1 (de) 1983-02-11

Similar Documents

Publication Publication Date Title
FI65779C (fi) Foerfarande foer framstaellning av en antimikrobisk cefemfoerening
EP0123024B1 (de) Cephalosporinverbindungen, ihre Herstellung, pharmazeutische Präparate und Eingangsprodukte
EP0001125B1 (de) Cephalosporinderivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate
US4487767A (en) 7-[Amino or carboxy substituted oxyimino]-3-[amino or alkoxy substituted heterocyclic thiomethyl] cephalosporin derivatives
EP0099553B1 (de) Cephem verbindungen, Verfahren sowie Zwischenprodukten zu ihrer Herstellung und diese enthaltende Pharmazeutische Zusammenstellungen
US4427677A (en) Cephem compounds
US4729991A (en) Cephem compounds
US4220761A (en) 7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives
US4698337A (en) Cephem compounds and processes for preparation thereof
GB2025933A (en) >Cephem and cepham compounds
US4427674A (en) Cephem compounds
US4923998A (en) Cephem and cepham compounds and processes for preparation thereof
JPS6361954B2 (de)
GB2033377A (en) New Cephem Compounds and Processes for Preparation Thereof
GB2103205A (en) New cephem compounds
US4399133A (en) Cephem compounds
US4393059A (en) Cephem compounds
EP0335390A2 (de) Cephalosporinverbindungen
US4400379A (en) Cephem compounds
GB2034692A (en) New cephem compounds and processes for preparation thereof
IE46674B1 (en) New cephem and cepham compounds and processes for preparation thereof
US4841062A (en) New cephem and cepham compounds and processes for preparation thereof
KR820000903B1 (ko) 신규의 세펨 및 세팜 화합물의 제조 방법
KR820000905B1 (ko) 신규의 세펨 및 세팜 화합물의 제조방법
HU182650B (en) Process for producing new cepheme- and cephame derivatives

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: FUJISAWA PHARMACEUTICAL CO. LTD.