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DK2655370T3 - Sammensætninger og fremgangsmåder til modulering af FXR-receptorer - Google Patents

Sammensætninger og fremgangsmåder til modulering af FXR-receptorer

Info

Publication number
DK2655370T3
DK2655370T3 DK11796872.7T DK11796872T DK2655370T3 DK 2655370 T3 DK2655370 T3 DK 2655370T3 DK 11796872 T DK11796872 T DK 11796872T DK 2655370 T3 DK2655370 T3 DK 2655370T3
Authority
DK
Denmark
Prior art keywords
compositions
methods
modulating fxr
fxr receptors
receptors
Prior art date
Application number
DK11796872.7T
Other languages
English (en)
Inventor
David C Tully
Paul Vincent Rucker
Phillip B Alper
Daniel Mutnick
Donatella Chianelli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK2655370T3 publication Critical patent/DK2655370T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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  • Diabetes (AREA)
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  • Molecular Biology (AREA)
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DK11796872.7T 2010-12-20 2011-11-30 Sammensætninger og fremgangsmåder til modulering af FXR-receptorer DK2655370T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061425189P 2010-12-20 2010-12-20
US201161554297P 2011-11-01 2011-11-01
PCT/US2011/062724 WO2012087519A1 (en) 2010-12-20 2011-11-30 Compositions and methods for modulating fxr

Publications (1)

Publication Number Publication Date
DK2655370T3 true DK2655370T3 (da) 2017-11-06

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DK11796872.7T DK2655370T3 (da) 2010-12-20 2011-11-30 Sammensætninger og fremgangsmåder til modulering af FXR-receptorer

Country Status (38)

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US (2) US9150568B2 (da)
EP (1) EP2655370B1 (da)
JP (1) JP5740483B2 (da)
KR (1) KR101626046B1 (da)
CN (1) CN103443099B (da)
AP (1) AP3414A (da)
AR (1) AR084425A1 (da)
AU (1) AU2011345233B2 (da)
BR (1) BR112013015452B1 (da)
CA (1) CA2819825C (da)
CL (1) CL2013001677A1 (da)
CO (1) CO6801729A2 (da)
CR (1) CR20130307A (da)
CU (1) CU24152B1 (da)
CY (1) CY1119530T1 (da)
DK (1) DK2655370T3 (da)
EA (1) EA025569B1 (da)
ES (1) ES2645728T3 (da)
GT (1) GT201300159A (da)
HR (1) HRP20171615T1 (da)
HU (1) HUE034150T2 (da)
IL (1) IL226853A (da)
JO (1) JO3297B1 (da)
LT (1) LT2655370T (da)
MA (1) MA34767B1 (da)
MX (1) MX338845B (da)
MY (1) MY163216A (da)
NZ (1) NZ613234A (da)
PE (1) PE20140207A1 (da)
PL (1) PL2655370T3 (da)
PT (1) PT2655370T (da)
RS (1) RS56335B1 (da)
SG (1) SG191046A1 (da)
SI (1) SI2655370T1 (da)
TW (1) TWI427078B (da)
UY (1) UY33815A (da)
WO (1) WO2012087519A1 (da)
ZA (1) ZA201304044B (da)

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CU24152B1 (es) * 2010-12-20 2016-02-29 Irm Llc 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
PE20150400A1 (es) 2012-05-22 2015-03-27 Genentech Inc Benzamidas n-sustituidas y su uso en el tratamiento del dolor
CN103007081B (zh) * 2012-11-27 2013-12-04 鞠法红 一种治疗非酒精性脂肪肝的中药组合物
EP2964230A4 (en) 2013-03-07 2016-10-26 Califia Bio Inc KINASEHEMMER WITH MIXED ABSTRACT AND TREATMENT PROCESS THEREWITH
CU24375B1 (es) * 2013-11-05 2018-12-05 Novartis Ag Derivados de pirazol fusionados activos como moduladores del receptor de farnesoide x
EP3034501A1 (en) 2014-12-17 2016-06-22 Gilead Sciences, Inc. Hydroxy containing FXR (NR1H4) modulating compounds
EP3034499A1 (en) 2014-12-17 2016-06-22 Gilead Sciences, Inc. Novel FXR (NR1H4) modulating compounds
RU2017125365A (ru) * 2014-12-18 2019-01-21 Новартис Аг Производные азабициклооктана в качестве агонистов fxr для применения при лечении заболеваний печени и желудочно-кишечных заболеваний
TWI698430B (zh) 2015-02-13 2020-07-11 南北兄弟藥業投資有限公司 三環化合物及其在藥物中的應用
SG11201707263XA (en) 2015-03-31 2017-10-30 Enanta Pharm Inc Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
CN106146483A (zh) * 2015-04-23 2016-11-23 上海迪诺医药科技有限公司 杂环类法尼酯衍生物x受体调节剂
CN106946867B (zh) * 2016-01-06 2019-11-12 广州市恒诺康医药科技有限公司 Fxr受体调节剂及其制备方法和用途
WO2017133521A1 (zh) * 2016-02-01 2017-08-10 山东轩竹医药科技有限公司 Fxr受体激动剂
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PT3419625T (pt) 2016-02-22 2021-07-07 Novartis Ag Métodos para utilizar agonistas de fxr
PT3419624T (pt) * 2016-02-22 2021-04-07 Novartis Ag Métodos para utilizar agonistas de fxr
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