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DK171454B1 - Fremgangsmåde til fremstilling af tørforarbejdede partikler, således opnåede tørforarbejdede partikler, og præparater indeholdende sådanne partikler - Google Patents

Fremgangsmåde til fremstilling af tørforarbejdede partikler, således opnåede tørforarbejdede partikler, og præparater indeholdende sådanne partikler Download PDF

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Publication number
DK171454B1
DK171454B1 DK054994A DK54994A DK171454B1 DK 171454 B1 DK171454 B1 DK 171454B1 DK 054994 A DK054994 A DK 054994A DK 54994 A DK54994 A DK 54994A DK 171454 B1 DK171454 B1 DK 171454B1
Authority
DK
Denmark
Prior art keywords
biocompatible polymer
stirring
active ingredient
particles
support phase
Prior art date
Application number
DK054994A
Other languages
Danish (da)
English (en)
Other versions
DK54994A (da
Inventor
Jean-Marc Ruiz
Original Assignee
Scras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras filed Critical Scras
Publication of DK54994A publication Critical patent/DK54994A/da
Application granted granted Critical
Publication of DK171454B1 publication Critical patent/DK171454B1/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
DK054994A 1993-05-15 1994-05-13 Fremgangsmåde til fremstilling af tørforarbejdede partikler, således opnåede tørforarbejdede partikler, og præparater indeholdende sådanne partikler DK171454B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939310030A GB9310030D0 (en) 1993-05-15 1993-05-15 Dry processed particles and process for the preparation of the same
GB9310030 1993-05-15

Publications (2)

Publication Number Publication Date
DK54994A DK54994A (da) 1994-11-16
DK171454B1 true DK171454B1 (da) 1996-11-04

Family

ID=10735537

Family Applications (1)

Application Number Title Priority Date Filing Date
DK054994A DK171454B1 (da) 1993-05-15 1994-05-13 Fremgangsmåde til fremstilling af tørforarbejdede partikler, således opnåede tørforarbejdede partikler, og præparater indeholdende sådanne partikler

Country Status (35)

Country Link
JP (1) JP3139913B2 (hu)
KR (1) KR100341261B1 (hu)
CN (1) CN1050534C (hu)
AT (1) AT406017B (hu)
AU (1) AU685094B2 (hu)
BE (1) BE1008323A3 (hu)
BR (1) BR9401968A (hu)
CA (1) CA2123481C (hu)
CH (1) CH688572A5 (hu)
DE (1) DE4416812C2 (hu)
DK (1) DK171454B1 (hu)
DZ (1) DZ1779A1 (hu)
ES (1) ES2097083B1 (hu)
FI (1) FI112915B (hu)
FR (1) FR2705232B1 (hu)
GB (2) GB9310030D0 (hu)
GR (1) GR1002034B (hu)
HK (1) HK1002831A1 (hu)
HU (1) HU220617B1 (hu)
IE (1) IE940392A1 (hu)
IN (1) IN182330B (hu)
IT (1) IT1269508B (hu)
LU (1) LU88482A1 (hu)
MA (1) MA23194A1 (hu)
NL (1) NL9400795A (hu)
NO (1) NO307403B1 (hu)
NZ (1) NZ260520A (hu)
OA (1) OA09939A (hu)
PL (1) PL175780B1 (hu)
PT (1) PT101518B (hu)
RU (1) RU2125869C1 (hu)
SE (1) SE519004C2 (hu)
SG (1) SG46631A1 (hu)
TN (1) TNSN94046A1 (hu)
ZA (1) ZA943316B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1203591B1 (en) * 1993-01-06 2007-12-19 Ipsen Manufacturing Ireland Limited biodegradable polyesters for forming ionic molecular conjugates with bioactive polypeptides
ES2196023T3 (es) * 1993-01-06 2003-12-16 Kinerton Ltd Conjugados moleculares ionicos de poliesteres biodegradables y polipeptidos bioactivos.
DE19604744A1 (de) 1996-02-09 1997-08-14 Henkel Kgaa Technische Di-/Triglyceridgemische
IE960308A1 (en) 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
DE19617137C1 (de) * 1996-04-29 1997-02-27 Henkel Kgaa Verwendung von Copolymerestern für die Herstellung von Mikrosphären
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US6867181B1 (en) 1997-06-02 2005-03-15 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
AU1375301A (en) 1999-11-15 2001-05-30 Bio Syntech Canada Inc Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
US6646083B2 (en) 2000-06-16 2003-11-11 Nippon Shokubai Co., Ltd. Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CH672887A5 (hu) * 1987-10-14 1990-01-15 Debiopharm Sa
AU2810189A (en) * 1987-10-30 1989-05-23 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
DE3916020C2 (de) * 1989-05-17 1994-06-01 Burkhard Dr Wichert Retardierende Mikropartikel aus bioabbaubaren Polyestern; Verfahren zu deren Herstellung unter Verzicht auf toxische Lösungsmittel und diese Mikropartikel enthaltende pharmazentische Zubereitungen
KR0168849B1 (ko) * 1990-04-12 1999-01-15 요시또시 가즈오 피목 조성물 및 그의 제조방법
JP3116311B2 (ja) * 1990-06-13 2000-12-11 エーザイ株式会社 マイクロスフィアの製法
GB2246514B (en) * 1990-08-01 1993-12-15 Scras Sustained release pharmaceutical compositions and the preparation of particles for use therein
GB9016885D0 (en) * 1990-08-01 1990-09-12 Scras Sustained release pharmaceutical compositions
SE9003296L (sv) * 1990-10-16 1992-04-17 Kabi Pharmacia Ab Foerfarande foer att formulera laekemedel
CA2055522A1 (en) * 1990-12-12 1992-06-13 Masako Andoh Microspheres for ophthalmic use
SE467815B (sv) * 1991-05-27 1992-09-21 Bengt Hjalmar Aagerup Med Firm Metod foer att framstaella reproducerbara partiklar av definierad storlek
GB9203689D0 (en) * 1992-02-20 1992-04-08 Euro Celtique Sa Pharmaceutical composition
AU668384B2 (en) * 1992-03-12 1996-05-02 Alkermes Controlled Therapeutics, Inc. Controlled release ACTH containing microspheres
SE9200858L (sv) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
ES2181691T5 (es) * 1992-06-11 2007-10-01 Alkermes Controlled Therapeutics, Inc. Sistema de distribucion de proteina eritropoyetina.
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
GB2273874A (en) * 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix

Also Published As

Publication number Publication date
JPH072652A (ja) 1995-01-06
KR100341261B1 (ko) 2002-09-27
DE4416812A1 (de) 1994-11-17
CN1104557A (zh) 1995-07-05
HK1002831A1 (en) 1998-09-18
RU2125869C1 (ru) 1999-02-10
FI942222A0 (fi) 1994-05-13
SG46631A1 (en) 1998-02-20
NO307403B1 (no) 2000-04-03
OA09939A (fr) 1994-11-15
CH688572A5 (fr) 1997-11-28
MA23194A1 (fr) 1994-12-31
ITMI940931A0 (it) 1994-05-11
AU6308494A (en) 1994-11-17
SE519004C2 (sv) 2002-12-17
ITMI940931A1 (it) 1995-11-11
SE9401557L (sv) 1994-11-16
DK54994A (da) 1994-11-16
AU685094B2 (en) 1998-01-15
CA2123481C (en) 2005-01-11
HUT67599A (en) 1995-04-28
AT406017B (de) 2000-01-25
ES2097083B1 (es) 1997-12-01
FI112915B (fi) 2004-02-13
SE9401557D0 (sv) 1994-05-05
IE940392A1 (en) 1994-11-16
GB9310030D0 (en) 1993-06-30
NL9400795A (nl) 1994-12-01
CN1050534C (zh) 2000-03-22
IN182330B (hu) 1999-03-20
FR2705232B1 (fr) 1995-08-25
PT101518B (pt) 2000-12-29
HU9401412D0 (en) 1994-08-29
NO941810L (no) 1994-11-16
JP3139913B2 (ja) 2001-03-05
HU220617B1 (hu) 2002-03-28
CA2123481A1 (en) 1994-11-16
DE4416812C2 (de) 2003-02-06
FR2705232A1 (fr) 1994-11-25
BE1008323A3 (fr) 1996-04-02
NZ260520A (en) 1994-12-22
GR1002034B (en) 1995-10-31
PT101518A (pt) 1995-03-01
TNSN94046A1 (fr) 1995-04-25
PL175780B1 (pl) 1999-02-26
NO941810D0 (no) 1994-05-13
ZA943316B (en) 1995-01-16
BR9401968A (pt) 1994-12-13
IT1269508B (it) 1997-04-01
ATA98794A (de) 1999-06-15
GB2277915B (en) 1997-10-29
ES2097083A1 (es) 1997-03-16
GB9409565D0 (en) 1994-07-06
DZ1779A1 (fr) 2002-02-17
FI942222A (fi) 1994-11-16
LU88482A1 (fr) 1994-12-01
GB2277915A (en) 1994-11-16

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