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BRPI0207566B8 - processo para preparação de (e)-5-(2-bromovinil)-2'-desoxiuridina - Google Patents

processo para preparação de (e)-5-(2-bromovinil)-2'-desoxiuridina

Info

Publication number
BRPI0207566B8
BRPI0207566B8 BRPI0207566A BRPI0207566B8 BR PI0207566 B8 BRPI0207566 B8 BR PI0207566B8 BR PI0207566 A BRPI0207566 A BR PI0207566A BR PI0207566 B8 BRPI0207566 B8 BR PI0207566B8
Authority
BR
Brazil
Prior art keywords
deoxyuridine
bromovinyl
preparing
solvents
brivudine
Prior art date
Application number
Other languages
English (en)
Inventor
Salimbeni Aldo
Alberto Maggi Carlo
Turozzi Damiano
Manzini Stefano
Original Assignee
Berlin Chemie Ag
Menarini Ricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7675814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0207566(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Berlin Chemie Ag, Menarini Ricerche Spa filed Critical Berlin Chemie Ag
Publication of BR0207566A publication Critical patent/BR0207566A/pt
Publication of BRPI0207566B1 publication Critical patent/BRPI0207566B1/pt
Publication of BRPI0207566B8 publication Critical patent/BRPI0207566B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

processo para preparação de (e)-5-(2-bromovinil)-2'-desoxiuridina. a presente invenção refere-se à preparação de (e)-5-(2- bromovinil)-2'-desoxiuridina (brivudina), caracterizado pelo fato de que solventes isentos de halogênio, são selecionados de ésteres ou éteres cíclicos, são usados na etapa de bromação de diacilato de 5-etil-2'-desoxiuridina. o uso dos ditos solventes é vantajoso com relação à toxicidade, custos de descarga e proteção ambiental.
BR0207566-0 2001-02-28 2002-02-21 processo para preparação de (e)-5-(2-bromovinil)-2'-desoxiuridina BRPI0207566B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10109657A DE10109657A1 (de) 2001-02-28 2001-02-28 Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin
DE10109657.7 2001-02-28
PCT/EP2002/001833 WO2002068443A1 (en) 2001-02-28 2002-02-21 Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine

Publications (3)

Publication Number Publication Date
BR0207566A BR0207566A (pt) 2004-09-14
BRPI0207566B1 BRPI0207566B1 (pt) 2019-04-24
BRPI0207566B8 true BRPI0207566B8 (pt) 2021-05-25

Family

ID=7675814

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0207566-0 BRPI0207566B8 (pt) 2001-02-28 2002-02-21 processo para preparação de (e)-5-(2-bromovinil)-2'-desoxiuridina

Country Status (32)

Country Link
US (1) US6864366B2 (pt)
EP (1) EP1363928B1 (pt)
JP (1) JP2004521132A (pt)
KR (1) KR100853280B1 (pt)
CN (1) CN1219789C (pt)
AR (1) AR032908A1 (pt)
AT (1) ATE294810T1 (pt)
BG (1) BG66333B1 (pt)
BR (1) BRPI0207566B8 (pt)
CA (1) CA2439319C (pt)
CZ (1) CZ299318B6 (pt)
DE (2) DE10109657A1 (pt)
DK (1) DK1363928T3 (pt)
EA (1) EA006156B1 (pt)
EE (1) EE05249B1 (pt)
ES (1) ES2239713T3 (pt)
HK (1) HK1060134A1 (pt)
HR (1) HRP20030671B1 (pt)
HU (1) HU229136B1 (pt)
IL (2) IL157573A0 (pt)
MA (1) MA26267A1 (pt)
MX (1) MXPA03007624A (pt)
MY (1) MY133371A (pt)
PE (1) PE20020892A1 (pt)
PL (1) PL210150B1 (pt)
PT (1) PT1363928E (pt)
RS (1) RS50761B (pt)
SK (1) SK287283B6 (pt)
TN (1) TNSN03049A1 (pt)
UA (1) UA75110C2 (pt)
WO (1) WO2002068443A1 (pt)
ZA (1) ZA200306639B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101066987B (zh) * 2007-06-14 2010-05-19 上海交通大学 溴呋啶的制备方法
EP2681227B1 (en) 2011-03-01 2016-02-10 Nucana Biomed Limited Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN115043894A (zh) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 一种溴夫定起始物料异构体单晶及其制备方法和应用
KR20240086637A (ko) 2022-12-10 2024-06-18 (주)일승 Ptc 히터

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB215399A (en) * 1922-11-07 1924-05-07 Frederic Valerius Hetzel Improvements in sprocket-wheels
GB1601020A (en) 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
HU187736B (en) * 1982-08-04 1986-02-28 Mta Koezponti Kemiai Kutato Intezet,Hu Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives
EP0512953B1 (de) * 1991-05-06 1995-06-07 Ciba-Geigy Ag Verfahren zur Herstellung von Benzolsulfonamiden

Also Published As

Publication number Publication date
ATE294810T1 (de) 2005-05-15
PE20020892A1 (es) 2002-12-26
CN1219789C (zh) 2005-09-21
JP2004521132A (ja) 2004-07-15
EP1363928A1 (en) 2003-11-26
TNSN03049A1 (en) 2005-12-23
PT1363928E (pt) 2005-07-29
US6864366B2 (en) 2005-03-08
US20040077586A1 (en) 2004-04-22
KR20030081465A (ko) 2003-10-17
MA26267A1 (fr) 2004-09-01
SK10642003A3 (sk) 2004-01-08
UA75110C2 (en) 2006-03-15
SK287283B6 (sk) 2010-05-07
CZ299318B6 (cs) 2008-06-18
MXPA03007624A (es) 2003-12-04
DK1363928T3 (da) 2005-12-12
RS50761B (sr) 2010-08-31
BG108129A (bg) 2004-12-30
ZA200306639B (en) 2004-08-26
ES2239713T3 (es) 2005-10-01
CA2439319A1 (en) 2002-09-06
HRP20030671B1 (en) 2011-11-30
PL210150B1 (pl) 2011-12-30
IL157573A0 (en) 2004-03-28
EA200300761A1 (ru) 2004-02-26
CA2439319C (en) 2010-10-19
HK1060134A1 (en) 2004-07-30
BRPI0207566B1 (pt) 2019-04-24
HUP0303323A3 (en) 2008-12-29
HU229136B1 (en) 2013-08-28
CZ20032295A3 (cs) 2004-01-14
IL157573A (en) 2009-09-22
EA006156B1 (ru) 2005-10-27
EE200300402A (et) 2003-12-15
WO2002068443A1 (en) 2002-09-06
EE05249B1 (et) 2009-12-15
HRP20030671A2 (en) 2005-06-30
EP1363928B1 (en) 2005-05-04
DE60203998D1 (de) 2005-06-09
YU67103A (sh) 2006-05-25
HUP0303323A2 (hu) 2004-01-28
PL363611A1 (en) 2004-11-29
BR0207566A (pt) 2004-09-14
AR032908A1 (es) 2003-12-03
DE10109657A1 (de) 2002-09-05
DE60203998T2 (de) 2005-09-22
CN1494550A (zh) 2004-05-05
BG66333B1 (bg) 2013-06-28
MY133371A (en) 2007-11-30
KR100853280B1 (ko) 2008-08-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2710 DE 13-12-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.