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BR112016016400A2 - Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos - Google Patents

Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos

Info

Publication number
BR112016016400A2
BR112016016400A2 BR112016016400A BR112016016400A BR112016016400A2 BR 112016016400 A2 BR112016016400 A2 BR 112016016400A2 BR 112016016400 A BR112016016400 A BR 112016016400A BR 112016016400 A BR112016016400 A BR 112016016400A BR 112016016400 A2 BR112016016400 A2 BR 112016016400A2
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BR
Brazil
Prior art keywords
chirally controlled
compositions
methods
pharmaceutical composition
controlled oligonucleotides
Prior art date
Application number
BR112016016400A
Other languages
English (en)
Inventor
Meena
Butler David
Iwamoto Naoki
Svrzikapa Nenad
L Verdine Gregory
Zlatev Ivan
Original Assignee
Wave Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wave Life Sciences Ltd filed Critical Wave Life Sciences Ltd
Publication of BR112016016400A2 publication Critical patent/BR112016016400A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Window Of Vehicle (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

COMPOSIÇÕES DE OLIGONUCLEOTÍDEOS QUIRALMENTE CONTROLADOS, SEU USO, SUA COMPOSIÇÃO FARMACÊUTICA, E MÉTODOS. A presente invenção está relacionada aos oligonucleotídeos quiralmente controlados de designs selecionados, composições de oligonucleotídeos quiralmente controlados, e métodos de sua produção e utilização. Em algumas modalidades, uma composição de oligonucleotídeos quiralmente controlados fornecida fornece padrões de clivagem diferentes de um polímero de ácido nucléico em relação a uma composição de oligonucleotídeos de referência. Em algumas modalidades, uma composição de oligonucleotídeos quiralmente controlados fornecida gera a clivagem em sítio único dentro de uma sequência complementar de um polímero de ácido nucléico.
BR112016016400A 2014-01-16 2015-01-16 Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos BR112016016400A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461928405P 2014-01-16 2014-01-16
US201462063359P 2014-10-13 2014-10-13
PCT/IB2015/000395 WO2015107425A2 (en) 2014-01-16 2015-01-16 Chiral design

Publications (1)

Publication Number Publication Date
BR112016016400A2 true BR112016016400A2 (pt) 2017-10-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016016400A BR112016016400A2 (pt) 2014-01-16 2015-01-16 Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos

Country Status (19)

Country Link
US (3) US10160969B2 (pt)
EP (2) EP4137572A1 (pt)
JP (4) JP6382344B2 (pt)
KR (3) KR102423317B1 (pt)
CN (2) CN106068325B (pt)
AU (3) AU2015207773B2 (pt)
BR (1) BR112016016400A2 (pt)
CA (1) CA2936712A1 (pt)
CL (1) CL2016001814A1 (pt)
DK (1) DK3094728T3 (pt)
ES (1) ES2917473T3 (pt)
IL (1) IL246703A0 (pt)
MX (1) MX2016009290A (pt)
MY (1) MY193116A (pt)
PL (1) PL3094728T3 (pt)
PT (1) PT3094728T (pt)
RU (1) RU2016133035A (pt)
SG (2) SG10201912897UA (pt)
WO (1) WO2015107425A2 (pt)

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]