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MX2016007541A - Moléculas modificadas de ácido nucleico y usos de las mismas. - Google Patents

Moléculas modificadas de ácido nucleico y usos de las mismas.

Info

Publication number
MX2016007541A
MX2016007541A MX2016007541A MX2016007541A MX2016007541A MX 2016007541 A MX2016007541 A MX 2016007541A MX 2016007541 A MX2016007541 A MX 2016007541A MX 2016007541 A MX2016007541 A MX 2016007541A MX 2016007541 A MX2016007541 A MX 2016007541A
Authority
MX
Mexico
Prior art keywords
nucleic acid
acid molecules
modified nucleic
nucleotides
methods
Prior art date
Application number
MX2016007541A
Other languages
English (en)
Inventor
De Fougerolles Antonin
Roy Atanu
R Conlee Christopher
w fraley Andrew
Original Assignee
Moderna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Moderna Therapeutics Inc filed Critical Moderna Therapeutics Inc
Publication of MX2016007541A publication Critical patent/MX2016007541A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7115Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona nucleósidos, nucleótidos, y ácidos nucleicos modificados, y métodos para usarlos.
MX2016007541A 2013-12-13 2014-12-15 Moléculas modificadas de ácido nucleico y usos de las mismas. MX2016007541A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361916052P 2013-12-13 2013-12-13
PCT/US2014/070413 WO2015089511A2 (en) 2013-12-13 2014-12-15 Modified nucleic acid molecules and uses thereof

Publications (1)

Publication Number Publication Date
MX2016007541A true MX2016007541A (es) 2016-12-08

Family

ID=51032941

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007541A MX2016007541A (es) 2013-12-13 2014-12-15 Moléculas modificadas de ácido nucleico y usos de las mismas.

Country Status (7)

Country Link
US (2) US20150167017A1 (es)
EP (3) EP3053585A1 (es)
JP (1) JP2017500034A (es)
CN (1) CN106170553A (es)
CA (1) CA2933568A1 (es)
MX (1) MX2016007541A (es)
WO (1) WO2015089511A2 (es)

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Publication number Publication date
EP2918275B1 (en) 2016-05-18
WO2015089511A3 (en) 2015-11-05
EP3080289A2 (en) 2016-10-19
EP3080289A4 (en) 2017-11-15
CA2933568A1 (en) 2015-06-18
EP3053585A1 (en) 2016-08-10
CN106170553A (zh) 2016-11-30
EP2918275A1 (en) 2015-09-16
US20150167017A1 (en) 2015-06-18
JP2017500034A (ja) 2017-01-05
WO2015089511A2 (en) 2015-06-18
US20160304552A1 (en) 2016-10-20

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