Nothing Special   »   [go: up one dir, main page]

NL300150I2 - 4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten. - Google Patents

4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.

Info

Publication number
NL300150I2
NL300150I2 NL300150C NL300150C NL300150I2 NL 300150 I2 NL300150 I2 NL 300150I2 NL 300150 C NL300150 C NL 300150C NL 300150 C NL300150 C NL 300150C NL 300150 I2 NL300150 I2 NL 300150I2
Authority
NL
Netherlands
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
NL300150C
Other languages
English (en)
Other versions
NL300150I1 (nl
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300150(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL300150I1 publication Critical patent/NL300150I1/nl
Publication of NL300150I2 publication Critical patent/NL300150I2/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NL300150C 1997-06-11 2004-05-10 4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten. NL300150I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (2)

Publication Number Publication Date
NL300150I1 NL300150I1 (nl) 2004-08-02
NL300150I2 true NL300150I2 (nl) 2004-09-01

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300150C NL300150I2 (nl) 1997-06-11 2004-05-10 4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.

Country Status (50)

Country Link
US (4) US6420536B1 (nl)
EP (1) EP0988310B9 (nl)
JP (2) JP3315704B2 (nl)
KR (1) KR100396168B1 (nl)
CN (4) CN101691390A (nl)
AP (1) AP1231A (nl)
AR (1) AR013086A1 (nl)
AT (1) ATE251173T1 (nl)
AU (1) AU749816B2 (nl)
BG (1) BG64391B1 (nl)
BR (1) BRPI9810519B8 (nl)
CA (1) CA2293823C (nl)
CO (1) CO4950611A1 (nl)
CZ (1) CZ298556B6 (nl)
DE (2) DE69818665T2 (nl)
DK (1) DK0988310T3 (nl)
DZ (1) DZ2514A1 (nl)
EA (1) EA002441B1 (nl)
EG (1) EG24081A (nl)
ES (1) ES2205487T3 (nl)
FR (1) FR04C0013I2 (nl)
GT (1) GT199800077A (nl)
HK (3) HK1028048A1 (nl)
HN (1) HN1998000086A (nl)
HR (1) HRP980314B1 (nl)
HU (2) HU228005B1 (nl)
ID (1) ID22992A (nl)
IL (1) IL132809A0 (nl)
IS (1) IS1998B (nl)
LU (1) LU91076I9 (nl)
MA (1) MA24564A1 (nl)
ME (1) ME00876B (nl)
MY (1) MY123354A (nl)
NL (1) NL300150I2 (nl)
NO (1) NO316911B1 (nl)
NZ (2) NZ514871A (nl)
OA (1) OA11224A (nl)
PA (1) PA8452201A1 (nl)
PE (1) PE79699A1 (nl)
PL (1) PL191601B1 (nl)
PT (1) PT988310E (nl)
RS (1) RS49675B (nl)
SI (1) SI0988310T1 (nl)
SK (1) SK284171B6 (nl)
TN (1) TNSN98082A1 (nl)
TW (1) TW472060B (nl)
UA (1) UA67744C2 (nl)
UY (1) UY25040A1 (nl)
WO (1) WO1998056802A1 (nl)
ZA (1) ZA985017B (nl)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
JP3897983B2 (ja) * 1999-05-18 2007-03-28 ファイザー・プロダクツ・インク マクロライド系抗生物質の新規結晶
BR0010938A (pt) * 1999-05-24 2002-03-19 Pfizer Prod Inc Derivados da 13-metil eritromicina
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
AU6748500A (en) * 1999-08-24 2001-03-19 Abbott Laboratories 9a-azalides with antibacterial activity
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
ATE243703T1 (de) * 2000-01-27 2003-07-15 Pfizer Prod Inc Antibiotische azalid-zusammensetzungen
AP2002002652A0 (en) * 2000-04-27 2002-12-31 Pfizer Prod Inc The use of azalide antibiotic composition for treating or preventing a bacterial or protozoal infection in mammals.
RU2263117C2 (ru) * 2001-04-27 2005-10-27 Пфайзер Продактс Инк. Способ получения 4"-замещенных производных 9-деоксо-9а-аза-9а-гомоэритромицина а
AU2002317415A1 (en) * 2001-08-01 2003-02-17 Pfizer Products Inc. Azalide antibiotic compositions
WO2004080391A2 (en) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
EP1689434A1 (en) * 2003-11-21 2006-08-16 Pfizer Products Inc. The use of anti biotics as vaccine adjuvants
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
ES2326002T3 (es) * 2005-01-14 2009-09-28 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoil y tiocarbamoil azalidos con actividad antipaludica.
US9453042B2 (en) 2007-10-25 2016-09-27 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
SI2358379T1 (sl) * 2008-10-24 2016-05-31 Cempra Pharmaceuticals, Inc. Postopki biološke obrambe z makrolidi, ki vsebujejo triazol
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
EP2550286B1 (en) 2010-03-22 2015-12-09 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2012038372A1 (en) 2010-09-20 2012-03-29 Novartis Ag Novel process for the preparation of 9-deoxo-9a-aza- 9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
AU2011313862A1 (en) * 2010-10-10 2013-05-30 Synovo Gmbh Anti-inflammatory macrolides
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ,インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普(天津)生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4512982A (en) 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5226958A (en) * 1991-04-11 1993-07-13 Pacemark, Inc. Sealant for pneumatic inner tubes and tubeless tires
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
HRP980314B1 (en) 2004-04-30
AU7347598A (en) 1998-12-30
ES2205487T3 (es) 2004-05-01
NO996106L (no) 2000-02-10
JP2002316933A (ja) 2002-10-31
IS1998B (is) 2005-03-15
HK1068893A1 (en) 2005-07-29
US20040180842A1 (en) 2004-09-16
CZ442199A3 (cs) 2000-07-12
BG103945A (en) 2000-07-31
YU58699A (nl) 2002-08-12
PE79699A1 (es) 1999-08-25
NZ500660A (en) 2002-03-01
CZ298556B6 (cs) 2007-11-07
CN1259136A (zh) 2000-07-05
BG64391B1 (bg) 2004-12-30
KR100396168B1 (ko) 2003-08-27
NZ514871A (en) 2003-08-29
DE122004000018I1 (de) 2004-09-30
IS5252A (is) 1999-11-16
CN1566129A (zh) 2005-01-19
EP0988310B1 (en) 2003-10-01
EA199901015A1 (ru) 2000-06-26
CA2293823C (en) 2004-02-17
SI0988310T1 (en) 2004-02-29
FR04C0013I2 (nl) 2005-10-21
US6777393B2 (en) 2004-08-17
EG24081A (en) 2008-05-11
ATE251173T1 (de) 2003-10-15
AP9801255A0 (en) 1998-06-30
HUS1200028I1 (hu) 2016-08-29
NO996106D0 (no) 1999-12-10
AU749816B2 (en) 2002-07-04
BRPI9810519B1 (pt) 2012-02-22
CO4950611A1 (es) 2000-09-01
AR013086A1 (es) 2000-12-13
IL132809A0 (en) 2001-03-19
CN101691390A (zh) 2010-04-07
NL300150I1 (nl) 2004-08-02
CN1793155B (zh) 2010-05-12
UY25040A1 (es) 2000-09-29
FR04C0013I1 (nl) 2004-06-11
RS49675B (sr) 2007-11-15
BRPI9810519B8 (pt) 2022-11-16
MA24564A1 (fr) 1998-12-31
HUP0002209A2 (hu) 2000-12-28
CN1793155A (zh) 2006-06-28
US20020061858A1 (en) 2002-05-23
LU91076I2 (fr) 2004-07-05
ID22992A (id) 1999-12-23
DE122004000018I2 (de) 2011-01-13
EA002441B1 (ru) 2002-04-25
PL337505A1 (en) 2000-08-28
MY123354A (en) 2006-05-31
ME00876B (me) 2012-06-20
SK284171B6 (sk) 2004-10-05
KR20010013632A (ko) 2001-02-26
DE69818665D1 (de) 2003-11-06
BRPI9810519A (pt) 2000-09-19
OA11224A (en) 2003-07-16
PA8452201A1 (es) 2000-05-24
HK1088014A1 (en) 2006-10-27
EP0988310B9 (en) 2006-03-08
HRP980314A2 (en) 1999-04-30
PT988310E (pt) 2003-12-31
DK0988310T3 (da) 2003-12-15
GT199800077A (es) 1999-12-02
JP3315704B2 (ja) 2002-08-19
US6420536B1 (en) 2002-07-16
HN1998000086A (es) 1999-03-08
WO1998056802A1 (en) 1998-12-17
CN1172947C (zh) 2004-10-27
LU91076I9 (en) 2018-07-02
NO316911B1 (no) 2004-06-21
CN1243766C (zh) 2006-03-01
JP2000514098A (ja) 2000-10-24
HU228005B1 (en) 2012-08-28
US6936592B2 (en) 2005-08-30
HUP0002209A3 (en) 2003-05-28
SK168399A3 (en) 2000-11-07
CA2293823A1 (en) 1998-12-17
EP0988310A1 (en) 2000-03-29
DE69818665T2 (de) 2004-04-29
DZ2514A1 (fr) 2003-02-01
UA67744C2 (uk) 2004-07-15
PL191601B1 (pl) 2006-06-30
HK1028048A1 (en) 2001-02-02
TW472060B (en) 2002-01-11
US20040023896A1 (en) 2004-02-05
AP1231A (en) 2003-12-11
ZA985017B (en) 1999-12-17
TNSN98082A1 (fr) 2005-03-15

Similar Documents

Publication Publication Date Title
NL300150I1 (nl) 4"-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.
NO2006016I1 (no) 7,8,9,10-tetrahydro-6H-6,10-metanoazepinoÄ4,5-gÜkinoksalintartrat
PT993456E (pt) 4,5-diaril-imidazoles 2-substituidos
DE69736711D1 (de) Substituierte 6,5-heterobicyclische-derivate
DK0925298T3 (da) Substituerede 6,6-heterobicykliske derivater
DK1000048T3 (da) Substituerede 1,2,3,4-tetrahydronapthalenderivater
PT901474E (pt) Derivados de aril-pirimidina.
ATE435861T1 (de) 12,13-cyclopropan-epothilonderivate
DE69718771D1 (de) Substituierte 1,2,3,4-tetrahydronaphthalinderivate
ATE257484T1 (de) 6,9-verbrückte erythromycin-derivate
TR199800988A3 (tr) 5' Deoksi-Sitidin türevleri.
ID21413A (id) Turunan-turunan 1,3,8,-triaza-spiro (4,5) dekan-4-on
ATE246199T1 (de) 3-descladinose-2,3-anhydroerythromycin-derivate
ATE239750T1 (de) 6,11-verbrückte erythromycinderivate
ATE227282T1 (de) 2,4-diaminopyrimidin-derivate
EE200000447A (et) 1,3,4-oksadiasolooni derivaadid
DE69714358D1 (de) 9,10-disubstituierte campothecinderivate mit antitumoraktivität
DK1068200T3 (da) 2,4,4-trisubstituerede-1,3-dioxolanfungicider
ID24047A (id) Turunan 5-tersubstitusi-3-oksaziazolil 1,6-naftiridin-2 1h-on
TR28915A (tr) Naftokinon türevleri.
DE69722064D1 (de) 1,25-Dihydroxy-16,22,23-trisdehydro-Cholecalciferol-Derivate
ES1038172Y (es) "caja-contenedor".
TR199700927A3 (tr) N-Benzilazolyum türevleri.
ES1038075Y (es) "capa-chubasquero ampliable".
IT1283187B1 (it) "elettrovalvola."