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NL300150I2 - 4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten. - Google Patents

4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.

Info

Publication number
NL300150I2
NL300150I2 NL300150C NL300150C NL300150I2 NL 300150 I2 NL300150 I2 NL 300150I2 NL 300150 C NL300150 C NL 300150C NL 300150 C NL300150 C NL 300150C NL 300150 I2 NL300150 I2 NL 300150I2
Authority
NL
Netherlands
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
NL300150C
Other languages
English (en)
Other versions
NL300150I1 (nl
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300150(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL300150I1 publication Critical patent/NL300150I1/nl
Publication of NL300150I2 publication Critical patent/NL300150I2/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NL300150C 1997-06-11 2004-05-10 4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten. NL300150I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (2)

Publication Number Publication Date
NL300150I1 NL300150I1 (nl) 2004-08-02
NL300150I2 true NL300150I2 (nl) 2004-09-01

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300150C NL300150I2 (nl) 1997-06-11 2004-05-10 4 "-Gesubstitueerde 9-deoxo-9A-AZA-9A-homoërythromycine-A-derivaten.

Country Status (50)

Country Link
US (4) US6420536B1 (nl)
EP (1) EP0988310B9 (nl)
JP (2) JP3315704B2 (nl)
KR (1) KR100396168B1 (nl)
CN (4) CN1793155B (nl)
AP (1) AP1231A (nl)
AR (1) AR013086A1 (nl)
AT (1) ATE251173T1 (nl)
AU (1) AU749816B2 (nl)
BG (1) BG64391B1 (nl)
BR (1) BRPI9810519B8 (nl)
CA (1) CA2293823C (nl)
CO (1) CO4950611A1 (nl)
CZ (1) CZ298556B6 (nl)
DE (2) DE122004000018I2 (nl)
DK (1) DK0988310T3 (nl)
DZ (1) DZ2514A1 (nl)
EA (1) EA002441B1 (nl)
EG (1) EG24081A (nl)
ES (1) ES2205487T3 (nl)
FR (1) FR04C0013I2 (nl)
GT (1) GT199800077A (nl)
HK (3) HK1028048A1 (nl)
HN (1) HN1998000086A (nl)
HR (1) HRP980314B1 (nl)
HU (2) HU228005B1 (nl)
ID (1) ID22992A (nl)
IL (1) IL132809A0 (nl)
IS (1) IS1998B (nl)
LU (1) LU91076I9 (nl)
MA (1) MA24564A1 (nl)
ME (1) ME00876B (nl)
MY (1) MY123354A (nl)
NL (1) NL300150I2 (nl)
NO (1) NO316911B1 (nl)
NZ (2) NZ500660A (nl)
OA (1) OA11224A (nl)
PA (1) PA8452201A1 (nl)
PE (1) PE79699A1 (nl)
PL (1) PL191601B1 (nl)
PT (1) PT988310E (nl)
RS (1) RS49675B (nl)
SI (1) SI0988310T1 (nl)
SK (1) SK284171B6 (nl)
TN (1) TNSN98082A1 (nl)
TW (1) TW472060B (nl)
UA (1) UA67744C2 (nl)
UY (1) UY25040A1 (nl)
WO (1) WO1998056802A1 (nl)
ZA (1) ZA985017B (nl)

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US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
JP2001515865A (ja) * 1997-09-10 2001-09-25 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての9a−アザライド
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
SK16472001A3 (sk) * 1999-05-18 2003-02-04 Pfizer Products Inc. Kryštalické formy makrolidového antibiotika
EP1180110A1 (en) * 1999-05-24 2002-02-20 Pfizer Products Inc. 13-methyl-erythromycin derivatives
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
WO2001014397A1 (en) * 1999-08-24 2001-03-01 Abbott Laboratories 9a-azalides with antibacterial activity
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
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AP2002002652A0 (en) * 2000-04-27 2002-12-31 Pfizer Prod Inc The use of azalide antibiotic composition for treating or preventing a bacterial or protozoal infection in mammals.
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
WO2003011266A2 (en) * 2001-08-01 2003-02-13 Pfizer Products Inc. Azalide antibiotic compositions
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
EP1689434A1 (en) * 2003-11-21 2006-08-16 Pfizer Products Inc. The use of anti biotics as vaccine adjuvants
ES2387881T3 (es) * 2004-03-16 2012-10-03 Boehringer Ingelheim International Gmbh Derivados de benceno sustituidos por glucopiranosilo, medicamentos que contienen estos compuestos, su uso y procedimiento para su preparación
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
ES2326002T3 (es) * 2005-01-14 2009-09-28 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoil y tiocarbamoil azalidos con actividad antipaludica.
JP5698979B2 (ja) * 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ,インコーポレイテッド マクロライド系抗菌剤の調製プロセス
ES2565083T3 (es) * 2008-10-24 2016-03-31 Cempra Pharmaceuticals, Inc. Biodefensas usando macrólidos que contienen triazol
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
BR112012023950A2 (pt) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc formas cristalinas de um macrolídeo, e usos dos mesmos
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ,インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
WO2012038372A1 (en) 2010-09-20 2012-03-29 Novartis Ag Novel process for the preparation of 9-deoxo-9a-aza- 9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
AU2011313862A1 (en) * 2010-10-10 2013-05-30 Synovo Gmbh Anti-inflammatory macrolides
WO2013004116A1 (zh) * 2011-07-06 2013-01-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ,インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法
WO2015014907A1 (en) * 2013-07-31 2015-02-05 Farma Grs, D.O.O. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普(天津)生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
US6420536B1 (en) 2002-07-16
OA11224A (en) 2003-07-16
DE69818665D1 (de) 2003-11-06
DE122004000018I2 (de) 2011-01-13
HU228005B1 (en) 2012-08-28
HK1088014A1 (en) 2006-10-27
NZ514871A (en) 2003-08-29
CZ442199A3 (cs) 2000-07-12
AP9801255A0 (en) 1998-06-30
BRPI9810519B1 (pt) 2012-02-22
CO4950611A1 (es) 2000-09-01
EP0988310B1 (en) 2003-10-01
NO996106L (no) 2000-02-10
HK1068893A1 (en) 2005-07-29
BRPI9810519B8 (pt) 2022-11-16
JP2002316933A (ja) 2002-10-31
RS49675B (sr) 2007-11-15
BRPI9810519A (pt) 2000-09-19
PA8452201A1 (es) 2000-05-24
NZ500660A (en) 2002-03-01
ES2205487T3 (es) 2004-05-01
SK168399A3 (en) 2000-11-07
DZ2514A1 (fr) 2003-02-01
CN1566129A (zh) 2005-01-19
EA002441B1 (ru) 2002-04-25
DK0988310T3 (da) 2003-12-15
JP2000514098A (ja) 2000-10-24
AP1231A (en) 2003-12-11
UY25040A1 (es) 2000-09-29
TNSN98082A1 (fr) 2005-03-15
ATE251173T1 (de) 2003-10-15
UA67744C2 (uk) 2004-07-15
AU749816B2 (en) 2002-07-04
IS1998B (is) 2005-03-15
KR20010013632A (ko) 2001-02-26
JP3315704B2 (ja) 2002-08-19
PL337505A1 (en) 2000-08-28
LU91076I2 (fr) 2004-07-05
IL132809A0 (en) 2001-03-19
NO316911B1 (no) 2004-06-21
CA2293823C (en) 2004-02-17
SI0988310T1 (en) 2004-02-29
GT199800077A (es) 1999-12-02
NO996106D0 (no) 1999-12-10
WO1998056802A1 (en) 1998-12-17
DE122004000018I1 (de) 2004-09-30
US20040023896A1 (en) 2004-02-05
CA2293823A1 (en) 1998-12-17
BG103945A (en) 2000-07-31
ZA985017B (en) 1999-12-17
ID22992A (id) 1999-12-23
MY123354A (en) 2006-05-31
US20040180842A1 (en) 2004-09-16
CN1243766C (zh) 2006-03-01
PT988310E (pt) 2003-12-31
IS5252A (is) 1999-11-16
HRP980314B1 (en) 2004-04-30
AU7347598A (en) 1998-12-30
US6936592B2 (en) 2005-08-30
CN1259136A (zh) 2000-07-05
FR04C0013I1 (nl) 2004-06-11
AR013086A1 (es) 2000-12-13
HK1028048A1 (en) 2001-02-02
ME00876B (me) 2012-06-20
HUP0002209A3 (en) 2003-05-28
KR100396168B1 (ko) 2003-08-27
HRP980314A2 (en) 1999-04-30
CN1793155B (zh) 2010-05-12
CN1793155A (zh) 2006-06-28
CN1172947C (zh) 2004-10-27
EA199901015A1 (ru) 2000-06-26
BG64391B1 (bg) 2004-12-30
TW472060B (en) 2002-01-11
SK284171B6 (sk) 2004-10-05
FR04C0013I2 (nl) 2005-10-21
EP0988310B9 (en) 2006-03-08
CZ298556B6 (cs) 2007-11-07
YU58699A (nl) 2002-08-12
NL300150I1 (nl) 2004-08-02
US20020061858A1 (en) 2002-05-23
EG24081A (en) 2008-05-11
PE79699A1 (es) 1999-08-25
PL191601B1 (pl) 2006-06-30
LU91076I9 (en) 2018-07-02
HN1998000086A (es) 1999-03-08
DE69818665T2 (de) 2004-04-29
MA24564A1 (fr) 1998-12-31
HUP0002209A2 (hu) 2000-12-28
HUS1200028I1 (hu) 2016-08-29
CN101691390A (zh) 2010-04-07
US6777393B2 (en) 2004-08-17
EP0988310A1 (en) 2000-03-29

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