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ATE227282T1 - 2,4-diaminopyrimidin-derivate - Google Patents

2,4-diaminopyrimidin-derivate

Info

Publication number
ATE227282T1
ATE227282T1 AT97923018T AT97923018T ATE227282T1 AT E227282 T1 ATE227282 T1 AT E227282T1 AT 97923018 T AT97923018 T AT 97923018T AT 97923018 T AT97923018 T AT 97923018T AT E227282 T1 ATE227282 T1 AT E227282T1
Authority
AT
Austria
Prior art keywords
diaminopyrimidine derivatives
diaminopyrimidine
derivatives
Prior art date
Application number
AT97923018T
Other languages
English (en)
Inventor
Philippe Guerry
Henri Stalder
Pierre-Charles Wyss
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Application granted granted Critical
Publication of ATE227282T1 publication Critical patent/ATE227282T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT97923018T 1996-05-15 1997-05-07 2,4-diaminopyrimidin-derivate ATE227282T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96107739 1996-05-15
PCT/EP1997/002355 WO1997043277A1 (en) 1996-05-15 1997-05-07 2,4-diaminopyrimidine derivatives

Publications (1)

Publication Number Publication Date
ATE227282T1 true ATE227282T1 (de) 2002-11-15

Family

ID=8222784

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97923018T ATE227282T1 (de) 1996-05-15 1997-05-07 2,4-diaminopyrimidin-derivate

Country Status (29)

Country Link
US (1) US5866583A (de)
EP (1) EP0901488B1 (de)
JP (1) JP3098259B2 (de)
KR (1) KR100295509B1 (de)
CN (1) CN1098260C (de)
AR (1) AR007088A1 (de)
AT (1) ATE227282T1 (de)
AU (1) AU726416B2 (de)
BR (1) BR9709251A (de)
CA (1) CA2254117C (de)
CO (1) CO4840509A1 (de)
CY (1) CY2425B1 (de)
CZ (1) CZ364698A3 (de)
DE (1) DE69716901T2 (de)
DK (1) DK0901488T3 (de)
ES (1) ES2184089T3 (de)
HR (1) HRP970260A2 (de)
IL (1) IL126702A0 (de)
MA (1) MA24182A1 (de)
NO (1) NO985335L (de)
NZ (1) NZ332481A (de)
PE (1) PE78898A1 (de)
PL (1) PL330277A1 (de)
PT (1) PT901488E (de)
TR (1) TR199802331T2 (de)
TW (1) TW438796B (de)
WO (1) WO1997043277A1 (de)
YU (1) YU51498A (de)
ZA (1) ZA973984B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0966464B1 (de) * 1997-03-03 2003-05-28 Basilea Pharmaceutica AG Substituierte 2,4-diaminopyrimidine
ES2198705T3 (es) * 1997-03-03 2004-02-01 Basilea Pharmaceutica Ag 2,4-diaminopiridinas sustituidas.
US6277860B1 (en) * 1999-10-29 2001-08-21 Pfizer Inc Furopyridine antibacterials
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
AU2004260636A1 (en) * 2003-06-13 2005-02-10 Arena Pharmaceuticals, Inc. 5-substituted 2H-pyrazole-3-carboxylic acid derivatives as agonists for the nicotinic acid receptor RUP25 for the treatment of dyslipidemia and related diseases
JP2007501789A (ja) * 2003-08-07 2007-02-01 メルク エンド カムパニー インコーポレーテッド 11−β−ヒドロキシステロイドデヒドロゲナーゼ−1の阻害剤としてのピラゾールカルボキサミド
WO2005016278A2 (en) 2003-08-12 2005-02-24 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
DE102005062987A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
AU2008285795A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as TAAR1 ligands
US8252790B2 (en) * 2008-11-21 2012-08-28 Raqualia Pharma Inc. Pyrazole-3-carboxamide derivative having 5-HT2B receptor antagonist activity
EP2389376A1 (de) * 2009-01-21 2011-11-30 Basilea Pharmaceutica AG Neue bicyclische antibiotika
CN102753531B (zh) * 2009-12-15 2015-07-01 拜尔农作物科学股份公司 制备1-烷基-/1-芳基-5-吡唑羧酸衍生物的方法
EA201391239A1 (ru) 2011-04-05 2014-03-31 Пфайзер Лимитед Пирроло[2,3-d]пиримидиновые производные в качестве ингибиторов тропомиозин-связанных киназ
DE102013208484B4 (de) 2013-05-08 2018-04-26 Wirtgen Gmbh Vorrichtung zum Bearbeiten von Straßen- oder Bodenoberflächen, sowie Verfahren zum Lenken einer Straßenfräsmaschine
WO2020041556A1 (en) * 2018-08-22 2020-02-27 The Regents Of The University Of Colorado, A Body Corporate N-substituted-1h-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same
AR117169A1 (es) * 2018-11-28 2021-07-14 Bayer Ag (tio)amidas de piridazina como compuestos fungicidas

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
US4515948A (en) * 1973-09-12 1985-05-07 Hoffmann-La Roche Inc. 2,4-Diamino-5-(4-amino and 4-dimethylamino-3,5-dimethoxy benzyl)pyrimidines
US4013644A (en) * 1976-03-15 1977-03-22 G. D. Searle & Co. [8 α(E), 13aβ]-5,8,13,13a-tetrahydro-2,3,10,11-tetramethoxy-8-(2-phenylethenyl)-6H-dibenzo[a,g]quinolizines and intermediates thereto
US4444770A (en) * 1980-05-29 1984-04-24 Bayer Aktiengesellschaft New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use
US4594199A (en) * 1983-09-19 1986-06-10 E. R. Squibb & Sons, Inc. Method for making phosphinic acid intermediates
EP0639075A1 (de) * 1990-11-14 1995-02-22 Chiron Corporation Spezifische hemmung der dihydrofolsäurereduktase und wirkstoffe dafür
BR9509768A (pt) * 1994-11-24 1998-07-07 Hoffmann La Roche Novas pirimidinas de benzila
EP0832069B1 (de) * 1995-06-07 2003-03-05 Pfizer Inc. Biphenyl-2-carbonsäure-tetrahydro-isochinolin-6-yl amid derivate, deren hestellung und deren verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und/oder der apolipoprotein b (apo b) sekretion
EP1149834A1 (de) * 1995-12-04 2001-10-31 F. Hoffmann-La Roche Ag Diaminopyrimidine, diese enthaltende pharmazeutische Zusammensetzungen und ihre Verwendung als antibakterielle Mittel

Also Published As

Publication number Publication date
KR100295509B1 (ko) 2001-09-17
IL126702A0 (en) 1999-08-17
PT901488E (pt) 2003-03-31
ZA973984B (en) 1997-11-17
DK0901488T3 (da) 2003-03-03
WO1997043277A1 (en) 1997-11-20
PL330277A1 (en) 1999-05-10
TW438796B (en) 2001-06-07
YU51498A (en) 1999-11-22
NO985335L (no) 1999-01-15
NZ332481A (en) 2000-04-28
CY2425B1 (en) 2004-11-12
CZ364698A3 (cs) 1999-02-17
US5866583A (en) 1999-02-02
MA24182A1 (fr) 1997-12-31
NO985335D0 (no) 1998-11-16
DE69716901D1 (de) 2002-12-12
AU2894297A (en) 1997-12-05
CN1098260C (zh) 2003-01-08
EP0901488B1 (de) 2002-11-06
AR007088A1 (es) 1999-10-13
AU726416B2 (en) 2000-11-09
JP3098259B2 (ja) 2000-10-16
CO4840509A1 (es) 1999-09-27
PE78898A1 (es) 1998-11-13
KR20000011053A (ko) 2000-02-25
CN1218465A (zh) 1999-06-02
JPH11511749A (ja) 1999-10-12
CA2254117C (en) 2003-03-11
CA2254117A1 (en) 1997-11-20
EP0901488A1 (de) 1999-03-17
ES2184089T3 (es) 2003-04-01
BR9709251A (pt) 1999-08-10
HRP970260A2 (en) 1998-04-30
DE69716901T2 (de) 2003-09-18
TR199802331T2 (xx) 1999-04-21

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