Nothing Special   »   [go: up one dir, main page]

ATE257484T1 - 6,9-verbrückte erythromycin-derivate - Google Patents

6,9-verbrückte erythromycin-derivate

Info

Publication number
ATE257484T1
ATE257484T1 AT98944680T AT98944680T ATE257484T1 AT E257484 T1 ATE257484 T1 AT E257484T1 AT 98944680 T AT98944680 T AT 98944680T AT 98944680 T AT98944680 T AT 98944680T AT E257484 T1 ATE257484 T1 AT E257484T1
Authority
AT
Austria
Prior art keywords
erythromycin derivatives
bridged erythromycin
bridged
derivatives
erythromycin
Prior art date
Application number
AT98944680T
Other languages
English (en)
Inventor
Yat Sun Or
Richard F Clark
Daniel T Chu
Jacob J Plattner
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE257484T1 publication Critical patent/ATE257484T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT98944680T 1997-09-08 1998-09-01 6,9-verbrückte erythromycin-derivate ATE257484T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/925,582 US5780605A (en) 1997-09-08 1997-09-08 6,9-bridged erythromycin derivatives
PCT/US1998/018225 WO1999012947A1 (en) 1997-09-08 1998-09-01 6,9-bridged erythromycin derivatives

Publications (1)

Publication Number Publication Date
ATE257484T1 true ATE257484T1 (de) 2004-01-15

Family

ID=25451953

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98944680T ATE257484T1 (de) 1997-09-08 1998-09-01 6,9-verbrückte erythromycin-derivate

Country Status (24)

Country Link
US (1) US5780605A (de)
EP (1) EP1015467B1 (de)
JP (1) JP2001515915A (de)
KR (1) KR20010023756A (de)
CN (1) CN1269803A (de)
AR (1) AR015434A1 (de)
AT (1) ATE257484T1 (de)
AU (1) AU9216298A (de)
BG (1) BG104288A (de)
BR (1) BR9812148A (de)
CA (1) CA2301643A1 (de)
CO (1) CO4970722A1 (de)
DE (1) DE69821009T2 (de)
DK (1) DK1015467T3 (de)
ES (1) ES2213915T3 (de)
HU (1) HUP0003571A2 (de)
IL (1) IL134220A0 (de)
NO (1) NO20001169L (de)
PL (1) PL339137A1 (de)
PT (1) PT1015467E (de)
SK (1) SK3032000A3 (de)
TR (1) TR200000620T2 (de)
WO (1) WO1999012947A1 (de)
ZA (1) ZA987688B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US7464097B2 (en) * 2002-08-16 2008-12-09 Sap Ag Managing data integrity using a filter condition
TW200420573A (en) * 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
MXPA05009430A (es) * 2003-03-05 2006-04-07 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para hacer y usar a los mismos.
US20070149463A1 (en) * 2003-10-30 2007-06-28 Oyelere Adegboyega K Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
WO2005080408A1 (en) * 2004-01-23 2005-09-01 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
EP1723159B1 (de) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Makrozyklische verbindungen, deren herstellung und verwendung
WO2006119313A2 (en) * 2005-05-04 2006-11-09 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
CN101855219B (zh) * 2007-09-17 2014-06-25 英安塔制药有限公司 6，11-桥联的联芳大环内酯类
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6248696A (ja) * 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
WO1993013780A1 (en) * 1992-01-21 1993-07-22 Abbott Laboratories 4''-deoxyerythromycin derivatives
EP0638584B1 (de) * 1992-04-22 1996-03-20 Taisho Pharmaceutical Co. Ltd 5-0-desosaminylerythronolid a derivate
MY113693A (en) * 1992-05-26 2002-05-31 Chugai Pharmaceutical Co Ltd Erythromycin derivatives having an enterokinesis stimulating action
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5712253A (en) * 1996-06-18 1998-01-27 Abbott Laboratories Macrocyclic 13-membered ring derivatives of erythromycins A and B

Also Published As

Publication number Publication date
ZA987688B (en) 1999-02-24
DK1015467T3 (da) 2004-05-03
CA2301643A1 (en) 1999-03-18
AR015434A1 (es) 2001-05-02
NO20001169D0 (no) 2000-03-07
EP1015467B1 (de) 2004-01-07
US5780605A (en) 1998-07-14
BR9812148A (pt) 2000-07-18
WO1999012947A1 (en) 1999-03-18
PL339137A1 (en) 2000-12-04
NO20001169L (no) 2000-04-05
IL134220A0 (en) 2001-04-30
CN1269803A (zh) 2000-10-11
DE69821009T2 (de) 2004-11-18
HUP0003571A2 (hu) 2001-02-28
ES2213915T3 (es) 2004-09-01
KR20010023756A (ko) 2001-03-26
TR200000620T2 (tr) 2000-09-21
CO4970722A1 (es) 2000-11-07
EP1015467A1 (de) 2000-07-05
SK3032000A3 (en) 2000-07-11
DE69821009D1 (de) 2004-02-12
JP2001515915A (ja) 2001-09-25
BG104288A (bg) 2001-01-31
PT1015467E (pt) 2004-05-31
AU9216298A (en) 1999-03-29

Similar Documents

Publication Publication Date Title
ATE435861T1 (de) 12,13-cyclopropan-epothilonderivate
IS4970A (is) Setnar 6,6-heteró-bísýklískar afleiður
ATE340176T1 (de) Substituierte 6,5-heterobicyclische-derivate
NO2006016I1 (no) 7,8,9,10-tetrahydro-6H-6,10-metanoazepinoÄ4,5-gÜkinoksalintartrat
PT993456E (pt) 4,5-diaril-imidazoles 2-substituidos
DK1000048T3 (da) Substituerede 1,2,3,4-tetrahydronapthalenderivater
ATE310742T1 (de) C-4ß-SUBSTITUTIERTE MACROLID-DERIVATE
ATE275151T1 (de) 3,6-ketal-makrolidantibiotika
ATE377018T1 (de) Erythromycinderivate
NO993876D0 (no) 3'-N-oksid, 3'-N-dimetylamin, 9-oksim erytromycin A derivater
DE69821009D1 (de) 6,9-verbrückte erythromycin-derivate
ATE231847T1 (de) Substituierte 1,2,3,4- tetrahydronaphthalinderivate
ATE239750T1 (de) 6,11-verbrückte erythromycinderivate
ID21413A (id) Turunan-turunan 1,3,8,-triaza-spiro (4,5) dekan-4-on
TR199800988A3 (tr) 5' Deoksi-Sitidin türevleri.
EE04089B1 (et) 1,3,4-oksadiasolooni derivaadid
LV11898A (lv) Eritromicina atvasinajumi
ATE234839T1 (de) 4,5-azolo-oxindole
DK1068200T3 (da) 2,4,4-trisubstituerede-1,3-dioxolanfungicider
ID24047A (id) Turunan 5-tersubstitusi-3-oksaziazolil 1,6-naftiridin-2 1h-on
ATE240941T1 (de) 1,25-dihydroxy-16,22,23-trisdehydro- cholecalciferol-derivate
PT984975E (pt) Derivados de eritromicina multiciclicos
BR1100453A (pt) derivados de eritromicina
ZA989848B (en) 6,11-bridged erythromycin derivatives
SI1027361T1 (en) 6,11-bridged erythromycin derivatives

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1015467

Country of ref document: EP

REN Ceased due to non-payment of the annual fee