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MX336813B - Anticuerpos humanos que ligan el tnfa humano. - Google Patents

Anticuerpos humanos que ligan el tnfa humano.

Info

Publication number
MX336813B
MX336813B MX2012010598A MX12010598A MX336813B MX 336813 B MX336813 B MX 336813B MX 2012010598 A MX2012010598 A MX 2012010598A MX 12010598 A MX12010598 A MX 12010598A MX 336813 B MX336813 B MX 336813B
Authority
MX
Mexico
Prior art keywords
antibodies
htnf alpha
human antibodies
alpha
htnf
Prior art date
Application number
MX2012010598A
Other languages
English (en)
Inventor
Deborah J Allen
Zehra Kaymakcalan
Boris Labkovsky
John A Mankovich
Brian T Mcguiness
Andrew J Roberts
Paul Sakorafas
Hendricus R J M Hoogenboom
David Schoenhaut
Tristan J Vaughan
Michael White
Alison J Wilton
Jochen G Alfeld
Original Assignee
Abbvie Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26707297&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX336813(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/599,226 external-priority patent/US6090382A/en
Application filed by Abbvie Biotechnology Ltd filed Critical Abbvie Biotechnology Ltd
Publication of MX336813B publication Critical patent/MX336813B/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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  • Pulmonology (AREA)

Abstract

La presente invención se refiere a anticuerpos humanos, de preferencia anticuerpos humanos recombinantes que se ligan específicamente a un facor de necrosis de tumor humano a (hTNFa). Estos anticuerpos tienen gran afinidad para hTNFa (v.g. Kd = 10-8 M o menos), un régimen de disociación lento para disociación de hTNFa. (v.g. Koff = 10-3 sec-1 o menos) y neutralizan la actividad de hTNFa in vitro e in vivo. Un anticuerpo de la invención puede ser un anticuerpo de longitud completa o una porción de ligazón de antígeno del mismo. Los anticuerpos o porciones de anticuerpo de la invención son útiles para detectar hTNFa y para inhibir la actividad de hTNFa v.g. en pacientes humanos que padecen de un trastorno en el cual es perjudicial la actividad de hTNFa. Los ácidos nucleicos, vectores y células huésped para expresar los anticuerpos humanos recombinantes de la invención y los métodos para sintetizar los anticuerpos humanos recombinantes, también quedan abarcados mediante la invención.
MX2012010598A 1996-02-09 1997-02-10 Anticuerpos humanos que ligan el tnfa humano. MX336813B (es)

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US08/599,226 US6090382A (en) 1996-02-09 1996-02-09 Human antibodies that bind human TNFα
US3147696P 1996-11-25 1996-11-25
PCT/US1997/002219 WO1997029131A1 (en) 1996-02-09 1997-02-10 HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a)

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