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ZA993777B - Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases. - Google Patents

Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases.

Info

Publication number
ZA993777B
ZA993777B ZA9903777A ZA993777A ZA993777B ZA 993777 B ZA993777 B ZA 993777B ZA 9903777 A ZA9903777 A ZA 9903777A ZA 993777 A ZA993777 A ZA 993777A ZA 993777 B ZA993777 B ZA 993777B
Authority
ZA
South Africa
Prior art keywords
vla
autoimmune
cell binding
dependent cell
respiratory diseases
Prior art date
Application number
ZA9903777A
Other languages
English (en)
Inventor
Allen Jacob Duplantier
Anthony John Milici
Louis Stanley Chupak
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ZA993777B publication Critical patent/ZA993777B/xx

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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ZA9903777A 1998-06-30 1999-06-04 Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases. ZA993777B (en)

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WO1999064401A2 (en) 1998-06-12 1999-12-16 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Imidazolyl derivatives and their use as somatostatin receptor ligands
CZ20004909A3 (cs) * 1998-06-30 2002-04-17 Pfizer Products Inc. Nepeptidové inhibitory VLA-4 dependentní buněčné vazby pouľitelné při léčení zánětlivých, autoimunitních a respiračních chorob
US6518292B1 (en) * 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
US6756378B2 (en) * 1999-06-30 2004-06-29 Pharmacopeia Drug Discovery, Inc. VLA-4 inhibitor compounds
WO2001000206A1 (en) * 1999-06-30 2001-01-04 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitor compounds
CN1413210A (zh) * 1999-12-28 2003-04-23 辉瑞产品公司 用于治疗炎症、自身免疫性疾病和呼吸系统疾病的vla－4依赖性细胞结合的非肽基抑制剂
WO2001056994A1 (en) * 2000-02-04 2001-08-09 Biogen, Inc. Integrin antagonists
EP1296949A2 (en) 2000-06-21 2003-04-02 Bristol-Myers Squibb Pharma Company Piperidine amides as modulators of chemokine receptor activity
ATE360620T1 (de) * 2000-08-01 2007-05-15 Sod Conseils Rech Applic Imidazolderivate
GB2367816A (en) 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
KR100884877B1 (ko) 2000-12-28 2009-02-23 다이이찌 세이야꾸 가부시기가이샤 Ｖｌａ-４ 저해제
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE60228954D1 (en) * 2001-05-03 2008-10-30 Galileo Lab Inc Pyruvatderivate
AU2002302783B2 (en) * 2001-06-06 2006-11-16 Aventis Pharma Limited Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
US6974869B2 (en) * 2001-09-18 2005-12-13 Bristol-Myers Squibb Pharma Company Piperizinones as modulators of chemokine receptor activity
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EP1656368A4 (en) 2002-07-09 2009-08-26 Bristol Myers Squibb Co SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AGENTS AND ANTIABESITY AND THEIR MANUFACTURING PROCESS
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GB0402812D0 (en) * 2004-02-09 2004-03-10 Tanabe Seiyaku Co Novel compounds
US7309709B2 (en) * 2004-04-01 2007-12-18 Pfizer Inc. Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders
TW200610754A (en) * 2004-06-14 2006-04-01 Daiichi Seiyaku Co Vla-4 inhibitor
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
WO2007069635A1 (ja) 2005-12-13 2007-06-21 Daiichi Sankyo Company, Limited Ｖｌａ－４阻害薬
EP2467159A1 (en) 2009-08-20 2012-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
AU2018311976B2 (en) 2017-08-04 2022-10-13 Takeda Pharmaceutical Company Limited Inhibitors of Plasma Kallikrein and uses thereof
WO2022162164A1 (en) 2021-01-29 2022-08-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists

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CN1308616A (zh) 2001-08-15
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HN1999000099A (es) 1999-11-11
EA200001238A1 (ru) 2001-08-27
HUP0102477A3 (en) 2002-08-28
KR20010083081A (ko) 2001-08-31
CZ20004909A3 (cs) 2002-04-17
TR200003848T2 (tr) 2001-06-21
UA66864C2 (uk) 2004-06-15
YU77600A (sh) 2004-03-12
EA004792B1 (ru) 2004-08-26
PL345308A1 (en) 2001-12-03
OA11577A (en) 2004-07-26
AR015312A1 (es) 2001-04-18
ATE311371T1 (de) 2005-12-15
AP9901561A0 (en) 1999-06-30
JP2002519344A (ja) 2002-07-02
US6306887B1 (en) 2001-10-23
IL139584A0 (en) 2002-02-10
CO5320599A1 (es) 2003-09-30
NZ508033A (en) 2002-12-20
JP3676677B2 (ja) 2005-07-27
BG105190A (en) 2001-12-29
BR9911701A (pt) 2001-03-20
HUP0102477A2 (hu) 2002-05-29
GT199900101A (es) 2000-12-16
AU758939B2 (en) 2003-04-03
MA26640A1 (fr) 2004-12-20
SK20052000A3 (sk) 2002-08-06
EP1091943B1 (en) 2005-11-30
DE69928667T2 (de) 2006-08-10
AU3841699A (en) 2000-01-17
PA8477001A1 (es) 2000-05-24
PE20000762A1 (es) 2000-08-24
CA2336625A1 (en) 2000-01-06
TNSN99110A1 (fr) 2005-11-10
HRP20000917A2 (en) 2002-02-28
EP1091943A1 (en) 2001-04-18
NO20006600L (no) 2001-02-21
ID27414A (id) 2001-04-05
IS5720A (is) 2000-11-21
DE69928667D1 (de) 2006-01-05
NO20006600D0 (no) 2000-12-22
US6355662B1 (en) 2002-03-12

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