ID27414A - Penghambat-penghambat non-peptidil dari pengikat sel tergantung vla-4 yang bermanfaat dalam pengobatan penyakit-penyakit inflamasi, autoimun dan pernafasan - Google Patents
Penghambat-penghambat non-peptidil dari pengikat sel tergantung vla-4 yang bermanfaat dalam pengobatan penyakit-penyakit inflamasi, autoimun dan pernafasanInfo
- Publication number
- ID27414A ID27414A IDW20002723A ID20002723A ID27414A ID 27414 A ID27414 A ID 27414A ID W20002723 A IDW20002723 A ID W20002723A ID 20002723 A ID20002723 A ID 20002723A ID 27414 A ID27414 A ID 27414A
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- ID
- Indonesia
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- autoimun
- peptidil
- inflamation
- vla
- obstacles
- Prior art date
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US9118098P | 1998-06-30 | 1998-06-30 |
Publications (1)
Publication Number | Publication Date |
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ID27414A true ID27414A (id) | 2001-04-05 |
Family
ID=22226483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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IDW20002723A ID27414A (id) | 1998-06-30 | 1999-05-31 | Penghambat-penghambat non-peptidil dari pengikat sel tergantung vla-4 yang bermanfaat dalam pengobatan penyakit-penyakit inflamasi, autoimun dan pernafasan |
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US (2) | US6355662B1 (id) |
EP (1) | EP1091943B1 (id) |
JP (1) | JP3676677B2 (id) |
KR (1) | KR20010083081A (id) |
CN (1) | CN1308616A (id) |
AP (1) | AP1236A (id) |
AR (1) | AR015312A1 (id) |
AT (1) | ATE311371T1 (id) |
AU (1) | AU758939B2 (id) |
BG (1) | BG105190A (id) |
BR (1) | BR9911701A (id) |
CA (1) | CA2336625A1 (id) |
CO (1) | CO5320599A1 (id) |
CZ (1) | CZ20004909A3 (id) |
DE (1) | DE69928667T2 (id) |
EA (1) | EA004792B1 (id) |
GT (1) | GT199900101A (id) |
HN (1) | HN1999000099A (id) |
HR (1) | HRP20000917A2 (id) |
HU (1) | HUP0102477A3 (id) |
ID (1) | ID27414A (id) |
IL (1) | IL139584A0 (id) |
IS (1) | IS5720A (id) |
MA (1) | MA26640A1 (id) |
NO (1) | NO20006600L (id) |
NZ (1) | NZ508033A (id) |
OA (1) | OA11577A (id) |
PA (1) | PA8477001A1 (id) |
PE (1) | PE20000762A1 (id) |
PL (1) | PL345308A1 (id) |
SK (1) | SK20052000A3 (id) |
TN (1) | TNSN99110A1 (id) |
TR (1) | TR200003848T2 (id) |
UA (1) | UA66864C2 (id) |
WO (1) | WO2000000477A1 (id) |
YU (1) | YU77600A (id) |
ZA (1) | ZA993777B (id) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
WO1999064401A2 (en) | 1998-06-12 | 1999-12-16 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Imidazolyl derivatives and their use as somatostatin receptor ligands |
CZ20004909A3 (cs) * | 1998-06-30 | 2002-04-17 | Pfizer Products Inc. | Nepeptidové inhibitory VLA-4 dependentní buněčné vazby pouľitelné při léčení zánětlivých, autoimunitních a respiračních chorob |
US6518292B1 (en) * | 1999-03-12 | 2003-02-11 | Bristol-Myers Squibb Co. | Heterocyclic aromatic compounds usefuls as growth hormone secretagogues |
US6756378B2 (en) * | 1999-06-30 | 2004-06-29 | Pharmacopeia Drug Discovery, Inc. | VLA-4 inhibitor compounds |
WO2001000206A1 (en) * | 1999-06-30 | 2001-01-04 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitor compounds |
CN1413210A (zh) * | 1999-12-28 | 2003-04-23 | 辉瑞产品公司 | 用于治疗炎症、自身免疫性疾病和呼吸系统疾病的vla-4依赖性细胞结合的非肽基抑制剂 |
WO2001056994A1 (en) * | 2000-02-04 | 2001-08-09 | Biogen, Inc. | Integrin antagonists |
EP1296949A2 (en) | 2000-06-21 | 2003-04-02 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
ATE360620T1 (de) * | 2000-08-01 | 2007-05-15 | Sod Conseils Rech Applic | Imidazolderivate |
GB2367816A (en) | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
KR100884877B1 (ko) | 2000-12-28 | 2009-02-23 | 다이이찌 세이야꾸 가부시기가이샤 | Vla-4 저해제 |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE60228954D1 (en) * | 2001-05-03 | 2008-10-30 | Galileo Lab Inc | Pyruvatderivate |
AU2002302783B2 (en) * | 2001-06-06 | 2006-11-16 | Aventis Pharma Limited | Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases |
GB2377933A (en) | 2001-07-06 | 2003-01-29 | Bayer Ag | Succinic acid derivatives useful as integrin antagonists |
DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
US6974869B2 (en) * | 2001-09-18 | 2005-12-13 | Bristol-Myers Squibb Pharma Company | Piperizinones as modulators of chemokine receptor activity |
AU2003276043A1 (en) | 2002-06-17 | 2003-12-31 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
EP1656368A4 (en) | 2002-07-09 | 2009-08-26 | Bristol Myers Squibb Co | SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AGENTS AND ANTIABESITY AND THEIR MANUFACTURING PROCESS |
ES2382806T3 (es) | 2003-07-24 | 2012-06-13 | Daiichi Sankyo Company, Limited | Compuesto ácido ciclohexanocarboxílico |
GB0402812D0 (en) * | 2004-02-09 | 2004-03-10 | Tanabe Seiyaku Co | Novel compounds |
US7309709B2 (en) * | 2004-04-01 | 2007-12-18 | Pfizer Inc. | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders |
TW200610754A (en) * | 2004-06-14 | 2006-04-01 | Daiichi Seiyaku Co | Vla-4 inhibitor |
US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
WO2007069635A1 (ja) | 2005-12-13 | 2007-06-21 | Daiichi Sankyo Company, Limited | Vla-4阻害薬 |
EP2467159A1 (en) | 2009-08-20 | 2012-06-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
AU2018311976B2 (en) | 2017-08-04 | 2022-10-13 | Takeda Pharmaceutical Company Limited | Inhibitors of Plasma Kallikrein and uses thereof |
WO2022162164A1 (en) | 2021-01-29 | 2022-08-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5294713A (en) * | 1991-08-23 | 1994-03-15 | Takeda Chemical Industries, Ltd. | 2-piperazinone compounds and their use |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
CZ20004909A3 (cs) * | 1998-06-30 | 2002-04-17 | Pfizer Products Inc. | Nepeptidové inhibitory VLA-4 dependentní buněčné vazby pouľitelné při léčení zánětlivých, autoimunitních a respiračních chorob |
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1999
- 1999-05-31 CZ CZ20004909A patent/CZ20004909A3/cs unknown
- 1999-05-31 ID IDW20002723A patent/ID27414A/id unknown
- 1999-05-31 YU YU77600A patent/YU77600A/sh unknown
- 1999-05-31 IL IL13958499A patent/IL139584A0/xx unknown
- 1999-05-31 AT AT99921046T patent/ATE311371T1/de not_active IP Right Cessation
- 1999-05-31 KR KR1020007015120A patent/KR20010083081A/ko active IP Right Grant
- 1999-05-31 CN CN99808134A patent/CN1308616A/zh active Pending
- 1999-05-31 WO PCT/IB1999/000973 patent/WO2000000477A1/en not_active Application Discontinuation
- 1999-05-31 NZ NZ508033A patent/NZ508033A/xx unknown
- 1999-05-31 TR TR2000/03848T patent/TR200003848T2/xx unknown
- 1999-05-31 UA UA2000127651A patent/UA66864C2/uk unknown
- 1999-05-31 CA CA002336625A patent/CA2336625A1/en not_active Abandoned
- 1999-05-31 BR BR9911701-0A patent/BR9911701A/pt not_active IP Right Cessation
- 1999-05-31 DE DE69928667T patent/DE69928667T2/de not_active Expired - Fee Related
- 1999-05-31 JP JP2000557238A patent/JP3676677B2/ja not_active Expired - Fee Related
- 1999-05-31 US US09/403,846 patent/US6355662B1/en not_active Expired - Fee Related
- 1999-05-31 PL PL99345308A patent/PL345308A1/xx not_active Application Discontinuation
- 1999-05-31 AU AU38416/99A patent/AU758939B2/en not_active Ceased
- 1999-05-31 EA EA200001238A patent/EA004792B1/ru not_active IP Right Cessation
- 1999-05-31 HU HU0102477A patent/HUP0102477A3/hu unknown
- 1999-05-31 SK SK2005-2000A patent/SK20052000A3/sk unknown
- 1999-05-31 EP EP99921046A patent/EP1091943B1/en not_active Expired - Lifetime
- 1999-05-31 OA OA1200000361A patent/OA11577A/en unknown
- 1999-06-03 AP APAP/P/1999/001561A patent/AP1236A/en active
- 1999-06-04 ZA ZA9903777A patent/ZA993777B/xx unknown
- 1999-06-07 MA MA25611A patent/MA26640A1/fr unknown
- 1999-06-09 TN TNTNSN99110A patent/TNSN99110A1/fr unknown
- 1999-06-16 AR ARP990102883A patent/AR015312A1/es not_active Application Discontinuation
- 1999-06-17 HN HN1999000099A patent/HN1999000099A/es unknown
- 1999-06-23 US US09/338,832 patent/US6306887B1/en not_active Expired - Fee Related
- 1999-06-25 GT GT199900101A patent/GT199900101A/es unknown
- 1999-06-25 PE PE1999000583A patent/PE20000762A1/es not_active Application Discontinuation
- 1999-06-29 PA PA19998477001A patent/PA8477001A1/es unknown
- 1999-06-30 CO CO99040934A patent/CO5320599A1/es not_active Application Discontinuation
-
2000
- 2000-11-21 IS IS5720A patent/IS5720A/is unknown
- 2000-12-22 NO NO20006600A patent/NO20006600L/no not_active Application Discontinuation
- 2000-12-29 HR HR20000917A patent/HRP20000917A2/hr not_active Application Discontinuation
-
2001
- 2001-01-26 BG BG105190A patent/BG105190A/xx unknown
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