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TNSN99110A1 - Inhibiteurs non peptidiques de l'adhesion cellulaire sous la dependance de vla-4, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Inhibiteurs non peptidiques de l'adhesion cellulaire sous la dependance de vla-4, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
TNSN99110A1
TNSN99110A1 TNTNSN99110A TNSN99110A TNSN99110A1 TN SN99110 A1 TNSN99110 A1 TN SN99110A1 TN TNSN99110 A TNTNSN99110 A TN TNSN99110A TN SN99110 A TNSN99110 A TN SN99110A TN SN99110 A1 TNSN99110 A1 TN SN99110A1
Authority
TN
Tunisia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
vla
cell adhesion
Prior art date
Application number
TNTNSN99110A
Other languages
English (en)
Inventor
Jacob Duplantier Allen
John Milici Anthony
Stanley Chupak Louis
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN99110A1 publication Critical patent/TNSN99110A1/fr

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE (1.0.0) : DANS LAQUELLE A, B, E, R ET Y REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT. APPLICATION :UTILISATION DE CES COMPOSES POUR LE TRAITEMENT OU LA PREVENTION DE MALADIES INFLAMMATOIRES, AUTO- IMMUNES OU RESPIRATOIRES.
TNTNSN99110A 1998-06-30 1999-06-09 Inhibiteurs non peptidiques de l'adhesion cellulaire sous la dependance de vla-4, procede pour leur preparation et compositions pharmaceutiques les contenant TNSN99110A1 (fr)

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WO1999064401A2 (fr) 1998-06-12 1999-12-16 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Derives d'imidazolyles
CZ20004909A3 (cs) * 1998-06-30 2002-04-17 Pfizer Products Inc. Nepeptidové inhibitory VLA-4 dependentní buněčné vazby pouľitelné při léčení zánětlivých, autoimunitních a respiračních chorob
US6518292B1 (en) * 1999-03-12 2003-02-11 Bristol-Myers Squibb Co. Heterocyclic aromatic compounds usefuls as growth hormone secretagogues
US6756378B2 (en) * 1999-06-30 2004-06-29 Pharmacopeia Drug Discovery, Inc. VLA-4 inhibitor compounds
WO2001000206A1 (fr) * 1999-06-30 2001-01-04 Daiichi Pharmaceutical Co., Ltd. Composes inhibiteurs de vla-4
CN1413210A (zh) * 1999-12-28 2003-04-23 辉瑞产品公司 用于治疗炎症、自身免疫性疾病和呼吸系统疾病的vla－4依赖性细胞结合的非肽基抑制剂
WO2001056994A1 (fr) * 2000-02-04 2001-08-09 Biogen, Inc. Antagonistes de l'integrine
EP1296949A2 (fr) 2000-06-21 2003-04-02 Bristol-Myers Squibb Pharma Company Amides de piperidine utilises comme modulateurs de l'activite des recepteurs des chimiokines
ATE360620T1 (de) * 2000-08-01 2007-05-15 Sod Conseils Rech Applic Imidazolderivate
GB2367816A (en) 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
KR100884877B1 (ko) 2000-12-28 2009-02-23 다이이찌 세이야꾸 가부시기가이샤 Ｖｌａ-４ 저해제
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE60228954D1 (en) * 2001-05-03 2008-10-30 Galileo Lab Inc Pyruvatderivate
AU2002302783B2 (en) * 2001-06-06 2006-11-16 Aventis Pharma Limited Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
DE10137595A1 (de) 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
US6974869B2 (en) * 2001-09-18 2005-12-13 Bristol-Myers Squibb Pharma Company Piperizinones as modulators of chemokine receptor activity
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EP1656368A4 (fr) 2002-07-09 2009-08-26 Bristol Myers Squibb Co Derives heterocycliqes substitues utiles comme agents antidiabetique et antiabesite et leur procede de fabrication
ES2382806T3 (es) 2003-07-24 2012-06-13 Daiichi Sankyo Company, Limited Compuesto ácido ciclohexanocarboxílico
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US7309709B2 (en) * 2004-04-01 2007-12-18 Pfizer Inc. Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders
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US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
WO2007069635A1 (fr) 2005-12-13 2007-06-21 Daiichi Sankyo Company, Limited Médicament inhibiteur de vla-4
EP2467159A1 (fr) 2009-08-20 2012-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Vla-4 en tant que biomarqueur pour le pronostic et le ciblage pour thérapie dans la dystrophie musculaire de duchenne
AU2018311976B2 (en) 2017-08-04 2022-10-13 Takeda Pharmaceutical Company Limited Inhibitors of Plasma Kallikrein and uses thereof
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CN1308616A (zh) 2001-08-15
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HN1999000099A (es) 1999-11-11
EA200001238A1 (ru) 2001-08-27
HUP0102477A3 (en) 2002-08-28
KR20010083081A (ko) 2001-08-31
CZ20004909A3 (cs) 2002-04-17
TR200003848T2 (tr) 2001-06-21
UA66864C2 (uk) 2004-06-15
YU77600A (sh) 2004-03-12
EA004792B1 (ru) 2004-08-26
PL345308A1 (en) 2001-12-03
OA11577A (en) 2004-07-26
AR015312A1 (es) 2001-04-18
ATE311371T1 (de) 2005-12-15
AP9901561A0 (en) 1999-06-30
JP2002519344A (ja) 2002-07-02
US6306887B1 (en) 2001-10-23
IL139584A0 (en) 2002-02-10
CO5320599A1 (es) 2003-09-30
NZ508033A (en) 2002-12-20
JP3676677B2 (ja) 2005-07-27
BG105190A (en) 2001-12-29
BR9911701A (pt) 2001-03-20
HUP0102477A2 (hu) 2002-05-29
GT199900101A (es) 2000-12-16
AU758939B2 (en) 2003-04-03
MA26640A1 (fr) 2004-12-20
SK20052000A3 (sk) 2002-08-06
ZA993777B (en) 2000-12-04
EP1091943B1 (fr) 2005-11-30
DE69928667T2 (de) 2006-08-10
AU3841699A (en) 2000-01-17
PA8477001A1 (es) 2000-05-24
PE20000762A1 (es) 2000-08-24
CA2336625A1 (fr) 2000-01-06
HRP20000917A2 (en) 2002-02-28
EP1091943A1 (fr) 2001-04-18
NO20006600L (no) 2001-02-21
ID27414A (id) 2001-04-05
IS5720A (is) 2000-11-21
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