TR200301723T4 - 1,3 Dihidro-2H-indol-2 one türevleri ve bunların, arginin-vasopressin' in V1B veya V1B reseptörleri için bağ maddeleri olarak kullanımı - Google Patents
1,3 Dihidro-2H-indol-2 one türevleri ve bunların, arginin-vasopressin' in V1B veya V1B reseptörleri için bağ maddeleri olarak kullanımıInfo
- Publication number
- TR200301723T4 TR200301723T4 TR2003/01723T TR200301723T TR200301723T4 TR 200301723 T4 TR200301723 T4 TR 200301723T4 TR 2003/01723 T TR2003/01723 T TR 2003/01723T TR 200301723 T TR200301723 T TR 200301723T TR 200301723 T4 TR200301723 T4 TR 200301723T4
- Authority
- TR
- Turkey
- Prior art keywords
- receptors
- vasopressin
- arginine
- indol
- dihydro
- Prior art date
Links
- 101800001144 Arg-vasopressin Proteins 0.000 title abstract 2
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 title abstract 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 title abstract 2
- 101000954141 Homo sapiens Vasopressin V1b receptor Proteins 0.000 title 1
- 102100037188 Vasopressin V1b receptor Human genes 0.000 title 1
- 239000011230 binding agent Substances 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
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-
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
Bulus, arginin-vasopressin V1b reseptörleri veya hem V1b hem V1a resptörlerine yakinlik gösteren formül bilesimleri ve bunlarin çözeltileri ve/veya hidratlariyla ilgilidir. Bulus ayrica bunlarin hazirlik islemi, hazirlanmalari için kullanilan ara formül (II) bilesimleri, bunlari içeren farmasötik bilesimler ve bunlarin ilçalrain hazirlanmasi için kullanimiyla ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0000958A FR2804115B1 (fr) | 2000-01-25 | 2000-01-25 | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200301723T4 true TR200301723T4 (tr) | 2004-02-23 |
Family
ID=8846308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2003/01723T TR200301723T4 (tr) | 2000-01-25 | 2001-01-24 | 1,3 Dihidro-2H-indol-2 one türevleri ve bunların, arginin-vasopressin' in V1B veya V1B reseptörleri için bağ maddeleri olarak kullanımı |
Country Status (13)
Country | Link |
---|---|
US (1) | US6624164B2 (tr) |
EP (1) | EP1254134B1 (tr) |
JP (1) | JP4861591B2 (tr) |
AT (1) | ATE245644T1 (tr) |
AU (1) | AU2001235596A1 (tr) |
DE (1) | DE60100506T2 (tr) |
DK (1) | DK1254134T3 (tr) |
ES (1) | ES2203596T3 (tr) |
FR (1) | FR2804115B1 (tr) |
HU (1) | HU225157B1 (tr) |
PT (1) | PT1254134E (tr) |
TR (1) | TR200301723T4 (tr) |
WO (1) | WO2001055134A2 (tr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2805536B1 (fr) * | 2000-02-25 | 2002-08-23 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
EP1659121A4 (en) * | 2003-08-28 | 2008-11-26 | Taisho Pharmaceutical Co Ltd | D RIV OF 1,3-DIHYDRO-2H-INDOL-2-ONE |
US8580842B2 (en) * | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US20050070718A1 (en) * | 2003-09-30 | 2005-03-31 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
WO2006070742A1 (ja) * | 2004-12-27 | 2006-07-06 | Kyoto University | 麻薬性鎮痛剤の耐性形成抑制剤 |
WO2006080574A1 (ja) * | 2005-01-28 | 2006-08-03 | Taisho Pharmaceutical Co., Ltd. | 1,3-ジヒドロ-2h-インドール-2-オン化合物、及び芳香族複素環が縮合したピロリジン-2-オン化合物 |
DE102005014936A1 (de) | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
JP2008534461A (ja) * | 2005-03-24 | 2008-08-28 | アボット ゲーエムベーハー ウント カンパニー カーゲー | 置換オキシインドール誘導体、前記誘導体を含む医薬およびそれの使用 |
DE102005014904A1 (de) * | 2005-03-26 | 2007-02-01 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
EP1957480A1 (de) | 2005-12-02 | 2008-08-20 | Abbott GmbH & Co. KG | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
TWI403508B (zh) * | 2006-08-26 | 2013-08-01 | Abbott Gmbh & Co Kg | 經取代苯并咪唑酮衍生物、包含其之醫藥品及其用途 |
DE102006040915A1 (de) * | 2006-08-26 | 2008-03-20 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
US20080167286A1 (en) * | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
CN102026995B (zh) | 2007-12-07 | 2014-10-29 | Abbvie德国有限责任两合公司 | 5,6-二取代的羟吲哚衍生物和其用途 |
NZ586651A (en) | 2007-12-07 | 2012-06-29 | Abbott Gmbh & Co Kg | 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases |
US8703774B2 (en) | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases |
US8703775B2 (en) * | 2007-12-07 | 2014-04-22 | AbbVie Deutschland GmbH & Co. KG | Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
MY157425A (en) | 2007-12-27 | 2016-06-15 | Abbvie Deutschland | Substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
FR2927625B1 (fr) * | 2008-02-19 | 2010-03-12 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique |
FR2930249B1 (fr) | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
EP2435080A2 (en) | 2009-05-29 | 2012-04-04 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5940149B2 (ja) * | 1977-11-09 | 1984-09-28 | 大塚製薬株式会社 | オキシインド−ル誘導体 |
JPS55129284A (en) * | 1979-03-27 | 1980-10-06 | Shionogi & Co Ltd | 3-(1-imipazolyl)indolin-2-one |
US4760083A (en) * | 1986-04-10 | 1988-07-26 | E. I. Dupont De Nemours & Company | 3,3-disubstituted indolines |
US5338755A (en) * | 1990-07-31 | 1994-08-16 | Elf Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
FR2714378B1 (fr) | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
2000
- 2000-01-25 FR FR0000958A patent/FR2804115B1/fr not_active Expired - Fee Related
-
2001
- 2001-01-24 EP EP01907687A patent/EP1254134B1/fr not_active Expired - Lifetime
- 2001-01-24 HU HU0204157A patent/HU225157B1/hu not_active IP Right Cessation
- 2001-01-24 DE DE60100506T patent/DE60100506T2/de not_active Expired - Lifetime
- 2001-01-24 WO PCT/FR2001/000228 patent/WO2001055134A2/fr active IP Right Grant
- 2001-01-24 PT PT01907687T patent/PT1254134E/pt unknown
- 2001-01-24 DK DK01907687T patent/DK1254134T3/da active
- 2001-01-24 TR TR2003/01723T patent/TR200301723T4/tr unknown
- 2001-01-24 JP JP2001560993A patent/JP4861591B2/ja not_active Expired - Fee Related
- 2001-01-24 ES ES01907687T patent/ES2203596T3/es not_active Expired - Lifetime
- 2001-01-24 AU AU2001235596A patent/AU2001235596A1/en not_active Abandoned
- 2001-01-24 US US10/182,638 patent/US6624164B2/en not_active Expired - Fee Related
- 2001-01-24 AT AT01907687T patent/ATE245644T1/de active
Also Published As
Publication number | Publication date |
---|---|
US6624164B2 (en) | 2003-09-23 |
DK1254134T3 (da) | 2003-11-03 |
DE60100506T2 (de) | 2004-05-13 |
HUP0204157A3 (en) | 2005-04-28 |
HUP0204157A2 (hu) | 2003-04-28 |
EP1254134A2 (fr) | 2002-11-06 |
JP2003523354A (ja) | 2003-08-05 |
US20030139413A1 (en) | 2003-07-24 |
DE60100506D1 (de) | 2003-08-28 |
ATE245644T1 (de) | 2003-08-15 |
FR2804115B1 (fr) | 2002-03-08 |
AU2001235596A1 (en) | 2001-08-07 |
WO2001055134A2 (fr) | 2001-08-02 |
PT1254134E (pt) | 2003-11-28 |
JP4861591B2 (ja) | 2012-01-25 |
WO2001055134A3 (fr) | 2002-03-14 |
EP1254134B1 (fr) | 2003-07-23 |
HU225157B1 (en) | 2006-07-28 |
FR2804115A1 (fr) | 2001-07-27 |
ES2203596T3 (es) | 2004-04-16 |
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