RU2016114098A - Новое производное аналога инсулина - Google Patents
Новое производное аналога инсулина Download PDFInfo
- Publication number
- RU2016114098A RU2016114098A RU2016114098A RU2016114098A RU2016114098A RU 2016114098 A RU2016114098 A RU 2016114098A RU 2016114098 A RU2016114098 A RU 2016114098A RU 2016114098 A RU2016114098 A RU 2016114098A RU 2016114098 A RU2016114098 A RU 2016114098A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- administered
- diabetes
- compound according
- same patient
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 206010012601 diabetes mellitus Diseases 0.000 claims 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims 1
- 229940125904 compound 1 Drugs 0.000 claims 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (12)
1. А14Е,В16Е,В25Н,В29К(N(эпс)-эйкозандиоил-gGlu-2хОЕG), дезВ30 человеческий инсулин (Соединение 1).
2. Соединение по п. 1 для применения в качестве лекарственного средства.
3. Соединение по п. 1 для применения в качестве лекарственного средства для лечения диабета.
4. Соединение по п. 1 для применения при лечении диабета, где соединение вводят одному и тому же пациенту каждый 2 день или менее часто, и в среднем в течение периода времени, составляющего по меньшей мере 1 месяц, 6 месяцев или 1 год, причем указанное соединение не вводят более часто одному и тому же пациенту.
5. Соединение по п. 1 для применения при лечении диабета, где соединение вводят два раза в неделю или менее часто, и в среднем в течение периода времени, составляющего по меньшей мере 1 месяц, 6 месяцев или 1 год, причем указанное соединение не вводят более часто одному и тому же пациенту.
6. Соединение по п. 1, для применения при лечении диабета, где соединение вводят один раз в неделю или менее часто, и в среднем в течение периода времени, составляющего по меньшей мере 1 месяц, 6 месяцев или 1 год, причем указанное соединение не вводят более часто одному и тому же пациенту.
7. Водный раствор, содержащий соединение по п. 1.
8. Водный раствор по п. 7, содержащий по меньшей мере 5 ионов цинка на гексамер инсулина.
9. Водный раствор по любому из пп. 7-8, имеющий рН в диапазоне от 7 до 8.
10. Фармацевтическая композиция, содержащая соединение по п. 1 и один или более эксципиентов.
11. Фармацевтическая композиция по п. 10, содержащая по меньшей мере 4,5 ионов цинка на гексамер инсулина.
12. Способ лечения или профилактики диабета, включающий введение субъекту, нуждающемуся в этом, терапевтически эффективного количества соединения по п. 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13187626.0 | 2013-10-07 | ||
| EP13187626 | 2013-10-07 | ||
| PCT/EP2014/071236 WO2015052088A1 (en) | 2013-10-07 | 2014-10-03 | Novel derivative of an insulin analogue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016114098A true RU2016114098A (ru) | 2017-11-15 |
| RU2016114098A3 RU2016114098A3 (ru) | 2018-05-21 |
| RU2673185C2 RU2673185C2 (ru) | 2018-11-22 |
Family
ID=49301382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016114098A RU2673185C2 (ru) | 2013-10-07 | 2014-10-03 | Новое производное аналога инсулина |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9896496B2 (ru) |
| EP (1) | EP3055325B1 (ru) |
| JP (1) | JP6499184B2 (ru) |
| KR (1) | KR20160065126A (ru) |
| CN (1) | CN105636979B (ru) |
| AU (1) | AU2014333979B2 (ru) |
| BR (1) | BR112016007166A2 (ru) |
| CA (1) | CA2926701A1 (ru) |
| DK (1) | DK3055325T3 (ru) |
| ES (1) | ES2676065T3 (ru) |
| HR (1) | HRP20180468T1 (ru) |
| HU (1) | HUE036702T2 (ru) |
| IL (1) | IL244507B (ru) |
| MX (1) | MX366636B (ru) |
| PL (1) | PL3055325T3 (ru) |
| PT (1) | PT3055325T (ru) |
| RS (1) | RS57004B1 (ru) |
| RU (1) | RU2673185C2 (ru) |
| SA (1) | SA516370893B1 (ru) |
| SI (1) | SI3055325T1 (ru) |
| WO (1) | WO2015052088A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| US11787837B2 (en) | 2016-11-07 | 2023-10-17 | Novo Nordisk A/S | DCHBS-active esters of PEG compounds and their use |
| US20180169190A1 (en) * | 2016-12-16 | 2018-06-21 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
| WO2019066609A1 (ko) | 2017-09-29 | 2019-04-04 | 한미약품 주식회사 | 링커로서 비펩타이드성 중합체 결합 지방산 유도체 화합물을 포함하는 단백질 결합체 및 이의 제조방법 |
| CN111909255A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 胰岛素衍生物及其制备方法 |
| US20230272030A1 (en) | 2020-07-24 | 2023-08-31 | Jiangsu Gensciences Inc. | Insulin-fc fusion protein and application thereof |
| AU2022283328A1 (en) * | 2021-05-24 | 2023-11-16 | Sunshine Lake Pharma Co., Ltd. | A novel acylated insulin analog |
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- 2014-10-03 RS RS20180322A patent/RS57004B1/sr unknown
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- 2014-10-03 WO PCT/EP2014/071236 patent/WO2015052088A1/en active Application Filing
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Also Published As
| Publication number | Publication date |
|---|---|
| DK3055325T3 (en) | 2018-04-16 |
| SI3055325T1 (en) | 2018-05-31 |
| MX2016004325A (es) | 2016-07-11 |
| KR20160065126A (ko) | 2016-06-08 |
| CA2926701A1 (en) | 2015-04-16 |
| CN105636979A (zh) | 2016-06-01 |
| RU2016114098A3 (ru) | 2018-05-21 |
| IL244507A0 (en) | 2016-04-21 |
| IL244507B (en) | 2018-05-31 |
| RU2673185C2 (ru) | 2018-11-22 |
| RS57004B1 (sr) | 2018-05-31 |
| SA516370893B1 (ar) | 2018-08-13 |
| PT3055325T (pt) | 2018-04-06 |
| JP6499184B2 (ja) | 2019-04-10 |
| PL3055325T3 (pl) | 2018-06-29 |
| HRP20180468T1 (hr) | 2018-05-04 |
| WO2015052088A1 (en) | 2015-04-16 |
| MX366636B (es) | 2019-07-17 |
| EP3055325B1 (en) | 2018-01-03 |
| US9896496B2 (en) | 2018-02-20 |
| EP3055325A1 (en) | 2016-08-17 |
| CN105636979B (zh) | 2020-01-10 |
| AU2014333979A1 (en) | 2016-03-24 |
| BR112016007166A2 (pt) | 2017-09-12 |
| JP2017502074A (ja) | 2017-01-19 |
| AU2014333979B2 (en) | 2018-02-15 |
| ES2676065T3 (es) | 2018-07-16 |
| US20160215037A1 (en) | 2016-07-28 |
| HUE036702T2 (hu) | 2018-07-30 |
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