|
US2832685A
(en)
|
1952-05-24 |
1958-04-29 |
Crest Foods Co Inc |
Solubilization of milk proteins
|
|
US3528960A
(en)
|
1968-10-07 |
1970-09-15 |
Lilly Co Eli |
N-carboxyaroyl insulins
|
|
US3719655A
(en)
|
1969-12-05 |
1973-03-06 |
Lilly Co Eli |
Process for the crystallization of the ammonium and alkali metal salts in insulin
|
|
US3950517A
(en)
|
1970-05-08 |
1976-04-13 |
National Research Development Corporation |
Insulin derivatives
|
|
US3869437A
(en)
|
1970-05-08 |
1975-03-04 |
Nat Res Dev |
Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4033941A
(en)
|
1975-12-17 |
1977-07-05 |
Eli Lilly And Company |
Process for purifying glucagon
|
|
GB1492997A
(en)
|
1976-07-21 |
1977-11-23 |
Nat Res Dev |
Insulin derivatives
|
|
JPS5767548A
(en)
|
1980-10-14 |
1982-04-24 |
Shionogi & Co Ltd |
Insulin analog and its preparation
|
|
PH25772A
(en)
|
1985-08-30 |
1991-10-18 |
Novo Industri As |
Insulin analogues, process for their preparation
|
|
PH23446A
(en)
|
1986-10-20 |
1989-08-07 |
Novo Industri As |
Peptide preparations
|
|
JPH01254699A
(ja)
|
1988-04-05 |
1989-10-11 |
Kodama Kk |
インスリン誘導体及びその用途
|
|
DK257988D0
(da)
|
1988-05-11 |
1988-05-11 |
Novo Industri As |
Nye peptider
|
|
US5149777A
(en)
|
1988-07-20 |
1992-09-22 |
Novo Nordisk A/S |
Human insulin analogs and preparations containing them
|
|
US5225323A
(en)
|
1988-11-21 |
1993-07-06 |
Baylor College Of Medicine |
Human high-affinity neurotransmitter uptake system
|
|
AU641631B2
(en)
|
1988-12-23 |
1993-09-30 |
Novo Nordisk A/S |
Human insulin analogues
|
|
US5716927A
(en)
|
1988-12-23 |
1998-02-10 |
Novo Nordisk A/S |
Insulin analogs having a modified B-chain
|
|
DE3844211A1
(de)
|
1988-12-29 |
1990-07-05 |
Hoechst Ag |
Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
|
|
EP0469084B1
(en)
|
1989-04-20 |
1995-04-05 |
Mount Sinai School Of Medicine Of The City University Of New York |
Hepatospecific insulin analogues
|
|
CA1340994C
(en)
|
1989-09-21 |
2000-05-16 |
Rudolf Edgar Dr. Falk |
Treatment of conditions and disease
|
|
CA2027930C
(en)
|
1989-10-19 |
1998-06-30 |
Tsuyoshi Miyazaki |
Polymer complexes of a sugar response type
|
|
US5179189A
(en)
|
1990-01-19 |
1993-01-12 |
Nova Pharmaceutical Corporation |
Fatty acid terminated polyanhydrides
|
|
DK45590D0
(sr)
|
1990-02-21 |
1990-02-21 |
Novo Nordisk As |
|
|
DK155690D0
(da)
|
1990-06-28 |
1990-06-28 |
Novo Nordisk As |
Nye peptider
|
|
DK158390D0
(da)
|
1990-07-02 |
1990-07-02 |
Novo Nordisk As |
Nye peptider
|
|
AU8091091A
(en)
|
1990-07-26 |
1992-02-18 |
University Of Iowa Research Foundation, The |
Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
|
|
DK10191D0
(da)
|
1991-01-22 |
1991-01-22 |
Novo Nordisk As |
Hidtil ukendte peptider
|
|
US5336782A
(en)
|
1991-04-24 |
1994-08-09 |
Kuraray Co., Ltd. |
Long chain carboxylic acid imide ester
|
|
AU739601B2
(en)
|
1991-07-03 |
2001-10-18 |
Meditech Research Limited |
Use of hyaluronan in gene therapy
|
|
US5268453A
(en)
|
1991-08-08 |
1993-12-07 |
Scios Inc. |
Tissue-selective insulin analogs
|
|
NZ245170A
(en)
|
1991-11-26 |
1994-07-26 |
Lilly Co Eli |
Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions
|
|
AU5171293A
(en)
|
1992-10-14 |
1994-05-09 |
Regents Of The University Of Colorado, The |
Ion-pairing of drugs for improved efficacy and delivery
|
|
US5359030A
(en)
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
US5506203C1
(en)
|
1993-06-24 |
2001-02-06 |
Astra Ab |
Systemic administration of a therapeutic preparation
|
|
US6869930B1
(en)
|
1993-09-17 |
2005-03-22 |
Novo Nordisk A/S |
Acylated insulin
|
|
PT792290E
(pt)
|
1993-09-17 |
2002-01-30 |
Novo Nordisk As |
Insulina acilada
|
|
GB9323588D0
(en)
|
1993-11-16 |
1994-01-05 |
Cortecs Ltd |
Hydrophobic preparation
|
|
CN1098679C
(zh)
|
1994-03-07 |
2003-01-15 |
吸入治疗系统 |
用于胰岛素肺部给药的方法和组合物
|
|
US6500645B1
(en)
|
1994-06-17 |
2002-12-31 |
Novo Nordisk A/S |
N-terminally extended proteins expressed in yeast
|
|
US5693609A
(en)
|
1994-11-17 |
1997-12-02 |
Eli Lilly And Company |
Acylated insulin analogs
|
|
US5646242A
(en)
|
1994-11-17 |
1997-07-08 |
Eli Lilly And Company |
Selective acylation of epsilon-amino groups
|
|
JP3872105B2
(ja)
|
1995-03-17 |
2007-01-24 |
ノボ ノルディスク アクティーゼルスカブ |
インスリン誘導体
|
|
US6251856B1
(en)
|
1995-03-17 |
2001-06-26 |
Novo Nordisk A/S |
Insulin derivatives
|
|
US5824638A
(en)
|
1995-05-22 |
1998-10-20 |
Shire Laboratories, Inc. |
Oral insulin delivery
|
|
US20030104981A1
(en)
|
1995-11-03 |
2003-06-05 |
Jelena Mandic |
Human insulin analogues
|
|
US6451970B1
(en)
|
1996-02-21 |
2002-09-17 |
Novo Nordisk A/S |
Peptide derivatives
|
|
AU3255397A
(en)
|
1996-07-05 |
1998-02-02 |
Novo Nordisk A/S |
Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides
|
|
DE69731105T2
(de)
|
1996-07-11 |
2005-11-17 |
Novo Nordisk A/S |
Verfahren zur selektiven acetylierung
|
|
ES2218622T3
(es)
|
1996-07-26 |
2004-11-16 |
Aventis Pharma Deutschland Gmbh |
Derivados de insulina con actividad de union al zinc incrementada.
|
|
US5898067A
(en)
|
1997-02-07 |
1999-04-27 |
Novo Nordisk A/S |
Crystallization of proteins
|
|
US6310038B1
(en)
|
1997-03-20 |
2001-10-30 |
Novo Nordisk A/S |
Pulmonary insulin crystals
|
|
PL340255A1
(en)
|
1997-10-24 |
2001-01-29 |
Lilly Co Eli |
Non-dissolving insulin compositions
|
|
PL195845B1
(pl)
|
1997-10-24 |
2007-10-31 |
Novo Nordisk As |
Rozpuszczalny w wodzie agregat pochodnych insuliny
|
|
ZA989744B
(en)
|
1997-10-31 |
2000-04-26 |
Lilly Co Eli |
Method for administering acylated insulin.
|
|
WO1999024071A1
(en)
|
1997-11-12 |
1999-05-20 |
Alza Corporation |
Method for decreasing self-association of polypeptides
|
|
CO4970787A1
(es)
|
1997-12-23 |
2000-11-07 |
Lilly Co Eli |
Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
|
|
AU8029798A
(en)
|
1998-06-12 |
2000-01-05 |
Deutsches Wollforschungsinstitut |
Insulin analogue
|
|
GB9814172D0
(en)
|
1998-06-30 |
1998-08-26 |
Andaris Ltd |
Formulation for inhalation
|
|
CA2341624C
(en)
|
1998-08-25 |
2008-12-02 |
Advanced Inhalation Research, Inc. |
Stable spray-dried protein formulations
|
|
TW570805B
(en)
|
1998-09-01 |
2004-01-11 |
Hoffmann La Roche |
Water-soluble pharmaceutical composition in an ionic complex
|
|
US7030083B2
(en)
|
1998-09-09 |
2006-04-18 |
University Of Washington |
Treatment of eclampsia and preeclampsia
|
|
ATE218364T1
(de)
|
1998-10-16 |
2002-06-15 |
Novo Nordisk As |
Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
|
|
US6660715B2
(en)
|
1998-11-19 |
2003-12-09 |
Massachusetts Institute Of Technology |
Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
|
|
JP2002535287A
(ja)
|
1999-01-26 |
2002-10-22 |
イーライ・リリー・アンド・カンパニー |
単分散性６量体のアシル化されたインスリンアナログ製剤
|
|
WO2000061178A1
(en)
|
1999-04-13 |
2000-10-19 |
Inhale Therapeutics Systems, Inc. |
Pulmonary administration of dry powder formulations for treating infertility
|
|
WO2000064940A1
(en)
|
1999-04-27 |
2000-11-02 |
Eli Lilly And Company |
Insulin crystals for pulmonary administration
|
|
US6746853B1
(en)
|
1999-05-19 |
2004-06-08 |
Xencor, Inc. |
Proteins with insulin-like activity useful in the treatment of diabetes
|
|
CA2372393A1
(en)
|
1999-05-19 |
2000-11-23 |
Bassil I. Dahiyat |
Novel proteins with insulin-like activity useful in the treatment of diabetes
|
|
US6309633B1
(en)
|
1999-06-19 |
2001-10-30 |
Nobex Corporation |
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
|
|
CN1141974C
(zh)
|
2000-06-07 |
2004-03-17 |
张昊 |
结肠定位释放的口服生物制剂
|
|
US6867183B2
(en)
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
CN1160122C
(zh)
|
2001-04-20 |
2004-08-04 |
清华大学 |
一种制备口服胰岛素油相制剂的方法
|
|
OA13136A
(en)
|
2001-05-21 |
2006-12-13 |
Nektar Therapeutics |
Pulmonary administration of chemically modified insulin.
|
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6858580B2
(en)
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7186797B2
(en)
|
2001-08-10 |
2007-03-06 |
Epix Pharmaceuticals, Inc. |
Polypeptide conjugates with extended circulating half-lives
|
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7030082B2
(en)
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
|
ATE446971T1
(de)
|
2001-09-07 |
2009-11-15 |
Biocon Ltd |
Verfahren zur synthese von insulinpolypeptid- oligomer-konjugaten und proinsulinpolypeptid- oligomer-konjugaten und verfahren zu deren synthese
|
|
EP1453860A2
(en)
|
2001-12-02 |
2004-09-08 |
Novo Nordisk A/S |
Novel glucose-dependant insulins
|
|
CA2468845C
(en)
|
2001-12-03 |
2011-08-23 |
Dor Biopharma Inc. |
Stabilized reverse micelle compositions and uses thereof
|
|
EP1456371A1
(en)
|
2001-12-05 |
2004-09-15 |
Dow Global Technologies Inc. |
Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
|
|
US20050014679A1
(en)
|
2001-12-20 |
2005-01-20 |
Beals John Michael |
Insulin molecule having protracted time action
|
|
EP1506230B1
(en)
|
2002-05-07 |
2011-01-19 |
Novo Nordisk A/S |
Soluble formulations comprising monomeric insulin and acylated insulin
|
|
EP1506003A1
(en)
|
2002-05-07 |
2005-02-16 |
Novo Nordisk A/S |
Soluble formulations comprising insulin aspart and insulin detemir
|
|
US7601688B2
(en)
|
2002-06-13 |
2009-10-13 |
Biocon Limited |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
CN1165549C
(zh)
|
2002-06-15 |
2004-09-08 |
江苏万邦生化医药股份有限公司 |
胰岛素的纯化方法
|
|
WO2004105790A1
(en)
|
2003-06-03 |
2004-12-09 |
Novo Nordisk A/S |
Stabilized pharmaceutical peptide compositions
|
|
WO2005005477A2
(en)
|
2003-07-11 |
2005-01-20 |
Novo Nordisk A/S |
Stabilised insulin compositions
|
|
EA008433B1
(ru)
|
2003-07-25 |
2007-06-29 |
Конджачем Биотекнолоджис Инк. |
Производные инсулина длительного действия и способы их использования
|
|
MXPA06001283A
(es)
|
2003-08-05 |
2006-04-11 |
Novo Nordisk As |
Derivados de insulina novedosos.
|
|
ES2445947T3
(es)
|
2003-08-13 |
2014-03-06 |
Biocon Limited |
Formulaciones para dosificación de sólidos de sales de ácidos grasos en forma de micropartículas para agentes terapéuticos
|
|
EP1670515A2
(en)
*
|
2003-09-19 |
2006-06-21 |
Novo Nordisk A/S |
Albumin-binding derivatives of therapeutic peptides
|
|
JP2007532096A
(ja)
|
2003-11-14 |
2007-11-15 |
ノボ ノルディスク アクティーゼルスカブ |
アシル化されたインスリンの製造方法
|
|
SI3300721T1
(sl)
|
2003-11-20 |
2019-07-31 |
Novo Nordisk A/S |
Peptidne formulacije, ki vsebujejo propilen glikol in ki so optimalne za proizvodnjo in uporabo v napravah za injiciranje
|
|
US7371381B2
(en)
|
2003-12-12 |
2008-05-13 |
Amgen Inc. |
Anti-galanin antibodies and uses thereof
|
|
DE10358387A1
(de)
|
2003-12-13 |
2005-07-07 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung
|
|
US7625865B2
(en)
|
2004-03-26 |
2009-12-01 |
Universita Degli Studi Di Parma |
Insulin highly respirable microparticles
|
|
WO2005115441A2
(en)
|
2004-05-10 |
2005-12-08 |
Nastech Pharmaceutical Company Inc. |
Compositions and methods for enhanced mucosal delivery of parathyroid hormone
|
|
US7872095B2
(en)
|
2004-07-19 |
2011-01-18 |
Biocon Limited |
Insulin-oligomer conjugates, formulations and uses thereof
|
|
US7820676B2
(en)
|
2004-08-23 |
2010-10-26 |
Mannkind Corporation |
Diketopiperazine salts for drug delivery and related methods
|
|
ES2540754T3
(es)
|
2004-12-03 |
2015-07-13 |
Rhode Island Hospital |
Diagnóstico y tratamiento de la Enfermedad de Alzheimer
|
|
EP1843790A2
(en)
|
2005-01-27 |
2007-10-17 |
Novo Nordisk A/S |
Insulin derivatives conjugated with structurally well defined branched polymers
|
|
ES2438145T3
(es)
|
2005-02-02 |
2014-01-16 |
Novo Nordisk A/S |
Nuevos derivados de insulina
|
|
US20080171695A1
(en)
|
2005-02-02 |
2008-07-17 |
Novo Nordisk A/S |
Insulin Derivatives
|
|
WO2006097521A1
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Pegylated single-chain insulin
|
|
WO2007006320A1
(en)
|
2005-07-12 |
2007-01-18 |
Sherine Hassan Abbas Helmy |
Drinkable oral insulin liquid and capsules
|
|
US20070086952A1
(en)
|
2005-09-29 |
2007-04-19 |
Biodel, Inc. |
Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
|
|
JP4710533B2
(ja)
|
2005-10-07 |
2011-06-29 |
株式会社豊田自動織機 |
牽引車両のドローバー装置
|
|
WO2007047948A2
(en)
|
2005-10-20 |
2007-04-26 |
Nastech Pharmaceutical Company Inc. |
Intranasal administration of rapid acting insulin
|
|
ES2371361T3
(es)
|
2005-12-28 |
2011-12-30 |
Novo Nordisk A/S |
Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
|
|
WO2007081824A2
(en)
|
2006-01-06 |
2007-07-19 |
Case Western Reserve University |
Fibrillation resistant proteins
|
|
JP2009527526A
(ja)
|
2006-02-21 |
2009-07-30 |
ノボ・ノルデイスク・エー／エス |
単鎖インスリンのアナログとその製薬的製剤
|
|
DE602007009496D1
(de)
|
2006-02-27 |
2010-11-11 |
Novo Nordisk As |
Insulinderivate
|
|
WO2007104737A1
(en)
|
2006-03-13 |
2007-09-20 |
Novo Nordisk A/S |
Acylated single chain insulin
|
|
ES2553154T3
(es)
|
2006-05-09 |
2015-12-04 |
Novo Nordisk A/S |
Derivado de la insulina
|
|
EP2386572B1
(en)
|
2006-05-09 |
2015-07-08 |
Novo Nordisk A/S |
Insulin derivative
|
|
WO2008015099A2
(en)
|
2006-07-31 |
2008-02-07 |
Novo Nordisk A/S |
Pegylated, extended insulins
|
|
JP5864834B2
(ja)
|
2006-09-22 |
2016-02-17 |
ノボ・ノルデイスク・エー／エス |
プロテアーゼ耐性のインスリンアナログ
|
|
US20100120660A1
(en)
|
2007-04-30 |
2010-05-13 |
Per Balschmidt |
Highly concentrated insulin solutions and compositions
|
|
RU2472492C2
(ru)
|
2007-06-01 |
2013-01-20 |
Ново Нордиск А/С |
Стабильные неводные фармацевтические композиции
|
|
EP2167032B1
(en)
*
|
2007-06-13 |
2019-08-07 |
Novo Nordisk A/S |
Pharmaceutical formulation comprising an insulin derivative
|
|
CN101743252A
(zh)
|
2007-07-16 |
2010-06-16 |
诺沃-诺迪斯克有限公司 |
蛋白酶稳定化的、peg化的胰岛素类似物
|
|
EP2178910B1
(en)
|
2007-08-15 |
2014-10-08 |
Novo Nordisk A/S |
Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
|
|
JP5730569B2
(ja)
|
2007-08-15 |
2015-06-10 |
ノボ・ノルデイスク・エー／エス |
アシル及びアルキレングリコール部分を有するインスリンアナログ
|
|
WO2009060071A1
(en)
*
|
2007-11-08 |
2009-05-14 |
Novo Nordisk A/S |
Insulin derivative
|
|
US9260502B2
(en)
|
2008-03-14 |
2016-02-16 |
Novo Nordisk A/S |
Protease-stabilized insulin analogues
|
|
MX2010009850A
(es)
|
2008-03-18 |
2010-09-30 |
Novo Nordisk As |
Analogos de insulina acilados y etabilizados contra proteasas.
|
|
ES2607003T3
(es)
*
|
2008-10-30 |
2017-03-28 |
Novo Nordisk A/S |
Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
|
|
AU2011252127B2
(en)
*
|
2010-05-10 |
2014-02-20 |
Novo Nordisk A/S |
Process for the preparation of insulin-zinc complexes
|
|
CN102947331B
(zh)
*
|
2010-06-23 |
2016-08-03 |
诺沃—诺迪斯克有限公司 |
包含额外的二硫键的胰岛素类似物
|
|
CN102985440B
(zh)
*
|
2010-06-23 |
2016-10-26 |
诺沃-诺迪斯克有限公司 |
包含额外的二硫键的胰岛素衍生物
|
|
PL2632478T3
(pl)
*
|
2010-10-27 |
2020-03-31 |
Novo Nordisk A/S |
Leczenie cukrzycy z zastosowaniem zastrzyków insuliny podawanych w różnych odstępach czasu
|
|
KR20150002777A
(ko)
|
2012-04-11 |
2015-01-07 |
노보 노르디스크 에이/에스 |
인슐린 제제
|