PL2928884T3 - Nowe pochodne benzoimidazoli jako antagoniści EP4 - Google Patents

Nowe pochodne benzoimidazoli jako antagoniści EP4

Info

Publication number: PL2928884T3
Authority: PL; Poland
Prior art keywords: antagonists; benzimidazole derivatives; novel benzimidazole; novel; derivatives
Prior art date: 2012-12-06

Application number

PL13798684T

Other languages

English (en)

Inventor

Olaf Peters

Nico Bräuer

Thorsten Blume

Laak Antonius Ter

Ludwig Zorn

Jens Nagel

Stefan Kaulfuss

Gernot Langer

Joachim Kuhnke

Original Assignee

Bayer Pharma Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-12-06

Filing date

2013-12-03

Publication date

2017-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47325927&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2928884(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-12-03 Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft

2017-11-30 Publication of PL2928884T3 publication Critical patent/PL2928884T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Oncology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

PL13798684T 2012-12-06 2013-12-03 Nowe pochodne benzoimidazoli jako antagoniści EP4 PL2928884T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP12195849		2012-12-06
EP13798684.0A EP2928884B1 (de)	2012-12-06	2013-12-03	Neuartige benzimidazolderivate als ep4-antagonisten

Publications (1)

Publication Number	Publication Date
PL2928884T3 true PL2928884T3 (pl)	2017-11-30

Family

ID=47325927

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL13798684T PL2928884T3 (pl)	2012-12-06	2013-12-03	Nowe pochodne benzoimidazoli jako antagoniści EP4

Country Status (41)

Country	Link
US (1)	US9708311B2 (pl)
EP (1)	EP2928884B1 (pl)
JP (1)	JP6367822B2 (pl)
KR (1)	KR20150092248A (pl)
CN (1)	CN104854098B (pl)
AP (1)	AP3862A (pl)
AR (1)	AR093840A1 (pl)
AU (1)	AU2013354226B2 (pl)
BR (1)	BR112015012555B1 (pl)
CA (1)	CA2893630C (pl)
CL (1)	CL2015001508A1 (pl)
CR (1)	CR20150296A (pl)
CU (1)	CU20150056A7 (pl)
CY (1)	CY1119200T1 (pl)
DK (1)	DK2928884T3 (pl)
EA (1)	EA028830B1 (pl)
EC (1)	ECSP15022555A (pl)
ES (1)	ES2637738T3 (pl)
GT (1)	GT201500138A (pl)
HK (1)	HK1210139A1 (pl)
HR (1)	HRP20171200T1 (pl)
IL (1)	IL239026A0 (pl)
JO (1)	JO3431B1 (pl)
LT (1)	LT2928884T (pl)
MA (1)	MA38146B1 (pl)
ME (1)	ME02950B (pl)
MX (1)	MX2015007135A (pl)
MY (1)	MY175272A (pl)
NI (1)	NI201500077A (pl)
NZ (1)	NZ707825A (pl)
PE (1)	PE20151065A1 (pl)
PH (1)	PH12015501289A1 (pl)
PL (1)	PL2928884T3 (pl)
PT (1)	PT2928884T (pl)
RS (1)	RS56121B1 (pl)
SI (1)	SI2928884T1 (pl)
TN (1)	TN2015000250A1 (pl)
TW (1)	TWI613198B (pl)
UA (1)	UA115576C2 (pl)
UY (1)	UY35177A (pl)
WO (1)	WO2014086739A1 (pl)

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TW201607943A (zh) *	2013-12-19	2016-03-01	拜耳製藥公司	作為ｅｐ４配體之新穎苯并咪唑衍生物

2013
- 2013-03-12 UA UAA201506493A patent/UA115576C2/uk unknown
- 2013-12-03 PE PE2015000750A patent/PE20151065A1/es active IP Right Grant
- 2013-12-03 CN CN201380063594.4A patent/CN104854098B/zh active Active
- 2013-12-03 EP EP13798684.0A patent/EP2928884B1/de active Active
- 2013-12-03 AU AU2013354226A patent/AU2013354226B2/en active Active
- 2013-12-03 JP JP2015545771A patent/JP6367822B2/ja active Active
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- 2013-12-03 EA EA201591087A patent/EA028830B1/ru not_active IP Right Cessation
- 2013-12-03 PT PT137986840T patent/PT2928884T/pt unknown
- 2013-12-03 MX MX2015007135A patent/MX2015007135A/es active IP Right Grant
- 2013-12-03 US US14/649,896 patent/US9708311B2/en active Active
- 2013-12-03 SI SI201330742T patent/SI2928884T1/sl unknown
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- 2013-12-03 MY MYPI2015701808A patent/MY175272A/en unknown
- 2013-12-03 RS RS20170790A patent/RS56121B1/sr unknown
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- 2013-12-03 KR KR1020157017666A patent/KR20150092248A/ko active IP Right Grant
- 2013-12-03 WO PCT/EP2013/075309 patent/WO2014086739A1/de active Application Filing
- 2013-12-03 LT LTEP13798684.0T patent/LT2928884T/lt unknown
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- 2013-12-03 BR BR112015012555-7A patent/BR112015012555B1/pt active IP Right Grant
- 2013-12-03 AP AP2015008463A patent/AP3862A/en active
- 2013-12-03 ES ES13798684.0T patent/ES2637738T3/es active Active
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2015
- 2015-05-27 IL IL239026A patent/IL239026A0/en active IP Right Grant
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- 2015-06-05 TN TNP2015000250A patent/TN2015000250A1/fr unknown
- 2015-06-05 PH PH12015501289A patent/PH12015501289A1/en unknown
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- 2015-06-05 EC ECIEPI201522555A patent/ECSP15022555A/es unknown
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- 2015-10-29 HK HK15110717.4A patent/HK1210139A1/xx unknown
2017
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Also Published As

Publication number	Publication date
RS56121B1 (sr)	2017-10-31
UY35177A (es)	2014-06-30
JP6367822B2 (ja)	2018-08-01
SI2928884T1 (sl)	2017-09-29
TN2015000250A1 (en)	2016-10-03
US9708311B2 (en)	2017-07-18
CY1119200T1 (el)	2018-02-14
US20160214977A1 (en)	2016-07-28
DK2928884T3 (en)	2017-09-11
CN104854098B (zh)	2018-01-09
KR20150092248A (ko)	2015-08-12
MA38146B1 (fr)	2018-08-31
GT201500138A (es)	2017-10-05
AU2013354226B2 (en)	2017-09-14
PT2928884T (pt)	2017-08-25
CU20150056A7 (es)	2015-10-27
ES2637738T3 (es)	2017-10-16
CA2893630C (en)	2021-02-23
EA201591087A1 (ru)	2015-12-30
LT2928884T (lt)	2017-08-25
HK1210139A1 (en)	2016-04-15
ECSP15022555A (es)	2016-01-29
AP3862A (en)	2016-10-31
BR112015012555A2 (pt)	2017-07-11
EP2928884A1 (de)	2015-10-14
EA028830B1 (ru)	2018-01-31
AP2015008463A0 (en)	2015-05-31
CR20150296A (es)	2015-08-10
TW201422608A (zh)	2014-06-16
CL2015001508A1 (es)	2015-07-24
MA38146A1 (fr)	2018-01-31
BR112015012555B1 (pt)	2022-02-15
AR093840A1 (es)	2015-06-24
NI201500077A (es)	2016-02-15
MY175272A (en)	2020-06-17
NZ707825A (en)	2019-06-28
AU2013354226A1 (en)	2015-06-18
PH12015501289B1 (en)	2015-08-24
TWI613198B (zh)	2018-02-01
PH12015501289A1 (en)	2015-08-24
WO2014086739A1 (de)	2014-06-12
JO3431B1 (ar)	2019-10-20
HRP20171200T1 (hr)	2017-12-15
IL239026A0 (en)	2015-07-30
JP2016501241A (ja)	2016-01-18
ME02950B (me)	2018-07-20
MX2015007135A (es)	2016-02-05
EP2928884B1 (de)	2017-05-24
UA115576C2 (uk)	2017-11-27
PE20151065A1 (es)	2015-08-19
CA2893630A1 (en)	2014-06-12
CN104854098A (zh)	2015-08-19

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IL232503A (en)	2015-08-31	H2 - Indazoles as antagonists of the ep2 receptor
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SG11201404325VA (en)	2014-08-28	Pyrimidooxazocine derivatives as mtor - inhibitors
PL2814825T3 (pl)	2016-08-31	Dihydrofuranowe pochodne azetydyny jako środki przeciwpasożytnicze