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CR20150296A - Novedosos derivados de bencimidazol como antagonistas de ep4 - Google Patents

Novedosos derivados de bencimidazol como antagonistas de ep4

Info

Publication number
CR20150296A
CR20150296A CR20150296A CR20150296A CR20150296A CR 20150296 A CR20150296 A CR 20150296A CR 20150296 A CR20150296 A CR 20150296A CR 20150296 A CR20150296 A CR 20150296A CR 20150296 A CR20150296 A CR 20150296A
Authority
CR
Costa Rica
Prior art keywords
bencimidazol
news
antagonists
derived
preparation
Prior art date
Application number
CR20150296A
Other languages
English (en)
Inventor
Olaf Peters
Nico Bräuer
Thorsten Blume
Laak Antonius Ter
Ludwig Zorn
Jens Nagel
Stefan Kaulfuss
Gernot Langer
Joachim Kuhnke
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47325927&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20150296(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CR20150296A publication Critical patent/CR20150296A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a novedosos deriva-dos de bencimidazol de la fórmula general (I), a procedi-mientos para su preparación, así como su uso para la pre-paración de agentes farmacéuticos para el tratamiento de enfermedades e indicaciones que están relacionadas con el receptor EP4.
CR20150296A 2012-12-06 2015-06-05 Novedosos derivados de bencimidazol como antagonistas de ep4 CR20150296A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12195849 2012-12-06
PCT/EP2013/075309 WO2014086739A1 (de) 2012-12-06 2013-12-03 Neuartige benzimidazolderivate als ep4-antagonisten

Publications (1)

Publication Number Publication Date
CR20150296A true CR20150296A (es) 2015-08-10

Family

ID=47325927

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150296A CR20150296A (es) 2012-12-06 2015-06-05 Novedosos derivados de bencimidazol como antagonistas de ep4

Country Status (41)

Country Link
US (1) US9708311B2 (es)
EP (1) EP2928884B1 (es)
JP (1) JP6367822B2 (es)
KR (1) KR20150092248A (es)
CN (1) CN104854098B (es)
AP (1) AP3862A (es)
AR (1) AR093840A1 (es)
AU (1) AU2013354226B2 (es)
BR (1) BR112015012555B1 (es)
CA (1) CA2893630C (es)
CL (1) CL2015001508A1 (es)
CR (1) CR20150296A (es)
CU (1) CU20150056A7 (es)
CY (1) CY1119200T1 (es)
DK (1) DK2928884T3 (es)
EA (1) EA028830B1 (es)
EC (1) ECSP15022555A (es)
ES (1) ES2637738T3 (es)
GT (1) GT201500138A (es)
HK (1) HK1210139A1 (es)
HR (1) HRP20171200T1 (es)
IL (1) IL239026A0 (es)
JO (1) JO3431B1 (es)
LT (1) LT2928884T (es)
MA (1) MA38146B1 (es)
ME (1) ME02950B (es)
MX (1) MX2015007135A (es)
MY (1) MY175272A (es)
NI (1) NI201500077A (es)
NZ (1) NZ707825A (es)
PE (1) PE20151065A1 (es)
PH (1) PH12015501289A1 (es)
PL (1) PL2928884T3 (es)
PT (1) PT2928884T (es)
RS (1) RS56121B1 (es)
SI (1) SI2928884T1 (es)
TN (1) TN2015000250A1 (es)
TW (1) TWI613198B (es)
UA (1) UA115576C2 (es)
UY (1) UY35177A (es)
WO (1) WO2014086739A1 (es)

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Also Published As

Publication number Publication date
RS56121B1 (sr) 2017-10-31
UY35177A (es) 2014-06-30
JP6367822B2 (ja) 2018-08-01
SI2928884T1 (sl) 2017-09-29
TN2015000250A1 (en) 2016-10-03
US9708311B2 (en) 2017-07-18
CY1119200T1 (el) 2018-02-14
US20160214977A1 (en) 2016-07-28
DK2928884T3 (en) 2017-09-11
CN104854098B (zh) 2018-01-09
KR20150092248A (ko) 2015-08-12
MA38146B1 (fr) 2018-08-31
GT201500138A (es) 2017-10-05
AU2013354226B2 (en) 2017-09-14
PT2928884T (pt) 2017-08-25
CU20150056A7 (es) 2015-10-27
ES2637738T3 (es) 2017-10-16
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EA201591087A1 (ru) 2015-12-30
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