PE20000136A1 - Proceso para la sintesis de 1,3-dioles - Google Patents
Proceso para la sintesis de 1,3-diolesInfo
- Publication number
- PE20000136A1 PE20000136A1 PE1998001245A PE00124598A PE20000136A1 PE 20000136 A1 PE20000136 A1 PE 20000136A1 PE 1998001245 A PE1998001245 A PE 1998001245A PE 00124598 A PE00124598 A PE 00124598A PE 20000136 A1 PE20000136 A1 PE 20000136A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- alkyl
- iii
- give
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B41/00—Formation or introduction of functional groups containing oxygen
- C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCESO PARA PREPARAR CIS-1,3-DIOLES DE FORMULA (I), EN LA CUAL : i) R ES ALQUILO DE 1 A 10 ATOMOS DE CARBONO; NC-CH2-; PG-O-CH2 DONDE PG ES UN GRUPO PROTECTOR, QUE PROTEGE UNA PORCION DE ALCOHOL, TAL COMO BENCILO Y SIMILARES ENTRE OTRAS OPCIONES; ii) R1 ES ALQUILO; -CH2-C02R6, SIENDO R6 ALQUILO. ESTE PROCESO COMPRENDE : a)TRATAR UN COMPUESTO DE FORMULA (II) O UN COMPUESTO DE FORMULA (III), SIENDO R Y R1 LOS YA DEFINIDOS, CON UN TRIALQUILBORANO, UN DIALQUILALCOXIBORANO O UNA MEZCLA DE AMBOS EN UN SOLVENTE, TAL COMO TETRAHIDROFURANO, METANOL O MEZCLA DE ELLOS; b) AGREGAR UN HIDRURO DE METAL ALCALINO A UNA TEMPERATURA ALREDEDOR DE -110°C Y -50°C; c) CONCENTRAR LA REACCION MEDIANTE DESTILACION PARA DAR UN COMPUESTO DE FORMULA (I) Y UN DESTILADO QUE CONTIENE ESPECIES ALQUILBORANO; d) TRATAR EL COMPUESTO ADICIONAL DE FORMULA (II) o (III) CON EL DESTILADO DEL PASO (c) QUE CONTIENE ESPECIES ALQUILBORANO RECUPERADAS Y REPETIR LOS PASOS (b) Y (c) SEGUN SE DESEE PARA DAR UN COMPUESTO ADICIONAL DE FORMULA (I). ESTE PROCESO PUEDE SER UTILIZADO PARA PREPARAR INHIBIDORES DE REDUCTASA HMG CoA, TAL COMO ATORVASTATINA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6819397P | 1997-12-19 | 1997-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20000136A1 true PE20000136A1 (es) | 2000-03-11 |
Family
ID=22081016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998001245A PE20000136A1 (es) | 1997-12-19 | 1998-12-18 | Proceso para la sintesis de 1,3-dioles |
Country Status (31)
Country | Link |
---|---|
US (4) | US6433213B1 (es) |
EP (1) | EP1054860B1 (es) |
JP (1) | JP2001526256A (es) |
KR (2) | KR100668575B1 (es) |
AR (1) | AR014943A1 (es) |
AT (1) | ATE360608T1 (es) |
AU (1) | AU755543B2 (es) |
BR (1) | BR9813760A (es) |
CA (1) | CA2305618C (es) |
CO (1) | CO4990941A1 (es) |
CU (1) | CU22939A3 (es) |
CY (1) | CY1106612T1 (es) |
DE (1) | DE69837681T2 (es) |
DK (1) | DK1054860T3 (es) |
ES (1) | ES2284219T3 (es) |
GT (2) | GT199800197A (es) |
HN (1) | HN1998000187A (es) |
HU (1) | HUP0100252A3 (es) |
IL (1) | IL135562A (es) |
IS (1) | IS5447A (es) |
MY (1) | MY118726A (es) |
NO (1) | NO20003139L (es) |
NZ (1) | NZ504346A (es) |
PA (1) | PA8464901A1 (es) |
PE (1) | PE20000136A1 (es) |
PL (1) | PL193678B1 (es) |
PT (1) | PT1054860E (es) |
SV (1) | SV1998000153A (es) |
TW (1) | TW444000B (es) |
WO (1) | WO1999032434A1 (es) |
ZA (1) | ZA9811586B (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60026737T2 (de) | 1999-12-17 | 2006-09-21 | Pfizer Science And Technology Ireland Ltd., Dun Laoghaire | Verfahren zur herstellung von kristallin atorvastin kalcium |
MXPA02004078A (es) | 1999-12-17 | 2002-10-11 | Warner Lambert Res & Dev | Un proceso a escala industrial para producir sal de hemi calcio de trihidrato de atorvastatin cristalino. |
US20040014195A1 (en) * | 1999-12-29 | 2004-01-22 | Diversa Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
US7521216B2 (en) | 1999-12-29 | 2009-04-21 | Verenium Corporation | Nitrilases and methods for making and using them |
US7300775B2 (en) | 1999-12-29 | 2007-11-27 | Verenium Corporation | Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents |
US7608445B1 (en) | 1999-12-29 | 2009-10-27 | Verenium Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
KR100838135B1 (ko) | 2001-04-05 | 2008-06-13 | 닛산 가가쿠 고교 가부시키 가이샤 | 7-퀴놀리닐-3,5-디히드록시헵트-6-엔산에스테르의 제조법 |
ATE457972T1 (de) * | 2001-07-06 | 2010-03-15 | Basf Se | Verfahren zur herstellung von 7-amino-syn-3,5- dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung |
EP1406860A1 (en) | 2001-07-06 | 2004-04-14 | Teva Pharmaceutical Industries Limited | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
GB0211715D0 (en) | 2002-05-22 | 2002-07-03 | Phoenix Chemicals Ltd | Process |
WO2003106415A2 (en) * | 2002-06-13 | 2003-12-24 | Diversa Corporation | Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid |
AU2003258187A1 (en) * | 2002-08-09 | 2004-02-25 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
US7232920B2 (en) * | 2003-04-22 | 2007-06-19 | Biocon | Process for stereoselective reduction of β-ketoesters |
US7790197B2 (en) * | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
US20050271717A1 (en) * | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
US7655692B2 (en) * | 2003-06-12 | 2010-02-02 | Pfizer Inc. | Process for forming amorphous atorvastatin |
US20040253305A1 (en) * | 2003-06-12 | 2004-12-16 | Luner Paul E. | Pharmaceutical compositions of atorvastatin |
AU2004266100A1 (en) | 2003-08-11 | 2005-03-03 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters |
US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CA2535147A1 (en) * | 2003-08-11 | 2005-05-19 | Codexis, Inc. | Improved glucose dehydrogenase polypeptides and related polynucleotides |
JP2007502124A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド |
BRPI0413501A (pt) * | 2003-08-11 | 2006-10-10 | Codexis Inc | polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh |
US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CN1852894A (zh) * | 2003-09-17 | 2006-10-25 | 沃尼尔·朗伯有限责任公司 | [R-(R*, R*)]-2-(4-氟苯基) -β,δ-二羟基-5-(1-甲基乙基) -3-苯基-4-[(苯基氨基)羰基] -1 H-吡咯-1-庚酸的结晶形式 |
WO2005026107A1 (en) * | 2003-09-18 | 2005-03-24 | Biocon Limited | Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate |
CA2645396A1 (en) * | 2003-12-24 | 2005-07-14 | Teva Pharmaceutical Industries, Ltd | Process for preparation of statins with high syn to anti ratio |
US7851624B2 (en) * | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
WO2005100313A1 (en) * | 2004-04-16 | 2005-10-27 | Pfizer Products Inc. | Process for forming amorphous atorvastatin calcium |
WO2005105738A2 (en) | 2004-05-05 | 2005-11-10 | Pfizer Products Inc. | Salt forms of atorvastatin |
US8044086B2 (en) * | 2004-07-16 | 2011-10-25 | Lek Pharmaceuticals D.D. | Oxidative degradation products of atorvastatin calcium |
EP1771412A2 (en) | 2004-07-20 | 2007-04-11 | Warner-Lambert Company LLC | Crystalline forms of [r-(r*)]-2-(4-fluorophenyl)-bet a,gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-hept anoic acid calcium salt (2:1) |
KR20070067175A (ko) * | 2004-10-28 | 2007-06-27 | 워너-램버트 캄파니 엘엘씨 | 무정형 아토르바스타틴 형성 방법 |
CA2589537A1 (en) * | 2004-12-02 | 2006-06-08 | Stephen Craig Dyar | Pharmaceutical compositions of amorphous atorvastatin and process for preparing same |
WO2007029217A1 (en) * | 2005-09-09 | 2007-03-15 | Pfizer Science And Technology Ireland Limited | Preparation of an atorvastatin intermediate |
US20090221839A1 (en) * | 2005-09-09 | 2009-09-03 | Pfizer Inc. | Preparation of an Atorvastatin Intermediate |
CA2547216A1 (en) * | 2005-09-21 | 2007-03-21 | Renuka D. Reddy | Process for annealing amorphous atorvastatin |
DK1957452T3 (da) | 2005-11-21 | 2010-07-26 | Warner Lambert Co | Nye former af [R-(R*,R*)]-2-(4-fluorphenyl)-B,B-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyre- magnesium |
KR20090083900A (ko) | 2006-10-02 | 2009-08-04 | 코덱시스, 인코포레이티드 | 입체이성질체적으로 순수한 스타틴 및 이의 합성 중간체 제조용 조성물 및 제조 방법 |
WO2008106662A2 (en) | 2007-03-01 | 2008-09-04 | Verenium Corporation | Nitrilases, nucleic acids encoding them and methods for making and using them |
WO2009137691A2 (en) * | 2008-05-09 | 2009-11-12 | The Scripps Research Institute | 1,3-diol synthesis via controlled, radical-mediated c-h functionalization |
US8187856B2 (en) | 2008-12-18 | 2012-05-29 | Codexis, Inc. | Recombinant halohydrin dehalogenase polypeptides |
WO2010069593A1 (en) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
US9273158B2 (en) | 2011-05-16 | 2016-03-01 | The Regents Of The University Of California | Methods for production of hydrocarbons and oxygen-containing hyrdrocarbons |
US20140335179A1 (en) | 2011-07-01 | 2014-11-13 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Micronized crystals of atorvastatin hemicalcium |
CN108033899B (zh) * | 2017-12-06 | 2020-04-10 | 浙江科技学院 | 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法 |
CN111978286A (zh) * | 2020-08-21 | 2020-11-24 | 江苏万年长药业有限公司 | 一种制备ats-8的方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR64043B (en) | 1977-10-01 | 1980-01-19 | Expansia Sa | Borane complexes |
DE2912708A1 (de) | 1979-03-30 | 1980-10-09 | Basf Ag | Datenspeichersystem und magnetscheiben dafuer |
US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
US4645854A (en) * | 1985-04-25 | 1987-02-24 | Merck & Co., Inc. | Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
US4898949A (en) * | 1987-02-25 | 1990-02-06 | Bristol-Myers Company | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds |
US4897490A (en) * | 1987-02-25 | 1990-01-30 | Bristol-Meyers Company | Antihypercholesterolemic tetrazole compounds |
DE3741509A1 (de) | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
US5001144A (en) * | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
FR2642065B1 (fr) * | 1989-01-24 | 1991-05-24 | Lipha | Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant |
FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
DE3929507A1 (de) * | 1989-09-06 | 1991-03-07 | Bayer Ag | Substituierte amino-pyridine |
US5039802A (en) | 1990-04-18 | 1991-08-13 | Merck & Co., Inc. | Arylation process for preparation of chiral catalysts for ketone reduction |
JP3528186B2 (ja) | 1991-06-24 | 2004-05-17 | 日産化学工業株式会社 | 光学活性キノリンメバロン酸のジアステレオマー塩 |
US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
US5218138A (en) * | 1992-09-02 | 1993-06-08 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds |
US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
-
1998
- 1998-12-02 CA CA002305618A patent/CA2305618C/en not_active Expired - Fee Related
- 1998-12-02 WO PCT/US1998/025493 patent/WO1999032434A1/en active IP Right Grant
- 1998-12-02 AT AT98961855T patent/ATE360608T1/de not_active IP Right Cessation
- 1998-12-02 JP JP2000525371A patent/JP2001526256A/ja not_active Abandoned
- 1998-12-02 NZ NZ504346A patent/NZ504346A/en unknown
- 1998-12-02 HU HU0100252A patent/HUP0100252A3/hu unknown
- 1998-12-02 EP EP98961855A patent/EP1054860B1/en not_active Expired - Lifetime
- 1998-12-02 AU AU17074/99A patent/AU755543B2/en not_active Ceased
- 1998-12-02 ES ES98961855T patent/ES2284219T3/es not_active Expired - Lifetime
- 1998-12-02 PT PT98961855T patent/PT1054860E/pt unknown
- 1998-12-02 DE DE69837681T patent/DE69837681T2/de not_active Expired - Fee Related
- 1998-12-02 KR KR1020007006762A patent/KR100668575B1/ko not_active IP Right Cessation
- 1998-12-02 US US09/581,798 patent/US6433213B1/en not_active Expired - Fee Related
- 1998-12-02 DK DK98961855T patent/DK1054860T3/da active
- 1998-12-02 BR BR9813760-3A patent/BR9813760A/pt not_active Application Discontinuation
- 1998-12-02 PL PL98341294A patent/PL193678B1/pl not_active IP Right Cessation
- 1998-12-02 KR KR1020067012766A patent/KR100681366B1/ko not_active IP Right Cessation
- 1998-12-02 IL IL13556298A patent/IL135562A/xx not_active IP Right Cessation
- 1998-12-09 HN HN1998000187A patent/HN1998000187A/es unknown
- 1998-12-14 GT GT199800197A patent/GT199800197A/es unknown
- 1998-12-14 GT GT199800197AK patent/GT199800197AA/es unknown
- 1998-12-17 MY MYPI98005721A patent/MY118726A/en unknown
- 1998-12-17 ZA ZA9811586A patent/ZA9811586B/xx unknown
- 1998-12-18 CO CO98075429A patent/CO4990941A1/es unknown
- 1998-12-18 AR ARP980106461A patent/AR014943A1/es active IP Right Grant
- 1998-12-18 PA PA19988464901A patent/PA8464901A1/es unknown
- 1998-12-18 PE PE1998001245A patent/PE20000136A1/es not_active Application Discontinuation
- 1998-12-18 SV SV1998000153A patent/SV1998000153A/es not_active Application Discontinuation
- 1998-12-18 TW TW087121215A patent/TW444000B/zh not_active IP Right Cessation
-
2000
- 2000-04-14 IS IS5447A patent/IS5447A/is unknown
- 2000-06-09 CU CU20000144A patent/CU22939A3/es not_active IP Right Cessation
- 2000-06-16 NO NO20003139A patent/NO20003139L/no not_active Application Discontinuation
-
2002
- 2002-06-11 US US10/166,990 patent/US6596879B2/en not_active Expired - Fee Related
-
2003
- 2003-04-11 US US10/411,886 patent/US6962994B2/en not_active Expired - Fee Related
-
2005
- 2005-04-29 US US11/119,151 patent/US7232915B2/en not_active Expired - Fee Related
-
2007
- 2007-05-21 CY CY20071100687T patent/CY1106612T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20000136A1 (es) | Proceso para la sintesis de 1,3-dioles | |
KR830007564A (ko) | 치환된 아미노이산의 제조방법 | |
KR910007926A (ko) | 1h-아미다조[4,5-c]퀴놀린의 제조방법 | |
AR008527A1 (es) | Procedimiento para preparar eteres mixtos | |
GB9721156D0 (en) | Novel vitamin d analogues | |
MX9206313A (es) | Composicion de aditivos, baños acidos de plaqueado de zinc y aleaciones de zinc y metodos para el electrodeposito de zinc y aleaciones de zinc | |
DK557281A (da) | Fremgangsmaade til indfoering af alkoxy- og aralkyloxygrupper i organiske forbindelser | |
Voelker et al. | o-Nitrobenzyl as a photocleavable nitrogen protecting group for indoles, benzimidazole, and 6-chlorouracil | |
DE69425176D1 (de) | Verfahren zur Herstellung von Alkylimidazolidone Acrylate | |
ES8704153A1 (es) | Un procedimiento para preparar derivados de pirimidina | |
DE69327789D1 (de) | Verfahren zur umwandung von taxanen in baccatin iii und 10-desacetylbaccatin iii | |
ES8300735A1 (es) | Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos. | |
BR8704825A (pt) | Composicao a base de terras raras para estabilizar os combustiveis para motores diesel | |
GB1503272A (en) | Aromatic cyanic acid esters | |
AR245727A1 (es) | Ditiofosfato de metal y composicion y concentrado que lo comprenden. | |
ES264044A1 (es) | Un metodo de reducir la corrosiën de metal en contacto con un hidrocarburo y un corroyente acido | |
KR840003674A (ko) | N,n'-비스(트리플로로메틸설포닐)옥사이드류 및 이를 함유하는 화학루미네센스 조성물 | |
Rulev et al. | Direct Access to Cumbersome Aminated Quaternary Centers by Hyperbaric Aza‐Michael Additions | |
KR840005107A (ko) | 피리미디온 및 그의 산부가염의 제조방법 | |
ATE38984T1 (de) | Isocyanato-azetidin-dionen. | |
RU2115767C1 (ru) | Способ защиты стали от кислотной коррозии | |
BR0116146A (pt) | Processo para preparação de ácidos formilfenilborÈnicos | |
ES8104182A1 (es) | Procedimiento para preparar diaminas alquiladas | |
MX9304677A (es) | Procedimiento para la preparacion de compuestos defenol polihidrico. | |
SU1541200A1 (ru) | 1,3-Бис(2-гидроксифенил)адамантан в качестве антиоксиданта дл масел |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |