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AR014943A1 - Proceso para la preparacion de un compuesto que comprende un grupo cis-1,3 diol, una combinacion sinergica y un metodo para utilizarla. - Google Patents

Proceso para la preparacion de un compuesto que comprende un grupo cis-1,3 diol, una combinacion sinergica y un metodo para utilizarla.

Info

Publication number
AR014943A1
AR014943A1 ARP980106461A ARP980106461A AR014943A1 AR 014943 A1 AR014943 A1 AR 014943A1 AR P980106461 A ARP980106461 A AR P980106461A AR P980106461 A ARP980106461 A AR P980106461A AR 014943 A1 AR014943 A1 AR 014943A1
Authority
AR
Argentina
Prior art keywords
formula
compound
hydrogen
cis
alkyl
Prior art date
Application number
ARP980106461A
Other languages
English (en)
Original Assignee
Warner Lambert Exp Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Exp Ltd filed Critical Warner Lambert Exp Ltd
Publication of AR014943A1 publication Critical patent/AR014943A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/20—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Un proceso para la preparacion de un compuesto que contienen un grupo cis-1,3 diol de formula I: donde R es alquilo NC-CH2-, PG-O-CH2 donde PG es un grupoprotector formula IV donde pF es un sustituyente fluor en posicion para en el grupo fenilo; yR2 es (H3C)2CH- o ciclopropilo formula V donde R3 es C6H5,(H3C)2-N- o (H3C)2CH- y R4 es hidrogeno, H3C-O-CH2-, H3C-CH2-C(CH3)2-CO2CH2-, o H3C-O2C-CH2-CH-CH(OH)-CH2-CH(OH)-CH=CH-, formulas VI donde R5 es formulas VII,R6 es hidrogeno o CH3, R7 eshidroge no o CH3, R8 es hidrogeno, OH, CH3, o H5C6-NHCO-O-, y R9 es hidrogeno o CH3, formulas VIII, R1 es alquilo, o -CH2-CO2R6donde R6 es alquilo; que comprende: paso (a), tratar un compuesto de formula II o un compuesto de formula III donde R y R1son lo a ntes definido, con untrialquilborano y un dialquilalcoxiborano o una mezcla de un trialquilborano y un dialquilalcoxiborano en un solvente; paso (b), agregar un hidruro de metalalcalino a alrededor de -110sC a alrededor de -50sC; paso (c)concentrar la reaccion mediante destilacion para dar un compuesto de formula I y un destiladoque contiene especies alquilborano; y paso (d) tratar el compuesto adicional de formula I y un destilado que contiene especies alquilborano; y paso (d)tratarel compues to adicional de formula II o con el destilado del paso (c) que contiene especies alquilborano recuperadas y repetir los pasos (b) y (c) segun sedesee para dar compuesto adicional de formula I. Combinacion sinergética que comprendeun trialquilborano y un dialquilalcoxiborano de utilidad en dichoproceso y método para utilizar dicha combinacion sinergética segun dicho proceso para reducir selectivamente una beta-hidroxicetona a un cis-1,3-diol.
ARP980106461A 1997-12-19 1998-12-18 Proceso para la preparacion de un compuesto que comprende un grupo cis-1,3 diol, una combinacion sinergica y un metodo para utilizarla. AR014943A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6819397P 1997-12-19 1997-12-19

Publications (1)

Publication Number Publication Date
AR014943A1 true AR014943A1 (es) 2001-04-11

Family

ID=22081016

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980106461A AR014943A1 (es) 1997-12-19 1998-12-18 Proceso para la preparacion de un compuesto que comprende un grupo cis-1,3 diol, una combinacion sinergica y un metodo para utilizarla.

Country Status (31)

Country Link
US (4) US6433213B1 (es)
EP (1) EP1054860B1 (es)
JP (1) JP2001526256A (es)
KR (2) KR100668575B1 (es)
AR (1) AR014943A1 (es)
AT (1) ATE360608T1 (es)
AU (1) AU755543B2 (es)
BR (1) BR9813760A (es)
CA (1) CA2305618C (es)
CO (1) CO4990941A1 (es)
CU (1) CU22939A3 (es)
CY (1) CY1106612T1 (es)
DE (1) DE69837681T2 (es)
DK (1) DK1054860T3 (es)
ES (1) ES2284219T3 (es)
GT (2) GT199800197A (es)
HN (1) HN1998000187A (es)
HU (1) HUP0100252A3 (es)
IL (1) IL135562A (es)
IS (1) IS5447A (es)
MY (1) MY118726A (es)
NO (1) NO20003139D0 (es)
NZ (1) NZ504346A (es)
PA (1) PA8464901A1 (es)
PE (1) PE20000136A1 (es)
PL (1) PL193678B1 (es)
PT (1) PT1054860E (es)
SV (1) SV1998000153A (es)
TW (1) TW444000B (es)
WO (1) WO1999032434A1 (es)
ZA (1) ZA9811586B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU780247B2 (en) 1999-12-17 2005-03-10 Pfizer Science And Technology Ireland Limited A process for producing crystalline atorvastatin calcium
IL149087A0 (en) 1999-12-17 2002-11-10 Warner Lambert Res & Dev Ie A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium
US7521216B2 (en) * 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
SK287922B6 (sk) * 2001-04-05 2012-04-03 Nissan Chemical Industries, Ltd. Method for preparing a 7-qunolinyl-3,5-dihydroxyhept-6-enoate
IL159719A0 (en) * 2001-07-06 2004-06-20 Teva Pharma Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
SK792004A3 (sk) * 2001-07-06 2005-03-04 Teva Pharmaceutical Industries Ltd. Syntéza a medziprodukty derivátov 3,5-dihydroxyheptánovej kyseliny
GB0211715D0 (en) * 2002-05-22 2002-07-03 Phoenix Chemicals Ltd Process
AU2003251523A1 (en) 2002-06-13 2003-12-31 Diversa Corporation Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
JP4578240B2 (ja) * 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
ES2323366T3 (es) * 2003-04-22 2009-07-14 Biocon Limited Procedimiento novedoso para la reduccion estereoselectiva de beta-cetoesteres.
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
MXPA06001719A (es) * 2003-08-11 2006-05-19 Codexis Inc Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados.
WO2005018579A2 (en) * 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
AU2004265693A1 (en) 2003-08-11 2005-02-24 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7629157B2 (en) * 2003-08-11 2009-12-08 Codexis, Inc. Ketoreductase polypeptides and related polynucleotides
JP2007505885A (ja) * 2003-09-17 2007-03-15 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー ［Ｒ−（Ｒ＊，Ｒ＊）］−２−（４−フルオロフェニル）−β，δ−ジヒドロキシ−５−（１−メチルエチル）−３−フェニル−４−［（フェニルアミノ）カルボニル］−１Ｈ−ピロール−１−ヘプタン酸の結晶性形態
US7557238B2 (en) * 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20050159615A1 (en) * 2003-12-24 2005-07-21 Entire Interest. Process for preparation of statins with high syn to anti ratio
MXPA06011987A (es) * 2004-04-16 2007-01-16 Pfizer Prod Inc Procedimiento para formar calcio de atorvastatina amorfa.
CA2564030C (en) 2004-05-05 2010-06-08 Pfizer Products Inc. Salt forms of [r-(r*, r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
HUE029911T2 (en) * 2004-07-16 2017-04-28 Lek Pharmaceuticals Products of atorvastatin calcium oxidative degradation
US8026376B2 (en) 2004-07-20 2011-09-27 Pfizer, Inc. Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoicacid calcium salt (2:1)
EP1807055A1 (en) 2004-10-28 2007-07-18 Warner-Lambert Company LLC Process for forming amorphous atorvastatin
WO2006059224A1 (en) * 2004-12-02 2006-06-08 Warner-Lambert Company Llc Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
WO2007029217A1 (en) * 2005-09-09 2007-03-15 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate
JP2009507821A (ja) * 2005-09-09 2009-02-26 ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド アトルバスタチン中間体の調製
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
PT1957452E (pt) * 2005-11-21 2010-05-25 Warner Lambert Co Novas formas de ácido [r-(r*,r*)]-2-(4-fluorofenil)-b,b--di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico magnésico
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
CA2679503A1 (en) 2007-03-01 2008-09-04 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
WO2009137691A2 (en) * 2008-05-09 2009-11-12 The Scripps Research Institute 1,3-diol synthesis via controlled, radical-mediated c-h functionalization
WO2010080635A2 (en) 2008-12-18 2010-07-15 Codexis, Inc. Recombinant halohydrin dehalogenase polypeptides
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
US9273158B2 (en) 2011-05-16 2016-03-01 The Regents Of The University Of California Methods for production of hydrocarbons and oxygen-containing hyrdrocarbons
US20140335179A1 (en) 2011-07-01 2014-11-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Micronized crystals of atorvastatin hemicalcium
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN111978286A (zh) * 2020-08-21 2020-11-24 江苏万年长药业有限公司 一种制备ats-8的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR64043B (en) * 1977-10-01 1980-01-19 Expansia Sa Borane complexes
DE2912708A1 (de) 1979-03-30 1980-10-09 Basf Ag Datenspeichersystem und magnetscheiben dafuer
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
US4645854A (en) * 1985-04-25 1987-02-24 Merck & Co., Inc. Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
US4898949A (en) * 1987-02-25 1990-02-06 Bristol-Myers Company Intermediates for the preparation of antihypercholesterolemic tetrazole compounds
US4897490A (en) * 1987-02-25 1990-01-30 Bristol-Meyers Company Antihypercholesterolemic tetrazole compounds
DE3741509A1 (de) 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
US5001144A (en) * 1987-12-21 1991-03-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
DE3929507A1 (de) * 1989-09-06 1991-03-07 Bayer Ag Substituierte amino-pyridine
US5039802A (en) 1990-04-18 1991-08-13 Merck & Co., Inc. Arylation process for preparation of chiral catalysts for ketone reduction
JP3528186B2 (ja) * 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5218138A (en) * 1992-09-02 1993-06-08 Rhone-Poulenc Rorer Pharmaceuticals Inc. Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
NZ504346A (en) 2001-11-30
IL135562A (en) 2005-08-31
ES2284219T3 (es) 2007-11-01
US6962994B2 (en) 2005-11-08
US20020161021A1 (en) 2002-10-31
DE69837681D1 (de) 2007-06-06
KR100668575B1 (ko) 2007-01-17
CA2305618A1 (en) 1999-07-01
US20040006231A1 (en) 2004-01-08
KR100681366B1 (ko) 2007-02-12
CY1106612T1 (el) 2012-01-25
DE69837681T2 (de) 2008-01-10
PL341294A1 (en) 2001-04-09
IS5447A (is) 2000-04-14
ZA9811586B (en) 1999-06-17
AU1707499A (en) 1999-07-12
HUP0100252A3 (en) 2002-12-28
TW444000B (en) 2001-07-01
KR20010033315A (ko) 2001-04-25
BR9813760A (pt) 2000-10-03
CU22939A3 (es) 2004-04-13
PL193678B1 (pl) 2007-03-30
US20050197500A1 (en) 2005-09-08
US6596879B2 (en) 2003-07-22
NO20003139L (no) 2000-06-16
JP2001526256A (ja) 2001-12-18
CA2305618C (en) 2004-08-17
PE20000136A1 (es) 2000-03-11
DK1054860T3 (da) 2007-07-02
US6433213B1 (en) 2002-08-13
US7232915B2 (en) 2007-06-19
HUP0100252A1 (hu) 2001-07-30
AU755543B2 (en) 2002-12-12
CO4990941A1 (es) 2000-12-26
NO20003139D0 (no) 2000-06-16
WO1999032434A1 (en) 1999-07-01
GT199800197A (es) 2000-06-06
EP1054860A1 (en) 2000-11-29
MY118726A (en) 2005-01-31
ATE360608T1 (de) 2007-05-15
EP1054860B1 (en) 2007-04-25
PT1054860E (pt) 2007-06-22
KR20060080941A (ko) 2006-07-11
PA8464901A1 (es) 2000-05-24
SV1998000153A (es) 1999-09-30
HN1998000187A (es) 1999-10-22
GT199800197AA (es) 2000-06-06
IL135562A0 (en) 2001-05-20

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